A new synthetic route of 4-Chloro-5-fluoropyrimidine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,347418-42-2, 4-Chloro-5-fluoropyrimidine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.347418-42-2, name is 4-Chloro-5-fluoropyrimidine, molecular formula is C4H2ClFN2, molecular weight is 132.52, as common compound, the synthetic route is as follows.Application In Synthesis of 4-Chloro-5-fluoropyrimidine

1) Pyridinium chlorochromate,Sodium ferrate,Phosphoric acid and tetrabutylammonium chloride are added to the water,Pass argon as a protective gas,Then heated to 120 C as reactant A;Dissolving 4-chloro-5-fluoropyrimidine in DMSO as reactant B;Maintain 120 C and protective gas conditions,Passing reactant A to drop B into A,Control the dropping time to 60min,After the completion of the dropwise addition, the system was further heated to 140 C.The reaction was completed at 4.5 h.The ratio of each material in the reaction is 4-chloro-5-fluoropyrimidine,Chlorination reagent,Ferrate,The ratio of acid to quaternary ammonium salt is 1:1.04:1.16:0.009:0.014;4-chloro-5-fluoropyrimidine and water,The amount ratio of disulfoxide was: 1 mmol: 2.2 ml: 1.4 ml.2) After cooling the system, the solid is removed by filtration.Then extracted with ethyl acetate,After washing and concentrating, a crude product is obtained.Decompression distillation gives a pure product,The yield was 97.5%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,347418-42-2, 4-Chloro-5-fluoropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Shandong Nong Pharmaceutical Xue Institute; Jinan Kehai Co., Ltd.; Fu Hongxin; Yang Chaohui; Wang Ling; (5 pag.)CN108997222; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia