The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Computed Properties of 109-12-6.
Zheng, You-Guang;Wang, Jin-An;Meng, Long;Pei, Xin;Zhang, Ling;An, Lin;Li, Cheng-Lin;Miao, Ying-Long research published 《 Design, synthesis, biological activity evaluation of 3-(4-phenyl-1H-imidazol-2-yl)-1H-pyrazole derivatives as potent JAK 2/3 and aurora A/B kinases multi-targeted inhibitors》, the research content is summarized as follows. A series of 3-(4-phenyl-1H-imidazol-2-yl)-1H-pyrazole I[R1 = 1-pyrrolidinyl, 1-piperidyl, morpholino; R2 = benzoyl, 4-methoxybenzoyl, 4-nitrobenzoyl, etc.] were designed, synthesized, and evaluated for their biol. activities was studied. Upon performing kinase assays, most of the compounds exhibited potent inhibition against JAK2/3 and Aurora A/B with the IC50 values ranging from 0.008 to 2.52μM. Among these derivatives, compound I [R1 = morpholino; R2 =3-chlorobenzoyl] expressed the most moderate inhibiting activities against all the four kinases with the IC50 values of 0.166μM (JAK2), 0.057μM (JAK3), 0.939μM (Aurora A), and 0.583μM (Aurora B), resp. Moreover, most of the derived compounds exhibited potent cytotoxicity against human chronic myeloid leukemia cells K562 and human colon cancer cells HCT116, while compound I[R1 = morpholino; R2 =3-chlorobenzoyl] expressed antiproliferative activities against K562 (IC50=6.726μM). According to western blot anal., compound I[R1 = morpholino; R2 =3-chlorobenzoyl] down-regulated the phosphorylation of STAT3, STAT5, Aurora A, and Aurora B in a dose-dependent manner in K562 and HCT116 cells. Cell cycle anal. revealed that compound I[R1 = morpholino; R2 =3-chlorobenzoyl] inhibited the proliferation of cells by inducing cell cycle arrest in the G2 phase. The mol. modeling suggested that compound I[R1 = morpholino; R2 =3-chlorobenzoyl] maintained a binding mode similar to the binding mode of AT9832, a common JAK 2/3 and Aurora A/B kinases multi-target kinase inhibitor. Therefore, compound I[R1 = morpholino; R2 =3-chlorobenzoyl] was a potential agent for cancer therapy deserving further research.
Computed Properties of 109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia