Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 626-48-2, Name is 6-Methylpyrimidine-2,4(1H,3H)-dione. In a document, author is Zhou, Qian, introducing its new discovery. Category: pyrimidines.
Detection of 5-Formylpyrimidines in DNA Based on Chemoselective Labeling
In addition to the four canonical nucleobases of A, G, T and C, hundreds of chemical modifications have been identified in genome DNA. Among them, 5-formylpyrimidines, including 5-formylcytosine (5fC) and 5-formyluracil (5fU) , are naturally occurring pyrimidine-covalent-modifications and are widely distributed in mammalian cells. Emerging evidence indicates that 5fC not only serves as a key intermediate in active DNA demethylation but also carry independent epigenetic significance; while 5fU was always considered to be an oxidative DNA lesion with high genotoxicity. In order to further understand their regulatory functions , it is necessary to develop accurate, sensitive and facile methods for qualitative, quantitative, and localized detection of 5-formylpyrimidines in the whole genome. In this review, we summarized the recent progress in detecting 5-formylpyrimidines from the perspective of selective chemical labeling.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 626-48-2 help many people in the next few years. Category: pyrimidines.
Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia