On March 18, 2016, Carson, Spencer; Wilson, James; Aksimentiev, Aleksei; Weigele, Peter R.; Wanunu, Meni published an article.Safety of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione The title of the article was Hydroxymethyluracil modifications enhance the flexibility and hydrophilicity of double-stranded DNA. And the article contained the following:
Oxidation of a DNA thymine to 5-hydroxymethyluracil is one of several recently discovered epigenetic modifications. Here, we report the results of nanopore translocation experiments and mol. dynamics simulations that provide insight into the impact of this modification on the structure and dynamics of DNA. When transported through ultrathin solid-state nanopores, short DNA fragments containing thymine modifications were found to exhibit distinct, reproducible features in their transport characteristics that differentiate them from unmodified mols. Mol. dynamics simulations suggest that 5-hydroxymethyluracil alters the flexibility and hydrophilicity of the DNA mols., which may account for the differences observed in our nanopore translocation experiments The altered physico-chem. properties of DNA produced by the thymine modifications may have implications for recognition and processing of such modifications by regulatory DNA-binding proteins. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Safety of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione
The Article related to dna hydroxymethyluracil flexibility hydrophilicity nanopore translocation mol dynamics simulation, General Biochemistry: Nucleic Acids and Their Constituents and other aspects.Safety of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia