Day: November 10, 2022

Antiviral potencies of BV-araU and related nucleoside analogs against varicella-zoster virus in different cell lines was written by Machida, Haruhiko; Ijichi, Katsushi; Ohta, Arihito; Honda, Mariko; Niimura, Michihito. And the article was included in Microbiology and Immunology in 1990.SDS of cas: 69256-17-3 The following contents are mentioned in the article:

The nucleoside analog 1-β-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) and 9 other anti-herpes nucleoside analogs were compared for their potencies against 4 strains of varicella-zoster virus (VZV) on 3 different cell lines: HEL cells, Vero cells, and MS cells established from a human malignant schwannoma. In contrast to the activity against herpes simplex virus type 1 previously reported, BV-araU showed extremely marked antiviral activity against VZV even on Vero cells. ED50, 50% plaque reduction dose, of BV-araU for VZV was 0.20-3.1 and 0.14-0.63 ng/mL on Vero cells and on HEL cells, resp. Potency of BV-araU on MS cells was similar to that on these cell lines. There was no variation in anti-VZV activity of the other nucleoside analogs on these 3 different cell lines except for a few combinations of VZV strain and test compound This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3SDS of cas: 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.SDS of cas: 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Selective inhibition of the proliferation of herpes simplex virus type 1 thymidine kinase gene-transformed murine mammary FM3A carcinoma cells by (E)-5-(2-bromovinyl)-2′-deoxyuridine and related compounds was written by Balzarini, J.; De Clercq, E.; Ayusawa, D.; Shimizu, K.; Seno, T.. And the article was included in Nucleic Acids Symposium Series in 1985.Computed Properties of C10H13FN2O5 The following contents are mentioned in the article:

Mouse mammary carcinoma FM3A cells deficient in thymidine kinase  [9002-06-6] were transformed by a cloned gene for herpes simplex virus type 1 thymidine kinase. Among several antiherpetic nucleoside analog, (E)-5-(2-bromovinyl)-2′-deoxyuridine  [69304-47-8], (E)-5-(2-iodovinyl)-2′-deoxyuridine  [69304-48-9], and (E)-5-(2-bromovinyl)-2′-deoxycytidine  [74131-09-2] inhibited the growth of the transformed cells at concentrations 5000- to 20000-fold lower than those required to inhibit the growth of their corresponding wild-type cells. The selective inhibitory action of these compounds was due to a specific phosphorylation by the viral thymidine kinase. From the transformed cells, thymidine-auxotrophic mutants that are deficient in thymidylate synthase were isolated. These mutant cell lines should prove useful in elucidating the mechanism of action of the antiherpetic nucleoside analogs. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Computed Properties of C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Computed Properties of C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Ab initio studies of the antiviral drug 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)thymine was written by Sapse, A. M.; Snyder, G.. And the article was included in Cancer Investigation in 1985.Recommanded Product: 69256-17-3 The following contents are mentioned in the article:

The antiviral drug 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)thymine (I) [69256-17-3] exhibits a high therapeutic index against a number of herpesviruses. As with other drugs which are nucleoside analogs, such as 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)-5-iodocytosine and others, the activity seems to be strongly related to the presence of a fluorine atom in the sugar moiety, in the arabino position. Theor. calculations, using quantum-chem. methods, are used to elucidate the role of the fluorine in the arabino position and to provide information about the sugar puckering. The results seem to indicate that the fluorine atom prevents the rotation of the base around the sugar-base bond, locking it into an anti-structure which might be related to its exposure to enzymic attack. The sugar study confirms the endo-position (above the plane) of the C’-2 carbon as opposed to the endo-position of the C’-3 carbon. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Recommanded Product: 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Recommanded Product: 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Treatment of genital herpes simplex virus infections in guinea pigs was written by Kern, Earl R.. And the article was included in UCLA Symposia on Molecular and Cellular Biology, New Series in 1984.Application of 69256-17-3 The following contents are mentioned in the article:

Intravaginal inoculation of guinea pigs with herpes simplex virus type 2 provides an excellent model for genital herpes in humans. The infection is characterized by local viral replication in the vaginal tract followed by the appearance of vesicular lesions on external genital skin. After recovery from the primary infection, spontaneous recurrent lesions appear on the external genitalia. Oral treatment with acyclovir  [59277-89-3], 2′-deoxy-2′-fluoro-5-iodoarabinosylcytosin  [69123-90-6], 2′-fluoro-5-iodoarabinosyluracil  [69123-98-4], 2′-fluoro-5-methylarabinosyluracil  [69256-17-3], 9-(1,3-dihydroxy-2′-propoxymethyl)guanine  [82410-32-0], and i.m. treatment with recombinant human interferon-αA all reduced the severity of the primary infection. All compounds administered during recurrent disease also reduced the frequency of recurrent episodes, however, the frequency of recurrences returned to the level of controls when therapy was terminated. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Application of 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Application of 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Exploring Atypical Fluorine-Hydrogen Bonds and Their Effects on Nucleoside Conformations was written by O’Reilly, Daniel; Stein, Robin S.; Patrascu, Mihai Burai; Jana, Sunit Kumar; Kurian, Jerry; Moitessier, Nicolas; Damha, Masad J.. And the article was included in Chemistry – A European Journal in 2018.Category: pyrimidines The following contents are mentioned in the article:

The ability of fluorine to serve as a hydrogen-bond acceptor has been debated for many years. Short fluorine-hydrogen contacts are thought to play a key role in stabilizing some complex supramol. systems. To directly probe the existence of fluorine-hydrogen bonds, we have performed NMR spectroscopy and computational modeling on a series of C2′-fluorinated nucleosides. Specifically, quantum mechanics/mol. mechanics (QM/MM) anal. and [19F,1H] HMBC NMR experiments provided direct evidence for a C-H…F hydrogen bond in a 2′-F,4′-C-α-alkyL-ribonucleoside analog. This interaction was also supported by QTAIM and NBO analyses, which confirmed a bond critical point for the C-H…F interaction (0.74 kcal mol-1). In contrast, although conformational anal. and NMR experiments of 2′-deoxy-2′-fluoro-arabinonucleosides indicated a close proximity between the 2′-fluorine and the H6/8 protons of the nucleobase, mol. simulations did not provide evidence for a C-H…F hydrogen bond. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Category: pyrimidines).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Category: pyrimidines

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

In vitro and in vivo anti-HSV activities of 1-β-D-arabinofuranosyl-E-5-(2-halogenovinyl)uracil was written by Machida, Haruhiko; Sakata, Shinji; Kuninaka, Akira; Yoshino, Hiroshi. And the article was included in International Congress Series in 1982.Safety of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione The following contents are mentioned in the article:

E-5-(2-bromovinyl)arabinosyluracil (I) [77181-69-2] and E-5-(2-chlorovinyl)arabinosyluracil  [77181-70-5] were slightly more effective against herpes simplex virus-1 (HSV-1) infection, but much less effective against HSV-2 infection as compared to 5-vinylarabinosyluracil  [74886-33-2]. Thus, substitution of a H with a halogen at C-2 of the vinyl group increased the anti-HSV-1 activity of vinylarabinosyluracil but weakened its anti-HSV-2 activity. The anti-HSV-1 activity of I was almost equal to that of E-5-(2-bromovinyl)-2′-deoxyuridine BV-dUrd) [69304-47-8], 2′-fluoro-5-iodoarabinosylcytosine  [69123-90-6], and 2′-fluoro-5-methylarabinosyluracil  [69256-17-3]. I was less inhibitory to the growth of HEL-F cells than BV-dUrd. Thus, replacement of the deoxyribose moiety by arabinose in 5-vinyl and 5-halogenvinyl derivatives of 2′-deoxyuridines seems to weaken anticellular activity without significant loss of antiviral activity. The selectivity of I against HVS-1 was confirmed in terms of inhibition of DNA formation in HSV-1 infected cells. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Safety of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Safety of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Integrating Dynamic Positron Emission Tomography and Conventional Pharmacokinetic Studies to Delineate Plasma and Tumor Pharmacokinetics of FAU, a Prodrug Bioactivated by Thymidylate Synthase was written by Li, Jing; Kim, Seongho; Shields, Anthony F.; Douglas, Kirk A.; McHugh, Christopher I.; Lawhorn-Crews, Jawana M.; Wu, Jianmei; Mangner, Thomas J.; Lo Russo, Patricia M.. And the article was included in Journal of Clinical Pharmacology in 2016.Application In Synthesis of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione The following contents are mentioned in the article:

FAU, a pyrimidine nucleotide analog, is a prodrug bioactivated by intracellular thymidylate synthase to form FMAU, which is incorporated into DNA, causing cell death. This study presents a model-based approach to integrating dynamic positron emission tomog. (PET) and conventional plasma pharmacokinetic studies to characterize the plasma and tissue pharmacokinetics of FAU and FMAU. Twelve cancer patients were enrolled into a phase 1 study, where conventional plasma pharmacokinetic evaluation of therapeutic FAU (50-1600 mg/m2) and dynamic PET assessment of 18F-FAU were performed. A parent-metabolite population pharmacokinetic model was developed to simultaneously fit PET-derived tissue data and conventional plasma pharmacokinetic data. The developed model enabled separation of PET-derived total tissue concentrations into the parent drug and metabolite components. The model provides quant., mechanistic insights into the bioactivation of FAU and retention of FMAU in normal and tumor tissues and has potential utility to predict tumor responsiveness to FAU treatment. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Application In Synthesis of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application In Synthesis of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Nucleosides. 133. Synthesis of 5-alkenyl-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)cytosines and related pyrimidine nucleosides as potential antiviral agents was written by Perlman, Michael E.; Watanabe, Kyoichi A.; Schinazi, Raymond F.; Fox, Jack J.. And the article was included in Journal of Medicinal Chemistry in 1985.Reference of 56632-83-8 The following contents are mentioned in the article:

The preparation of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)cytosines with a halovinyl or vinyl substituent at C-5 (I, R = CH:CHBr, CH:CHI, CH:CH2) was accomplished from the corresponding 5-iodo and/or 5-chloromercuri nucleoside analog with use of Li2PdCl4- and Pd(OAc)2-mediated coupling reactions. Thiation of the benzoylated derivative of 2′-fluoro-5-ethyl-ara-U followed by S-methylation and then ammonolysis provided I (R = Et). 5-Ethynyl-2′-fluoro-ara-C and 5-ethynyl-2′-fluoro-ara-U (II; R1 = CCH; Z = NH, O) were obtained from the perisilylated 5-iodo nucleosides by PdII/CuI catalyzed coupling with (trimethylsilyl)acetylene. Most of the new compounds showed activity in vitro against both HSV-1 and HSV-2, as did the known corresponding 5-alkenyluracil nucleosides synthesized earlier. The therapeutic indexes of these compounds are in some cases superior to those of 2′-fluoro-5-methyl-ara-U. Moderate antileukemic activity was observed in vitro for the 5-alkynyl and 5-vinyl compounds The competition of these compounds with thymidine for viral-induced thymidine kinases was also studied. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Reference of 56632-83-8).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Reference of 56632-83-8

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Substrate/inhibitor specificities of human deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2) was written by Kierdaszuk, Borys; Krawiec, Krzysztof; Kazimierezuk, Zygmunt; Jacobsson, Ulla; Johansson, Nils G.; Munch-Petersen, Birgitte; Eriksson, Staffan; Shugar, David. And the article was included in Advances in Experimental Medicine and Biology in 1998.Reference of 56632-83-8 The following contents are mentioned in the article:

Substrate/inhibitor specificities of nucleoside analogs with modified sugar moieties towards highly purified deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2) from human leukemic spleen have been examined Substrate activities of cytosine nucleosides vs. dCK were as follows: 2′-fluoro-dC > 2′-O-methyl-C > araC > 2′-fluoro-2′-deoxy-araC > 3′-O-methyl-dC = 3′-fluoro-2′,3′-ddC > cytosine β-L-riboside > 2′,3′-ddC > C= 1-(4-hydroxy-1,2-butadienyl)-cytosine (cytallene) = 2′-azido-dC. Modified purine nucleosides were only feeble substrates: ara-A > 2′-fluoro-2′-3′-dideoxy-ara-A = 2′-O-methyl-A. With TK1 and TK2, similar sugar-modified analogs of dU and dT were feeble substrates. Surprisingly α-dT was a relatively good substrate, as well some β-L-ribonucleosides. Several 5′-substituted analogs of dC were good non-substrate inhibitors of dCK and, to a lesser extent, of TK2. The overall data are relevant to the role of these enzymes in “”activation”” (by phosphorylation) of nucleoside analogs with antiviral and antitumor activities. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Reference of 56632-83-8).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Reference of 56632-83-8

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Drug resistant and hypersensitive herpes simplex virus mutants: isolation and application to dissection of the pol locus was written by Coen, Donald M.; Chiou, Henry C.; Fleming, H. Edward Jr.; Leslie, Laurel K.; Retondo, Margaret J.. And the article was included in UCLA Symposia on Molecular and Cellular Biology, New Series in 1984.Category: pyrimidines The following contents are mentioned in the article:

Herpes simplex virus mutants resistant to antiviral drugs and aphidicolin are readily isolated in a single-step selection procedure. However, it was found that mutants resistant to one drug are often not substantially cross-resistant to others suggesting possible solutions to potential clin. resistance. Repeated plaque purification has proven essential for such analyses. Previous studies have identified PAA-, ACG-, and araA-resistance mutations in the DNA polymerase (pol) locus. Mutations conferring hypersensitivity to araA, PAA, FMAU, FIAU, BVdU, 2’NDG, and aphidicolin (Aph) were identified and several of these were mapped to the pol locus. The existence of either type of mutation in the pol locus implies that polymerase is a target for the drugs or otherwise mediates drug-sensitivity. Addnl., cross-resistance patterns of the mutants suggest that polymerases capable of discriminating against one nucleoside analog are incapable of discriminating against closely related compounds Mutations conferring altered sensitivity to the same drug map at different locations in the pol locus. Anal. of these mutations should aid in the functional dissection of the polymerase. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Category: pyrimidines).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Category: pyrimidines

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3