Day: November 3, 2022

Hao, Yiming; Yuan, Xue; Qian, Peng; Bai, Guanfeng; Wang, Yiqin published an article in 2017, the title of the article was The serum analysis of dampness syndrome in patients with coronary heart disease and chronic renal failure based on the theory of “same syndromes in different diseases”.Application In Synthesis of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione And the article contains the following content:

Aim. To analyze the serum metabolites in patients with coronary heart disease (CHD) showing dampness syndrome and patients with chronic renal failure (CRF) showing dampness syndrome and to seek the substance that serves as the underlying basis of dampness syndrome in “same syndromes in different diseases.” Methods. Metabolic spectrum by GC-MS was performed using serum samples from 29 patients with CHD showing dampness syndrome and 32 patients with CRF showing dampness syndrome. The principal component anal. and statistical anal. of partial least squares were performed to detect the metabolites with different levels of expression in patientswith CHDand CRF. Furthermore, by comparing the VIP value and data mining inMETLIN and HMDB, we identified the common metabolites in both patient groups. Results. (1) Ten differential metabolites were found in patients with CHD showing dampness syndrome when compared to healthy subjects. Meanwhile, nine differential metabolites were found in patients with CRF showing dampness syndrome when compared to healthy subjects. (2) There were 9 differential metabolites identified when the serum metabolites of the CHD patients with dampness syndrome were compared to those of CRF patients with dampness syndrome.There were 4 common metabolites found in the serums of both patient groups. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Application In Synthesis of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

The Article related to human chd renal failure serum analysis dampness syndrome, Mammalian Pathological Biochemistry: Cardiovascular Diseases and other aspects.Application In Synthesis of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

D’Antonio, Matteo; Nguyen, Jennifer P.; Arthur, Timothy D.; Matsui, Hiroko; Donovan, Margaret K. R.; D’Antonio-Chronowska, Agnieszka; Frazer, Kelly A. published an article in 2022, the title of the article was In heart failure reactivation of RNA-binding proteins is associated with the expression of 1,523 fetal-specific isoforms.COA of Formula: C5H6N2O2 And the article contains the following content:

Reactivation of fetal-specific genes and isoforms occurs during heart failure. However, the underlying mol. mechanisms and the extent to which the fetal program switch occurs remains unclear. Limitations hindering transcriptome-wide analyses of alternative splicing differences (i.e. isoform switching) in cardiovascular system (CVS) tissues between fetal, healthy adult and heart failure have included both cellular heterogeneity across bulk RNA-seq samples and limited availability of fetal tissue for research. To overcome these limitations, we have deconvoluted the cellular compositions of 996 RNA-seq samples representing heart failure, healthy adult (heart and arteria), and fetal-like (iPSC-derived cardiovascular progenitor cells) CVS tissues. Comparison of the expression profiles revealed that reactivation of fetal-specific RNA-binding proteins (RBPs), and the accompanied re-expression of 1,523 fetal-specific isoforms, contribute to the transcriptome differences between heart failure and healthy adult heart. Of note, isoforms for 20 different RBPs were among those that reverted in heart failure to the fetal-like expression pattern. We determined that, compared with adult-specific isoforms, fetal-specific isoforms encode proteins that tend to have more functions, are more likely to harbor RBP binding sites, have canonical sequences at their splice sites, and contain typical upstream polypyrimidine tracts. Our study suggests that compared with healthy adult, fetal cardiac tissue requires stricter transcriptional regulation, and that during heart failure reversion to this stricter transcriptional regulation occurs. Furthermore, we provide a resource of cardiac developmental stage-specific and heart failure-associated genes and isoforms, which are largely unexplored and can be exploited to investigate novel therapeutics for heart failure. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).COA of Formula: C5H6N2O2

The Article related to transcriptome mbnl1 fmr1 matr3 ipsc exoc7 heart failure adult, Mammalian Pathological Biochemistry: Cardiovascular Diseases and other aspects.COA of Formula: C5H6N2O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On June 30, 2022, Bonifacio, Lillian Gonzalez; Melo, Mirele; Ayo, Christiane Maria; Assoni, Leticia Carolina Paraboli; Olimpio, Larissa Martins; Nogueira, Mariana Reis; Spegiorin, Ligia Cosentino Junqueira Franco; Barbosa, Deusenia Machado Ulisses; de Mattos, Luiz Carlos; Pereira-Chioccola, Vera Lucia; Brandao, Cinara Cassia published an article.Formula: C5H6N2O2 The title of the article was TNFalpha rs1799964 TT genotype may be a susceptibility factor for vertical transmission of Toxoplasma gondii and clinical signs in newborns from pregnant women with acute toxoplasmosis. And the article contained the following:

One of the main impacts of Toxoplasma gondii infection occurs during pregnancy and is related to the vertical transmission of the parasite (congenital toxoplasmosis), which can cause severe clin. outcomes and fetal death. During acute infection, in order to control the rapid replication of tachyzoites, different host immune response genes are activated, and these include cytokine-encoding genes. Considering that polymorphisms in cytokine genes may increase susceptibility to vertical transmission of T. gondii by determining the immune status of the pregnant woman, this study evaluated the influence of polymorphisms of tumor necrosis factor alpha (TNFα) rs1799964 (- 1031) and interleukin 1 beta (IL1β) rs16944 (- 511) genes on gestational toxoplasmosis and on the vertical transmission of the parasite and verified the allele and genotype frequency of these polymorphisms in pregnant patients whose resp. newborn did or did not present clin. abnormalities suggestive of congenital toxoplasmosis. Methods and results: A total of 204 pregnant patients with (n = 114) or without (n = 90) infection by T. gondii were enrolled. No associations were found involving the polymorphisms rs1799964 (- 1031) of the TNFα gene and rs16944 (- 511) of the IL1β gene with the increased chance of T. gondii infection during pregnancy. However, it was observed that the maternal TT genotype referring to the polymorphism of the TNFα gene seems to influence the vertical transmission of the parasite (P = 0.01; χ2 = 6.05) and the presence of clin. manifestation in newborns from pregnancies with acute toxoplasmosis (P = 0.007; χ2 = 9.68). Conclusion: The TNFα rs1799964 TT genotype may act as a susceptibility factor for the vertical transmission of parasite and for the presence of clin. signs in newborns from pregnant women with acute toxoplasmosis. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).Formula: C5H6N2O2

The Article related to toxoplasma tnfalpha genotype acute toxoplasmosis pregnancy newborn, gestational toxoplasmosis, polymorphisms, tnfα and il1β, toxoplasmosis, Mammalian Pathological Biochemistry: Obstetrics – Gynecology and other aspects.Formula: C5H6N2O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 16, 2015, Liang, Ruiyong; Gao, Hai published a patent.Category: pyrimidines The title of the patent was Waterborne sloughing-resistant coating. And the patent contained the following:

The title coating is composed of (by weight parts): ethylene-acrylic acid copolymer 100-120, ammonium aluminum sulfate 1-2, sodium borohydride 0.5-1, epoxidized triglyceride 2-3, expanded perlite 3-5, hydroxypropyl methylcellulose 1-2, tristearin 2-3, 2-mercaptobenzimidazole 0.6-2, mannitol 1-2, talc powder 10-13, bis-imidazolidinyl urea 0.5-1, silicon carbide micropowder 4-6, flame retardant aid 2-4, and deionized water 25-30. The flame retardant aid is composed of: microcapsulated red phosphorus, polycarbonate, aluminum magnesium silicate, lithium-based bentonite, trimethoprim lactate, trimethylolpropane, and isooctyl acrylate. The coating can be used for spray coating of metal material, and is adapted to aerial spraying. The coating film formed from the coating has high surface resistance, high impact strength, and good protective effect. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Category: pyrimidines

The Article related to aqueous coating, Coatings, Inks, and Related Products: Other Coating Materials and other aspects.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On April 22, 2015, Zhou, Chang; Li, Shouguo published a patent.Related Products of 23256-42-0 The title of the patent was Waterborne antirust paint having coating process without rust surface pretreatment. And the patent contained the following:

The present invention discloses waterborne antirust paint having coating process without rust surface pretreatment. The paint is composed of (by parts) isophorone oxide 0.3-1, alkyd resin 10-13, tea saponin 1-2, 2-mercaptobenzimidazole 1-2, slag powder 0.3-0.5, Capsicum frutescens powder 0.7-1, polyhexamethylene guanidine 0.8-2, barium metaborate 3-4, bauxite 4-6, polyacrylamide 0.7-1, potassium dihydrogen phosphate 1-2, isooctyl methacrylate 4-5, waterborne acrylic emulsion 100-110 sodium hexametaphosphate 0.5-1, additives 2-3, dimethicone 0.1-0.2 and deionized water 6-10. The additive is composed of chlorinated polyether resin, calcium aluminate powder, zinc borate, propylene glycol Bu ether, trimethoprim lactate, sodium myristate soap, hydroxyethyl cellulose and deionized water. The antirust paint of the present invention has excellent corrosion resistance and no environmental pollution (by using water as solvent), and can be applied directly to surface without rust pretreatment by spray coating or brush coating. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Related Products of 23256-42-0

The Article related to waterborne antirust coating, Coatings, Inks, and Related Products: Other Coating Materials and other aspects.Related Products of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On February 15, 2017, Nguyen, Kim; Fazio, Michael; Kubota, Miles; Nainar, Sarah; Feng, Chao; Li, Xiang; Atwood, Scott X.; Bredy, Timothy W.; Spitale, Robert C. published an article.Formula: C5H6N2O3 The title of the article was Cell-Selective Bioorthogonal Metabolic Labeling of RNA. And the article contained the following:

Stringent chem. methods to profile RNA expression within discrete cellular populations remains a key challenge in biol. To address this issue, the authors developed a chem.-genetic strategy for metabolic labeling of RNA. Cell-specific labeling of RNA can be profiled and imaged using bioorthogonal chem. The authors anticipate that this platform will provide the community with a much-needed chem. toolset for cell-type specific profiling of cell-specific transcriptomes derived from complex biol. systems. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Formula: C5H6N2O3

The Article related to cell bioorthogonal labeling rna, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.Formula: C5H6N2O3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 14, 2015, Xia, Mingcai published a patent.COA of Formula: C17H24N4O6 The title of the patent was Hydrophobic wear-resistant coatings and their preparation method. And the patent contained the following:

The coatings contain trimethoprim lactate salt 0.6-1, polyethylene benzenesulfonic acid (sic) 0.5-1, allyl alc. 2-3, anhydrous CaCl2 1-2, polyacrylamide 2-3, MgCl2 2-4, phthalate 3-4, potassium dihydrogen phosphate 1-2, 2-thiobenzimidazole 1-2, triammonium molybdate 1-2, dry carbide slags 4-6, bentonite 10-13, hexamethylcyclotrisiloxane 80-100, Bu methacrylate 60-100, Et methacrylate 50-60, hexyl acrylate 130-200, deionized water 500-600, potassium persulfate 2-4, OP-10 3-4, and binders 3-6 parts. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).COA of Formula: C17H24N4O6

The Article related to hydrophobic wear resistant coating, Coatings, Inks, and Related Products: Other Coating Materials and other aspects.COA of Formula: C17H24N4O6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 6, 2018, Fan, Pingchen; Lange, Christopher W.; Lui, Rebecca M.; Malathong, Viengkham; Mali, Venkat Reddy; Punna, Sreenivas; Singh, Rajinder; Tanaka, Hiroko; Zeng, Yibin; Zhang, Penglie published a patent.Category: pyrimidines The title of the patent was 6-5 Fused ring as C5a inhibitors and their preparation. And the patent contained the following:

The disclosure provides, inter alia, compounds of formula I or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathol. activation from C5a and non-pharmaceutical applications. Compounds of formula I wherein A0 is Nh and CO; A1 and A3 are independently N, NH, CH, CO and CR4; A2, A5 and A6 are independently N, CH and CR4; A4 is N, NC1-4 alkyl, CH and CR4; provided that no more than two of A3, A4, A5 and A6 are N; dashed bonds are single and double bonds; n is 0, 1, 2 and 3; R1 is heteroaryl, C6-10 aryl, C1-8 alkylene-heteroaryl, etc.; each R2a is independently C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, etc.; each R2b is independently H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, CN, etc.; each R3 is independently C1-4 alkyl, C1-4 haloalkyl, and OH; two R3 groups can be taken together to form oxo; each R4 is independently C1-6 alkyl, C1-6 alkoxy, C1-6 hydroxyalkyl, halo, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their C5a inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of < 5 nM. The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Category: pyrimidines

The Article related to indazole preparation c5a inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On May 31, 2021, Tang, Lei published an article.Recommanded Product: 4433-40-3 The title of the article was Walking through chromatin modifications. And the article contained the following:

The Cell-TALKING technique probes DNA modifications around a histone modification in fixed cells. Chromatin is a highly organized structure composed of repeating DNA-histone complexes decorated with DNA modifications and histone post-translational modifications (PTMs). To study the composition of chromatin modifications, Zhao’s lab developed Cell-TALKING, a method that leverages DNA walking to index one-to-many combinations of a histone modification with various DNA modifications within a 10-nm nanoenvironment. In Cell-TALKING, the PTM target site is labeled with a DNA walking probe (WP), and DNA modifications including 5-hydroxymethyluracil (5hmU), 5-hydroxymethylcytosine (5hmC) and 5-formyluracil (5fU) are labeled with unique barcoding probes (BPs) that are inactivated with blocked 3′ ends. The researchers applied Cell-TALKING to study the changes in chromatin modifications during the cell cycle and identified combinations of DNA modifications and histone modifications near each other. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Recommanded Product: 4433-40-3

The Article related to cell talking chromatin modification, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.Recommanded Product: 4433-40-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On September 30, 2015, Gong, Canfeng published a patent.Synthetic Route of 23256-42-0 The title of the patent was Flame-retardant antimicrobial coating. And the patent contained the following:

The title flame-retardant antimicrobial coating is prepared from (by parts) furfuryl alc. resin 6-10, butylhydroxyanisole 15-30, polyhexamethylene guanidine 8-16, zirconite powder 10-25, trimethoprim lactate 8-10, bismaleimide resin 4-10, antimony trioxide 12-20, cobalt blue 0.5-1, chlorothalonil 0.1-0.5, magnesium stearate 5-15, isophorone diisocyanate 1-3, and deionized water 30-100. The invention also provides a preparation method of the flame-retardant antimicrobial coating. The inventive flame-retardant antimicrobial coating has good antimicrobial property and flame retardance. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Synthetic Route of 23256-42-0

The Article related to flame retardant antimicrobial coating, Coatings, Inks, and Related Products: Other Coating Materials and other aspects.Synthetic Route of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia