On June 30, 2018, Kataev, V. A.; Meshcheryakova, S. A.; Meshcheryakova, E. S.; Tyumkina, T. V.; Khalilov, L. M.; Lazarev, V. V.; Kuznetsov, V. V. published an article.HPLC of Formula: 626-48-2 The title of the article was Direction of the Reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione with 2-Chloromethylthiirane: N1- or N3-Thietanyl Derivative. And the article contained the following:
The reaction of 6-methylpyrimidine-2,4(1H,3H)-dione with 2-chloromethylthiirane gave 6-methyl-N-thietan-3-ylpyrimidine-2,4(1H,3H)-dione. Its oxidation and subsequent reaction of the resulting N-1,1-dioxo-λ6-thietan-3-yl derivative with Et chloroacetate afforded the corresponding Et pyrimidinylacetate. The structure of the latter was determined by X-ray anal., which confirmed the formation of N3-thietan-3-yl derivative rather than its N1-substituted isomer in the title reaction. According to the results of B3LYP/6-31G++d,p, PBE/3ζ, MP2/6-31G++d,p quantum chem. calculations, the N3-thietanyl derivative is more stable than the N1-isomer. It was also found that the calculated barrier to internal rotation of the thietanyl group about the N-C bond in 6-methyl-3-thietan-3-yl-pyrimidine-2,4(1H,3H)-dione is lower than in the N1-isomer. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).HPLC of Formula: 626-48-2
The Article related to methyl thietanylpyrimidine dione preparation, chloromethylthiirane methylpyrimidine dione, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.HPLC of Formula: 626-48-2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia