Electric Literature of 3680-69-1, Adding some certain compound to certain chemical reactions, such as: 3680-69-1, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine,molecular formula is C6H4ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3680-69-1.
A mixture of compound Int-4-1 (14.5 g, 94.42 mmol, 1 eq.) and Selectfluor (50.17 g, 141.63 mmol, 1.5 eq.) was addedACN (725 mE),AcOH (152.25 g, 2.54 mol, 145 mE, 26.85 eq.) and degassed and purged with N2 for 3 times, and then the mixture was stirred at 70 C. for 16 hr under N2 atmosphere. ECMS showed no compound Int-4-1 was remained. Several new peaks were shown on ECMS and 45% of desired compound was detected. The reaction mixture was concentrated under reduced pressure to remove solvent. The residue was diluted with toluene (200 mE) and concentrated under reduced pressure to remove solvent twice. The residue was purified by column chromatography (Si02, petroleum ether/ethyl acetate=30/1 to 8/1) to give compound Int-4 (10 g, 54.46 mmol, 57.68% yield, ECMS purity 93.43%) as a yellow solid. ?H NMR (400 MHz, DMSO-d5) oe ppm 12.49 (br s, 1H) 8.55-8.67 (m, 1H) 7.71 (t, J=2.63 Hz, 1H); ECMS: (M+Hj: 171.9.
According to the analysis of related databases, 3680-69-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Prelude Therapeutics, Incorporated; Lin, Hong; Luengo, Juan; Shetty, Rupa; Hawkins, Michael; (96 pag.)US2019/48014; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia