Day: November 2, 2022

On March 28, 2019, Wailes, Jeffrey Steven; Briggs, Emma; Carter, Neil Brian; Morris, Melloney; Tate, Joseph Andrew published a patent.Related Products of 785777-98-2 The title of the patent was Preparation of pyrimidinyl carbamate or urea derivatives as herbicides. And the patent contained the following:

The present invention relates to herbicidally active pyridyl-(or pyrimidyl-) pyrimidine derivatives I [X1 = N or CR1; R1 = H, halo, CN, etc.; R2 = halo, CN, NO2, etc.; R3 = C(O)X2R12; X2 = O or NR10; R4 = H, alkyl, alkoxy, etc.; when X2 = O, R12 = alkyl, alkoxyalkyl, haloalkyl, etc.; when X2 = NR10, R12 = H, alkyl, alkoxy, etc.; R10 = (independently) H, alkyl, cycloalkyl; n = 0-1] or salts or N-oxides thereof, as well as to processes and intermediates used for the preparation of such derivatives E.g., a 2-step synthesis of II, starting from 2-chloro-4-methylpyrimidine-5-carboxylic acid, was described. Exemplified compounds I were evaluated for their pre-emergence and post-emergence herbicidal activities (data given). The invention further extends to herbicidal compositions comprising such derivatives I, as well as to the use of I and compositions in controlling undesirable plant growth: in particular the use in controlling weeds, in crops of useful plants. The experimental process involved the reaction of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine(cas: 785777-98-2).Related Products of 785777-98-2

The Article related to pyrimidinyl pyridylpyrimidinyl pyrimidylpyrimidinyl carbamate urea preparation herbicide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Related Products of 785777-98-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 1, 2011, Barba, Oscar; Bell, James Charles; Dupree, Tom Banksia; Fry, Peter Timothy; Bertram, Lisa Sarah; Fyfe, Matthew Colin Thor; Gattrell, William; Jeevaratnam, Revathy Perpetua; Keily, John; Krulle, Thomas Martin; Mcdonald, Russell Walker; Morgan, Trevor; Rasamison, Chrystelle Marie; Schofield, Karen Lesley; Stewart, Alan John William; Swain, Simon Andrew; Withall, David Matthew published a patent.Name: 2-Chloro-5-isopropylpyrimidine The title of the patent was Preparation of heteroarylpiperidinylmethoxypyrimidinylpyrrolidinylamine derivatives and analogs for use as GPR119 antagonists. And the patent contained the following:

Title compounds I [A = para-substituted Ph or para-substituted heteroaryl containing 1 to 3 N atoms; each Q independently = (CHR9)p; X = O, CH2, NH, etc.; Y = O, CH2, N-alkyl, etc.; Z = CO2aryl, SO2heteroaryl, C(O)alkyl, etc.; R1 = H, halo, CN, alkyl, etc.; R2 = (un)substituted Ph, pyridyl, N-pyrazolyl, etc.; R9 = H, halo, OH, alkyl, etc.; R11 = H, halo, alkyl, haloalkyl, or alkoxy; n = 0 or 1; each p independently = 0 to 2; with provisions], and their pharmaceutically acceptable salts, are prepared and disclosed as GPR119 antagonists. Thus, e.g., II·HCl was prepared by a multistep procedure (preparation given). Select I were evaluated in GPR119 yeast reporter assays (data given). The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Name: 2-Chloro-5-isopropylpyrimidine

The Article related to pyrimidinylpyrrolidinylamine piperidinylmethoxy derivative preparation gpr119 antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Name: 2-Chloro-5-isopropylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On June 30, 2018, Kataev, V. A.; Meshcheryakova, S. A.; Meshcheryakova, E. S.; Tyumkina, T. V.; Khalilov, L. M.; Lazarev, V. V.; Kuznetsov, V. V. published an article.HPLC of Formula: 626-48-2 The title of the article was Direction of the Reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione with 2-Chloromethylthiirane: N1- or N3-Thietanyl Derivative. And the article contained the following:

The reaction of 6-methylpyrimidine-2,4(1H,3H)-dione with 2-chloromethylthiirane gave 6-methyl-N-thietan-3-ylpyrimidine-2,4(1H,3H)-dione. Its oxidation and subsequent reaction of the resulting N-1,1-dioxo-λ6-thietan-3-yl derivative with Et chloroacetate afforded the corresponding Et pyrimidinylacetate. The structure of the latter was determined by X-ray anal., which confirmed the formation of N3-thietan-3-yl derivative rather than its N1-substituted isomer in the title reaction. According to the results of B3LYP/6-31G++d,p, PBE/3ζ, MP2/6-31G++d,p quantum chem. calculations, the N3-thietanyl derivative is more stable than the N1-isomer. It was also found that the calculated barrier to internal rotation of the thietanyl group about the N-C bond in 6-methyl-3-thietan-3-yl-pyrimidine-2,4(1H,3H)-dione is lower than in the N1-isomer. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).HPLC of Formula: 626-48-2

The Article related to methyl thietanylpyrimidine dione preparation, chloromethylthiirane methylpyrimidine dione, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.HPLC of Formula: 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On July 31, 2014, Rudrapal, M.; Babu, T. Mariya; Chandra, T. Ravi; Durga, U. Divya; Swathi, V.; Usha Naga Chandrika, B.; Ravishankar, K. published an article.Recommanded Product: 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was Synthesis and evaluation of heterocyclic scaffold-based styrene conjugates as new antibacterial agents. And the article contained the following:

The conjugation of different substituted styryl (-CH=CH-Aryl) moieties with the biol. relevant heteroaromatic scaffolds such as 4-benzylidene-2-methyloxazol-5-one, 3-methyl-1-phenylpyrazol-5-one, 2-methylbenzimidazole, 6-methyluracil afforded the newer series (four different series), I, II, III, IV [R = H, p-Cl, p-OCH3] of styrene derivatives and their antibacterial effectiveness was tested against both Gram-pos. and Gram-neg. bacteria by in-vitro agar well diffusion method (zone of inhibition in mm) and also by the determination of min. inhibitory concentration (MIC in μg/mL). The results of the antibacterial activity study reveal that the synthesized compounds I, II, III and IV possess in-vitro activity against the tested bacterial strains, which, however, was comparatively very less than that of the standard drug, amikacin sulfate. The structure-activity relationship study could be attributed that the overall antibacterial efficacy of the conjugated series of styrene derivatives I, II, III and IV is the sum of bio-effectiveness of styryl moieties and heterocyclic scaffolds. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Recommanded Product: 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to styrene benzimidazole oxazole pyrazole uracil preparation antibacterial structure activity, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On August 27, 2004, Ondi, Levente; Lefebvre, Olivier; Schlosser, Manfred published an article.SDS of cas: 785777-98-2 The title of the article was Brominated 4-(trifluoromethyl)pyrimidines: A convenient access to versatile intermediates. And the article contained the following:

An expedient route to all three monobrominated and all three dibrominated isomers of 4-(trifluoromethyl)pyrimidine, and to several other halogenated pyrimidines, is described. Key steps are the electrophilic introduction of the halogen in the 5-position of 2- or 4-pyrimidinones, the bromodeoxygenation of pyrimidinones or thiopyrimidinones using phosphorus tribromide, and the partial debromination of dibromo-4-(trifluoromethyl)pyrimidines. The experimental process involved the reaction of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine(cas: 785777-98-2).SDS of cas: 785777-98-2

The Article related to brominated trifluoromethylpyrimidine preparation, pyrimidine trifluoromethyl bromo preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.SDS of cas: 785777-98-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 31, 1981, Yamaguchi, Hitoshi; Ishikawa, Fumiyoshi published an article.Formula: C8H6Cl2N2S The title of the article was Synthesis and reactions of 2-chloro-3,4-dihydrothienopyrimidines and -quinazolines. And the article contained the following:

Reaction of 2,4-dichlorothienopyrimidines and -quinazolines with NaBH4 gave the corresponding 2-chloro-3,4-dihydro derivatives, e.g. I, II, and III (R = Me, R1 = H; R = R1 = Cl). Some nucleophilic substitutions of I afforded 2-substituted derivatives; reaction of III (R = Me, R1 = H; R = R1 = Cl) with BrCH2CO2Et yielded selectively the corresponding 3-substituted compounds, which were converted to imidazoquinazolinones IV. The experimental process involved the reaction of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine(cas: 42518-42-3).Formula: C8H6Cl2N2S

The Article related to thienopyrimidine chloro dihydro reaction, quinazoline chloro dihydro reaction, imidazoquinazolinone, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Formula: C8H6Cl2N2S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On May 23, 2013, Madge, David; Chan, Fiona; John, Derek Edward; Edwards, Simon D.; Blunt, Richard; Hartzoulakis, Basil; Brown, Lindsay published a patent.SDS of cas: 42518-42-3 The title of the patent was Thienopyrimidines, furopyrimidines, thienopyridines and furopyridines useful as potassium channel inhibitors and their preparation. And the patent contained the following:

The invention provides compounds of formula I which are potassium channel inhibitors. The invention further provides pharmaceutical compositions comprising the compounds of formula I and their use in therapy, in particular in treatment of diseases or conditions that are mediated by Kir3.1 and/or Kir3.4 or any heteromultimers thereof, or that require inhibition of Kir3.1 and/or Kir3.4 or any heteromultimers thereof. Compounds of formula I wherein A is O and S; X, V and Z are independently N and CR4, wherein one of two of V, X and Z are N; R1 is (un)substituted alkyl, (un)substituted cycloalkyl, (un)substituted aryl and (un)substituted heteroaryl; R2 is H, halo, CN, CF3, etc.; R3 is H, halo, CN, CF3, (un)substituted alkyl, etc.; each R4 is independently H, halo, CN, CF3, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by N-alkylation of 2-(1-methylpyrrolidin-2-yl)ethanamine with 4-[4-(bromomethyl)-1-piperidyl]-5-phenyl-thieno[2,3-d]pyrimidine. The invention compounds were evaluated for their potassium channel inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of less than 500 nM. The experimental process involved the reaction of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine(cas: 42518-42-3).SDS of cas: 42518-42-3

The Article related to thienopyrimidine furopyrimidine thienopyridine furopyridine preparation potassium channel inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.SDS of cas: 42518-42-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On September 7, 1999, Pamukcu, Rifat; Piazza, Gary published a patent.Product Details of 42518-42-3 The title of the patent was Inhibition of neoplastic cells by exposure to thienopyrimidines. And the patent contained the following:

A method for inhibiting growth of neoplastic cells comprises administration of title compounds [I; R1, R2 = H, A, OA, alkenyl, alkynyl, NO2, CF3, halo; R3, R4 = H, A, OA, halo, NO2, amino; R3R4 = OCH2CH2, OCH2O, OCH2CH2O; X = substituted 5-7 membered heterocyclyl, isocyclyl; A = H, alkyl; n = 0-3; with provisos]. Thus, 2,4-dichloro-6-methylthieno[2,3-d]pyrimidine, 3,4-methylenedioxybenzylamine, and Et3N were stirred in CH2Cl2 to give 2-chloro-6-methyl-4-(3,4-methylenedioxybenzylamino)thieno[2,3-d]pyrimidine. The experimental process involved the reaction of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine(cas: 42518-42-3).Product Details of 42518-42-3

The Article related to thienopyrimidine preparation neoplasm inhibitor, precancerous lesion treatment thienopyrimidine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Product Details of 42518-42-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On October 11, 2004, Ondi, Levente; Lefebvre, Olivier; Schlosser, Manfred published an article.HPLC of Formula: 785777-98-2 The title of the article was Brominated 4-(trifluoromethyl)pyrimidines: A convenient access to versatile intermediates. [Erratum to document cited in CA141:395506]. And the article contained the following:

Throughout the paper, the incorrect reagent names “phosphorus tribromide” and “phosphorus trichloride” should be replaced by the correct names “phosphoric tribromide” (POBr3) and “phosphoric trichloride” (POCL3). The experimental process involved the reaction of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine(cas: 785777-98-2).HPLC of Formula: 785777-98-2

The Article related to erratum brominated trifluoromethylpyrimidine preparation, pyrimidine trifluoromethyl bromo preparation erratum, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.HPLC of Formula: 785777-98-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On July 19, 2007, Epp, Jeffrey Brian; Schmitzer, Paul Richard; Ruiz, James Melvin; Balko, Terry William; Siddall, Thomas Lyman; Yerkes, Carla Nanette published a patent.Synthetic Route of 944129-00-4 The title of the patent was Preparation of 2-(polysubstituted aryl)-6-amino-5-halo-4-pyrimidinecarboxylic acids as herbicides.. And the patent contained the following:

Title compounds [I; Q = halo; R1, R2 = H, alkyl, alkenyl, alkynyl, OH, alkoxy, amino, acyl, carboalkoxy, alkylcarbamyl, alkylsulfonyl, trialkylsilyl, dialkylphosphonyl; NR1R2 = 5- or 6-membered saturated ring; Ar = polysubstituted aryl; and agrochem. acceptable derivatives thereof], were prepared Thus, Me 5-chloro-2-(4-chloro-3-ethoxy-2-fluorophenyl)-6-methanesulfonylpyrimidine-4-carboxylate (preparation given) was stirred 3 h with NH3 in dioxane/MeOH to give 54% Me 6-amino-5-chloro-2-(4-chloro-3-ethoxy-2-fluorophenyl)pyrimidine-4-carboxylate. The latter at 140 g/ha post-emergent gave 100% control of Chenopodium album, Abutilon theophrasti, and Helianthus annus. The experimental process involved the reaction of Methyl 6-amino-2-chloropyrimidine-4-carboxylate(cas: 944129-00-4).Synthetic Route of 944129-00-4

The Article related to arylaminohalopyrimidinecarboxylate preparation herbicide, pyrimidinecarboxylate aryl amino halo preparation weed killer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Synthetic Route of 944129-00-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia