On May 31, 2021, Tang, Lei published an article.Recommanded Product: 4433-40-3 The title of the article was Walking through chromatin modifications. And the article contained the following:
The Cell-TALKING technique probes DNA modifications around a histone modification in fixed cells. Chromatin is a highly organized structure composed of repeating DNA-histone complexes decorated with DNA modifications and histone post-translational modifications (PTMs). To study the composition of chromatin modifications, Zhao’s lab developed Cell-TALKING, a method that leverages DNA walking to index one-to-many combinations of a histone modification with various DNA modifications within a 10-nm nanoenvironment. In Cell-TALKING, the PTM target site is labeled with a DNA walking probe (WP), and DNA modifications including 5-hydroxymethyluracil (5hmU), 5-hydroxymethylcytosine (5hmC) and 5-formyluracil (5fU) are labeled with unique barcoding probes (BPs) that are inactivated with blocked 3′ ends. The researchers applied Cell-TALKING to study the changes in chromatin modifications during the cell cycle and identified combinations of DNA modifications and histone modifications near each other. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Recommanded Product: 4433-40-3
The Article related to cell talking chromatin modification, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.Recommanded Product: 4433-40-3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia