Xing, Qifeng et al. published their patent in 2019 |CAS: 160377-42-4

The Article related to organic light emitting device tetrasubstituted anthracene, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Spectrometers and Optical Apparatus and other aspects.Recommanded Product: 160377-42-4

On February 5, 2019, Xing, Qifeng; Li, Zhiyang; Liu, Shuyao; Ren, Xueyan published a patent.Recommanded Product: 160377-42-4 The title of the patent was 2,6,9,10-Tetrasubstituted anthracene compound, and its application in organic light-emitting device. And the patent contained the following:

The inventive organic light-emitting device comprises a substrate, an anode layer, a 2,6,9,10-tetrasubstituted anthracene compound-containing organic functional layer (I; where Ar1 is a substituted or unsubstituted nitrogen containing heteroaryl group; Ar3 is a substituted or unsubstituted Ph, naphthyl, or biphenyl group; Ar2 is a substituted or unsubstituted aryl or ring group; and R1 can be a hydrogen, alkyl, halogen, nitro, cyano, or aryl group) and a cathode layer. The organic functional layer comprises a hole injection layer, a hole transport layer, a light emitting layer, an electron transport layer, and an electron injection layer. One 2,6,9,10-tetrasubstituted anthracene compound (A1: 2,2′-((2,6-diphenylanthracene-9,10-diyl)bis(4,1-phenylene))dipyridine) is prepared by (1) stirring 2,6-dibromoanthracene-9,10-dione, phenylboronic acid, potassium carbonate, Pd2(dba)3, toluene, ethanol, and water under protection of nitrogen gas, heating to 100°C, and reacting under reflux for 12 h to obtain intermediate M2; (2) adding 2-(4-bromophenyl)pyridine and THF in a reactor, stirring, cooling to (-90)-(-80)°C, dropwise adding Bu lithium in 30 min, adding the intermediate M2, and stirring at room temperature for 8 h to obtain intermediate M3; (3) adding acetic acid in a reactor, stirring, heating to 60°C, adding the intermediate M3, KI, and sodium dihydrogen phosphate, and reacting under reflux at 120°C for 5 h. The invention has good voltage, efficiency and long service life. The experimental process involved the reaction of 5-(4-Bromophenyl)pyrimidine(cas: 160377-42-4).Recommanded Product: 160377-42-4

The Article related to organic light emitting device tetrasubstituted anthracene, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Spectrometers and Optical Apparatus and other aspects.Recommanded Product: 160377-42-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Culver, Heidi R. et al. published their research in Biomacromolecules in 2020 |CAS: 65-71-4

The Article related to oligonucleotide click nucleic acid dna binding, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.COA of Formula: C5H6N2O2

On October 12, 2020, Culver, Heidi R.; Sinha, Jasmine; Prieto, Tania R.; Calo, Christopher J.; Fairbanks, Benjamin D.; Bowman, Christopher N. published an article.COA of Formula: C5H6N2O2 The title of the article was Click Nucleic Acid-DNA Binding Behavior: Dependence on Length, Sequence, and Ionic Strength. And the article contained the following:

Click nucleic acids (CNAs) are a new, low-cost class of xeno nucleic acid (XNA) oligonucleotides synthesized by an efficient and scalable thiol-ene polymerization In this work, a thorough characterization of oligo(thymine) CNA-oligo(adenine) DNA ((dA)20) hybridization was performed to guide the future implementation of CNAs in applications that rely on sequence-specific interactions. Microscale thermophoresis provided a convenient platform to rapidly and systematically investigate the effects of several factors (i.e., sequence, length, and salt concentration) on the CNA-DNA dissociation constant (Kapp). Because CNAs have limited water solubility, all studies were performed in aqueous-DMSO mixtures CNA-DNA hybrids between oligo(thymine) CNA (average length of 16 bases) and (dA)20 DNA have good stability despite the high organic content, a favorable attribute for many emerging applications of XNAs. In particular, the Kapp of CNA-DNA hybrids in 65 vol % DMSO with 10 mM sodium chloride (NaCl) was 0.74 ± 0.1μM, whereas the Kapp for (dT)20-(dA)20 DNA-DNA was found to be 45 ± 2μM in a buffer without DMSO but at the same NaCl concentration CNA hybridized with DNA following Watson-Crick base pairing with excellent sequence specificity, discriminating even a single-base-pair mismatch, with Kapp values of 0.74 ± 0.1 and 3.7 ± 0.6μM for complementary and single-base-pair mismatch sequences, resp. As with dsDNA, increasing CNA length led to more stable hybrids as a result of increased base pairing, where Kapp decreased from 5.6 ± 0.8 to 0.27 ± 0.1μM as the CNA average length increased from 7 to 21 bases. However, unlike DNA-DNA duplexes, which are largely unstable at low salt concentrations, the CNA-DNA stability does not depend on salt concentration, with Kapp remaining consistent between 1.0 and 1.9μM over a NaCl concentration range of 1.25-30 mM. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).COA of Formula: C5H6N2O2

The Article related to oligonucleotide click nucleic acid dna binding, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.COA of Formula: C5H6N2O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Mejdrova, Ivana et al. published their research in New Journal of Chemistry in 2017 |CAS: 4433-40-3

The Article related to dihydroxypropoxymethyluracil analog regioselective preparation, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Computed Properties of 4433-40-3

Mejdrova, Ivana; Brulikova, Lucie; Volna, Tereza; Hlavac, Jan published an article in 2017, the title of the article was Regioselective synthesis of 5-[(2,3-dihydroxypropoxy)methyl]uracil analogues.Computed Properties of 4433-40-3 And the article contains the following content:

Herein, the authors report the regioselective synthesis of 5-[(2,3-dihydroxypropoxy)methyl]uracil analogs with hydroxy alkyl chains that mimic the natural C-nucleoside pseudouridine. The authors developed multiple disparate synthetic procedures and approaches for the preparation of a wide range of derivatives, such as amino, acyl, halogen or azido compounds Their synthesis was based on the different reactivity of the primary and secondary hydroxy groups. The final compounds might be further considered as new building blocks for oligonucleotide synthesis. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Computed Properties of 4433-40-3

The Article related to dihydroxypropoxymethyluracil analog regioselective preparation, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Computed Properties of 4433-40-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Gimadieva, A. R. et al. published their research in Pharmaceutical Chemistry Journal in 2014 |CAS: 626-48-2

The Article related to succinic fumaric acid uracil complex preparation hypoxia treatment, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Reference of 6-Methylpyrimidine-2,4(1H,3H)-dione

On May 31, 2014, Gimadieva, A. R.; Myshkin, V. A.; Mustafin, A. G.; Chernyshenko, Yu. N.; Borisova, N. S.; Zimin, Yu. S.; Abdrakhmanov, I. B. published an article.Reference of 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was Preparation and Antihypoxic Activity of Complexes of Uracil Derivatives with Dicarboxylic Acids. And the article contained the following:

Water-soluble low-toxicity complexes of 6-methyluracil and its derivatives with succinic acid and fumaric acids were prepared The synthesized complexes were tested for anti-hypoxic activity. The title compounds thus formed included butanedioic acid compound with 6-methyl-2,4(1H,3H)-pyrimidinedione (uracil-succinic acid complex), butanedioic acid compound with 5-hydroxy-6-methyl-2,4(1H,3H)-pyrimidinedione (oxymetacil-succinic acid complex), (2E)-2-butenedioic acid compound with 6-methyl-2,4(1H,3H)-pyrimidinedione (uracil-fumaric acid complex). etc. Butanedioic acid compound with 2-ethyl-6-methyl-3-pyridinol (1:1) (mexidol) was used as a reference compound The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Reference of 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to succinic fumaric acid uracil complex preparation hypoxia treatment, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Reference of 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Michalak, Olga et al. published their research in Organic & Biomolecular Chemistry in 2019 |CAS: 626-48-2

The Article related to alkylation acylation uracil thymine methyluracil regioselectivity dft, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.COA of Formula: C5H6N2O2

Michalak, Olga; Cmoch, Piotr; Krzeczynski, Piotr; Cybulski, Marcin; Les, Andrzej published an article in 2019, the title of the article was A diversity of alkylation/acylation products of uracil and its derivatives: Synthesis and a structural study.COA of Formula: C5H6N2O2 And the article contains the following content:

Tert-Bu dicarbonate (Boc2O) and Et iodide react with uracil (U), thymine (T) and 6-methyluracil (6-MU) following routine procedures in pyridine/DMF solvents and with DMAP as the catalyst. Among 20 synthesized compounds, a derivative of 6-methyluracil substituted by the Boc-pyridine moiety at the C5 position appeared unexpectedly. The NMR spectra confirmed the mol. structure of all uracil derivatives Parallel quantum mech. DFT calculations supported the exptl. findings. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).COA of Formula: C5H6N2O2

The Article related to alkylation acylation uracil thymine methyluracil regioselectivity dft, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.COA of Formula: C5H6N2O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Michalak, Olga et al. published their research in Journal of Organic Chemistry in 2021 |CAS: 626-48-2

The Article related to uracil thymine methyluracil acetic anhydride dichloromethane reaction, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.SDS of cas: 626-48-2

On November 5, 2021, Michalak, Olga; Cmoch, Piotr; Les, Andrzej; Cybulski, Marcin; Krzeczynski, Piotr; Trzcinska, Kinga; Miszta, Przemyslaw; Mehta, Pakhuri; Filipek, Slawomir published an article.SDS of cas: 626-48-2 The title of the article was Unexpected Reaction Products of Uracil and Its Methyl Derivatives with Acetic Anhydride and Methylene Chloride. And the article contained the following:

New acetyl derivatives of uracil, 6-methyluracil, and thymine were obtained in the course of an unconventional synthesis in methylene chloride. It was shown that products with the acetyloxymethyl fragment are formed according to a mechanism different from that for products with the acetyloxyethyl group. In particular, for uracil it was proven that the reaction with Ac2O, TEA, and CH2Cl2 leads to 1-acetyloxymethyluracil, where the N1 substituent is composed of the -CH2- fragment that originated from CH2Cl2 and the 1-acetyloxy moiety from Ac2O. The reaction of uracil with Ac2O, TEA, CH2Cl2, and DMAP leads to an acetyloxyethyl derivative in which the -CH2-CH2- fragment originates from TEA and the 1-acetyloxy moiety from Ac2O. A possible mechanism for the formation of new compounds was suggested and supported by the d. functional theory/B3LYP quantum mech. calculations New compounds (39 in total, including seven deuterated) were fully characterized by NMR and high-resolution mass spectrometry techniques. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).SDS of cas: 626-48-2

The Article related to uracil thymine methyluracil acetic anhydride dichloromethane reaction, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.SDS of cas: 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Gimadieva, A. R. et al. published their research in Russian Journal of Applied Chemistry in 2022 |CAS: 626-48-2

The Article related to hydroxymethyluracil hydroxytrimethyluracil preparation immunomodulator antioxidant, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Synthetic Route of 626-48-2

On March 31, 2022, Gimadieva, A. R.; Khazimullina, Yu. Z.; Abdrakhmanov, I. B.; Mustafin, A. G. published an article.Synthetic Route of 626-48-2 The title of the article was A Procedure for Preparing Effective Immunomodulators and Antioxidants: 5-Hydroxy-6-methyluracil and 5-Hydroxy-1,3,6-trimethyluracil. And the article contained the following:

5-Hydroxy-6-methyluracil is an acting agent of Oxymethyluracilum drug, an immunostimulator with a broad spectrum of pharmacol. activity. Its synthesis is based on the 6-methyluracil oxidation with (NH4)2S2O8 under the conditions of Elbs reaction. The Elbs oxidation of 6-methyluracil in the presence of metal phthalocyanine oxidation catalysts was studied. Conditions allowing the 5-hydroxy-6-methyluracil yield to be increased to 95% were found. The most active catalysts are Fe(II), Fe(III), and Co phthalocyanines. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Synthetic Route of 626-48-2

The Article related to hydroxymethyluracil hydroxytrimethyluracil preparation immunomodulator antioxidant, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Synthetic Route of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Luo, Zhi et al. published their patent in 2018 |CAS: 1209459-32-4

The Article related to haloaryloxymethylallylamine preparation ssao inhibitor treatment nonalc steatohepatitis, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ethers, Sulfides, and The Corresponding Onium Compounds and other aspects.SDS of cas: 1209459-32-4

On December 27, 2018, Luo, Zhi; Li, Xiaolin; Yang, Yaxun; Yang, Lele; Li, Peng; He, Haiying; Li, Jian; Chen, Shuhui published a patent.SDS of cas: 1209459-32-4 The title of the patent was Preparation of 3-halo-2-(aryloxymethyl)allylamine derivatives useful as semicarbazide-sensitive amine oxidase (SSAO) inhibitors for the treatment of nonalcohol steatohepatitis. And the patent contained the following:

The invention relates to 3-halo-2-(aryloxymethyl)allylamine derivatives of formula I, method for their preparation and their use as semicarbazide-sensitive amine oxidase (SSAO) inhibitors for the treatment of nonalc. steatohepatitis. Compounds of formula I, wherein one of R4 and R5 is H and another is F, Cl, Br and I; R1 is H, halo, CO2H, (un)substituted Ph, etc.; L1 is a bond, SO2O, NHCO, NH, etc.; n is 0 to 3; R is H, F, Cl, CONH2, etc.; ring A is R substituted 5- to 6-membered heterocycle, Ph and 5- to 9-membered heteroaryl, and their pharmaceutically acceptable salts, are claimed. Example compound II was prepared via a multistep procedure (procedure given). All the invention compounds were evaluated for their VAP-1/SSAO inhibitory activity. From the assay, it was determined that example compound II exhibited IC50 value of 0.3 nM towards VAP-1/SSAO. The experimental process involved the reaction of 4-(2-Bromopyrimidin-4-yl)morpholine(cas: 1209459-32-4).SDS of cas: 1209459-32-4

The Article related to haloaryloxymethylallylamine preparation ssao inhibitor treatment nonalc steatohepatitis, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ethers, Sulfides, and The Corresponding Onium Compounds and other aspects.SDS of cas: 1209459-32-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Jaiswal, Vishal K. et al. published their research in Physical Chemistry Chemical Physics in 2020 |CAS: 65-71-4

The Article related to pyrimidine purine singlet excited state uv spectra, Physical Organic Chemistry: Theoretical Organic Chemical Concepts, Including Quantum and Molecular Mechanical Studies and other aspects.Product Details of 65-71-4

Jaiswal, Vishal K.; Segarra-Marti, Javier; Marazzi, Marco; Zvereva, Elena; Assfeld, Xavier; Monari, Antonio; Garavelli, Marco; Rivalta, Ivan published an article in 2020, the title of the article was First-principles characterization of the singlet excited state manifold in DNA/RNA nucleobases.Product Details of 65-71-4 And the article contains the following content:

An extensive theor. characterization of the singlet excited state manifold of the five canonical DNA/RNA nucleobases (thymine, cytosine, uracil, adenine and guanine) in gas-phase is carried out with time-dependent d. functional theory (TD-DFT) and restricted active space second-order perturbation theory (RASPT2) approaches. Both ground state and excited state absorptions are analyzed and compared between these different theor. approaches, assessing the performance of the hybrid B3LYP and CAM-B3LYP (long-range corrected) functionals with respect to the RASPT2 reference By comparing the TD-DFT estimates with our reference for high-lying excited states, we are able to narrow down specific energetic windows where TD-DFT may be safely employed to qual. reproduce the excited state absorption (ESA) signals registered in non-linear and time-resolved spectroscopy for monitoring photoinduced phenomena. Our results show a qual. agreement between the RASPT2 reference and the B3LYP computed ESAs of pyrimidines in the near-IR/Visible spectral probing window while for purines the agreement is limited to the near-IR ESAs, with generally larger discrepancies obtained with the CAM-B3LYP functional. This outcome paves the way for appropriate application of cost-effective TD-DFT approaches to simulate linear and non-linear spectroscopies of realistic multichromophoric DNA/RNA systems with biol. and nanotechnol. relevance. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).Product Details of 65-71-4

The Article related to pyrimidine purine singlet excited state uv spectra, Physical Organic Chemistry: Theoretical Organic Chemical Concepts, Including Quantum and Molecular Mechanical Studies and other aspects.Product Details of 65-71-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Ilyina, Margarita G. et al. published their research in Computational & Theoretical Chemistry in 2016 |CAS: 626-48-2

The Article related to uracil anion stability substituent effect solvent effect, Physical Organic Chemistry: Theoretical Organic Chemical Concepts, Including Quantum and Molecular Mechanical Studies and other aspects.Product Details of 626-48-2

On February 15, 2016, Ilyina, Margarita G.; Khamitov, Eduard M.; Ivanov, Sergey P.; Mustafin, Akhat G.; Khursan, Sergey L. published an article.Product Details of 626-48-2 The title of the article was Anions of uracils: N1 or N3? That is the question. And the article contained the following:

The relative stability of N1 and N3 anions of twelve 5,6-substituted uracils in aqueous solutions was studied in IEFPCM (SMD) – TPSSTPSS/6-311+G(d,p) approximation Specific solvation was simulated by the first hydrate shell of uracil and anions containing 5 water mols. Based on ΔGwater = G0(N3) – G0(N1), the series of relative stability was determined as: 5OH6MeU (-3.4) – 5OHU (-2.0) – 5NH2U (2.4) – U (3.5) – 5FU (4.5) – 5MeU (4.6) – 6MeU (4.6) – 5ClU (9.2) – 5BrU (9.5) – 5NO2U (18.6) – 6ClU (31.9) – 6FU (33.9), kJ/mol. The factors that determine the relative stability in the N1/N3 pair were identified. In the gas phase, the N1 anion is much more stable than the N3 anion: ΔGgas varies in the range from 23.3 (5OHU) to 80.0 (6FU) kJ/mol due to more efficient delocalization of excess charge over the uracil frame in the N1 anion, which was characterized using HOMA aromaticity indexes. The solvent makes the Gibbs energies of the N1 and N3 states much more close. Two reasons of the stabilizing effect of water can be distinguished. First, the aromaticity of N3 anions increases considerably in aqueous solutions, leading to almost complete equalization of HOMA indexes. Second, the polar solvent more efficiently stabilizes the more polar N3 states of the uracils studied. The effect of substituents on the relative stability ΔGwater was studied using the Hammett method. It was found that substituents with a strong (+R)-effect at position 5 decreased ΔGwater down to neg. values. Substituents at position 6 affect the relative stability of uracil anions by the inductive mechanism. In this case the formation of N1 anions becomes much more preferable than the formation of N3 anions. The mesomeric effect is weak in this case. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Product Details of 626-48-2

The Article related to uracil anion stability substituent effect solvent effect, Physical Organic Chemistry: Theoretical Organic Chemical Concepts, Including Quantum and Molecular Mechanical Studies and other aspects.Product Details of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia