Month: February 2023

Synthesis of Benzazolyl Pyrimidines Under Ultrasonication and Their Antimicrobial Activity was written by Kayathi, Narendra Babu;Sowmya, Donthamsetty V.;Adivireddy, Padmaja;Venkatapuram, Padmavathi. And the article was included in Journal of Heterocyclic Chemistry in 2018.Related Products of 40230-24-8 This article mentions the following:

The benzoxazolyl/benzothiazolyl/benzimidazolyl pyrimidines were prepared under ultrasonication in the presence of pyridine/dimethylaminopyridine and triethylamine. Better yields were recorded in 4-(N,N-dimethylamino)pyridine and Et₃N. The presence of electron withdrawing chloro, bromo, and nitro substituents enhanced antimicrobial activity (N-(benzo[d]thiazol-2-ylmethyl)-4,6-bis(4-chlorophenyl) pyrimidin-2-amine, N-(benzo[d]thiazol-2-ylmethyl)-4,6-bis(4-nitrophenyl) pyrimidin-2-amine, N-((1H-benzo[d]imidazol-2-yl)methyl)-4,6-bis(4-nitrophenyl)pyrimidin-2-amine: min. inhibitory concentration = 6.25 μg/well against Bacillus subtilis; N-(benzo[d]thiazol-2-ylmethyl)-4,6-bis(4-nitrophenyl) pyrimidin-2-amine, N-((1H-benzo[d]imidazol-2-yl)methyl)-4,6-bis(4-nitrophenyl)pyrimidin-2-amine: min. inhibitory concentration = 6.25 μg/well against Aspergillus niger). In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Related Products of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Related Products of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine derivatives. I. Synthesis of thiazolo[5,4-d]-pyrimidines and related compounds. 1 was written by Takahashi, Torizo;Naito, Takio;Inoue, Shoji. And the article was included in Chemical & Pharmaceutical Bulletin in 1958.Reference of 69785-94-0 This article mentions the following:

The title compounds were prepared as possible purine antagonists through derivatives of 4-thiocyano-5-nitropyrimidine (I) or 4-mercapto-5-aminopyrimidine (II) as intermediates. The 2,4-Cl₂ derivative (III) of 5-nitropyrimidine (IV) (1.94 g.) in 5 cc. AcOH stirred 15 min. at 10° with 0.97 g. KSCN and the mixture poured into ice water yielded 1.84 g. 2-Cl derivative (V) of I, m. 141° (C₆H₆). V (2 g.) in 10 cc. MeOH or EtOH refluxed 5 hrs. on a water bath gave unexpectedly 5-nitrouracil, m. above 300°. However, 5 g. V added below 10° to 100 cc. EtOH containing 1.2 g. Na, the mixture stirred 2 hrs., the EtOH distilled, the residue diluted with H₂O, and extracted with ether yielded from the extract 1.8-2.0 g. 2,4-(EtO)₂ derivative (VI) of IV containing 2 moles EtONa, m. 45° (also prepared from III with EtONa), and from the acidified aqueous layer 2-2.5 g. 2,4-(EtO)(HS) derivative (VII) of IV, m. 133°. Similarly, 1.1 g. V added to 30 cc. MeOH containing 0.25 g. Na at 0° yielded 0.75 g. 2,4-(MeO)₂ derivative (VIII) of IV, m. 95°. V (4.3 g.) in 60 cc. EtOH added dropwise at 0-5° to 1 mole EtSNa in 30 cc. EtOH gave after 2 hrs. at room temperature and concentration to 1/3 volume 2-(EtS) derivative (IX) of I, m. 131°. VI (3 g.) (or VIII) in 15 cc. AcOH heated 1 hr. at 60° on a water bath with 3 g. Fe powder, the filtrate from the mixture evaporated in vacuo, and the residue diluted with H₂O and extracted with ether yielded 2.1 g. 2,4-(EtO)₂ derivative of 5-aminopyrimidine (X), m. 64° [or the 2,4-(MeO)₂ derivative of X, m. 89°. IX (0.3 g.) similarly reduced with Fe and AcOH yielded through ring closure 0.24 g. 2,5-H₂N(EtS) derivative of thiazolo[5,4-d]-pyrimidine (XI), m. 123°; Ac derivative, m. 125-6°. VII (1.2 g.) in 5 cc. 10% NaOH stirred 15 min. at 50° with 5-7 g. Na₂S₂O₄, cooled, and extracted with AcOEt yielded 0.7 g. 2-EtO derivative of II, m. 127°, and this (0.2 g.) refluxed 2 hrs. with 5 cc. HCO₂H (or 5 cc. Ac₂O), excess reagent removed in vacuo, and the residue made alk. and extracted with ether was cyclized to 0.09 g. 5-EtO derivative (XII) of XI, m. 95° [or 0.1 g. 2-Me derivative (XIII) of XII, m. 93°]. VII (0.5 g.) refluxed 15 hrs. with K methylxanthate (from 0.32 g. CS₂ shaken with 0.3 g. KOH in 2 cc. H₂O and 10 cc. MeOH), the mixture concentrated on a water bath, diluted with 5 cc. H₂O, and neutralized with AcOH yielded 0.5 g. 2-HS derivative (XIV) of XII, m. about 234°, decompose above 280°. XIV (0.2 g.) refluxed 30 min. with 0.07 g. KOH in 15 cc. dilute EtOH and 0.11 g. EtBr (or 0.12 g. PhCH₂Br), the solvent removed, and the resulting oil extracted with ether yielded 0.19 g. 2-EtS derivative of XII, m. 66° [or (omitting the ether extraction) 0.22 g. 2-PhCH₂S derivative of XII, m. 102°]. In the experiment, the researchers used many compounds, for example, 5-Aminopyrimidin-4(3H)-one (cas: 69785-94-0Reference of 69785-94-0).

5-Aminopyrimidin-4(3H)-one (cas: 69785-94-0) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Reference of 69785-94-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist was written by Zheng, Yajun;Zhuang, Linghang;Fan, Kristi Yi;Tice, Colin M.;Zhao, Wei;Dong, Chengguo;Lotesta, Stephen D.;Leftheris, Katerina;Lindblom, Peter R.;Liu, Zhijie;Shimada, Jun;Noto, Paul B.;Meng, Shi;Hardy, Andrew;Howard, Lamont;Krosky, Paula;Guo, Joan;Lipinski, Kerri;Kandpal, Geeta;Bukhtiyarov, Yuri;Zhao, Yi;Lala, Deepak;Van Orden, Rebecca;Zhou, Jing;Chen, Guozhou;Wu, Zhongren;McKeever, Brian M.;McGeehan, Gerard M.;Gregg, Richard E.;Claremon, David A.;Singh, Suresh B.. And the article was included in Journal of Medicinal Chemistry in 2016.Name: Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate This article mentions the following:

This article describes the application of Contour to the design and discovery of a novel, potent, orally efficacious liver X receptor β (LXRβ) agonist ((R)-(2-(4-(4-(hydroxymethyl)-3-(methylsulfonyl)phenyl)-2-isopropylpiperazin-1-yl)-4-(trifluoromethyl)pyrimidin-5-yl)methanol (17)). Contour technol. is a structure-based drug design platform that generates mols. using a context perceptive growth algorithm guided by a contact sensitive scoring function. The growth engine uses binding site perception and programmable growth capability to create drug-like mols. by assembling fragments that naturally complement hydrophilic and hydrophobic features of the protein binding site. Starting with a crystal structure of LXRβ and a docked 2-(methylsulfonyl)benzyl alc. fragment, Contour was used to design agonists containing a piperazine core. Compound (17) binds to LXRβ with high affinity and to LXRα to a lesser extent, and induces the expression of LXR target genes in vitro and in vivo. This mol. served as a starting point for further optimization and generation of a candidate which is currently in human clin. trials for treating atopic dermatitis. In the experiment, the researchers used many compounds, for example, Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate (cas: 187035-79-6Name: Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate).

Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate (cas: 187035-79-6) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Name: Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In situ application of the diffusive gradients in thin film technique in aquaculture ponds for monitoring antibiotics, hormones, and herbicides was written by Chen, Yiqin;Wen, Ju;Wu, Meng;Li, Juan-Ying;Wang, Qian;Yin, Jie. And the article was included in Environmental Science and Pollution Research in 2022.Safety of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

In recent years, as the abuse of antibiotics, hormones, and herbicides has worsened in aquaculture industry, it is important to monitor the concentrations of those trace contaminants in aquaculture water more effortlessly. The aim of this study was to develop a reliable sampling method for chem. monitoring in aquaculture ponds based on the technique of diffusive gradients in thin films (DGT). A binding material (XDA-1 resin) with high adsorption capacity for antibiotics, hormones, and herbicides was selected. In laboratory, the diffusion coefficients of 11 antibiotics, 3 hormones, and 3 herbicides of the XDA-1-DGT devices were tested and ranged from 1.0×10-6 to 8.7×10-5 cm2/s. During the in situ application of XDA-1-DGT devices in different aquaculture ponds, concentrations of 11 antibiotics, 3 hormones, and 3 herbicides in aquaculture water (CSOLN) via grab sampling were also analyzed and found ranging from 0.03 to 6.3 ng/L, lower than the results based on DGT (CDGT) (1.2-1.3×102 ng/L). The values of CDGT/CSOLN were larger than one unit, suggesting that the rates of resupply of target chems. (antibiotics, hormones, and herbicides) by the desorption and diffusion of pond water were higher than the rates of uptake by XDA-1-DGT, and pond water was proved a sufficient reservoir of antibiotics for DGT application. The value of Log (CDGT/CSOLN) of 1.1 derived from the application in the aquaculture ponds of 14 regions in Eastern China can be a reference value for future chem. monitoring based on DGT technique. And the accuracy of this value was found hardly affected by the phys. and chem. properties of chems. with pKa ranging from -1 to 12, Log Kow ranging from 0 to 4.5, and Log solubility ranging from 0.0 to 4.0. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Safety of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Safety of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Four products from the cyanoacetylation of pyrimidines: hydrogen-bonded dimers, π-stacked hydrogen-bonded chains and hydrogen-bonded chains of edge-fused rings was written by Trilleras, Jorge;Low, John N.;Cobo, Justo;Marchal, Antonio;Glidewell, Christopher. And the article was included in Acta Crystallographica, Section C: Crystal Structure Communications in 2008.Category: pyrimidines This article mentions the following:

The mols. of 2-[6-amino-3-methyl-2-(methylsulfanyl)-4-oxo-3,4-dihydropyrimidin-5-ylcarbonyl]acetonitrile, C₉H₁₀N₄O₂S, (I), are linked in pairs by N-H···O hydrogen bonds to form cyclic centrosym. R₂²(4) dimers. Similar dimers formed by 2-(6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-ylcarbonyl)acetonitrile, C₉H₁₀N₄O₃, (II), are reinforced by paired N-H···N hydrogen bonds and linked into chains of rings by C-H···O hydrogen bonds. The mols. of 2-cyano-N-[6-methoxy-2-(methylsulfanyl)pyrimidin-4-yl]acetamide, C₉H₁₀N₄O₂S, (III), are linked into simple C(6) chains by an N-H···N hydrogen bond, and the chains are weakly linked into sheets by a π-π stacking interaction. A combination of one two-center N-H···N hydrogen bond and one three-center C-H···(N,O) hydrogen bond links the mols. of 2-cyano-N-[6-chloro-2-(methylsulfanyl)pyrimidin-4-yl]acetamide, C₈H₇ClN₄OS, (IV), into a chain of alternating edge-fused R₂¹(6) and R₁²(6) rings. The crystal structures reported in this study, and those of some related examples from the recent literature, show a wide variation in hydrogen-bonded aggregation consequent upon rather small changes in mol. constitution. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Category: pyrimidines).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Assessment of veterinary antibiotics from animal manure-amended soil to growing alfalfa, alfalfa silage, and milk was written by Huang, Rongcai;Guo, Zitai;Gao, Shengtao;Ma, Lu;Xu, Jianchu;Yu, Zhongtang;Bu, Dengpan. And the article was included in Ecotoxicology and Environmental Safety in 2021.Safety of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

Using animal manure as organic fertilizer to grow fodder crops is causing public health concerns because animal manure is the major reservoir of veterinary antibiotics. In this study, we used a math. model to estimate the risk of human exposure to veterinary antibiotics when using swine manure as organic fertilizer to grow alfalfa (Medicago sativa L.). Alfalfa was planted in a greenhouse and fertilized with swine manure spiked with oxytetracycline (OTC, at 0, 150, and 1500 mg/kg of manure), ofloxacin (OFL, at 0, 15, and 150 mg/kg), or sulfamonomethoxine (SMM, at 0, 5, 15 and 150 mg/kg). Alfalfa was harvested at the budding stage and ensiled for 60 days. Results showed that OTC and OFL could be detected in the alfalfa root, stem, and leaf with a concentration ranging from 8.85 to 59.17 μg OTC /kg and from 1.50 to 4.10 μg OFL/kg dry matter, but SMM could only be detected in the root ranging from 29.10 to 63.75 μg/kg dry matter. The ensiling for 60 days decreased the OFL concentration by 68.7% but only slightly decreased the OTC concentration The maximum daily exposures of humans to OTC and OFL through liquid milk consumption were estimated to be 5.84E-8 and 1.63E-8 μg, resp., both of which are well below the intake levels of OTC (72 μg) and OFL (54 μg) mandated by the European Union. The results of the present study indicate that using swine manure as organic fertilizer to grow alfalfa poses a limited risk for human exposure to veterinary antibiotics through the consumption of liquid milk. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Safety of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Safety of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Evaluation of growth and biochemical responses of freshwater microalgae Chlorella vulgaris due to exposure and uptake of sulfonamides and copper was written by Li, Shuangxi;Yu, Yunjiang;Gao, Xinxin;Yin, Zhihong;Bao, Jianfeng;Li, Zhuo;Chu, Ruoyu;Hu, Dan;Zhang, Jin;Zhu, Liandong. And the article was included in Bioresource Technology in 2021.COA of Formula: C11H12N4O3S This article mentions the following:

Sulfonamides (SAs) and heavy metals are frequently detected together in livestock wastewater. In this study, evaluations regarding their potentially adverse effects on microalgae and according removals were investigated. Results showed that the growth of C. vulgaris was inhibited by SAs and Cu. There was an obvious recovery period in photosynthetic activity (Fv/Fm), indicating that the damage to the photosystem of microalgae was reversible. The co-existence of SAs and Cu significantly affected the biochem. characteristics, including the activities of antioxidant enzyme and the contents of photosynthetic pigments, proteins and polysaccharides. The addition of Cu obviously promoted the removal efficiencies of SMZ, SMX and SMM, which might be ascribed to the bridging effect of Cu in the bioadsorption of SAs. This study is conducive to understand the changes in the biochem. responses of microalgae under the combined impacts of SAs and Cu, and provides a new insight for the simultaneous removals. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3COA of Formula: C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.COA of Formula: C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Highly efficient one-pot synthesis of α-aminophosphonates using nanoporous AlSBA-15 catalyst in a three-component system was written by Kolli, Murali Krishna;Palani, Elamathi;Govindasamy, Chandrasekar;Katta, Vishweshwar Rao. And the article was included in Research on Chemical Intermediates in 2020.Product Details of 90905-32-1 This article mentions the following:

Nanoporous AlSBA-15 catalysts with different nSi/nAl ratios (41, 129, and 210) were synthesized using a hydrothermal method. These catalysts were characterized by XRD, N₂ sorption, TPD-NH₃, FT-IR, SEM and TEM. XRD analyses of AlSBA-15 catalysts confirmed the presence of well-ordered crystalline structure with p6mm symmetry. The sp. surface area and specific pore volume of the AlSBA-15 catalysts are in the range of 480 to 757 m²/g and 0.65 to 0.95 cm³/g, resp. The catalytic performance of nanoporous AlSBA-15 catalysts are used as an outstanding catalytic system for one-pot synthesis of α-aminophosphonates via Kabachnik-Fields reaction in a three-component system using amines (primary/secondary), carbonyl compounds (aldehydes/ketones) and di-Et phosphite. The major advantages of the present contributions are excellent yields, short reaction time, simple exptl. technique, high chemo-selectivity, catalyst recyclability, easy work-up procedure and green approach. Three-component synthesis of α-aminophosphonates follows first imine formation from amine and aldehyde/ketone followed by phosphate addition The exptl. findings suggest that the nanoporous AlSBA-15 catalysts can be recycled and reused up to six cycles without any loss in the catalytic performance. In the experiment, the researchers used many compounds, for example, 2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1Product Details of 90905-32-1).

2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Product Details of 90905-32-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Aminopyrimidines and derivatives. XIV. Preparation and study of 5-amino-4-(glycosylamino)-2-methoxy-(and 2-(methylthio))-6-oxopyrimidines was written by Nogueras Montiel, M.;Sanchez Rodrigo, A.;Asenjo Asenjo, R.;Melgarejo Sampedro, M.;Rodriguez Alonso, M.;Rodriguez Melgarejo, C.. And the article was included in Anales de Quimica, Serie C: Quimica Organica y Bioquimica in 1984.Formula: C6H9N3OS This article mentions the following:

(Glycosylamino)pyrimidinones (I; R = H, Me; R¹ = H; R² = H, CH₂OH; Z = O, S; 7 compounds) on treatment with NaNO₂ in AcOH or HCl gave the corresponding 5-nitroso compounds (I; R¹ = NO), which on reduction with (NH₄)₂S gave the title compounds (I; R¹ = NH₂). In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Formula: C6H9N3OS).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Formula: C6H9N3OS

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Three component one-pot synthesis of novel pyrimidino thiazolidin-4-ones catalyzed by activated fly ash was written by Kanagarajan, V.;Thanusu, J.;Gopalakrishnan, M.. And the article was included in Green Chemistry Letters and Reviews in 2009.Safety of 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

The title compounds I (R¹ = H, Cl, MeO; R² = H, Cl, Me, F, MeO; R³ = H, Cl) were synthesized in good yields in a short reaction time by the “one-pot” multicomponent reaction of the corresponding 2-amino-4,6-diarylpyrimidines, benzaldehyde, and thioglycolic acid under microwave irradiation in the presence of activated fly ash catalyst. These compounds characterized by m.p., elemental anal., MS, FT-IR, and one-dimensional NMR (¹H and ¹³C) spectroscopic data. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Safety of 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Safety of 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia