Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5750-76-5, name is 2,4,5-Trichloropyrimidine. A new synthetic method of this compound is introduced below., COA of Formula: C4HCl3N2
2-Amino-N-methylbenzamide 10 was prepared according tothe general procedure in literature 19. The prepared 2-amino-Nmethylbenzamide10 (10.00 g, 66.67 mmol) was added in one portionto 2,4,5-trichloropyrimidine (12.23 g, 66.67 mmol) and N,Ndiisopropylethylamine(DIPEA) (12.93 g, 100 mmol) in isopropanol(100 mL). The resulting mixture was stirred at 80 C for 6 h. Themixture was evaporated to dryness. The organic phase was evaporatedto dryness and the residue was recrystallised from MeCN/water 20:1 to yield 2-(2,5-dichloropyrimidin-4-ylamino)-Nmethylbenzamide16.87 g, 85%.
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Reference:
Article; Qu, Menghua; Liu, Zhihao; Zhao, Dan; Wang, Changyuan; Zhang, Jianbin; Tang, Zeyao; Liu, Kexin; Shu, Xiaohong; Yuan, Hong; Ma, Xiaodong; Bioorganic and Medicinal Chemistry; vol. 25; 15; (2017); p. 3989 – 3996;,
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