Adding a certain compound to certain chemical reactions, such as: 5750-76-5, 2,4,5-Trichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5750-76-5, blongs to pyrimidines compound. 5750-76-5
(0225) To a solution of 27-4 in DMF at 0 C was added 60% NaH (2.6 g, 66.8 mmol). After stirring at 0 C for 1 h, a solution of 2,4,5-trichloro-pyrimidine (1.91 mL g, 16.7 mmol) in DMF (20 mL) was added dropwise. After stirring at 0 C for 3 hr, the reaction mixture was quenched with a saturated aqueous solution of NH4Cl. The reaction mixture was partitioned between EtOAc (200 mL) and water (200 mL). The organic layer was washed with water (3 ¡Á 50 mL), brine (1 ¡Á 50 mL), dried (MgSO4), filtered, and concentrated to give the crude compound which was purified by silica gel chromatography (20% EtOAc in hexanes) to provide 27-5. MS (ESI): mass calculated for C13H13Cl2N3O2S, 346.2; m/z found 346.1 [M]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5750-76-5, its application will become more common.
Reference:
Patent; Sunesis Pharmaceuticals, Inc.; HANSEN, Stig; ERLANSON, Dan; CANCILLA, Mark; EP2257637; (2015); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia