Day: November 3, 2022

On December 31, 2022, Zhang, Hua; Zhao, Lin; Jiang, Jingjing; Zheng, Jie; Yang, Li; Li, Yanyan; Zhou, Jian; Liu, Tianshu; Xu, Jianmin; Lou, Wenhui; Yang, Weige; Tan, Lijie; Liu, Weiren; Yu, Yiyi; Ji, Meiling; Xu, Yaolin; Lu, Yan; Li, Xiaomu; Liu, Zhen; Tian, Rong; Hu, Cheng; Zhang, Shumang; Hu, Qinsheng; Deng, Yangdong; Ying, Hao; Zhong, Sheng; Zhang, Xingdong; Wang, Yunbing; Wang, Hua; Bai, Jingwei; Li, Xiaoying; Duan, Xiangfeng published an article.Category: pyrimidines The title of the article was Multiplexed nanomaterial-assisted laser desorption/ionization for pan-cancer diagnosis and classification. And the article contained the following:

As cancer is increasingly considered a metabolic disorder, it is postulated that serum metabolite profiling can be a viable approach for detecting the presence of cancer. By multiplexing mass spectrometry fingerprints from two independent nanostructured matrixes through machine learning for highly sensitive detection and high throughput anal., we report a laser desorption/ionization (LDI) mass spectrometry-based liquid biopsy for pan-cancer screening and classification. The Multiplexed Nanomaterial-Assisted LDI for Cancer Identification (MNALCI) is applied in 1,183 individuals that include 233 healthy controls and 950 patients with liver, lung, pancreatic, colorectal, gastric, thyroid cancers from two independent cohorts. MNALCI demonstrates 93% sensitivity at 91% specificity for distinguishing cancers from healthy controls in the internal validation cohort, and 84% sensitivity at 84% specificity in the external validation cohort, with up to eight metabolite biomarkers identified. In addition, across those six different cancers, the overall accuracy for identifying the tumor tissue of origin is 92% in the internal validation cohort and 85% in the external validation cohort. The excellent accuracy and min. sample consumption make the high throughput assay a promising solution for non-invasive cancer diagnosis. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Category: pyrimidines

The Article related to liver lung pancreatic colorectal gastric thyroid cancer diagnosis biomarker, Biochemical Methods: Spectral and Related Methods and other aspects.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Qin, Zhen; Liu, Jia; Qiu, Bo; Luo, Hai published an article in 2012, the title of the article was Reactive desorption electrospray ionization mass spectrometry of self-assembled quintets of uracil and its homologues.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione And the article contains the following content:

The authors use reactive desorption electrospray ionization (DESI) to investigate the formation of quintets of uracil and homologs (thymine, 6-methyluracil, 5-ethyluracil, 5,6-dimethyluracil) sep. in the spray solvent and on the surface. Exchange reactions for the subunit(s) of the quintet are observed Furthermore, the different signal distributions of the homo-subunit and hetero-subunit quintets formed from any two of the uracil homologs can be compared by using the values of a specially defined molar ration Rm. The results provide a relative stability order for the quintets formed by each of the homologs, which is in agreement with that obtained by DFT calculations The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to reactive desorption electrospray ionization mass spectrometry uracil homolog quintet, Biochemical Methods: Spectral and Related Methods and other aspects.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On July 10, 2020, Qin, Chao; Hu, Xiaojie; Waigi, Michael Gatheru; Yang, Bing; Gao, Yanzheng published an article.HPLC of Formula: 65-71-4 The title of the article was Amino and hydroxy substitution influences pyrene-DNA binding. And the article contained the following:

Polycyclic aromatic hydrocarbon (PAH)-DNA binding is an essential step in PAH-induced carcinogenesis. A large number of PAHs contain substituents, it is unclear whether functional groups will influence the PAH-DNA binding. Here, we investigated amino (-NH2) and hydroxy (-OH) substitution on pyrene-DNA binding. Because of the considerable effects of electrostatic surface potential (ESP), -NH2 substitution significantly facilitated binding by increasing the binding constant (log KA) from 4.14 L mol-1 to 12.31 L mol-1, while -OH substitution inhibited binding by reducing log KA to 3.68 L mol-1. Spectroscopy results revealed that pyrene and its derivatives were able to bind with thymine to induce DNA damage or double helix distortion. Quantum chem. calculations showed that -NH2 substitution induces hydrogen bond formation, thereby enhancing the binding of pyrene with DNA; moreover, binding force changes due to -OH substitution may not be an essential factor. All structural descriptors were not correlated with the quenching constant (KSV) or binding constant, indicating that changes in physicochem. properties shows no influence on pyrene-DNA binding. The results of this study will improve our understanding of the contribution of functional groups to PAH-DNA binding. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).HPLC of Formula: 65-71-4

The Article related to pyrene dna damage amino hydroxy group substitution, carcinogenesis, dna, functional groups, pahs, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.HPLC of Formula: 65-71-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Green, James A.; Jouybari, Martha Yaghoubi; Aranda, Daniel; Improta, Roberto; Santoro, Fabrizio published an article in 2021, the title of the article was Nonadiabatic absorption spectra and ultrafast dynamics of DNA and RNA photoexcited nucleobases.Electric Literature of 65-71-4 And the article contains the following content:

We have recently proposed a protocol for Quantum Dynamics (QD) calculations, which is based on a parameterisation of Linear Vibronic Coupling (LVC) Hamiltonians with Time Dependent (TD) D. Functional Theory (TD-DFT), and exploits the latest developments in multiconfigurational TD-Hartree methods for an effective wave packet propagation. In this contribution we explore the potentialities of this approach to compute nonadiabatic vibronic spectra and ultrafast dynamics, by applying it to the five nucleobases present in DNA and RNA. For all of them we computed the absorption spectra and the dynamics of ultrafast internal conversion (100 fs timescale), fully coupling the first 2-3 bright states and all the close by dark states, for a total of 6-9 states, and including all the normal coordinates. We adopted two different functionals, CAM-B3LYP and PBE0, and tested the effect of the basis set. Computed spectra are in good agreement with the available exptl. data, remarkably improving over pure electronic computations, but also with respect to vibronic spectra obtained neglecting inter-state couplings. Our QD simulations indicate an effective population transfer from the lowest energy bright excited states to the close-lying dark excited states for uracil, thymine and adenine. Dynamics from higher-energy states show an ultrafast depopulation toward the more stable ones. The proposed protocol is sufficiently general and automatic to promise to become useful for widespread applications. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).Electric Literature of 65-71-4

The Article related to dna rna photoexcitation nucleobase absorption spectra, nonadiabatic interactions, nucleobases, photoinduced processes, quantum dynamics, vibronic spectra, Biochemical Methods: Spectral and Related Methods and other aspects.Electric Literature of 65-71-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On November 30, 2009, Kim, S. A.; Lee, Y. M.; Hwang, I. G.; Kang, D. H.; Woo, G. J.; Rhee, M. S. published an article.Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the article was Eight enrichment broths for the isolation of Campylobacter jejuni from inoculated suspensions and ground pork. And the article contained the following:

Aims: The efficiency of eight enrichment broths for the selective isolation of Campylobacter jejuni was compared to identify an optimal enrichment broth. Methods and Results: Brucella-FBP, Preston, Doyle and Roman, modified CCD (mCCD), Park and Sanders, Bolton, Hunt and Radle and Hunt broths were compared for their recovery of (i) Camp. jejuni in suspension, (ii) Camp. jejuni from inoculated ground pork, (iii) heat-injured Camp. jejuni (55°C for 20 min) in suspension and (iv) heat-injured Camp. jejuni from inoculated ground pork. Hunt broth and Bolton broth showed the highest and most rapid enrichment efficacy for the cell suspensions and ground pork, resp. Preston, Park and Sanders and mCCD broths had relatively high enrichment efficiencies, while Brucella-FBP broth was significantly inferior to the other broths (P < 0.05). Conclusions: Cell recovery from the eight enrichment broths was dependent on the sample type and the state of the cells. The use of the appropriate broth is important for the rapid and efficacious enrichment of Camp. jejuni. In particular, heat-injured Camp. jejuni require a longer cultivation time and a suitable enrichment broth. Significance and Impact of the Study: The results from the present study provide information for selecting the most appropriate enrichment broth for Camp. jejuni and may contribute to improved detection methods for the organism. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to meat pork campylobacter broth food contamination, Food and Feed Chemistry: Contaminants and Toxicants and other aspects.Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On May 8, 2020, Yan, Tzu-Hsien; Lin, Yi-Hsin; Huang, Chao-Wei published a patent.Related Products of 160377-42-4 The title of the patent was Compound with pyridine ring, synthetic method and application as light-emitting element. And the patent contained the following:

The invention disclosed a kind of pyridine containing compound, its preparation method and application as light-emitting element in OLED. The claimed compound is shown in structure I (ring A and the ring B = (un)substituted pyridine ring; A1,A2 = same or different organic groups; R1,R2 = same or different substituent groups; m,n = 0, 1, 2 or 3). The claimed compound is prepared via coupling etc. multiple steps (procedure given). The prepared compound can be applied as electron transport layer material with good electron mobility. The experimental process involved the reaction of 5-(4-Bromophenyl)pyrimidine(cas: 160377-42-4).Related Products of 160377-42-4

The Article related to pyridine derivative preparation coupling electron transport oled, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Related Products of 160377-42-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 14, 2010, Bertram, Lisa Sarah; Fyfe, Matthew Colin Thor; Jeevaratnam, Revathy Perpetua; Keily, John; Krulle, Thomas Martin; Rasamison, Chrystelle Marie; Sambrook-Smith, Colin Peter; Swain, Simon Andrew published a patent.Related Products of 596114-50-0 The title of the patent was Piperidinyl compounds as GPCR agonists and their preparation, and use in the treatment of diabetes and obesity. And the patent contained the following:

The invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of diabetes and obesity. Compounds of formula I wherein Q is CH and N; one of W, Y and Z is N and CH and the others are CR5; R1 is SO2Me and CONH2 and derivatives; R2, R3 and R4 are independently H and Me; n is 0, 1, and 2; R5 is C1-4 alkyl, C1-4 alkoxy, F, Cl, C1-3 fluoroalkyl and Bn; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a general procedure (procedure given). All the invention compounds were evaluated for their GPCR agonistic activity (some data given). The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Related Products of 596114-50-0

The Article related to piperidinyl compound preparation gpcr agonist treatment diabetes obesity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Related Products of 596114-50-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On March 31, 2019, Hlusicka, Jiri; Loster, Tomas; Lischkova, Lucie; Vaneckova, Manuela; Diblik, Pavel; Urban, Pavel; Navratil, Tomas; Kacer, Petr; Kacerova, Tereza; Zakharov, Sergey published an article.Product Details of 4433-40-3 The title of the article was Markers of nucleic acids and proteins oxidative damage in acute methanol poisoning. And the article contained the following:

Abstract: The aim of the study is to measure serum concentrations of markers of nucleic acids and proteins oxidative damage in humans to study the dynamics and clin. determinants of oxidative stress caused by acute methanol poisoning. Acute blood serum samples for this study were collected from 28 patients with methanol poisoning and the follow-up samples from 36 survivors of poisoning were collected 2 years after discharge. Serum concentrations of 8-hydroxy-2′-deoxyguanosine (8-OHdG), 8-hydroxyguanosine (8-OHG), 5-(hydroxymethyl)uracil (5-OHMU), ortho-tyrosine (o-Tyr), nitrotyrosine (NO-Tyr), and chlorotyrosine (Cl-Tyr) were measured by liquid chromatog.-electrospray ionization-tandem mass spectrometry. Acute concentrations of 8-OHdG and o-Tyr were significantly higher than the follow-up concentrations (94.4 ± 6.2 vs. 78.0 ± 10.0 pg cm-3; p = 0.009 and 163.0 ± 11.0 vs. 124.0 ± 17.0 pg cm-3; p < 0.001, correspondingly). Survivors of methanol poisoning had higher acute 8-OHdG and 8-OHG concentrations than those who died (97.3 ± 7.4 vs. 50.0 ± 23.0 pg cm-3; p < 0.001 and 97.9 ± 7.2 vs. 83.7 ± 6.7 pg cm-3; p = 0.047). Acute concentrations of 8-OHdG, 8-OHG, 5-OHMU, and o-Tyr were higher in the patients who survived without health sequelae than in those who survived with visual and CNS sequelae (all p < 0.05). Acute concentrations of markers of proteins and nucleic acids damage correlated with laboratory parameters of acidemia (anion gap) and serum ethanol concentration on admission (both p < 0.05). Acute elevation of the concentration of markers of nucleic acids and proteins oxidative damage in the patients with methanol poisoning suggest that mild-to-moderate oxidative stress may play an important role in the non-specific mechanisms of brain protection against direct neurotoxic effects of formic acid. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Product Details of 4433-40-3

The Article related to forensic biomarker nucleic acid protein oxidative stress methanol poisoning, Toxicology: Forensic Chemistry (Including Analysis) and other aspects.Product Details of 4433-40-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 4, 2017, Saji, Hideo; Kimura, Hiroyuki; Matsuda, Hirokazu; Nakanishi, Shuichi published a patent.Related Products of 175357-98-9 The title of the patent was Preparation of pyridopyrimidine derivatives as nuclear medicine diagnostic imaging agents. And the patent contained the following:

Provided is a radioactive labeled compound that can detect a secondary mutation of an epidermal growth factor receptor and which is a compound represented by formula I or a pharmaceutically acceptable salt thereof. Compounds of formula I, wherein L1 is an alkanediyl group having 1 to 5 carbon atoms or an alkenediyl carbonyl group having 3 to 8 carbon atoms; R1 is a radioactive halogen atom, or 5- to 7-membered monocyclic nitrogen-containing heterocycloalkyl that may have one substituent, R2 is a 6- to 8-membered aryl group or nitrogen-containing heteroaryl group with one substituent; R1 or R2 contains a radioactive halogen atom or a radioactive carbon atom (11C), and Y is NH or O; are claimed. Example compound II was prepared by a multistep procedure (preparation given). The invention compounds were evaluated for their tyrosine kinase inhibiting activity (some data given). The experimental process involved the reaction of 4-Chloro-6-fluoropyrido[3,4-d]pyrimidine(cas: 175357-98-9).Related Products of 175357-98-9

The Article related to pyridopyrimidine derivative nuclear medicine imaging agent tyrosine kinase inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Related Products of 175357-98-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On May 5, 2020, Herl, Thomas; Matysik, Frank-Michael published an article.Electric Literature of 65-71-4 The title of the article was Investigation of the Electrooxidation of Thymine on Screen-Printed Carbon Electrodes by Hyphenation of Electrochemistry and Mass Spectrometry. And the article contained the following:

The electrooxidation of thymine on screen-printed C electrodes was studied using different complementary instrumental approaches. The potential-dependent product profile was obtained by recording real-time mass voltammograms. Electrochem. flow cells with integrated disposable electrodes were directly coupled with mass spectrometry to facilitate a very fast detection of electrogenerated species. Thymine dimers were found at a potential of ∼1.1 V in ammonium acetate (pH 7.0) and 1.25 V in ammonium H carbonate electrolyte (pH 8.0). Electrochem.-capillary electrophoresis-mass spectrometry measurements revealed that two isobaric isomers of a dimeric oxidation product were formed. Separations at different time intervals between end of oxidation and start of separation showed that these were hydrated over time. A study of the pKa values by changing the separation conditions in electrochem.-capillary electrophoresis-UV-visible spectroscopy measurements allowed for further characterization of the primary oxidation products. Both isomers exhibited two deprotonation steps. The oxidation products were further characterized by HPLC-tandem mass spectrometry. Based on the obtained data, the main oxidation products of thymine in aqueous solution could most likely be identified as N(1)-C(5′) and N(1)-C(6′) linked dimer species evolving into the corresponding dimer hydrates over time. The presented methods for online characterization of electrochem. pretreated samples showed that not only mass spectrometric data can be obtained by electrochem.-mass spectrometry but also further characterizations such as the study of product stability and the pH-dependent protonation or deprotonation behavior are possible. This is valid not only for stable oxidation products but also for intermediates, as anal. can be carried out within a short time scale. Thus, a vast amount of valuable exptl. data can be acquired, which can help in understanding electrooxidation processes. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).Electric Literature of 65-71-4

The Article related to electrooxidation thymine screen printed carbon electrode electrochem mass spectrometry, Electrochemistry: Electrochemical Cells and Systems and other aspects.Electric Literature of 65-71-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia