Day: November 2, 2022

Okafor, Charles O.; Steenberg, Marie L.; Buckley, Joseph P. published an article in 1977, the title of the article was Studies in the heterocyclic series. XIII. New CNS-depressants derived from 1,9-diazaphenoxazine and two isomeric triazaphenothiazine ring systems.Application In Synthesis of 5-Bromo-2,4,6-trichloropyrimidine And the article contains the following content:

Triazaphenothiazines I (R = NH2, H, SMe, OMe; R1 = NH2, Me, Cl, OH, OMe) and II (R = H, NH2, Cl; R1 = NH2, OH, Cl; R2 = MeO, Cl) were prepared in 78-93% yield. Reaction of 2-amino-3-mercapto-6-picoline with 2-amino-5-bromo-4-chloro-6-methylpyrimidine in the presence of H2SO4 and Na2SO3 gave 77% I (R = NH2, R1 = Me). All I and II showed appreciable CNS depressant activities comparable with the activity of chlorpromazine when tested in mice and rats; I (R = H, R1 = NH2) and II (R = R1 = Cl, R2 = MeO) were the most promising. All I and II decreased motor activity and rate of respiration within 30 min and body temperature was decreased by 0.5-1.9° compared to 0.8° with chlorpromazine. The experimental process involved the reaction of 5-Bromo-2,4,6-trichloropyrimidine(cas: 63931-21-5).Application In Synthesis of 5-Bromo-2,4,6-trichloropyrimidine

The Article related to depressant triazaphenothiazine, triazaphenothiazine, phenothiazine triaza, Heterocyclic Compounds (More Than One Hetero Atom): Thiazines (Including Cephalosporins) and other aspects.Application In Synthesis of 5-Bromo-2,4,6-trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Qiu, Ran; Sun, Jiamu; Zhang, Xin; Zhao, Wenbo; Qin, Zhen; Luo, Hai published an article in 2016, the title of the article was Isomer differentiation through supramolecular self-assembly in microdroplets of milliseconds life-time.Product Details of 626-48-2 And the article contains the following content:

Supramol. recognition of thymine (or its analogs) with various central cations can form magic number clusters. Dual nano-ESI via theta tip emitters was used to online synthesize clusters. Even thermodynamically unstable clusters can be detected by MS thanks to the very short life-time ( approx. ms) of the generated microdroplets. By recording characteristic cluster distributions, isomers can be clearly differentiated in a novel bottom-up way. Theor. calculations were performed to explain the MS results. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Product Details of 626-48-2

The Article related to isomer differentiation supramol selfassembly microdroplet millisecond lifetime, Physical Organic Chemistry: Degradation Reactions, Including Mass Spectral Fragmentation and other aspects.Product Details of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On March 2, 2017, Kubica, Dominika; Molchanov, Sergey; Gryff-Keller, Adam published an article.Reference of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione The title of the article was Solvation of Uracil and Its Derivatives by DMSO: A DFT-Supported 1H NMR and 13C NMR Study. And the article contained the following:

1H NMR and 13C NMR spectra of uracil, thymine, 5-hydroxymethyluracil, 5,6-dihydrouracil, and 5,6-dihydrothymine in DMSO-d6 solutions have been measured. Addnl., mol. structures as well as NMR parameters of these compounds and their various solvates have been calculated using DFT B3LYP/6-311++G(2d,p) PCM(DMSO) method. The anal. of the chem. shift data for these compounds has shown that, indeed, in DMSO solutions they occur as equilibrium mixtures of free mols. and solvates in which solute and solvent mols. are joined by NH···O or OH···O hydrogen bonds. The populations of particular species present in the solutions have been estimated Moreover, it has been found that 5,6-dihydrothymine exists in DMSO solution preferentially in conformation with the Me group occupying the pseudoequatorial position. This finding is based on the mol. energy calculations and remains in full agreement with the interpretation of NMR data and theor. calculations of NMR parameters. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Reference of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

The Article related to uracil thymine hydroxymethyluracil dihydrouracil dihydrothymine solvation dmso nmr dft, Phase Equilibriums, Chemical Equilibriums, and Solutions: Phase Equilibriums, Solubility and other aspects.Reference of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sahin, Saliha; Karkar, Buesra published an article in 2019, the title of the article was The antioxidant properties of the chestnut bee pollen extract and its preventive action against oxidatively induced damage in DNA bases.Quality Control of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione And the article contains the following content:

Chestnut bee pollen has potential nutritional and medicinal effects and is an important natural bee product. This study focused on the investigation of the antioxidant capacity and DNA damage inhibition ability of chestnut bee pollen (CBP) from Bursa (Turkey). The phenolic compounds (rosmarinic acid, vitexin, hyperoside, pinocembrin, trans-chalcone, apigenin, protocatechuic, and galangin) and carotenoids in CBPE were determined by HPLC-DAD (high-performance liquid chromatog.-diode array detection). Addnl., the protective ability of CBPE against DNA damage by oxidation was investigated. In this study, it was determined that CBPE has a high total phenolic compound content, and the antioxidant capacity of CBPE inhibits DNA oxidation (34% reduction of DNA damage in Fenton reaction media). This study could reveal new information regarding the use of CBPE as a protective agent for DNA in the future. Practical applications : Phenolic compounds and carotenoids prevent some diseases because of their important biol. activities. One of the potential food sources chestnut bee pollen contains sugar, carbohydrates, amino acids, proteins, lipids, vitamins, hormones, enzymes, and flavonoids. Chestnut bee pollen, which has protective activity against DNA oxidation, could be an excellent potential source of a protective agent against some degenerative diseases through future applications. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Quality Control of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

The Article related to antioxidant property chestnut bee pollen extract, dna oxidation, fenton, antioxidant, carotenoid, phenolic content, Food and Feed Chemistry: Additives, Sweeteners, Flavorings, Condiments, and Confectionery and other aspects.Quality Control of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 20, 2012, Kawamura, Madoka; Kobashi, Yohei; Matsuda, Daisuke; Shiozawa, Fumiyasu; Suga, Yoichiro; Fusegi, Keiko; Kakinuma, Hiroyuki; Otake, Norikazu published a patent.Name: 2-Chloro-5-isopropylpyrimidine The title of the patent was Preparation of azaspiroalkane compounds as GPR119 agonists. And the patent contained the following:

Title compounds I [p = 0-2; q = 1 or 2; ring A = benzene ring or 6-membered heteroaryl; R11-R13 = independently H, halo, carbamoyl, etc.; X = -O- or -NR3-; R3 = H or alkyl; Y = alkanediyl; R2 = alkyl (optionally substituted with cycloalkyl or aryl), alkylsulfonyl, alkylcarbonyl, etc.; or pharmaceutically acceptable salts thereof], useful for the treatment of diabetes, were prepared For example, treatment of tert-Bu 2-(methoxymethylidene)-7-azaspiro[3.5]nonane-7-carboxylate (preparation given) with CF3CO2H/water, reaction with NaH/triethyl phosphonoacetate, hydrogenation, reduction using LiAlH4, reaction with 4-cyano-3-fluorophenol in the presence of N,N,N’,N’-tetramethylazodicarbamide, hydrolysis, and EDCI-mediated amidation with 2-aminoethanol afforded compound II. In GPR119 agonist activity test, EC50 of II was 9 nM. Pharmaceutical compositions comprising I are disclosed. The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Name: 2-Chloro-5-isopropylpyrimidine

The Article related to azaspiroalkane preparation gpr119 agonist, diabetes treatment azaspiroalkane gpr119 agonist, Heterocyclic Compounds (One Hetero Atom): Spiro Compounds With One Hetero Atom In Each Ring and other aspects.Name: 2-Chloro-5-isopropylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On September 4, 2014, Kawamura, Madoka; Shiozawa, Fumiyasu; Matsuda, Daisuke; Kakinuma, Hiroyuki; Otake, Kenichi published a patent.Related Products of 596114-50-0 The title of the patent was Preparation of azaspiroalkane compounds as GPR119 agonists. And the patent contained the following:

Title compounds I [spiro moiety represented by Q1 in I is optionally substituted with alkyl or fluoro, may combine with cycloalkane to form a spiro ring, and may form a bridged ring with alkanediyl or alkenediyl; p = 0-3; q = 1-3; n1 = 0-2; n2 = 0-2 such as n1 + n2 = 1 or 2; ring A = benzene ring or 6-membered heteroaryl; R11-R13 = independently H, halo, carbamoyl, etc.; X = -O-, -S- or -NRx-; Rx = H or alkyl; Y = alkanediyl; R2 = alkyl (optionally substituted with cycloalkyl), haloalkyl, cycloalkyl, etc.; or pharmaceutically acceptable salts thereof], useful for the treatment of diabetes, were prepared For example, treatment of tert-Bu 2-(methoxymethylidene)-7-azaspiro[3.5]nonane-7-carboxylate (preparation given) with CF3CO2H/water, reaction with NaH/triethyl phosphonoacetate, hydrogenation, reduction, reaction with 4-cyano-3-fluorophenol in the presence of N,N,N’,N’-tetramethylazodicarbamide, hydrolysis, and EDCI-mediated amidation with 2-aminoethanol afforded compound II. In GPR119 agonist activity test, EC50 of II was 9 nM. Pharmaceutical compositions comprising I are disclosed. The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Related Products of 596114-50-0

The Article related to azaspiroalkane preparation gpr119 agonist, diabetes treatment azaspiroalkane gpr119 agonist, Heterocyclic Compounds (One Hetero Atom): Spiro Compounds With One Hetero Atom In Each Ring and other aspects.Related Products of 596114-50-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On June 30, 2014, Kawamura, Madoka; Shiozawa, Fumiyasu; Kakinuma, Hiroyuki; Otake, Kenichi; Matsuda, Daisuke; Kobashi, Yohei; Suga, Yoichiro; Fusegi, Keiko published a patent.Quality Control of 2-Chloro-5-isopropylpyrimidine The title of the patent was Preparation of azaspiroalkane compounds as GPR119 agonists. And the patent contained the following:

The title compounds [I; p = 0-2; q = 1 or 2; ring A = benzene ring or 6-membered heteroaryl; R11-R13 = independently H, halo, carbamoyl, etc.; X = -O- or -NR3-; R3 = H or alkyl; Y = alkanediyl; R2 = alkyl (optionally substituted with cycloalkyl or aryl), alkylsulfonyl, alkylcarbonyl, etc.; or pharmaceutically acceptable salts thereof], useful for the treatment of diabetes, were prepared For example, treatment of tert-Bu 2-(methoxymethylidene)-7-azaspiro[3.5]nonane-7-carboxylate (preparation given) with CF3CO2H/water, reaction with NaH/triethyl phosphonoacetate, hydrogenation, reduction using LiAlH4, reaction with 4-cyano-3-fluorophenol in the presence of N,N,N’,N’-tetramethylazodicarbamide, hydrolysis, and EDCI-mediated amidation with 2-aminoethanol afforded compound (II). In GPR119 agonist activity test, EC50 of II was 9 nM. Pharmaceutical compositions comprising I are disclosed. The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Quality Control of 2-Chloro-5-isopropylpyrimidine

The Article related to azaspiroalkane preparation gpr119 agonist, diabetes treatment azaspiroalkane gpr119 agonist, Heterocyclic Compounds (One Hetero Atom): Spiro Compounds With One Hetero Atom In Each Ring and other aspects.Quality Control of 2-Chloro-5-isopropylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 24, 2014, Wang, Heshan published a patent.Application of 23256-42-0 The title of the patent was Coating material containing white ointment and manufacture method. And the patent contained the following:

Title coating material is manufactured from white ointment 1-2, trimethoprim lactate 0.5-1, tetrabutylammonium bromide 1-2, sodium carbonate 2-3, allyl poly(ethylene glycol) 1-2, celestite powder 6-10, precipitated silica 5-8, dibutyltin dilaurate 0.8-1, polyacrylamide 0.8-1, styrene 120-160, Me acrylate 80-100, Bu methacrylate 40-60, ammonium peroxydisulfate 3-4, OP-10 6-8, bonding additive 5-7, and deionized water 500-600 weight parts. The bonding additive is manufactured from isobornyl acrylate 6-8, acrylic-silicone emulsion 25-30, microcapsule rose essential oil 2-3, dimethylaminoethyl methacrylate 4-6, potassium persulfate 1-2, redwood powder 2-3, poly(N-vinylpyrrolidone) 0.6-1, and deionized water 10-16 weight parts. The invention also provides methods for manufacturing the title coating material and the bonding additive. The white ointment in the title coating material effectively improves compatibility among the materials, promotes uniform and leveling of coating film, and improves film-forming effect and adhesion. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Application of 23256-42-0

The Article related to coating white ointment manufacture, Coatings, Inks, and Related Products: Acrylic and Water-Sol (Electrophoretic) Resin Coatings and other aspects.Application of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On September 30, 2013, Bakavoli, Mehdi; Eshghi, Hossein; Shiri, Ali; Afrough, Toktam; Tajabadi, Javad published an article.Product Details of 626-48-2 The title of the article was Synthesis, characterization and theoretical evaluations of HMDS promoted chemoselective O-alkylation of uracils. And the article contained the following:

The sodium salts of the conjugated bases of uracils undergo highly chemoselective O4-monoalkylation when treated with various alkyl halides in dry DMF, while the use of Me iodide results in N1+N3-dimethylation. Theor. evaluations of the chemo- and regioselectivity along with x-ray crystallog. data are presented. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Product Details of 626-48-2

The Article related to hmds chemoselective o alkylation uracil, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Product Details of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On October 28, 2013, Bakavoli, Mehdi; Eshghi, Hossein; Shiri, Ali; Afrough, Toktam; Tajabadi, Javad published an article.Synthetic Route of 626-48-2 The title of the article was Synthesis, characterization and theoretical evaluations of HMDS promoted chemoselective O-alkylation of uracils [Erratum to document cited in CA159:399291]. And the article contained the following:

On page 8470, the third paragraph in the first column contained incorrect text; the corrected text is given. On page 8474, an important citation was omitted from the Exptl. section; the omitted citation is given. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Synthetic Route of 626-48-2

The Article related to erratum hmds chemoselective o alkylation uracil, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Synthetic Route of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia