Day: November 3, 2022

On January 12, 2018, Wang, Fang; Li, Chong; Zhang, Zhaochao; Zhang, Xiaoqing published a patent.Computed Properties of 160377-42-4 The title of the patent was Organic compound based on triazine and quinoxaline and its application in organic light-emitting device. And the patent contained the following:

The invention relates to organic compound based on triazine and quinoxaline and its application in organic light-emitting device. The inventive organic compound has high glass transition temperature and mol. thermal stability, has low light absorption and high refractive index in visible light field, and can effectively improve light extraction efficiency of OLED device when applied in CPL layer of OLED device. The inventive compound has deep HOMO level and a high electron mobility, can be applied as hole blocking/electron transporting layer material of OLED device, and can effectively block transportation of hole or energy from light-emitting layer to the side of electron layer, thereby improving recombination efficiency of holes and electrons in light-emitting layer and improving light-emitting efficiency and service life of OLED device. The experimental process involved the reaction of 5-(4-Bromophenyl)pyrimidine(cas: 160377-42-4).Computed Properties of 160377-42-4

The Article related to triazine quinoxaline preparation oled, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Computed Properties of 160377-42-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 31, 2017, Akbarzadeh, Marzieh; Bakavoli, Mehdi; Eshghi, Hossein; Shiri, Ali published an article.HPLC of Formula: 626-48-2 The title of the article was Synthesis of novel derivatives of (benz)imidazo[2,1-b]pyrimido[4,5-d][1,3]thiazine. And the article contained the following:

Several derivatives of the novel heterocyclic systems 2-substituted-imidazo- and benzimidazo-[2,1-b]pyrimido[4,5-d][1,3]thiazine were synthesized through the one-pot cyclocondensation of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine with imidazolidine-2-thione and 1H-benzimidazole-2(3H)-thione and subsequently substituted by various secondary amines in moderately good yields. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).HPLC of Formula: 626-48-2

The Article related to amino imidazopyrimidothiazine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazines and other aspects.HPLC of Formula: 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 6, 2018, Fan, Pingchen; Lange, Christopher W.; Lui, Rebecca M.; Malathong, Viengkham; Mali, Venkat Reddy; Punna, Sreenivas; Zeng, Yibin; Zhang, Penglie published a patent.Related Products of 596114-50-0 The title of the patent was 5-5 Fused ring as C5a inhibitors and their preparation. And the patent contained the following:

The disclosure provides, inter alia, compounds of formula I or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathol. activation from C5a and non-pharmaceutical applications. Compounds of formula I wherein A1 is N, CH, CO and CR4; A2 is N, CH and CR4; A3, A4, A5 and A6 are independently CH and CR4; dashed bonds are single and double bonds; n is 0, 1, 2 and 3; R1 is C1-8 alkylene-C6-10 aryl, C1-8 alkylene-heteroaryl, C1-8 alkyl, etc.; each R2a is independently C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, etc.; each R2b is independently H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, CN, etc.; each R3 is independently C1-4 alkyl, C1-4 haloalkyl, halo and OH; two R3 groups can be taken together to form oxo or a 3- to 5-membered ring; each R4 is independently C1-6 alkyl, C1-6 alkoxy, C1-6 hydroxyalkyl, halo, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their C5a inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of < 5 nM. The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Related Products of 596114-50-0

The Article related to pyrrolopyrazole preparation c5a inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Related Products of 596114-50-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On September 30, 2020, Li, Qian; Zhao, Jiemin; Liu, Longfei; Jonchhe, Sagun; Rizzuto, Felix J.; Mandal, Shankar; He, Huawei; Wei, Sansen; Sleiman, Hanadi F.; Mao, Hanbin; Mao, Chengde published an article.Computed Properties of 65-71-4 The title of the article was A poly(thymine)-melamine duplex for the assembly of DNA nanomaterials. And the article contained the following:

Abstract: The diversity of DNA duplex structures is limited by a binary pair of hydrogen-bonded motifs. Here we show that poly(thymine) self-associates into antiparallel, right-handed duplexes in the presence of melamine, a small mol. that presents a triplicate set of the hydrogen-bonding face of adenine. X-ray crystallog. shows that in the complex two poly(thymine) strands wrap around a helical column of melamine, which hydrogen bonds to thymine residues on two of its three faces. The mech. strength of the thymine-melamine-thymine triplet surpasses that of adenine-thymine base pairs, which enables a sensitive detection of melamine at 3 pM. The poly(thymine)-melamine duplex is orthogonal to native DNA base pairing and can undergo strand displacement without the need for overhangs. Its incorporation into two-dimensional grids and hybrid DNA-small-mol. polymers highlights the poly(thymine)-melamine duplex as an addnl. tool for DNA nanotechnol. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).Computed Properties of 65-71-4

The Article related to polythymine melamine duplex dna nanomaterial, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.Computed Properties of 65-71-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 22, 2019, Xing, Qifeng; Li, Zhiyang; Liu, Shuyao; Ren, Xueyan published a patent.HPLC of Formula: 160377-42-4 The title of the patent was Preparation of pyrazoloindazole derivatives and their application in OLED. And the patent contained the following:

The invention relates to pyrazoloindazole derivative of formula I [wherein Ar1 = H, (un)substituted C6-30 aryl or fused aryl, and (un)substituted C3-30 heteroaryl or fused heteroaryl; Ar2 = (un)substituted C6-30 aryl or fused aryl, and (un)substituted C3-30 heteroaryl or fused heteroaryl], method for their preparation and their application in OLED. The inventive compound can be applied in OLED to effectively reduce the work voltage and improve the light-emitting efficiency of the OLED. The experimental process involved the reaction of 5-(4-Bromophenyl)pyrimidine(cas: 160377-42-4).HPLC of Formula: 160377-42-4

The Article related to pyrazoloindazole derivative preparation oled, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.HPLC of Formula: 160377-42-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On September 25, 2014, Chan, Bryan; Estrada, Anthony; Shore, Daniel; Sweeney, Zachary published a patent.Formula: C8H10BrN3O The title of the patent was Preparation of pyrazolopyridine compounds as LRRK2 inhibitors. And the patent contained the following:

The invention relates to pyrazolopyridine compounds of formula I and II, or pharmaceutically acceptable salts thereof that are useful for the treatment of the diseases associated with LRRK2. Compounds of formula I and II wherein R1 is (un)substituted alkyl, heterocycloalkyl, cycloalkyl, etc.; for formula I, one, two, or three of X1-X4 are N and the remainder are each independently CR2; or X1-X4 are independently CR2; for formula II, X4 is C or N; and one or two of X1-X3 are independently N or NR8, and the remainder are each independently CR2; each R2 is independently H, alkyl, cyano, halo, heteroaryl, OR4, CONR5R6, SO2R7, etc.; each R8 is independently H or (un)substituted alkyl; R4-R7 are independently H or alkyl; R5 and R6 together with nitrogen to which they are attached are linked to form a ring; are claimed. Example compound III was prepared by cyclocondensation of compound IV with hydrazine hydrate, followed by deprotection in 25% yield over two steps. The invention compounds were evaluated for the LRRK2 inhibitory activity and compound III shows 0.0005 μM of Ki. The experimental process involved the reaction of 4-(2-Bromopyrimidin-4-yl)morpholine(cas: 1209459-32-4).Formula: C8H10BrN3O

The Article related to pyrazolopyridine preparation lrrk2 inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Formula: C8H10BrN3O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 18, 2020, Nguyen, Kim; Kubota, Miles; Arco, Jon del; Feng, Chao; Singha, Monika; Beasley, Samantha; Sakr, Jasmine; Gandhi, Sunil P.; Blurton-Jones, Matthew; Fernandez Lucas, Jesus; Spitale, Robert C. published an article.COA of Formula: C5H6N2O3 The title of the article was A Bump-Hole Strategy for Increased Stringency of Cell-Specific Metabolic Labeling of RNA. And the article contained the following:

Profiling RNA expression in a cell-specific manner continues to be a grand challenge in biochem. research. Bioorthogonal nucleosides can be used to track RNA expression; however, these methods currently have limitations due to background and incorporation of analogs into undesired cells. Herein, the authors design and demonstrate that uracil phosphoribosyltransferase can be engineered to match 5-vinyluracil for cell-specific metabolic labeling of RNA with exceptional specificity and stringency. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).COA of Formula: C5H6N2O3

The Article related to rna expression vinyl uracil metabolic labeling, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.COA of Formula: C5H6N2O3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On October 30, 2020, Yang, Chuluo; Ni, Fan published a patent.Electric Literature of 160377-42-4 The title of the patent was Chiral organic luminescent material and application thereof in electronic device. And the patent contained the following:

The title chiral organic luminescent material has a structural formula I as shown in claim 1, wherein A1 is alkenyl alkynyl, amino, etc.; A2 is alkenyl alkynyl, amino, etc.; R1-R3 are independently selected from hydrogen, deuterium, etc.; and A1, A2, R1, R2 and R3 are not connected or bonded via covalent bonds. The charge transfer-state chiral organic luminescent material with a D-A structure is formed by introducing a suitable electron acceptor (A) into chiral dihydroindenoacridine as an electron donor (D). The chiral dihydroindenoacridine as the D has large steric hindrance, is favorable for forming large torsion between D and A so as to reduce overlap of frontier mol. orbits, to further reduce the singlet-triplet energy level difference (ΔEST), activate the reverse intersystem crossing process so as to realize delayed fluorescence emission, and improve the exciton utilization rate of the device. The rigid chiral quaternary carbon in the chiral dihydroindenoacridine can enable the chiral organic light-emitting material to have circularly polarized luminescent properties, so that an organic electroluminescent device based on the chiral dihydroindenoacridine has circularly polarized luminescent properties, and effective guarantee is provided for electroluminescence to pass through a quarter-wave plate and a polarizing plate. The chiral organic luminescent material can be applied to electronic devices such as the organic light-emitting device, organic solar cell, organic field effect transistor, organic light emitting field-effect transistor, organic laser, organic sensor or organic spin electronic device. The experimental process involved the reaction of 5-(4-Bromophenyl)pyrimidine(cas: 160377-42-4).Electric Literature of 160377-42-4

The Article related to chiral organic luminescent material preparation oled, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Electric Literature of 160377-42-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On April 22, 2015, Zhou, Chang; Li, Shouguo published a patent.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Environmentally friendly antirust paint having coating process without rust surface pretreatment. And the patent contained the following:

The present invention discloses environmentally friendly antirust paint having coating process without rust surface pretreatment. The paint is composed of (by parts) sodium antimonate 0.3-1, tetrahydrofurfuryl alc. 1-2, chromium methionine 0.3-1, glycerol polyoxyethylene ether cocoate 0.5-1, lanolin 2-3, magnesium powder 2-3, ammonium zirconium carbonate 1-2, fluorapatite 3-5, leveling and thickening agent of polyurethane pu-8080 1-2, oleic acid polyoxyethylene ester, 2-3, acrylate-silicone emulsion 70-80, antioxidant 168 0.8-1, anhydrous calcium chloride 1-2, additives 2-3, dimethicone 0.1-0.2, sodium CM-cellulose 1-2 and deionized water 5-10. The additive is composed of chlorinated polyether resin, calcium aluminate powder, zinc borate, propylene glycol Bu ether, trimethoprim lactate, sodium myristate soap, hydroxyethyl cellulose and deionized water. The antirust paint has the advantages of: excellent corrosion resistance, good antirust effect, high safety and low environmental pollution, and convenient use. The added additive can effectively improve the film wear resistance and flame retardancy, and enhance the protective effect to the matrix. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to environmentally friendly antirust paint coating process, Coatings, Inks, and Related Products: Other Coating Materials and other aspects.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On July 14, 2017, Zhang, Zhaochao; Tang, Dandan; Li, Chong published a patent.Reference of 5-(4-Bromophenyl)pyrimidine The title of the patent was Organic compound based on triazine and benzimidazole as core and application in organic electroluminescence device. And the patent contained the following:

The invention disclosed a kind of organic compound based on triazine and benzimidazole as core, its preparation method and application in organic electroluminescence device. The claimed compound is shown in structure I (x = 1 or 2; z = 1 or 2; m,n = 0, 1, or 2, and m+n+z = 3; Ar1,Ar2,Ar3 = C1-10 alkyl, or halogen atom, protium, deuterium, tritium substituted or unsubstituted Ph, naphthyl, di-Ph or pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, dibenzofuran, etc.; R1 = C1-10 alkyl, or halogen atom, protium, deuterium, tritium substituted or unsubstituted Ph, naphthyl, etc.; R2,R3 = (un)substituted benzoimidazoyl). The claimed compound is prepared via coupling etc. multiple steps (procedure given). The prepared compound has higher glass transition temperature and mol. thermal stability, low absorption and high refractive index in visible light field, and light extraction efficiency of OLED device can be effectively improved after the compound is applied to the CPL layer of OLED device. The prepared compound also has deep HOMO energy level and high electron mobility, and can be used as hole blocking / electron transport layer material for OLED device to effectively block hole or energy from being transmitted to the electron layer side from the luminescent layer, thus improving recombination efficiency of hole and electron in the luminescent layer so as to improve luminous efficiency and service life of OLED device. The experimental process involved the reaction of 5-(4-Bromophenyl)pyrimidine(cas: 160377-42-4).Reference of 5-(4-Bromophenyl)pyrimidine

The Article related to triazine benzimidazole based core derivative preparation coupling green oled, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Reference of 5-(4-Bromophenyl)pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia