Inhibitory effects of antiherpesviral thymidine analogs against varicella-zoster virus was written by Machida, Haruhiko; Kuninaka, Akira; Yoshino, Hiroshi. And the article was included in Antimicrobial Agents and Chemotherapy on February 28,1982.Synthetic Route of C10H13FN2O5 The following contents are mentioned in the article:
Thymidine analogs highly active against herpes simplex virus were compared in their inhibitory action against 7 strains of varicella-zoster virus by a plaque reduction assay. E-5-bromovinyl-arabinosyluracil (I) [77181-69-2] was most active, followed by E-5-chlorovinyl-arabinosyluracil [77181-70-5], E-5-bromovinyl-2′-deoxyuridine (II) [69304-47-8], 2′-fluoro-5-methyl-arabinosyluracil [69256-17-3], 2′-fluoro-5-iodo-arabinosylcytosine [69123-90-6], arabinosylthymine [605-23-2], 5-vinyl-arabinosyluracil [74886-33-2], acycloguanosine [59277-89-3], and 5-iodo-2′-deoxyuridine [54-42-2], in order of decreasing activity. I was >10-fold as active as II and almost completely inhibited plaque development of 5 strains of varicella-zoster virus at a concentration as low as 1 ng/mL. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Synthetic Route of C10H13FN2O5).
1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Synthetic Route of C10H13FN2O5
69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3