Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31462-54-1, name is 2-Iodopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. name: 2-Iodopyrimidine
To a solution of 2-iodopyrimidine (100 mg, 0.48 mmol, 1 eq) in dioxane (2 mL) and H20 (0.4 mL) were added CS2CO3 (316 mg, 0.97 mmol, 2 eq), Pd(PPh3) (28 mg, 24.2 umol, 0.05 eq) and methyl 3-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-4-((4- (trifluoromethyl)phenyl)amino)benzoate (245.4 mg, 0.58 mmol, 1.2 eq). The mixture was stirred at 90C for 16 hr. The reaction mixture was concentrated in vacuum and the residue was diluted with EA (20 mL), washed with brine (5 mL), dried over Na2S04, filtered and concentrated in vacuum. The crude product was purified by prep-HPLC to give the title compound (33 mg, 90.9 umol, 18.7% yield). Mass calcd. For CI8HI2F3N302, 359.09 m/z found 359.8 [M+H] +. 1H NMR (400 MHz, DMS0 ) d 12.68 (br s, 1H), 11.64 (s, 1H), 9.15 (d, J= 2.0 Hz, 1H), 9.01 (d, J= 5.0 Hz, 2H), 7.93 (dd, J= 2.0, 8.8 Hz, 1H), 7.70 (d, J= 8.5 Hz, 2H), 7.55 – 7.49 (m, 4H).
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Reference:
Patent; VIVACE THERAPEUTICS, INC.; KONRADI, Andrei, W.; LIN, Tracy, Tzu-Ling Tang; (238 pag.)WO2019/113236; (2019); A1;,
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