Month: October 2022

Chen, Bang-Chi; Quinlan, Sandra L.; Reid, J. Gregory; Spector, Richard H. published an article on February 19 ,1998. The article was titled 《A new thymine free synthesis of the anti-AIDS drug d4T via regio/stereo controlled β-elimination of bromoacetates》, and you may find the article in Tetrahedron Letters.Formula: C17H16N2O5 The information in the text is summarized as follows:

The anti-AIDS drug d4T was prepared without contamination of the nucleoside bond cleaved byproduct thymine from the readily available ribonucleoside 5-methyluridine. This was accomplished by using a new strategy which involved a regio/stereo controlled β-elimination of trans-bromoacetates. The experimental process involved the reaction of ((2S,5R)-5-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methyl benzoate(cas: 122567-97-9Formula: C17H16N2O5)

((2S,5R)-5-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methyl benzoate(cas: 122567-97-9) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Formula: C17H16N2O5

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 1978,Tetrahedron Letters included an article by Lapachev, V. V.; Zagulyaeva, O. A.; Bichkov, S. F.; Mamaev, V. P.. Formula: C9H9N3O2. The article was titled 《Tautomerism in the pyrimidylmethane systems》. The information in the text is summarized as follows:

The tautomerism of pyrimidyl-4-methanes I [R = CH(CN)CO2Et, R1 = Me, CF3; R = CH2NO2, R1 = Me, H] was studied by 13C and 1H NMR methods. In the presence of DMSO pyrimidine, ortho quinoid and para quinoid forms were observed; the tautomeric equilibrium between these forms, especially between pyrimidylidene tautomers, depends strongly on solvent and is more complicated than suggested by H. Feuer and J. P. Lawrence (1972). Pyrimidine-pyrimidylidene equilibrium were also observed in the pyrimidyl-2-methanes II (R = H, R1 = H, Me, Br, Cl, OMe, NMe2; R = Me, Ph, OMe, R1 = H).Ethyl 2-cyano-2-(pyrimidin-2-yl)acetate(cas: 65364-63-8Formula: C9H9N3O2) was used in this study.

Ethyl 2-cyano-2-(pyrimidin-2-yl)acetate(cas: 65364-63-8) is a member of pyrimidine. Pyrimidine derivatives are an important class of N-heterocycles. They are well-known for their wide spectrum of promising biological activities such as antitumors, bactericidals, and fungicidal.Formula: C9H9N3O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2016,Gower, Carrie M.; Thomas, Jason R.; Harrington, Edmund; Murphy, Jason; Chang, Matthew E. K.; Cornella-Taracido, Ivan; Jain, Rishi K.; Schirle, Markus; Maly, Dustin J. published 《Conversion of a Single Polypharmacological Agent into Selective Bivalent Inhibitors of Intracellular Kinase Activity》.ACS Chemical Biology published the findings.Product Details of 3764-01-0 The information in the text is summarized as follows:

Loss-of-function studies are valuable for elucidating kinase function and the validation of new drug targets. While genetic techniques, such as RNAi and genetic knockouts, are highly specific and easy to implement, in many cases post-translational perturbation of kinase activity, specifically pharmacol. inhibition, is preferable. However, due to the high degree of structural similarity between kinase active sites and the large size of the kinome, identification of pharmacol. agents that are sufficiently selective to probe the function of a specific kinase of interest is challenging, and there is currently no systematic method for accomplishing this goal. Here, the authors present a modular chem. genetic strategy that uses antibody mimetics as highly selective targeting components of bivalent kinase inhibitors. The authors demonstrate that it is possible to confer high kinase selectivity to a promiscuous ATP-competitive inhibitor by tethering it to an antibody mimetic fused to the self-labeling protein SNAPtag. With this approach, a potent bivalent inhibitor of the tyrosine kinase Abl was generated. Profiling in complex cell lysates, with competition-based quant. chem. proteomics, revealed that this bivalent inhibitor possesses greatly enhanced selectivity for its target, BCR-Abl, in K562 cells. Importantly, the authors show that both components of the bivalent inhibitor can be assembled in K562 cells to block the ability of BCR-Abl to phosphorylate a direct cellular substrate. Finally, the authors demonstrate the generality of using antibody mimetics as components of bivalent inhibitors by generating a reagent that is selective for the activated state of the serine/threonine kinase ERK2. The results came from multiple reactions, including the reaction of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Product Details of 3764-01-0)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Product Details of 3764-01-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Phenyl- and Pyrazolyl-Functionalized Pyrimidine: Versatile Chromophore of Bis-Tridentate Ir(III) Phosphors for Organic Light-Emitting Diodes》 were Chen, Yi-Kuang; Kuo, Hsin-Hung; Luo, Dian; Lai, Yi-Ning; Li, Wei-Cheng; Chang, Chih-Hao; Escudero, Daniel; Jen, Alex K.-Y.; Hsu, Ling-Yang; Chi, Yun. And the article was published in Chemistry of Materials in 2019. Recommanded Product: 3764-01-0 The author mentioned the following in the article:

There is growing interest in the bis-tridentate Ir(III) emitters as they are expected to display both improved emission efficiency and improved photostability. Herein, the authors turned to the new emitters m2h-1-3 and m6h-1-3, bearing a pincer carbene ancillary and a chromophoric chelate derived from judiciously selected phenyl-pyrimidine-pyrazole entities (pzm2hF)H2 and (pzm6hF)H2, which differ in terms of the location of Ph and pyrazole substituents on the central pyrimidine. D. functional theory calculations revealed a notable change in the spin d. distribution from the pyrimidine-pyrazolate entity in m2h to the pyrimidine-Ph fragment in m6h. As a consequence, the m6h emitters exhibited both shortened emission lifetimes and improved stabilities during extensive photolysis in solution, while corresponding organic light-emitting diodes (OLEDs) doped with green-emitting m6h-1 and sky-blue-emitting m6h-2 and m6h-3 exhibited external quantum efficiencies of 17.6, 15.9, and 17.6%, resp., superior to those of all of their m2h counterparts at a practical luminance of 103 cd/m2. This finding suggests a new methodol. for fine-tuning the electronic transition that is important to high-performance and durable phosphorescent OLEDs. In the experimental materials used by the author, we found 2,4,6-Trichloropyrimidine(cas: 3764-01-0Recommanded Product: 3764-01-0)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Recommanded Product: 3764-01-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Achieving efficient deep-blue TADF in carbazole-pyrimidine compounds》 was published in Organic Electronics in 2020. These research results belong to Serevicius, Tomas; Skaisgiris, Rokas; Fiodorova, Irina; Steckis, Vytautas; Dodonova, Jelena; Banevicius, Dovydas; Kazlauskas, Karolis; Jursenas, Saulius; Tumkevicius, Sigitas. COA of Formula: C4H2Cl2N2 The article mentions the following:

An approach for achieving deep blue thermally activated delayed fluorescence (TADF) is presented. A simple carbazole-pyrimidine compound Cbz-PYR with near-UV emission and simultaneous room-temperature phosphorescence (RTP) was selectively modified by lowering the singlet state energy, simultaneously preserving high triplet energy. The modified compound tCbz-mPYRs was shown to be efficient TADF emitter with 0.5 solid-state emission yield and peak wavelength of 428 nm. When used in OLED device, tCbz-mPYRs based OLED showed electroluminescence with 8.7% external quantum efficiency (EQE) and Commission Internationale de l′Eclairage (CIE) coordinates of (0.16; 0.12). In the part of experimental materials, we found many familiar compounds, such as 4,6-Dichloropyrimidine(cas: 1193-21-1COA of Formula: C4H2Cl2N2)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.COA of Formula: C4H2Cl2N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Nitrogen Enables the Intensity Modulation of Charge Transfer and Spin Paramagnetism in Graphdiyne》 was written by Zhang, Mingjia; Guan, Zhaoyong; Yang, Ze; Hu, Xiuli; Wang, Xiaoxiong; Long, Yun-Ze; Huang, Changshui. Recommanded Product: 2,4,6-Trichloropyrimidine And the article was included in Chemistry of Materials in 2020. The article conveys some information:

The modulation of intrinsic properties, including magnetism in 2-dimensional materials, has attracted considerable interest as it expands device performance and allows for advanced flexible electronics. Herein, a facile way is developed to modulate the magnetic and elec. response of graphdiyne (GDY) by precise N doping. The introduced N exists only as specific pyridine N and can meet the relative change of 1:2:3 between different materials, which can be used as a switch-like property to manipulate charge transfer and spin. Among these, triazine-graphdiyne (TA-GDY) with the most N content achieves the highest saturation magnetization of up to 3.0 emu/g at 2 K. The accompanying moderate band gap and mobility of up to 7.56 cm2 V-1 s-1 endow it a broad application prospect. These results revealed that controllable N doping can modulate the phys. properties of C-based materials, thus providing a critical way to extend their application in future C electronics involving spin. The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Recommanded Product: 2,4,6-Trichloropyrimidine)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Recommanded Product: 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Product Details of 3934-20-1In 2019 ,《Synthesis, Characterization, Anticancer and Antimicrobial Activity Studies of Novel Isomeric 2,4-Disubstituted Ureide Derivatives of Pyrimidinopiperidines》 appeared in ChemistrySelect. The author of the article were Bhavanam, Lourdu Rani; Kotra, Vijay; Mule, Sivanagi Reddy; Krishna Khandapu, Bala Murali; Bollikolla, Hari Babu. The article conveys some information:

A series of isomeric ureide derivatives of novel 2,4-disubstituted pyrimidinopiperidines, e.g., I were synthesized starting from 2,4-dichloropyrimidine. All the final products were purified on silica and characterized by spectral anal. Both the 2,4-disubstituted pyrimidinopiperidines were analyzed for their in vitro anticancer activity on the cell lines HCT116, MIA-PaCa2 and MDA-MB 231 by using MTT cell proliferation assay. Further, the antimicrobial studies were carried out against different bacterial and fungal strains by employing cup plate method. These compounds showed significant anticancer activity on tested three cancer cell lines and exhibited potent antimicrobial activity in tested strains of bacteria and fungi. In addition to this study using 2,4-Dichloropyrimidine, there are many other studies that have used 2,4-Dichloropyrimidine(cas: 3934-20-1Product Details of 3934-20-1) was used in this study.

2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Product Details of 3934-20-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Design, synthesis and antibacterial activities of triazole-pyrimidine derivatives as SecA inhibitors》 was written by Bamba, Fante; Etienne, Camara Tchambaga; Siomenan, Coulibali; Jacques, Akpa Sagne; Souleymane, Coulibaly; Ane, Adjou. Recommanded Product: 3764-01-0This research focused ontriazole pyrimidine preparation antibacterial activity. The article conveys some information:

Background: To highlight the magnitude of the important challenge now facing scientists, drug resistance needs exploration of novel antimicrobial agents. The identification of new and vital target in bacteria and then designing their inhibitors can be explored. Thus, targeting SecA, a central component of the bacterial general secretion system, is a promising strategy for the development of novel antimicrobials. Objective: To evaluate new compounds as SecA inhibitors synthesized by structural modification of bistriazole SCA-21. Method: A new compounds were synthesized and evaluated for antibacterial activity against Escherichia coli NR698 (E. coli a leaky mutant), Staphylococcus aureus (S. aureus) and Bacillus anthracis (B. anthracis). Results: Some novel triazole-pyrimidine derivatives by structural modification of known SecA inhibitor SCA 21 were synthesized and their structures were confirmed by 1H NMR, 13C NMR and Mass spectral anal. The synthesized compound showed antimicrobial activity against E. coli NR698 (a leaky mutant), S. aureus and B. anthracis Sterne. Conclusion: Five novel triazole-pyrimidine derivatives were designed, synthesized and evaluated as SecA inhibitors. At the end of this study, compound SCA 259 with azide pentyl group was found as the most potent inhibitor. It expressed better inhibitory activity against SecA ATPase than else known inhibitor SCA 21. The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Recommanded Product: 3764-01-0)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Recommanded Product: 3764-01-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Product class 12: pyrimidines》 was written by von Angerer, S.. Recommanded Product: 2-Methoxy-4-methylpyrimidine And the article was included in Science of Synthesis in 2004. The article conveys some information:

A review. Methods for preparing pyrimidines are reviewed including cyclization, ring transformation, aromatization and substituent modification. After reading the article, we found that the author used 2-Methoxy-4-methylpyrimidine(cas: 14001-60-6Recommanded Product: 2-Methoxy-4-methylpyrimidine)

2-Methoxy-4-methylpyrimidine(cas: 14001-60-6) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Recommanded Product: 2-Methoxy-4-methylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Pyrimidine synthesis from ethyl ethoxymethylenecyanoacetate and amidines》 was published in Tetrahedron Letters in 1969. These research results belong to Nishigaki, Sadao; Aida, Kyoko; Senga, Keitaro; Yoneda, Fumio. Synthetic Route of C7H10N4O2 The article mentions the following:

Treatment of 1 equivalent EtOH:C(CN)CO2Et(I) with 3 equivalents MeC(:NH)NH2 (II) in cold EtOH and maintaining the mixture at 0° 18 hrs. yielded 85.5% 5-cyano-4-hydroxy-2-methylpyrimidine acetamidinate (III, R = Me) (IV), m. 184-8° (EtOAc). Use of 2 or 1 equivalent II decreased the yields of IV to 69.0 and 20.3%, resp. A small amount of ethyl 4-amino-2-methyl-5-pyrimidinecarboxylate (V) was extracted from the reactions mixtures with Et2O. IV neutralized with AcOH gave 5-cyano-4-hydroxy-2-methylpyrimidine, reconverted to IV by treating with an equimolar amount of II in alc. The mass spectrum of IV revealed the strong parent ions m/e 135, 58 but no mol. ion, m/e 193, corresponding to N-(3-acetamidino-2-cyanoacryloyl)acetamidine, H2NCR:NCH:C(CN)CONHCR:-NH (VI, R = Me) (VII). The reactions of I with 2-ethyl-2-thiopseudourea (VIII) in MeOH readily gave Et 3-[[amino-(ethylthio)methylene]amino]-2-cyanoacrylate (IX); III (R = EtS) (X), m. 175-7°; and traces of V. Increase of the ratio of VIII to I from 1:1 to 4:1 led to decrease of the % yield of IX and increase of X. The reactions of guanidine with I in cold alc. gave predominantly Et 2,4-diamino-5-pyrimidinecarboxylate (XI), m. 215-17° (alc.), along with a trace of III (R = NH2) (XII), m. >300° (MeOH), converted to 2-amino-5-cyano-4-hydroxypyrimidine, m. >300° (AcOH), by treating with AcOH. Use of a large excess of guanidine increased the yield of XI to 95% in the absence of XII. After reading the article, we found that the author used Ethyl 2,4-diaminopyrimidine-5-carboxylate(cas: 15400-54-1Synthetic Route of C7H10N4O2)

Ethyl 2,4-diaminopyrimidine-5-carboxylate(cas: 15400-54-1) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Synthetic Route of C7H10N4O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia