Design, synthesis, spectral analysis and in vitro microbiological evaluation of 2-phenyl-3-(4,6-diarylpyrimidin-2-yl)thiazolidin-4-ones was written by Gopalakrishnan, M.;Thanusu, J.;Kanagarajan, V.. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2009.Formula: C16H13N3 This article mentions the following:
A series of novel 2-phenyl-3-(4,6-diarylpyrimidin-2-yl)thiazolidin-4-ones were synthesized. Their in vitro antibacterial and antifungal activities against clin. isolated strains were studied. Generally compounds possessing electron donating groups showed good antibacterial activity. Compound I containing both electron withdrawing chloro and electron donating Me groups showed potent activity against all the tested Gram pos. and Gram neg. bacterial strains whereas compounds containing electron donating methoxy functional group at the para position of the Ph ring attached to pyrimidine ring showed promising activity against S.aureus, S.typhii and E.coli. Compounds containing electron withdrawing groups (-Cl, -F) showed excellent activities against all the tested A. flavus, Mucor, Rhizopus and M.gypsuem fungal strains. Also compound I showed potent activity against A. flavus and Rhizopus. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Formula: C16H13N3).
4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Formula: C16H13N3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia