With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3977-29-5, name is 2-Amino-6-methylpyrimidin-4(1H)-one, molecular formula is C5H7N3O, molecular weight is 125.13, as common compound, the synthetic route is as follows.Quality Control of 2-Amino-6-methylpyrimidin-4(1H)-one
A. 2-Amino-4-methyl-6-benzyloxypyrimidine 2-Amino-4-methyl-6-hydroxypyrimidine (62.5 g., 0.50 mole) is dissolved in 500 ml of dimethylformamide and sodium hydride (0.5 mole) is added over a 1 hour period under a nitrogen atmosphere. The mixture is heated at 75¡ã C. for 11/2 hours. Benzyl chloride (69.3 g., 0.55 moles) is then added over 15 minutes and the mixture is heated at 90¡ã C. and stirred for 11/2 hours. After cooling, the reaction mixture is filtered and concentrated under vacuum to an oil from which 2-amino-4-methyl-6-benzyloxypyrimidine melting at 108¡ã-109.5¡ã C. is obtained by crystallization from n-butyl chloride.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,3977-29-5, 2-Amino-6-methylpyrimidin-4(1H)-one, and friends who are interested can also refer to it.
Reference:
Patent; Merck & Co., Inc.; US4144338; (1979); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia