Day: February 13, 2023

Action of guanidine and urea on some hydroxymethylene ketones was written by Benayr, Erich. And the article was included in Berichte der Deutschen Chemischen Gesellschaft [Abteilung] B: Abhandlungen in 1930.Formula: C6H9N3 This article mentions the following:

In general, aliphatic and aliphatic-aromatic hydroxymethylene ketones readily yield the corresponding aminomethylene compounds with primary or secondary organic bases (C. A 24, 4507). In this connection the behavior of MeCOCH:CHOH (I) toward guanidine (II) was also studied. The Na derivative of I reacts with salts of II in alc. at room temperature with formation of 2-amino-4-methylpyrimidine (III), i. e., not only is the HO group replaced by the guanidine residue but ring formation, with further elimination of water, also takes place. The reaction is quite general: analogous products were obtained with the hydroxymethylene derivatives of MeCOEt, MeCOPr, methylheptenone (IV), MeCOPh, MeCOC₆H₄Me and MeCOC₆H₄OMe. The III, now readily available, gives with Br in water a Br derivative (V) in which the Br is held exceedingly firmly and must, therefore, be on the nucleus, probably in position 5. With acid chlorides, however, it readily forms N-derivatives; the ClCH₂CO compound (VI) with hot alc. NH₃ regenerates III in most part while a small part remains unchanged. The pyrimidine formation also takes place with the derivatives of cyclic ketones. Hydroxymethylenecyclohexanone yields Bz-tetrahydro-2-aminoquinazoline (VII) and the hydroxymethylene derivatives of cyclopentanone, menthone and carvone behave in the same way; as these require heat for the reaction and are, in general, more stable than the aliphatic compounds, the desired products are most simply obtained by boiling the free hydroxymethylene compounds with I carbonate in alc. The reaction can be used quite generally to characterize those cyclic ketones which can yield hydroxymethylene derivatives All the bases so obtained do not turn litmus blue and their NH₂ group is held very firmly. The bases can be boiled a long time with dilute HCl without appreciable change and HNO₂ also generally has no action on them. Hydroxymethylenecamphor (VIII) treated as above gives only a trace of quinazoline (IX) which, however, is obtained quite smoothly in boiling AmOH instead of EtOH. Rupe found that with urea VIII splits off only 1 mol. water to form methylenecamphorurea, and B. has now found that ring formation likewise does not occur in the reaction of VIII with CS(NH₂)₂ or of hydroxymethylenecyclohexanone with urea. MeCOC(:CHOH)Me behaves in the same way. The hydroxymethylene ketones, therefore, resemble AcCH₂CO₂Et in their behavior toward urea and II. With hydroxymethyleneacetoacetic ester, II gives iminomethyluracil, resulting from the action of II on AcCH₂CO₂Et, i. e., the HOCH group is split off in the reaction. III is obtained in 51% yield. 5-Br derivative (V), m. 195鎺? N-Chloroacetyl derivative (VI), turns green about 165鎺? then brown and completely decomposes 235鎺? 5-Me derivative, from MeCOC(:CHOH)Me, m. 216-7鎺?(N-chloroacetyl derivative, m. 145-8鎺?. 4-Pr homolog of III, m. 122-3鎺? 4-Ph analog, m. 165鎺? easily soluble in dilute HCl. 4-p-Tolyl homolog, m. 189-91鎺? 4-p-Methoxyphenyl compound, m. 185-7鎺? 4-(4′-Methyl-4′-pentene)-2-aminopyrimidine, from the hydroxymethylene derivative of IV, m. 155-9鎺? VII, m. 206-10鎺? 4,5-Trimethylene-2-aminopyrimidine, from hydroxymethylenecyclopentanone, m. 206-8鎺? 5-Methyl-8-isopropyl-2-aminoquinazoline, m. 139-41鎺? Ac derivative, m. 125-7鎺? 2-Amino-5,6-dihydro-5-isopropenyl-8-methylquinazoline, from hydroxymethylenecarvone, m. 165-7鎺?(13 g. from 45 g. carvone). 2-Aminobornylenepyrimidine (IX) (yield, 55%), m. 249-53鎺? Ac derivative, m. 154-5鎺? chloroacetyl derivative, m. 156-9鎺? Methylenecamphorthiourea, m. 213-4鎺? Methylenecyclohexanoneurea, light yellow, m. 229-30鎺?(decomposition). Methylenemethylethyl ketoneurea, MeCOC(:CHNHCONH₂)Me, m. 156鎺? In the experiment, the researchers used many compounds, for example, 4,5-Dimethylpyrimidin-2-amine (cas: 1193-74-4Formula: C6H9N3).

4,5-Dimethylpyrimidin-2-amine (cas: 1193-74-4) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Formula: C6H9N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Hemilabile MICN^{铏?/sup> ligands allow oxidant-free Au(I)/Au(III) arylation-lactonization of 绾?alkenoic acids was written by Font, Pau;Valdes, Hugo;Guisado-Barrios, Gregorio;Ribas, Xavi. And the article was included in Chemical Science in 2022.Name: 2-Ethynylpyrimidine This article mentions the following:}

Here authors describe the synthesis of two Au(I) complexes bearing bidentate hemilabile MICN^{铏?/sup> ligands ligands, [AuI(MICN铏?/sup>)Cl], and their ability to stabilize square-planar Au(III) species (MIC = mesoionic carbene). The presence of the hemilabile N-ligand contributed to stabilize the ensuing Au(III) species acting as a five-membered ring chelate upon its coordination to the metal center. The Au(III) complexes can be obtained either by using external oxidants or, alternatively, by means of feasible oxidative addition with strained biphenylene C_sp2-C_sp2 bonds as well as with aryl iodides. Based on the fundamental knowledge gained on the redox properties on these Au(I)/Au(III) systems, authors successfully develop a novel Au(I)-catalytic procedure for the synthesis of 绾?substituted 绾?butyrolactones through the arylation-lactonization reaction of the corresponding 绾?alkenoic acid. The oxidative addition of the aryl iodide, which in turn is allowed by the hemilabile nature of the MICN铏?/sup> ligand, is an essential step for this transformation. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Name: 2-Ethynylpyrimidine).}

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Name: 2-Ethynylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Photoelectron spectra and electronic structures of substituted pyrimidines was written by Lottermoser, Ursula;Rademacher, Paul;Mazik, Monika;Kowski, Klaus. And the article was included in European Journal of Organic Chemistry in 2005.Related Products of 37972-24-0 This article mentions the following:

The electronic structures of pyrimidine and its substituted derivatives were studied by UPS and quantum chem. methods. The ionization potentials corresponding to the 锜?MOs 锜?sub>1-锜?sub>3 and the two n_N orbitals of the pyrimidine unit could be determined and assigned for all compounds Multiple linear regression analyses of the IPs related to these orbitals with different substituent constants indicated that Hammett 锜?sub>P values performed well for all these IPs, whereas the resonance parameters R and R⁺ were satisfactory for 锜?and poor for n_N ionizations. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Related Products of 37972-24-0).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Related Products of 37972-24-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Antibiotics in urine from general adults in Shenzhen, China: Demographic-related difference in exposure levels was written by Zhong, Shihua;Wu, Xiaoling;Zhang, Duo;Du, Sijin;Shen, Junchun;Xiao, Lehan;Zhu, Ying;Xu, Yuanyuan;Lin, Yuli;Yin, Liuyi;Rao, Manting;Lu, Shaoyou. And the article was included in Science of the Total Environment in 2022.Product Details of 1220-83-3 This article mentions the following:

Misuse or overuse of antibiotics can have a variety of detrimental microbial effects. However, the body burden of antibiotics in the general population is currently unclear. In this cross-sectional study, we determined four classes of widely-applied antibiotics (3 imidazoles, 2 sulfonamides, 5 quinolones, and 2 chloramphenicols) in urine samples from 1170 adult residents in Shenzhen, China. Antibiotics were detected in 30.8% of all urine samples with concentrations ranging from <LOD to 3517娓璯/mL, among which metronidazole, ofloxacin and florfenicol were predominant. Notably, antibiotics prohibited for human or veterinary use were detected in 21.0% of samples, indicating that these antibiotics may still be overused in daily life. We found that the presence of antibiotics in urine is associated with being overweight (OR: 1.386, 95% CI: 1.056-1.819, p = 0.019) and obesity (OR: 1.862, 95% CI: 1.103-3.146, p = 0.020) in the adult population. Multilinear regression anal. showed that a percent increase of hydroxy metronidazole was related to 9.86% pos. change of body mass index (p = 0.029). Interestingly, we also found total antibiotic concentration higher in the unmarried group (p = 0.006). Besides, consumption of smoked foods was correlated with urinary antibiotic levels (p = 0.001), indicating smoked meat may be a potential exposure source of veterinary antibiotics. These results highlight the need to reduce human exposure to banned antibiotics. Future research could focus on assessing the health risk and other outcomes of antibiotic overuse. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Product Details of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Product Details of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

5-(2-Hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)-3-methyl-2-(methylsulfanyl)-6-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4(3H)-one monohydrate: complex sheets generated by multiple hydrogen bonds was written by Cruz, Silvia;Quiroga, Jairo;de la Torre, Jose M.;Cobo, Justo;Low, John N.;Glidewell, Christopher. And the article was included in Acta Crystallographica, Section C: Crystal Structure Communications in 2006.Name: 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one This article mentions the following:

In 5-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)-3-methyl-2-(methylsulfanyl)-6-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4(3H)-one monohydrate, C₂₂H₂₃N₃O₃S璺疕₂O, the nonaromatic carbocyclic ring adopts a half-chair conformation. The mols. are linked into complex sheets by a combination of 1 N-H璺矾璺疧 H bond and 3 O-H璺矾璺疧 H bonds. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Name: 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Name: 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis and biological evaluations of new pyrazole hydrazides as potent anti-microbial agent was written by S., Gunasekar;M., Saamanthi;S., Aruna. And the article was included in Materials Today: Proceedings in 2021.Application In Synthesis of 2-Methoxypyrimidine-5-carbaldehyde This article mentions the following:

A sequence of pyrazole hydrazides I (R = 4-methoxy-2,3-dimethylphenyl, 6-chloropyridin-3-yl, 2-methoxypyrimidin-5-yl, 4-(benzyloxy)benzen-1-yl, etc.) was synthesized I (R = 4-methoxy-2,3-dimethylphenyl), and its anti-microbial activities were studied for its in vitro anti-microbial activities against staphylococcus aureus and Escherichia coli and found almost all synthesized mols. I are active. Also synthesized mols. were ascertained by ¹H NMR, ¹³C NMR and mass spectroscopy and pyrazole hydrazide I was synthesized by dehydration reaction of N-(5-[(hydrazinecarbonyl)methyl]-1H-pyrazol-3-yl)-4-(trifluoromethyl)benzamide with different aldehydes RCHO. All the reaction progress were monitored by TLC. Min. inhibition values of synthesized mols. were studied using Staphylococcus aureus and Escherichia coli and some of the compounds show good MIC values such as I (R = 2,3-dichlorophenyl (24), 6-chloropyridin-3-yl (23), 2-methoxypyrimidin-5-yl (23)) as compared to existing drug cefotaxime. In the experiment, the researchers used many compounds, for example, 2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1Application In Synthesis of 2-Methoxypyrimidine-5-carbaldehyde).

2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Application In Synthesis of 2-Methoxypyrimidine-5-carbaldehyde

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

An Efficient Synthetic Strategy for sp³(C)-N Amination on 4-thiazolidinone with Primary Heteroaryl Amines was written by Mudaliar, Sulochana S.;Shaikh, Mohammedumar M.;Chikhalia, Kishor H.. And the article was included in ChemistrySelect in 2017.HPLC of Formula: 40230-24-8 This article mentions the following:

An efficient sp³(C)-N amination reaction between 4-thiazolidinone and primary heteroaryl amine has been developed under C-H functionalization. Cross-coupling reaction between non-prefunctionalized slightly more acidic sp³ C-H bond of 4-thiazolidinones and different heteroaryl amines involving one-pot synthetic strategy, single step reaction as well as aerial oxidation make this amination more effective than existing methods for the construction of sp³(C)-N bond. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8HPLC of Formula: 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.HPLC of Formula: 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine derivatives. IV. 4 was written by Inoue, Shoji. And the article was included in Chemical & Pharmaceutical Bulletin in 1958.HPLC of Formula: 69785-94-0 This article mentions the following:

The 2,4-(HS)₂ derivative of 5-nitropyrimidine (I) (2 g.) (cf. Part II) in 40 cc. N NaOH reduced by stirring with Na₂S₂O₄ until the red color disappeared and then warmed 15 min. at 50鎺?yielded 1.2 g. 2,4-(HS)₂ derivative (II) of 5-aminopyrimidine (III), decompose above 270鎺? tri-Ac derivative, m. above 300鎺? II (2 g.) refluxed 5 hrs. on an oil bath with 60 cc. Ac₂O, excess reagent removed in vacuo, and the residue extracted with ether cyclized to 2 g. 2,5-Me(AcS) derivative of thiazolo[5,4-d]pyrimidine (IV), m. 135鎺? Hydrolysis of the residue from another 2 g. II with 10% NaOH in place of ether and acidification of the filtrate yielded 1.5 g. 2,5-Me(HS) derivative (V) of IV, decompose above 242鎺? identified as the 2,5-Me(EtS) derivative (VI) of IV, m. 56鎺?(from KOH and EtBr on V, identical with VIII of Part III). V (0.65 g.) in 20 cc. H₂O catalytically desulfurized by refluxing 3 hrs. with 5 g. Raney Ni in 5 cc. 25% NH₄OH and the concentrated filtrate from the mixture extracted with ether gave the 2-Me derivative of IV, m. 76-7鎺? II (1 g.) in 20 cc. C₅H₅N treated slowly with 8 cc. BzCl precipitated the tri-Bz derivative, but refluxing the mixture 3 hrs. in an oil bath, pouring on ice, and making alk. gave 2 g. 2,5-Ph(BzS) derivative of IV, m. 180-1鎺? which was hydrolyzed by heating 2-3 hrs. on a water bath with N NAOH, filtering, and acidifying to give 2,5-Ph(HS) derivative of IV, identified as was V by the 2,5-Ph(EtS) derivative of IV, m. 131鎺? or the 2,5-Ph(PhCH₂S) derivative of IV, m. 184鎺? II (0.5 g.) refluxed 15 hrs. with K methylxanthate (from 0.6 g. KOH in 4 cc. H₂O and 20 cc. MeOH shaken with 0.64 g. CS₂) and the mixture acidified gave crude 2,5-(HS)₂ derivative of IV, isolated and purified as the 2,5-(EtS)₂ derivative of IV (as was V), m. 69鎺? The 2,4-EtS(HO) derivative of III, prepared according to Boarland and McOmie (C.A. 48, 2072f), the H₂N group acylated to HCONH (or AcNH), the product refluxed 5 hrs. in an oil bath with 1.5 g. P₂S₅ and 10 cc. xylene, cooled, the solid left standing with 30 cc. 5% NH₄OH, and then extracted with ether gave the 5-EtS derivative of IV, m. 82鎺?[or the 2,5-Me(EtS) derivative of IV, m. 56鎺? identical with VI]. These last 2 ring closures probably proceed through the intermediate 2,4,5-EtS(HS)(RCSNH) derivative of pyrimidine by the liberation of H₂S. In the experiment, the researchers used many compounds, for example, 5-Aminopyrimidin-4(3H)-one (cas: 69785-94-0HPLC of Formula: 69785-94-0).

5-Aminopyrimidin-4(3H)-one (cas: 69785-94-0) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.HPLC of Formula: 69785-94-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Combining Ultraviolet Photolysis with In-Situ Electrochemical Oxidation for Degrading Sulfonamides in Wastewater was written by Zheng, Zhijie;Yuan, Julin;Jiang, Xinwei;Han, Gang;Tao, Yufang;Wu, Xiaogang. And the article was included in Catalysts in 2022.Synthetic Route of C11H12N4O3S This article mentions the following:

UV photolysis (UVC, 254 nm) was coupled with an electrochem. oxidation process to degrade three kinds of veterinary sulfonamide (sulfamethazine [SMZ] tablets, sulfamonomethoxine [SMM] tablets, and compound sulfamethoxazole [SMX] tablets). The treatment was applied using a flat ceramic microfiltration membrane to study the effects of photocatalysts. The effectiveness of degradation of the three sulfonamides was evaluated under different conditions. Dissolved oxygen was provided via aeration, but this resulted in a large decrease in the degradation effectiveness due to the inhibition of free chlorine electrogeneration. The photocatalysts had no promotional effect on sulfonamide removal from wastewater due to reduced UV penetration. Because of the different distribution coefficients of sulfonamides, UV irradiation had different effects on different sulfonamide species. For SMZ and SMM, anionic species exhibited a higher degradation rate, whereas for SMX, degradation was most effective for neutral species. In addition, the free chlorine yield increased as the pH increased. Free chlorine conversion reactions occurred under UV irradiation, with the reactions possibly restrained by sulfonamides. Reactive chlorine species promoted SMM degradation Compared to UV irradiation or electrochem. oxidation alone, the UV/in-situ electrochem. oxidation process was more effective and is suitable for treating real wastewater under various environmental pH levels. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Synthetic Route of C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Synthetic Route of C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Unfused heterobicycles as amplifiers of phleomycin. II. Some 2,4′-, 4,5′- and 5,5′-bipyrimidines was written by Brown, Desmond J.;Cowden, William B.;Strekowski, Lucjan. And the article was included in Australian Journal of Chemistry in 1981.Quality Control of 2-Chloropyrimidine-4-carbonitrile This article mentions the following:

Methoxy, methylthio, dimethylamino, 灏?dimethylaminoethylamino, and 灏?dimethylaminoethylthio substituted 2,4′-, 4,5′- and 5,5′-bipyrimidines were prepared Thus, the pyrimidine I (R = Cl, R¹ = CN) was treated with Me₂NH and the resulting I (R = Me₂N, R¹ = CN) treated with PhSO₃^–.NH₄⁺ to give I (R = Me₂N, R¹ = C(:NH)NH₂).PhSO₃H, which was cyclized with H₂C(CO₂Me)₂ to give the bipyrimidine II. II was chlorinated by POCl₃ and then treated with Me₂NH and Me₂NCH₂CH₂NH₂ to give the bipyrimidine III. In the experiment, the researchers used many compounds, for example, 2-Chloropyrimidine-4-carbonitrile (cas: 75833-38-4Quality Control of 2-Chloropyrimidine-4-carbonitrile).

2-Chloropyrimidine-4-carbonitrile (cas: 75833-38-4) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Quality Control of 2-Chloropyrimidine-4-carbonitrile

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia