Related Products of 59989-18-3 ,Some common heterocyclic compound, 59989-18-3, molecular formula is C6H4N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
EXAMPLE 8 2′-Deoxy-5-ethynyl-4′-thiouridine Starting with 5-ethynyluracil, this compound was prepared in a similar manner to that described in Example 5. 5ethynyluracil may be prepared from 5-ioduracil using the methodology analogous to that described by M. J. Robins et al (ibid). A sample of the pure beta-anomer of this compound was obtained by boiling the crude anomer mixture with MeOH and filtering off the product. 1 H-200 MHz NMR DMSO-d6 delta:11.6 (br s, 1H, NH); 8.42 (s, 1H, beta-6-H); 6.23(t, 1H, beta-1′-H); 5.1-5.35 (m, 2H, beta-3’+5′-OH); 4.25-4.45 (m, 1H, beta-3′-H); 4.15 (s, 1H CH); 3.55-3.75 (m,2H, beta-5′-H); 3.1-3.5 (beta-4’H, obscured by DOH); 2.1-2.4 (m,2H, beta-5′-H2). Mass spectrum: observed m/z 268 for C11 H11 N2 O4 S.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,59989-18-3, its application will become more common.
Reference:
Patent; University of Birmingham; US5356882; (1994); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia