On March 18, 2021, Minchinton, Andrew Ivor; Kyle, Alastair Hugh; Evans, James; Mann, Samuel Edward; Hynd, George published a patent.SDS of cas: 944129-00-4 The title of the patent was 1,6-Naphthridine derivatives as DNA-PK inhibiting compounds and prodrugs. And the patent contained the following:
The present disclosure relates to DNA-PK inhibiting compounds of formula I and prodrugs thereof that are useful in the treatment of diseases, including cancer, by sensitizing cancers to therapies such as chemotherapy and radiotherapy and the preparation of such compounds Compound I, wherein Y is O and NR5; each R1 is independently C1-6 alkyl and C1-6 haloalkyl; R2 is H, C1-6 alkyl, C1-6 haloalkyl, etc.; each R3 is independently halo, cyano, C1-6 alkyl, R4 is L1L2R9a, etc.; R5 is independently H, C1-6 alkyl, etc.; L1 is independently absent and (un)substituted C1-6 alkylene; L2 is absent and L3L4; L3 is (un)substituted C1-6 alkylene, (un)substituted C3-6 cycloalkyl, (un)substituted 3- to 11-membered heterocycloalkyl, etc.; L4 is absent, NR13a and O; R9a are Ph, naphthyl, 3- to 8-membered heterocycloalkyl, etc.; R13a is H and C1-6 alkyl; n is 0, 1, 2 and 3; m is 0, 1, 2, 3 and 4; and prodrug, pharmaceutically acceptable salts and N-oxide of compound I and prodrug thereof, are claimed. Compound II was prepared using a multistep procedure (procedure given). Compound II was evaluated for DNA-PK inhibition yielding an IC50 of 82 nM using ADP-Glo and 832 nM using MSD FaDu. The experimental process involved the reaction of Methyl 6-amino-2-chloropyrimidine-4-carboxylate(cas: 944129-00-4).SDS of cas: 944129-00-4
The Article related to naphthridine preparation dna pk inhibition cancer, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.SDS of cas: 944129-00-4
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia