Related Products of 2927-71-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2927-71-1, name is 2,4-Dichloro-5-fluoropyrimidine, molecular formula is C4HCl2FN2, molecular weight is 166.9685, as common compound, the synthetic route is as follows.
A solution of morpholine(870 mg, 10 mmol) in 10 mL EtOH was added slowly to a cooled solution of 18 (1.84g,11 mmol) and K2CO3 (2.76 g, 20 mmol) in EtOH (30 mL), and the mixture wasstirred for about 30 min at 0oC. Stirring was continued for 4h at room temperature andthe reaction was monitored by TLC. The reaction mixture was concertrated, dilutedwith ethyl acetate, washed, intandem, with water and brine. The organic phase wasdried, filtered and concentratedin vacuo to give the title compound (1.87 g) which wasused in the next step without further purification, yield 86%.
The chemical industry reduces the impact on the environment during synthesis 2927-71-1, I believe this compound will play a more active role in future production and life.
Reference:
Article; Wu, Xiaoai; Fang, Zhen; Yang, Bo; Zhong, Lei; Yang, Qiuyuan; Zhang, Chunhui; Huang, Shenzhen; Xiang, Rong; Suzuki, Takayoshi; Li, Lin-Li; Yang, Sheng-Yong; Bioorganic and Medicinal Chemistry Letters; vol. 26; 9; (2016); p. 2284 – 2288;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia