4318-56-3, Name is 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione, molecular formula is C5H5ClN2O2, Application In Synthesis of 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione, belongs to pyrimidines compound, is a common compound. In a patnet, author is Lee, Won Dong, once mentioned the new application about 4318-56-3.
Tumor Reliance on Cytosolic versus Mitochondrial One-Carbon Flux Depends on Folate Availability
Folate metabolism supplies one-carbon (1C) units for biosynthesis and methylation and has long been a target for cancer chemotherapy. Mitochondrial serine catabolism is considered the sole contributor of folate-mediated 1C units in proliferating cancer cells. Here, we show that under physiological folate levels in the cell environment, cytosolic serine-hydroxymethyltransferase (SHMT1) is the predominant source of 1C units in a variety of cancers, while mitochondrial 1C flux is overly repressed. Tumor-specific reliance on cytosolic 1C flux is associated with poor capacity to retain intracellular folates, which is determined by the expression of SLC19A1, which encodes the reduced folate carrier (RFC). We show that silencing SHMT1 in cells with low RFC expression impairs pyrimidine biosynthesis and tumor growth in vivo. Overall, our findings reveal major diversity in cancer cell utilization of the cytosolic versus mitochondrial folate cycle across tumors and SLC19A1 expression as a marker for increased reliance on SHMT1.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 4318-56-3 help many people in the next few years. Application In Synthesis of 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione.
Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia