Day: November 9, 2022

Epstein-Barr virus: inhibition of replication by three new drugs was written by Lin, Jung Chung; Smith, M. Carolyn; Cheng, Yung Chi; Pagano, Joseph S.. And the article was included in Science (Washington, DC, United States) on August 5,1983.Related Products of 69256-17-3 The following contents are mentioned in the article:

Acyclovir  [59277-89-3], the first clin. useful drug effective against replication of Epstein-Barr virus (EBV) was without effect against latent or persistent EBV infection. Three nucleoside analogs, E-5-(2-bromovinyl)-2′-deoxyuridine (I) [69304-47-8], 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (II) [69123-90-6] and 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-methyluracil (III) [69256-17-3] were potent inhibitors of EBV replication in vitro. Moreover, in contrast to the reversibility of viral inhibition by acyclovir, these 3 drugs have prolonged effects in suppressing viral replication even after the drugs are removed from persistently infected cell cultures. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Related Products of 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Related Products of 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

4�C-Aminomethyl-2�deoxy-2�fluoroarabinonucleoside increases the nuclease resistance of DNA without inhibiting the ability of a DNA/RNA duplex to activate RNase H was written by Tsuchihira, Tatsuya; Kajino, Ryohei; Maeda, Yusuke; Ueno, Yoshihito. And the article was included in Bioorganic & Medicinal Chemistry on August 15,2020.Related Products of 69256-17-3 The following contents are mentioned in the article:

An antisense oligonucleotide is expected as an innovative drug for cancer and hereditary diseases. In this paper, we designed and synthesized DNAs containing a novel nucleoside analog, 1-(4-C-aminomethyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)thymine, and evaluated their properties. It was revealed that the analog slightly decreases the thermal stability of the DNA/RNA duplex but significantly increases the stability of DNA in a buffer containing bovine serum. Furthermore, it turned out that the DNA/RNA duplex containing the analog is a good substrate for Escherichia coli RNase H. Thus, DNAs containing the nucleoside analog would be good candidates for the development of therapeutic antisense oligonucleotides. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Related Products of 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Related Products of 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Synthesis and anti-HIV-1 activity of 2′-“”up””-fluoro analogs of active anti-AIDS nucleosides 3′-azido-3′-deoxythymidine (AZT) and 2′,3′-dideoxycytidine (DDC) was written by Watanabe, Kyoichi A.; Harada, Kazuho; Zeidler, Joanna; Matulic-Adamic, Jasenka; Takahashi, Kiyobumi; Ren, Wu Yun; Cheng, Ling Chin; Fox, Jack J.; Chou, Ting Chao. And the article was included in Journal of Medicinal Chemistry on August 31,1990.Synthetic Route of C9H12FN3O4 The following contents are mentioned in the article:

1-(3-Azido-2,3-dideoxy-2-fluoro-β-D-arabinofuranosyl)thymine (I) and 1-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)cytosine (II) were synthesized from the potent antiherpes virus nucleosides 1-(2-fluoro-β-D-arabinofuranosyl)thymine and 1-(2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine in the hope that introduction of a 2′-“”up””-fluoro substituent might potentiate the anti-HIV activity of 3′-azido-3′-deoxythymidine (AZT) and 2′,3′-dideoxycytidine. I did not exhibit any significant activity against the human immunodeficiency virus (HIV) in vitro. II, however, showed activity against HIV-1, but the therapeutic index was much inferior to that of AZT. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Synthetic Route of C9H12FN3O4).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Synthetic Route of C9H12FN3O4

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Separation of minoxidil and its intermediates by overpressured layer chromatography using a stationary phase bonded with tricaprylmethylammonium chloride was written by Kovacs-Hadady, Katalin; Szilagyi, Judit. And the article was included in Journal of Chromatography on August 16,1991.Safety of 2,6-Diamino-4-chloropyrimidine-1-oxide The following contents are mentioned in the article:

The retention behavior of minoxidil (I) and its intermediates (2,4-diamino-6-hydroxypyrimidine, 2,4-diamino-6-chloropyrimidine and 2,4-diamino-3-N-oxo-6-chloropyrimidine) was studied by using silica gel layers impregnated with tricaprylmethylammonium chloride (TCMA). The retention of the compounds increases with increasing concentration of TCMA adsorbed on the silica gel. The pH and the ionic strength of the eluents do not affect the retention at all. The retention of the solutes decreases with increasing methanol content of the eluent, because of the TCMA-desorbing effect of methanol. On the basis of these and earlier findings, it was concluded that no ion-pairing occurs during the separation A monolayer is formed on the silica surface at 0.1-0.2 M TCMA concentration in the impregnating solution, and hydrophobic interactions play an important role in the separation mechanism. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Safety of 2,6-Diamino-4-chloropyrimidine-1-oxide).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Safety of 2,6-Diamino-4-chloropyrimidine-1-oxide

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Synthesis and anti-HCV activity of 3′,4′-oxetane nucleosides was written by Chang, Wonsuk; Du, Jinfa; Rachakonda, Suguna; Ross, Bruce S.; Convers-Reignier, Serge; Yau, Wei T.; Pons, Jean-Francois; Murakami, Eisuke; Bao, Haiying; Steuer, Holly Micolochick; Furman, Phillip A.; Otto, Michael J.; Sofia, Michael J.. And the article was included in Bioorganic & Medicinal Chemistry Letters on August 1,2010.Product Details of 56632-83-8 The following contents are mentioned in the article:

Hepatitis C virus afflicts approx. 180 million people worldwide and currently there are no direct acting antiviral agents available to treat this disease. Our first generation nucleoside HCV inhibitor, RG7128 has already established proof-of-concept in the clinic and is currently in phase IIb clin. trials. As part of our continuing efforts to discover novel anti-HCV agents, 3′,4′-oxetane cytidine and adenosine nucleosides were prepared as inhibitors of HCV RNA replication. These nucleosides were shown not to be inhibitors of HCV as determined in a whole cell subgenomic replicon assay. However, 2′-mono/diflouro analogs were readily phosphorylated to their monophosphate metabolites by deoxycytidine kinase and their triphosphate derivatives were shown to be inhibitors of HCV NS5B polymerase in vitro. Lack of anti-HCV activity in the replicon assay may be due to the inability of the monophosphates to be converted to their corresponding diphosphates. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Product Details of 56632-83-8).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Product Details of 56632-83-8

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

2′-fluoro-5-[11C]-methyl-1-β-d-arabinofuranosyluracil ([11C]-FMAU): a potential nucleoside analog for in vivo study of cellular proliferation with PET was written by Conti, Peter S.; Alauddin, Mian M.; Fissekis, John R.; Schmall, Bernard; Watanabe, Kyochi A.. And the article was included in Nuclear Medicine and Biology on August 31,1995.SDS of cas: 69256-17-3 The following contents are mentioned in the article:

Rapid in vivo catabolism limits the use of currently available radiotracers used in tumor proliferation studies with positron emission tomog. (PET). This is manifested by the need to develop complex math. models to interpret kinetic and metabolite data obtained from imaging studies with agents such as carbon-11 labeled thymidine. A potential carbon-11 labeled radiotracer for cellular proliferation, 2′-fluoro-5-([11C]-methyl)-1-β-D-arabinofuranosyluracil (FMAU), has been prepared using a previously described method for preparation of [11C]methyl-thymidine where selective alkylation of a pyrimidyl dianion is accomplished with [11C]methyl iodide at the 5-position of the pyrimidine ring. FMAU shares many in vivo characteristics of thymidine, including cellular transport, phosphorylation by mammalian kinase, and incorporation into DNA. Most importantly, in vivo catabolism of FMAU is limited, potentially yielding simplified kinetic models for determination of cellular proliferation with positron emission tomog. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3SDS of cas: 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.SDS of cas: 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Synthesis and anti-HIV activity of several 2′-fluoro-containing pyrimidine nucleosides was written by Sterzycki, Roman Z.; Ghazzouli, Ismail; Brankovan, Vera; Martin, John C.; Mansuri, Muzammil M.. And the article was included in Journal of Medicinal Chemistry on August 31,1990.Quality Control of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione The following contents are mentioned in the article:

Several 2′-fluoroarabino-2′,3′-dideoxy- and 2′-fluoro-2′,3′-unsaturated 2′,3′-dideoxy pyrimidine nucleoside analogs are reported. The saturated analogs 1-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)thymine or -uracil (I; R = Me or H, resp.) were readily prepared from the resp. 2′-deoxy-2′-fluoroarabinosyl nucleoside analog by radical deoxygenation of 3′-OH. The cytosine derivative II and the unsaturated compounds III and IV were also synthesized. The novel compounds were evaluated in vitro against human immunodeficiency virus (HIV) (LAV isolate). II was the most active of the newly synthesized substances against HIV with an ID50 of 0.8 μg/mL; ddC had an ID50 of 0.00m μg/mL. Because of its potency in the initial tests, II was further evaluated in both T cells and macrophage/monocyte cell lines, with several different isolates of HIV. Although II exhibited good antiviral activity in these systems, it was less active than AZT in these assays. At 1 μM the inhibition of CFU-GM by II was found to be 35-40%; this is slightly higher than seen with AZT. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Quality Control of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Quality Control of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Structure-activity relationship of the affinity of 5-substituted uracil nucleoside analogs for varicella-zoster virus thymidine kinase and their activity against varicella-zoster virus was written by Ashida, Noriyuki; Watanabe, Yoko; Miura, Shinji; Kano, Fumitaka; Sakata, Shinji; Yamaguchi, Toyohumi; Suzutani, Tatsuo; Machida, Haruhiko. And the article was included in Antiviral Research on August 31,1997.Quality Control of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione The following contents are mentioned in the article:

We investigated structure-activity relationships of 5-substituted uracil nucleoside analogs for their selective antiviral activity against varicella-zoster virus (VZV) and affinity for VZV thymidine kinase (TK). Anti-proliferative activity of the compounds was measured using human lymphoblastoid cells. Most 2′-deoxyribofuranosyluracil, arabinofuranosyluracil (araU) and 2′-deoxy-2′-fluoro-arabinofuranosyluracil derivatives showed selective anti-VZV activity as well as activity against herpes simplex virus types 1 and 2. 2′-Deoxyuridine derivatives showed higher affinity than the corresponding araU analogs. A correlation was seen between the 50% EDs for VZV and the Ki values for VZV TK, except for 5-ethyl-2′-deoxyuridine and 5-Et araU that showed relatively high affinity for VZV TK without showing any activity against VZV. 5-Halogenovinyluracil nucleosides showed the highest affinity and the most potent and selective anti-VZV activity. 2′-Deoxy-2′-fluoro-arabinofuranosyluracil derivatives exhibited high anti-VZV potency though they showed relatively low affinity for VZV TK. Some 3′-deoxythymidine analogs having anti-human immunodeficiency virus activity were inactive against herpesviruses. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Quality Control of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Quality Control of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Substrate/inhibitor properties of human deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2) towards the sugar moiety of nucleosides, including O’-alkyl analogs was written by Kierdaszuk, Borys; Krawiec, Krzysztof; Kazimierczuk, Zygmunt; Jacobsson, Ulla; Johansson, Nils G.; Munch-Petersen, Birgitte; Eriksson, Staffan; Shugar, David. And the article was included in Nucleosides & Nucleotides on August 31,1999.Recommanded Product: 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one The following contents are mentioned in the article:

Nucleoside analogs with modified sugar moieties have been examined for their substrate/inhibitor specificities towards highly purified deoxycytidine kinase (dCK) and thymidine kinases (tetrameric high-affinity form of TK1-cytoplasmic and TK2-mitochondrial) from human leukemic spleen. In particular, the analogs included the mono- and di-O’-Me derivatives of dC, dU and dA, syntheses of which are described. In general, purine nucleosides with modified sugar rings were feebler substrates than the corresponding cytosine analogs. Sugar-modified analogs of dU were also relatively poor substrates of TK1 and TK2, but were reasonably good inhibitors, with generally lower Ki values vs TK2 than TK1. An excellent discriminator between TK1 and TK2 was 3′-hexanoylamino-2′,3′-dideoxythymidine, with a Ki of âˆ?00 μM for TK1 and âˆ?.1 μM for TK2. 3′-OMe-dC was a superior inhibitor of dCK to its 5′-O-Me congener, consistent with possible participation of the oxygen of the (3′)-OH or (3′)-OMe as proton acceptor in hydrogen bonding with the enzyme. Surprisingly α-dT was a good substrate of both TK1 and TK2, with Ki values of 120 and 30 μM for TK1 and TK2, resp.; and a 3′-branched α-L-deoxycytidine analog proved to be as good a substrate as its α-D-counterpart. Several 5′-substituted analogs of dC were good non-substrate inhibitors of dCK and, to a lesser extent, of TK2. Finally, some ribonucleosides are substrates of the foregoing enzymes; in particular C is a good substrate of dCK, and 2′-OMe-C is an even better substrate than dC. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Recommanded Product: 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Recommanded Product: 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Anti-herpesvirus activity profile of 4′-thioarabinofuranosyl purine and uracil nucleosides and activity of 1-β-D-2′-fluoro-4′-thioarabinofuranosyl guanine and 2,6-diaminopurine against clinical isolates of human cytomegalovirus was written by Machida, Haruhiko; Ashida, Noriyuki; Miura, Shinji; Endo, Mikari; Yamada, Kohei; Kitano, Kenji; Yoshimura, Yuichi; Sakata, Shinji; Ijichi, Osamu; Eizuru, Yoshito. And the article was included in Antiviral Research on August 31,1998.Synthetic Route of C10H13FN2O5 The following contents are mentioned in the article:

Newly synthesized 4′-thio- and 2′-fluoro-4′-thioarabinofuranosyl purine and pyrimidine nucleosides were compared with the corresponding 4′-oxo type arabinosyl nucleosides for anti-herpesvirus and anti-cell proliferative potencies. 4′-Thioarabinosyl- and 2′-fluoro-4′-thioarabinofuranosyl 5-substituted uracils had selective antiviral activities, but were not superior to 4′-oxo nucleosides, except for the activity of 5-ethyluracil-4′-thio nucleosides against herpes simplex virus. Furthermore, 4′-thio substituted derivatives of sorivudine (BV-araU) and related compounds, and 2′-fluoro-5-methylarabinosyluracil exhibited reduced activity against varicella-zoster virus compared with the parent compounds The 4′-thioarabinosyluracils, except for 5-methyluracil derivatives, were inactive against human cytomegalovirus (HCMV). 4′-Thioarabinofuranosyl guanine and diaminopurine had the most potent anti-HCMV and anti-proliferative activities, whereas arabinosyl guanine and diaminopurine had only marginal antiviral activity. 2′-Fluoro-4′-thioarabinofuranosyl derivatives of guanine (4′-thio-FaraG) and 2,6-diaminopurine (4′-thio-FaraDAP), however, had particularly high activity against all herpesviruses tested with anti-proliferative activity equipotent to that of arabinosyl guanine and diaminopurine. 4′-Thio- and 2′-fluoro-4′-thioarabinofuranosyladenines exhibited biol. activities similar to that of arabinosyladenine. Both 4′-thio-FaraG and 4′-thio-FaraDAP had a 6-fold lower ED50 than ganciclovir against clin. isolates of HCMV. A ganciclovir-resistant isolate, obtained from a patient who had received long-term ganciclovir-treatment, was susceptible to 4′-thio-FaraG and 4′-thio-FaraDAP. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Synthetic Route of C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Synthetic Route of C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3