Adding a certain compound to certain chemical reactions, such as: 4489-34-3, 4,6-Dichloro-2-methylsulfonylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 4,6-Dichloro-2-methylsulfonylpyrimidine, blongs to pyrimidines compound. Recommanded Product: 4,6-Dichloro-2-methylsulfonylpyrimidine
General procedure: The general synthetic route for the preparation of tozasertib (a-d) and tozasertib analogs (B: a, e-g; A: a, h-j) is shown in Fig. 1. Reagents and conditions: (a) 3-chloroperoxybenzoic acid, DCM, rt, 3h; (b) N-(4- mercaptophenyl)cyclopropanecarboxamide, TEA, CH3CN, 80 C, 3-1 Oh; (c) 5-methyl- 1 H-pyrazol-3-amine, DIPEA, DMF, 95 C, 16h; (d) amine (1-methylpiperazine or morpholine), DMF, DIPEA, 90 C, 6-12h; (e) corresponding thiol, TEA, CH3CN, 80 C, 3-1 Oh; (f) 5-methyl-1 H-pyrazol-3-amine, DIPEA, dioxane, 95 C, 3-6 h, (g) amine (1-methylpiperazine or morpholine), DMF, DIPEA, 90 C, 6-12h; (h) thiophenol, TEA, THF, 50 C; (i) corresponding amine, DIPEA, dioxane, 95 C, 3-6 h; (j) amine (1- methylpiperazine or morpholine), DMF, DIPEA, 90 C, 6-12h. (0097) The structures and batch purities (>90%) of the compounds have been confirmed by using standard analytical methods (LC/MS and NMR).
The synthetic route of 4489-34-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BIOMED X GMBH; SAMEH, Eid; FULLE, Simone; MERGET, Benjamin; TURK, Samo; (43 pag.)WO2019/101843; (2019); A1;,
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