As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1193-21-1, name is 4,6-Dichloropyrimidine, molecular formula is C4H2Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 4,6-Dichloropyrimidine
Weigh 2 ‘, 3′, 4’-trisubstituted phenylboronic acid 28 (0.016 mol)4,6-dichloropyrimidine 2.458 (0.016 mol), tetrakis (triphenyl-palladium 0.2 g and anhydrous sodium carbonate 3.0 g were placed in a 120 mL sealed tube,With tetrahydrofuran 20 mLwithDeionized water 20mL of the mixed solution as a solvent placed in the tube, add a stir, cover the stopper.The entire device vacuum nitrogen nitrogen replacement 3 ~ 4 times, placed in the oil bath pot,The mixture was heated to 120 C for about 8 h with stirring on a magnetic stirrer.After completion of the reaction, the sealing tube was cooled to room temperature,The solution in the sealed tube was placed in a rotary vial, and the tetrahydrofuran solvent was distilled off under reduced pressure by rotary evaporator.And then extracted with ethyl acetate and water organic products 3 ~ 4 times, vacuum distillation solvent,The spheroidized product was separated by column chromatography using petroleum ether: dichloromethane = 2: 1 to give about 1.13 g of white powder (4-chloro-6-phenylpyrimidine) in 36.3%
With the rapid development of chemical substances, we look forward to future research findings about 1193-21-1.
Reference:
Patent; Anhui University of Technology; Tong Bihai; He Yuheng; Liu Yuanyuan; Jin Long; Zuo Dashuai; Wang Song; (25 pag.)CN106632488; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia