Month: November 2022

Incorporation of metabolites of 2′-fluoro-5-iodo-1-β-D-arabinofuranosylcytosine into deoxyribonucleic acid of neoplastic and normal mammalian tissues was written by Grant, Alan J.; Feinberg, Aaron; Chou, Ting-Chao; Watanabe, Kyoichi A.; Fox, Jack J.; Philips, Frederick S.. And the article was included in Biochemical Pharmacology on March 15,1982.Reference of 56632-83-8 The following contents are mentioned in the article:

Following treatment of mice with 2-14C-labeled 2′-fluoro-5-iodo-1-β-D-arabinofuranosylcytosine (I) [69123-90-6], a new and potent antiherpetic agent, enzyme degradation of highly purified DNA from the small intestine and anal. of the resulting nucleosides failed to reveal the presence of unchanged I. Three metabolites were found, namely the 2′-fluoro-1-β-D-arabinofuranosyl nucleosides of cytosine, thymine, and 5-iodouracil. Labeled metabolites of I were also found in the DNA isolated from P815 leukemia cells of mice given I-2-14C. These metabolites are also potent antiherpetic agents. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Reference of 56632-83-8).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Reference of 56632-83-8

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Inhibitory effects of 2′-fluorinated arabinosylpyrimidine nucleosides on woodchuck hepatitis virus replication in chronically infected woodchucks was written by Fourel, I.; Hantz, O.; Watanabe, K. A.; Jacquet, C.; Chomel, B.; Fox, J. J.; Trepo, C.. And the article was included in Antimicrobial Agents and Chemotherapy on March 31,1990.Computed Properties of C10H13FN2O5 The following contents are mentioned in the article:

The treatment of woodchuck hepatitis virus infections with 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-iodocytosine and 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-methyluracil given i.p. caused complete and permanent decrease of serum virus endogenous DNA polymerase and viral DNA in all treated woodchucks but was associated with severe toxicity. By contrast, 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-ethyluracil (FEAU) induced a sustained, although less dramatic, decrease of viral replication without apparent toxic effect. FEAU was also effective when given orally, but in both cases the inhibitory effect was transient. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Computed Properties of C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Computed Properties of C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Effect of 2′-fluoro-5-methyl-ara-uracil and cyclophosphamide on herpes simplex virus infection in guinea pigs was written by Zheng, Zhiming; Landry, M. L.; Mayo, D. R.; Hsiung, G. D.. And the article was included in Zhongguo Yaoli Xuebao on March 31,1987.Application In Synthesis of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione The following contents are mentioned in the article:

2′-Fluoro-5-methylarauracil (FMAU) (50 mg/kg, i.p. daily for 3 days) starting 1 day post-vaginal inoculation of herpes simplex virus-2 (HSV-2) in guinea pigs almost completely inhibited the appearance of primary genital lesions (GL) but did not reduce the establishment of HSV latency. When cyclophosphamide (Cy) (50 mg/kg, i.p. daily for 7 days) was simultaneously given, mild delayed GL were occasionally noticed in FMAU-treated animals. During HSV-2 latent infection, i.p. Cy 50 mg/kg, for 10 d could induce genital herpes recurrence in FMAU-treated animals. Cy, 300 mg/kg 3 times at weekly intervals could increase the incidence of recurrent GL, suggesting that the reactivation of latent HSV by Cy was dosage related. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Application In Synthesis of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Application In Synthesis of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Deglycosylation of antiherpesviral 5-substituted arabinosyluracil derivatives by rat liver extract and enterobacteria cells was written by Machida, Haruhiko; Watanabe, Yohko; Kano, Fumitaka; Sakata, Shinji; Kumagai, Masao; Yamaguchi, Toyofumi. And the article was included in Biochemical Pharmacology on March 15,1995.COA of Formula: C10H13FN2O5 The following contents are mentioned in the article:

A number of antiherpesviral 5-substituted derivatives of 1-β-D-arabinofuranosyluracil (araU) were significantly resistant to phosphorolysis by rat liver extract (S-9), but were gradually deglycosylated in a 2% enterobacteria cell suspension. The relative order of the resistance conferred by the different C-5 substituents was: 5-propynyl > 5-(E)-2-bromovinyl > 5-(E)-2-chlorovinyl > 5-Me > 5-iodo. The 2′-fluoro derivatives of araU were completely resistant to phosphorolysis by both liver extract and enterobacteria, whereas the corresponding ribofuranosyl and 2′-deoxyribofuranosyl nucleosides were easily phosphorolyzed by S-9, and were immediately cleaved in a 1% enterobacteria cell suspension. These findings suggest that antiherpesviral 5-substituted araU analogs can be relatively stable in vivo, when injected i.v., and that degradation of 1-β-D-arabinofuranosyl-5-(E-2-bromovinyl)uracil (sorivudine) following oral administration is due primarily to the action of enterobacteria. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3COA of Formula: C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.COA of Formula: C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Differential mechanism of the cytostatic effect of (E)-5-(2-bromovinyl)-2′-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2 was written by Balzarini, Jan; Bohman, Christina; De Clercq, Erik. And the article was included in Journal of Biological Chemistry on March 25,1993.Name: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione The following contents are mentioned in the article:

After they have been transfected with the herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2) thymidine kinase (TK) gene murine mammary carcinoma (FM3A) cells become highly sensitive to the growth inhibitory properties of the antiherpetic agents (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU), 9-[(2-hydroxyethoxy)methyl]guanine (acyclovir, ACV), 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine (DHPG, ganciclovir), and 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-methyluracil (FMAU). BVDU was 100-fold more potent an inhibitor of HSV TK gene-transfected tumor cell growth (50% inhibitory concentration (IC50), 0.0020-0.0047 μM) than FMAU or DHPG (IC50, 0.051-0.277 μM) and 1000-fold more potent than ACV (IC50, 0.42-4.9 μM). As a rule, the test compounds were more cytostatic to HSV-2 TK than HSV-1 TK gene-transfected FM3A cells. This may be ascribed to the higher phosphorylating capacity (Vmax/Km) of HSV-2 TK than HSV-1 TK and/or to the higher TK enzyme levels of the HSV-2 TK gene-transfected FM3A cells than the HSV-1 TK gene-transfected FM3A cells. Thymidylate synthase of the HSV TK gene-transfected FM3A cells appears to be the target enzyme for the cytostatic action of BVDU, but not FMAU, DHPG, or ACV. Instead, the cytostatic activity of DHPG seems to be correlated with its conversion to the triphosphate form and subsequent incorporation into the DNA of HSV TK gene-transfected FM3A cells. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Name: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Name: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Kinetics and substrate specificity of human and canine cytidine deaminase was written by Fanucchi, Michael P.; Watanabe, Kyoichi A.; Fox, Jack J.; Chou, Ting Chao. And the article was included in Biochemical Pharmacology on April 1,1986.Name: 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one The following contents are mentioned in the article:

The reaction kinetics and specificity of human and canine liver cytidine deaminase (I) for the virucide 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (FIAC) and some other 5-substituted arabinofuranosylcytosine analogs are reported. The Km and Vmax values of human and canine I for FIAC differed significantly; marked kinetic differences of human and canine I were also observed with cytidine, deoxycytidine, arabinofuranosylcytidine, and deoxyfluoroarabinofuranosylcytosine. Studies with human I showed that substitution at the 5-position affected enzyme activity. Thus, although deoxyfluoroarabinofuranosylethylcytosine is a potent antiviral compound in vitro, it was not deaminated by human I. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Name: 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Name: 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Structural requirements for the enzymic deamination of cytosine nucleosides was written by Kreis, W.; Watanabe, K. A.; Fox, J. J.. And the article was included in Helvetica Chimica Acta on April 19,1978.SDS of cas: 56632-83-8 The following contents are mentioned in the article:

Thirty-three 1-β-D-pentofuranosylcytosine nucleosides were examined as substrates of crude cytidine deaminase from mouse kidney. Modification of the aglycone moiety by substitution of a F atom at C(5) resulted in a several-fold increase in the deamination velocity relative to cytidine, whereas insertion of a Me group at C(5) decreased the deamination velocity. This decrease was even more pronounced when a Me group was substituted at C(6). Though xylosylcytosine and 3′-deoxy-3′-fluoroxylocytosine were not substrates for this deaminase, those xylofuranosylcytosines bearing good leaving groups (e.g., bromo, mesyloxy, or tosyloxy) at C(3′) were deaminated with substantial deamination velocities. This is probably due to a prior chem. reaction leading to arabino nucleosides bearing a free 3′-OH in a down configuration. A different situation was obtained with arabino nucleosides. Though 1-β-D-arabinofuranosylcytosine and 2′-deoxy-2′-fluoro-1-β-D-arabinofuranosylcytosine were substrates for this deaminase, substitution of bulky groups (e.g., chloro, bromo, or mesyloxy) at C(2′) substantially decreased the susceptibility to deamination. A hypothesis is offered to explain these differences between xylo- and arabino-cytosines. The presence of a free OH group at the 5′-position is not essential for enzymic deamination. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8SDS of cas: 56632-83-8).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.SDS of cas: 56632-83-8

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Inhibition of Epstein-Barr virus replication by a novel L-nucleoside, 2′-fluoro-5-methyl-β-L-arabinofuranosyluracil was written by Yao, Gang-Qing; Liu, Shwu-Huey; Chou, Edgar; Kukhanova, Marina; Chu, Chung K.; Cheng, Yung-Chi. And the article was included in Biochemical Pharmacology on April 12,1996.HPLC of Formula: 69256-17-3 The following contents are mentioned in the article:

A novel L-nucleoside analog, 2′-fluoro-5-methyl-β-L-arabinofuranosyluracil (L-FMAU), was a potent and selective inhibitor of Epstein-Barr virus (EBV) replication. The decrease in the amount of viral production was concentration dependent with a 90% inhibitory concentration of approx. 5 μM. Upon removal of the drug from treated cells, virus production resumed in 21 days. Metabolism studies indicated that L-FMAU could be converted to its mono-, di- and triphosphate metabolites in both EBV producing and non-producing cells. However, the amount of L-FMAU nucleotides formed was three times larger in EBV producing cells than in EBV non-producing cells. The mechanism of selectivity of L-FMAU against EBV does not appear to be due solely to the preferential phosphorylation of L-FMAU in EBV producing cells. The triphosphate of L-FMAU could not be utilized as a substrate by EBV DNA polymerase or the human DNA polymerases α, β, γ, or δ. Therefore, the incorporation of L-FMAU residues into viral DNA may not be the mechanism of antiviral activity. This compound appears to have a mechanism of action different from that of any other antiherpes virus nucleoside analogs. In addition, L-FMAU has very low cytotoxicity with 50% inhibition of cell growth occurring at a concentration of 1 mM. Given the potent inhibitory activity of this compound against EBV and its inability to be incorporated into cellular DNA, L-FMAU analogs should be explored as a new class of anti-EBV agents. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3HPLC of Formula: 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.HPLC of Formula: 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Fialuridine and its metabolites inhibit DNA polymerase γ at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts was written by Lewis, William; Levine, Eric S.; Griniuviene, Brone; Tankersley, Kevin O.; Colacino, Joseph M.; Sommadossi, Jean-Pierre; Watanabe, Kyoichi A.; Perrino, Fred W.. And the article was included in Proceedings of the National Academy of Sciences of the United States of America on April 16,1996.Synthetic Route of C10H13FN2O5 The following contents are mentioned in the article:

The thymidine analog fialuridine [1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil (FIAU)] was toxic in trials for chronic hepatitis B infection. One mechanism postulated that defective mtDNA replication was mediated through inhibition of DNA polymerase-γ (DNA pol-γ) by FIAU triphosphate (FIAUTP) or by triphosphates of FIAU metabolites. Inhibition kinetics and primer-extension analyses determined biochem. mechanisms of FIAU, 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-methyluracil (FAU), and 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)uracil triphosphate (TP) inhibition of DNA pol-γ. DTMP incorporation by DNA poly-γ was inhibited competitively by FIAUTP, FMAUTP, and FAUTP (Ki = 0.015, 0.03, and 1.0 μM, resp.). By using oligonucleotide template-primers, DNA poly-γ incorporated each analog into DNA opposite a single adenosine efficiently without effects on DNA chain elongation. Incorporation of multiple adjacent analogs at positions of consecutive adenosines dramatically impaired chain elongation by DNA pol-γ. Effects of FIAU, FMAU, and FAU on HepG2 cell mtDNA abundance and ultrastructure were determined After 14 days, mtDNA decreased by 30% with 20 μM FIAU or 20 μM FMAU and decreased less than 10% with 100 μM FAU. FIAU and FMAU disrupted mitochondria and caused accumulation of intracytoplasmic lipid droplets. Biochem. and cell biol. findings suggest that FIAU and its metabolites inhibit mtDNA replication, most likely at positions of adenosine tracts, leading to decreased mtDNA and mitochondrial ultrastructural defects. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Synthetic Route of C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Synthetic Route of C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Relative Reactivity in Piperidino-Dechlorination of 2,4-Diamino-6-chloropyrimidine and 2,4-Diamino-6-chloropyrimidine N(3)-Oxide and Their Acetylamino Analogs was written by Maltese, M.. And the article was included in Journal of Organic Chemistry on April 21,1995.Name: 2,6-Diamino-4-chloropyrimidine-1-oxide The following contents are mentioned in the article:

The second-order rate constants kA for the piperidino-dechlorination of 2,4-diamino-6-chloropyrimidine (1a), 2,4-bis(acetylamino)-6-chloropyrimidine (1b), 2,4-diamino-6-chloropyrimidine N(3)-oxide (2a), and 2,4-bis(acetylamino)-6-chloropyrimidine N(3)-oxide (2b) have been determined from the corresponding pseudo-first-order rate constants, kψ, measured in DMSO at 21.0 °C by the UV spectrophotometric procedure. The second-order rate coefficients of the less reactive substrates 1a and 2a at 21 °C have been obtained as extrapolated values from Arrhenius plots of kA values, calculated through the pseudo-first-order-type relationship, kψ = kA[P] (where [P] is the amine concentration), from the kψ measured at higher temperatures (kA(1a) = 1.36 × 10-5 and kA(2a) = 3.44 × 10-5 L mol-1 min-1). The reactivities of the acetyl derivatives 1b and 2b are remarkably higher than that of the parent compounds 1a and 2a. The pseudo-first-order rate constants of the more reactive substrates 1b and 2b, measured as a function of piperidine concentration, increase linearly for 1b, with a decreasing curvilinear slope only in the higher concentration region of base; in contrast, the reactivity of 2b remains almost constant and lower than that of 1b for most of the employed base concentrations This behavior is due to the acidic character of compound 2b, which is almost totally transformed by excess piperidine into an anionic form, much less reactive than the protonated one toward the nucleophilic attack, even at relatively low base concentrations Compound 1b is much less acidic than 2b and shows deviations from the second-order-type linear behavior only for the higher base concentrations The equilibrium constant for the acid-base reaction of 2b with piperidine has been obtained spectrophotometrically (K = 0.007 ± 0.001), and the second-order rate coefficient kA has been calculated from the constant apparent reactivity k by means of the formula kA = kψ[PH+]/K (where [PH+] is the piperidinium ion concentration) (kA(2b) = 2.7 L mol-1 min-1). That of 1b is given by the slope of the exptl. curve kψ vs [P] in the proximity of the origin (kA(1b) = 0.15 L mol-1 min-1). The results indicate that both the acetylation of the exocyclic -NH2 groups and the oxidation of the cyclic N(3)-atom increase the reactivity of the parent compounds toward piperidinolysis, but that the first modification is much more effective than the second one. The dependence of kψ of 1b and 2b on the amine concentration does not give any evidence for base catalysis, as expected in the model of the intermediate complex mechanism when the leaving group is fast to sep. (as the -Cl group is) and/or the complex formation is rate-limiting. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Name: 2,6-Diamino-4-chloropyrimidine-1-oxide).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Name: 2,6-Diamino-4-chloropyrimidine-1-oxide

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4