Month: October 2022

Hu, Xiaohan; Tang, Sheng; Yang, Feiyi; Zheng, Pengwu; Xu, Shan; Pan, Qingshan; Zhu, Wufu published their research in Molecules in 2021. The article was titled 《Design, synthesis, and antitumor activity of olmutinib derivatives containing acrylamide moiety》.Synthetic Route of C4HCl3N2 The article contains the following contents:

Two series of olmutinib derivatives containing an acrylamide moiety I [R1 = 3-NCC6H4NH, 3-MeOC6H4NH, 4-morpholino; R2 = C(O)CH=CH2, C(O)CH=CHMe, C(O)CH=CMe2, etc.; X = CH, N; R3 = H, CH2NMe2, CH2NEt2] were designed and synthesized and their IC50 values against cancer cell lines (A549, H1975, NCI-H460, LO2, and MCF-7) were evaluated. Most of the compounds I exhibited moderate cytotoxic activity against the five cancer cell lines. The most promising compound, I [R1 = 4-morpholinyl, R2 = C(O)CH=CHMe, X = N; R3 = CH2NMe2 (II)] showed not only excellent activity against EGFR kinase but also pos. biol. activity against PI3K kinase. The structure-activity relationship (SAR) suggested that the introduction of dimethylamine scaffolds with smaller spatial structures was more favorable for antitumor activity. Addnl., the substitution of different acrylamide side chains had different effects on the activity of compounds Generally, compounds I [R1 = 3-MeOC6H4NH, R2 = C(O)CH=CHMe, X = CH, R3 = H] and II were confirmed as promising antitumor agents. The results came from multiple reactions, including the reaction of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Synthetic Route of C4HCl3N2)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Synthetic Route of C4HCl3N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Vapor-Liquid Equilibrium Study of the Monochlorobenzene-4,6-Dichloropyrimidine Binary System》 was written by Haaz, Eniko; Fozer, Daniel; Thangaraj, Ravikumar; Szori, Milan; Mizsey, Peter; Toth, Andras Jozsef. Formula: C4H2Cl2N2This research focused onvapor liquid equilibrium monochlorobenzene dichloropyrimidine binary system. The article conveys some information:

The number of newly synthesized and produced organic chems. has increased extremely quickly. However, the measurements of their phys. properties, including their vapor-liquid equilibrium (VLE) data, are time-consuming. It so happens that there is no phys. property data about a brand-new chem. Therefore, the importance of calculating their physicochem. properties has been playing a more and more important role. 4,6-Dichloropyrimidine (DCP) is also a relatively new mol. of high industrial importance with little existing data. Therefore, their measurements and the comparison with the calculated data are of paramount concern. DCP is a widespread heterocyclic moiety that is present in synthetic pharmacophores with biol. activities as well as in numerous natural products. Isobaric VLE for the binary system of 4,6-dichloropyrimidine and its main solvent monochlorobenzene (MCB) was measured using a vapor condensate and liquid circulation VLE apparatus for the first time in the literature. D. functional-based VLE was calculated using the COSMO-SAC protocol to verify the laboratory results. The COSMO-SAC calculation was found to be capable of representing the VLE data with high accuracy. Adequate agreement between the exptl. and calculated VLE data was acquired with a minimal deviation of 3.0 x 10-3, which allows for broader use of the results. The experimental part of the paper was very detailed, including the reaction process of 4,6-Dichloropyrimidine(cas: 1193-21-1Formula: C4H2Cl2N2)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Formula: C4H2Cl2N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2006,Plant disease included an article by Luan, Y S; Feng, L; An, L J. Formula: C6H7N3O2S. The article was titled 《First Report of Blueberry Leaf Spot Caused by Cylindrocladium colhounii in China.》. The information in the text is summarized as follows:

During late July and early August of 2005, leaf spot symptoms were observed in a blueberry nursery at a plantation in Dalian, which to our knowledge, lies within the largest blueberry-production area in China. Symptoms were observed primarily on lowbush species, for example Blomidon, as well as half-highbush cultivars. A slow-growing, white mycelium from the margin of necrotic leaf spots was recovered on potato dextrose agar (PDA). The following morphological traits were observed: erect conidiophores that branch twice and were terminated in a stiped, clavate phialide; hyaline, cylindrical, four-celled conidia; and globose, reddish brown, aggregated chlamydospores. Conidiophores (including stipes and terminal phialides) were 305 to 420 × 5 to 9 μm; primary branches were 9 to 45 × 5 to 6.3 μm; secondary branches were 9 to 17.3 × 3.1 to 4.5 μm; phialides were 7.8 to 17.5 × 2.5 to 6 μm; stipes (from the highest branch area to vesicle) were 150 to 270 μm long; and vesicles were 13 to 30 × 2 to 4.5 μm. Conidia were 50 to 72 × 4 to 5.5 μm. Chlamydospores were 15 to 20 μm in diameter. Koch’s postulates were fulfilled by spray inoculating two healthy cultivars with conidiophores homogenized in axenic water. As a control, two healthy plants were sprayed with axenic water. Plants were placed inside plastic bags to maintain humidity and incubated in a growth chamber at 26°C under fluorescent light for 14 h and 20°C in darkness for 10 h. After 2 days, the plastic bags were removed and plants were maintained under the same conditions. After 4 days, small-to-medium brown spots with purplish margins were observed on the adaxial side of leaves from inoculated plants, but not from control plants. Fungi isolated from these lesions had the same morphological traits as the ones isolated previously from field plants. The morphological descriptions and measurements were similar to Cylindorocladium colhounii (2). The 5.8S subunit and flanking internal transcribed spacers (ITS1 and ITS2) of rDNA and the β-tubulin gene were amplified from DNA extracted from single-spore cultures using the ITS1/ITS4 primers and T1/Bt2b primers, respectively, and sequenced (1). The ITS and β-tubulin gene sequences were similar to C. colhounii STE-U 1237 (99%; GenBank Accession Number AF231953) and C. colhounii STE-U 705 (99%; GenBank Accession Number AF231954), respectively. The morphology, secondary conidiation, and sequences of ITS and β-tubulin gene identify the causal fungus as C. colhounii. To our knowledge, this is the first report of C. colhounii on blueberry in China or in the world. References: (1) P. W. Crous et al. Can. J. Bot. 77:1813, 1999. (2) T. Watanabe. Page 222 in: Dictorial Atlas of Soil and Seed Fungi. CRC Press, Inc., Boca Raton, Fl, 1994. In the part of experimental materials, we found many familiar compounds, such as 4-Amino-2-(methylthio)pyrimidine-5-carboxylic acid(cas: 771-81-3Formula: C6H7N3O2S)

4-Amino-2-(methylthio)pyrimidine-5-carboxylic acid(cas: 771-81-3) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Formula: C6H7N3O2S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2022,Kruppa, Marco; Sommer, Gereon A.; Mueller, Thomas J. J. published an article in Molecules. The title of the article was 《Concise Syntheses of Marine (Bis)indole Alkaloids Meridianin C, D, F, and G and Scalaridine A via One-Pot Masuda Borylation-Suzuki Coupling Sequence》.Computed Properties of C4H2Cl2N2 The author mentioned the following in the article:

N-Protected 3-iodoindoles were reacted with (di)azine halides in a sequentially Pd-catalyzed one-pot fashion, i.e., by Masuda borylation-Suzuki coupling (MBSC) sequence. This methodol. was successfully applied to the concise syntheses of marine indole alkaloids meridianin C, D, F, and G, as well as to the bisindole alkaloid scalaridine A, which were obtained in moderate to excellent yield. The experimental process involved the reaction of 2,4-Dichloropyrimidine(cas: 3934-20-1Computed Properties of C4H2Cl2N2)

2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Computed Properties of C4H2Cl2N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2022,Sun, Yiping; Qu, Hongmei; Zhang, Jiacai; Duan, Xingyu; Zhang, Xiaokun published an article in Tetrahedron. The title of the article was 《Room temperature phosphorescence, thermally activated delayed fluorescence and multicolor mechanochromic luminescence of emitters through molecular interaction and conformational modulations》.Name: 2,4-Dichloropyrimidine The author mentioned the following in the article:

Two novel heavy atom-free pure organic pyrimidine-based asym. donor-acceptor type emitters were designed and synthesized. The twisted D-A conformation was favored to produce small ΔEst and effective ISC. Excitingly, PMBT and CzPMBT showed precious fluorescence-RTP-TADF triple emission. Furthermore, PMBT responded to external stimuli of volatile solvents fumigation and different intensity grinding to generate a multicolor switching system, which included charming white light due to the dual emission of fluorescence and phosphorescence. Crystallog. anal. was conducted to explain the reasons for the differences in photophys. properties produced by the two compounds This research provides insight into the mechanism of action of RTP, TADF and multicolor MCL through intermol. interactions and conformational modulation. The experimental process involved the reaction of 2,4-Dichloropyrimidine(cas: 3934-20-1Name: 2,4-Dichloropyrimidine)

2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Name: 2,4-Dichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Han, Shuwen; Zhuang, Chunlin; Zhou, Wei; Chen, Fener published an article in 2021. The article was titled 《Structural-based optimizations of the marine-originated meridianin C as glucose uptake agents by inhibiting GSK-3β》, and you may find the article in Marine Drugs.COA of Formula: C4H2Cl2N2 The information in the text is summarized as follows:

Glycogen synthase kinase 3β (GSK-3β) is a widely investigated mol. target for numerous diseases, and inhibition of GSK-3β activity has become an attractive approach for the treatment of diabetes. Meridianin C, an indole-based natural product isolated from marine Aplidium meridianum, has been reported as a potent GSK-3β inhibitor. In the present study, applying the structural-based optimization strategy, the pyrimidine group of meridianin C was modified by introducing different substituents based on the 2-aminopyrimidines-substituted pyrazolo pyridazine scaffold. Among them, compounds B29 and B30 showed a much higher glucose uptake than meridianin C (<5%) and the pos. compound 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD-8, 16%), with no significant toxicity against HepG2 cells at the same time. Furthermore, they displayed good GSK-3β inhibitory activities (IC 50 = 5.85; 24.4 μM). These results suggest that these meridianin C analogs represent novel lead compounds with therapeutic potential for diabetes.2,4-Dichloropyrimidine(cas: 3934-20-1COA of Formula: C4H2Cl2N2) was used in this study.

2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.COA of Formula: C4H2Cl2N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Quality Control of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidineIn 2010 ,《Synthesis of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine and 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine》 appeared in Youji Huaxue. The author of the article were Hao, Baoyu; Chen, Xinzhi; Zhang, Weihan. The article conveys some information:

An efficient route for the preparation of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine and 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine was designed and the synthesis of the target compounds was achieved using di-Et malonate as a starting material for a five-step sequence and the products were obtained in 45.8% and 44.8%, resp. In the experimental materials used by the author, we found 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Quality Control of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Quality Control of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《A pharmacological network for lifespan extension in Caenorhabditis elegans》 was written by Ye, Xiaolan; Linton, James M.; Schork, Nicholas J.; Buck, Linda B.; Petrascheck, Michael. Recommanded Product: 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine And the article was included in Aging Cell on April 30 ,2014. The article conveys some information:

Summary: One goal of aging research is to find drugs that delay the onset of age-associated disease. Studies in invertebrates, particularly Caenorhabditis elegans, have uncovered numerous genes involved in aging, many conserved in mammals. However, which of these encode proteins suitable for drug targeting is unknown. To investigate this question, we screened a library of compounds with known mammalian pharmacol. for compounds that increase C. elegans lifespan. We identified 60 compounds that increase longevity in C. elegans, 33 of which also increased resistance to oxidative stress. Many of these compounds are drugs approved for human use. Enhanced resistance to oxidative stress was associated primarily with compounds that target receptors for biogenic amines, such as dopamine or serotonin. A pharmacol. network constructed with these data reveal that lifespan extension and increased stress resistance cluster together in a few pharmacol. classes, most involved in intercellular signaling. These studies identify compounds that can now be explored for beneficial effects on aging in mammals, as well as tools that can be used to further investigate the mechanisms underlying aging in C. elegans. In the experiment, the researchers used 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(cas: 213743-31-8Recommanded Product: 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine)

7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(cas: 213743-31-8) belongs to pyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Recommanded Product: 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Design, Synthesis and Evaluation of Triazole-Pyrimidine Analogues as SecA Inhibitors》 was written by Cui, Jianmei; Jin, Jinshan; Chaudhary, Arpana Sagwal; Hsieh, Ying-hsin; Zhang, Hao; Dai, Chaofeng; Damera, Krishna; Chen, Weixuan; Tai, Phang C.; Wang, Binghe. Recommanded Product: 2,4,6-TrichloropyrimidineThis research focused ontriazole pyrimidine analog preparation SecA inhibitors antimicrobial resistance; SecA inhibitors; antimicrobials; protein secretion; pyrimidines; triazoles. The article conveys some information:

SecA, a key component of the bacterial Sec-dependent secretion pathway, is an attractive target for the development of new antimicrobial agents. Through a combination of virtual screening and exptl. exploration of the surrounding chem. space, we identified a hit bistriazole SecA inhibitor, SCA-21, and studied a series of analogs by systematic dissections of the core scaffold. Evaluation of these analogs allowed us to establish an initial structure-activity relationship in SecA inhibition. The best compounds in this group are potent inhibitors of SecA-dependent protein-conducting channel activity and protein translocation activity at low- to sub-micromolar concentrations They also have minimal inhibitory concentration (MIC) values against various strains of bacteria that correlate well with the SecA and protein translocation inhibition data. These compounds are effective against methicillin-resistant Staphylococcus aureus strains with various levels of efflux pump activity, indicating the capacity of SecA inhibitors to null the effect of multidrug resistance. Results from studies of drug-affinity-responsive target stability and protein pull-down assays are consistent with SecA as a target for these compounds The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Recommanded Product: 2,4,6-Trichloropyrimidine)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Recommanded Product: 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2016,Sabat, Nazarii; Naus, Petr; Matyasovsky, Jan; Dziuba, Dmytro; Slavetinska, Lenka Postova; Hocek, Michal published 《Synthesis of fluorescent 2-substituted 6-(Het)aryl-7-deazapurine bases {4-(Het)aryl-pyrrolo[2,3-d]pyrimidines} by aqueous Suzuki-Miyaura cross-coupling reactions》.Synthesis published the findings.Quality Control of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine The information in the text is summarized as follows:

A series of 4-(het)aryl-pyrrolo[2,3-d]pyrimidines [6-(het)aryl-7-deazapurine bases] bearing a H, NH2, CH3, F, or Cl group at the 2-position and either H or F at the 5-position (position 7 of 7-deazapurine) were prepared in a single step by the aqueous Suzuki-Miyaura cross-coupling reactions of the corresponding 6-chloro-7-deazapurines with (het)arylboronic acids. Unlike their ribonucleoside derivatives, which are potent cytostatics, the deazapurine bases did not show significant biol. activity but most of them exerted bright fluorescence with emission maxima 368-468 nm and high quantum yields up to 0.83. In the experimental materials used by the author, we found 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Quality Control of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Quality Control of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia