Therapeutic activities of 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)-5-iodocytosine and -thymine alone and in combination with acyclovir and vidarabine in mice infected intracerebrally with herpes simplex virus was written by Schinazi, Raymond F.; Peters, Jeanne; Sokol, M. Kathleen; Nahmias, Andre J.. And the article was included in Antimicrobial Agents and Chemotherapy on July 31,1983.Electric Literature of C10H13FN2O5 The following contents are mentioned in the article:
The therapeutic effectiveness of 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)-5-iodocytosine (I) [69123-90-6] and 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)thymine (II) [69256-17-3] was compared with that of acyclovir  [59277-89-3] and vidarabine  [5536-17-4]. In mice inoculated intracerebrally with high 50% LDs of herpes simplex virus type 2, nontoxic i.p. or oral treatments with the 2 new fluorinated antiviral agents were highly effective in reducing mortality. The 2 drugs were also effective when treatment was begun as late as 48 h after virus inoculation. The relative order of potencies of the drugs when compared on a molar basis or in terms of therapeutic index was II â?I > vidarabine â?acyclovir. The new pyrimidine analogs were also found to lack immunosuppressive activity in mice. The combination of I and vidarabine was the most effective; significantly greater reduction in mortality was achieved with this combination than with either drug alone. Thirty minutes after i.p. treatment with the fluorinated analogs, the drugs (or their metabolites) were transported to the brains of virus-inoculated and normal mice at levels about 1/3rd to 2/3rds those in the blood. The levels of II in the blood or brain were consistently higher than those found with equivalent i.p. doses of I. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Electric Literature of C10H13FN2O5).
1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Electric Literature of C10H13FN2O5
69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3