Pelclova, Daniela; Zdimal, Vladimir; Schwarz, Jaroslav; Dvorackova, Stepanka; Komarc, Martin; Ondracek, Jakub; Kostejn, Martin; Kacer, Petr; Vlckova, Stepanka; Fenclova, Zdenka; Popov, Alexey; Lischkova, Lucie; Zakharov, Sergey; Bello, Dhimiter published an article in 2018, the title of the article was Markers of oxidative stress in the exhaled breath condensate of workers handling nanocomposites.Formula: C5H6N2O3 And the article contains the following content:
This study investigated airway oxidative stress status in the exhaled breath condensate (EBC). Nineteen employees (42.4 ± 11.4 y/o), working in nanocomposites research for 18.0 ± 10.3 years were examined pre-shift and post-shift on a random workday, together with nineteen controls (45.5 ± 11.7 y/o). Panels of oxidative stress biomarkers derived from lipids, nucleic acids, and proteins were analyzed in the EBC. Aerosol exposures were monitored during three major nanoparticle generation operations: smelting and welding (workshop 1) and nanocomposite machining (workshop 2) using a suite of real-time and integrated instruments. Mass concentrations during these operations were 0.120, 1.840, and 0.804 mg/m3, resp. Median particle number concentrations were 4.8 × 104, 1.3 × 105, and 5.4 × 105 particles/cm3, resp. Nanoparticles accounted for 95, 40, and 61%, resp., with prevailing Fe and Mn. All markers of nucleic acid and protein oxidation, malondialdehyde, and aldehydes C6-C13 were elevated, already in the pre-shift samples relative to controls in both workshops. Significant associations were found between working in nanocomposite synthesis and EBC biomarkers. More research is needed to understand the contribution of nanoparticles from nanocomposite processing in inducing oxidative stress, relative to other co-exposures generated during welding, smelting, and secondary oxidation processes, in these workshops. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Formula: C5H6N2O3
The Article related to exhaled breath condensate oxidative stress nanocomposite, exhaled breath condensate, inhalation, nanocomposites, nanoparticles, occupational exposure, oxidative stress, workers and other aspects.Formula: C5H6N2O3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia