Month: October 2022

Quality Control of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidineOn March 15, 2008, Doherty, Elizabeth M.; Retz, Daniel; Gavva, Narender R.; Tamir, Rami; Treanor, James J. S.; Norman, Mark H. published an article in Bioorganic & Medicinal Chemistry Letters. The article was 《4-Aminopyrimidine tetrahydronaphthols: A series of novel vanilloid receptor-1 antagonists with improved solubility properties》. The article mentions the following:

8-{6-[4-(Trifluoromethyl)phenyl]pyrimidin-4-ylamino}-1,2,3,4-tetrahydronaphthalen-2-ol and its analogs were shown to be potent inhibitors of human and rat TRPV1 in vitro with increased solubility Synthesis, SAR, and improvements in metabolic stability and absorption of these compounds are described. The experimental process involved the reaction of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine(cas: 659729-09-6Quality Control of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine)

4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine(cas: 659729-09-6) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. Quality Control of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidineThey have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Atkinson, Benjamin N.; Steadman, David; Mahy, William; Zhao, Yuguang; Sipthorp, James; Bayle, Elliott D.; Svensson, Fredrik; Papageorgiou, George; Jeganathan, Fiona; Frew, Sarah; Monaghan, Amy; Bictash, Magda; Jones, E. Yvonne; Fish, Paul V. published an article on February 1 ,2020. The article was titled 《Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.SDS of cas: 108831-66-9 The information in the text is summarized as follows:

The carboxylesterase Notum is a key neg. regulator of the Wnt signaling pathway by mediating the depalmitoleoylation of Wnt proteins. Our objective was to discover potent small mol. inhibitors of Notum suitable for exploring the regulation of Wnt signaling in the central nervous system. Scaffold-hopping from thienopyrimidine acids 1 and 2, supported by X-ray structure determination, identified 3-methylimidazolin-4-one amides 20-24 as potent inhibitors of Notum with activity across three orthogonal assay formats (biochem., extra-cellular, occupancy). A preferred example 24 demonstrated good stability in mouse microsomes and plasma, and cell permeability in the MDCK-MDR1 assay albeit with modest P-gp mediated efflux. Pharmacokinetic studies with 24 were performed in vivo in mouse with single oral administration of 24 showing good plasma exposure and reasonable CNS penetration. We propose that 24 is a new chem. tool suitable for cellular studies to explore the fundamental biol. of Notum. In the experiment, the researchers used many compounds, for example, 6-Methyl-3H-thieno[2,3-d]pyrimidin-4-one(cas: 108831-66-9SDS of cas: 108831-66-9)

6-Methyl-3H-thieno[2,3-d]pyrimidin-4-one(cas: 108831-66-9) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.SDS of cas: 108831-66-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Lefebvre, Carole-Anne; Forcellini, Elsa; Boutin, Sophie; Cote, Marie-France; C.-Gaudreault, Rene; Mathieu, Patrick; Lague, Patrick; Paquin, Jean-Francois published an article on January 15 ,2017. The article was titled 《Synthesis of novel substituted pyrimidine derivatives bearing a sulfamide group and their in vitro cancer growth inhibition activity》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Name: 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine The information in the text is summarized as follows:

The synthesis of two series of novel substituted pyrimidine derivatives bearing a sulfamide group have been described and their in vitro cancer growth inhibition activities have been evaluated against three human tumor cell lines (HT-29, M21, and MCF7). In general, growth inhibition activity has been enhanced by the introduction of a bulky substituent on the aromatic ring with the best compound having GI50 < 6 μM for all the human tumor cell lines. The MCF7 selective compounds were evaluated on four addnl. human invasive breast ductal carcinoma cell lines (MDA-MB-231, MDA-MB-468, SKBR3, and T47D) and were selective against T47D cell line in all cases except one, suggesting a potential antiestrogen activity. In addition to this study using 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine, there are many other studies that have used 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine(cas: 659729-09-6Name: 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine) was used in this study.

4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine(cas: 659729-09-6) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. Name: 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidineThey have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《5-Nitro-2,4-dichloropyrimidine as an universal model for low-energy electron processes relevant for radiosensitization》 was written by Luxford, Thomas F. M.; Pshenichnyuk, Stanislav A.; Asfandiarov, Nail L.; Perecko, Tomas; Falk, Martin; Kocisek, Jaroslav. Recommanded Product: 3934-20-1 And the article was included in International Journal of Molecular Sciences in 2020. The article conveys some information:

We report exptl. results of low-energy electron interactions with 5-nitro-2,4- dichloropyrimidine isolated in the gas phase and hydrated in a cluster environment. The mol. exhibits a very rare combination of many so far hypothesized low-energy electron induced mechanisms, which may be responsible for synergism in concurrent chemo-radiation therapy of cancer. In contrast to many previous efforts to design an ideal radiosensitizer based on one mode of action, the present model mol. presents an alternative approach, where several modes of action are combined. With respect to the processes induced by the low-energy electrons, this is not a trivial task because of strong bond specificity of the dissociative electron attachment reaction, as it is discussed in the present paper. Unfortunately, low solubility and high toxicity of the mol., as obtained from preliminary MTT assay tests, do not enable further studies of its activity in real biol. systems but it can advantageously serve as a model or a base for rational design of radiosensitizers. The results came from multiple reactions, including the reaction of 2,4-Dichloropyrimidine(cas: 3934-20-1Recommanded Product: 3934-20-1)

2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Recommanded Product: 3934-20-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Synthesis and Spectral Characterization of New Bis(2-(pyrimidin-2-yl)ethoxy)alkanes and Their Pharmacological Activity》 were Rani, Vangavaragu Jhansi; Aminedi, Raghavendra; Polireddy, Kishore; Jagadeeswarareddy, Kanala. And the article was published in Archiv der Pharmazie (Weinheim, Germany) in 2012. Name: Ethyl 2-(pyrimidin-2-yl)acetate The author mentioned the following in the article:

The pyrimidine nucleus is an important component of nucleic acids (DNA and RNA) and vitamins (B2 and folic acid). It is evident from the literature that pyrimidine derivatives possess a wide spectrum of biol. activities such as antioxidant, anticancer, antibacterial, and anti-inflammatory activities. On the basis of diverse biol. activities, the authors attempted to synthesize a series of novel bis(2-(pyrimidin-2-yl)ethoxy)alkanes 5a-j in four steps with good yields. 2-Chloropyrimidine (1) was reacted with di-Et malonate in the presence of sodium hydride in dry DMF to yield the intermediate di-Et 2-(pyrimidin-2-yl)malonate (2), which on further reaction with sodium chloride and DMSO yielded Et 2-(pyrimidin-2-yl)ethanoate (3). Reduction with sodium borohydride (NaBH4) resulted in the formation of 2-(pyrimidin-2-yl)ethanol (4). This was further reacted with various dibromoalkanes to obtain the title compounds 5a-j. Next, the authors evaluated the antioxidant properties of the title compounds using four in vitro test systems: the 2,2-diphenyl-2-picrylhydrazyl radical-, superoxide radical-, and hydroxyl radical-scavenging assays, and the anti-lipid peroxidation activity test. The title compounds showed promising antioxidant activity when compared to butylated hydroxytoluene. The potency of their antioxidant activity was mainly influenced by the alkyl fragment attached to 2-(pyrimidin-2-yl)ethanol. The Et and Bu fragments linked to oxygen led to increased antioxidant activity of the title compounds (i.e., 5b and 5d) in all the in vitro assays. The results came from multiple reactions, including the reaction of Ethyl 2-(pyrimidin-2-yl)acetate(cas: 63155-11-3Name: Ethyl 2-(pyrimidin-2-yl)acetate)

Ethyl 2-(pyrimidin-2-yl)acetate(cas: 63155-11-3) is a member of pyrimidine. Pyrimidine derivatives are an important class of N-heterocycles. They are well-known for their wide spectrum of promising biological activities such as antitumors, bactericidals, and fungicidal.Name: Ethyl 2-(pyrimidin-2-yl)acetate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

COA of Formula: C6H7N3O2SOn March 1, 2005, Du, Miao; Jiang, Xiu-Juan; Zhao, Xiao-Jun published an article in Acta Crystallographica, Section E: Structure Reports Online. The article was 《Diaquabis(2,5-di-3-pyridyl-1,3,4-oxadiazole)dithiocyanatomanganese(II): a three-dimensional supramolecular network formed through O-H···N and C-H···S interactions》. The article mentions the following:

Crystals of the neutral mononuclear title complex are triclinic, space group P1̅, with a 8.1951(19), b 8.762(2), c 10.619(3) Å, α 82.472(3), β 77.181(3), γ 79.873(3)°; Z = 1, dc = 1.494; R = 0.035, w(F2) = 0.099 for 2540 reflections. The structure is centrosym.; the MnII atom lies on an inversion center and is six-coordinate (MnN4O2), with an octahedral geometry comprising two trans monodentate 2,5-di-3-pyridyl-1,3,4-oxadiazole ligands, two thiocyanate ligands and two bound H2O mols. Intermol. O-H···N H bonds between these monomeric units result in two-dimensional supramol. layers with a parallel arrangement, which are stabilized by intralayer aromatic stacking and further extended to a three-dimensional network via interlayer weak C-H···S interactions. The results came from multiple reactions, including the reaction of 4-Amino-2-(methylthio)pyrimidine-5-carboxylic acid(cas: 771-81-3COA of Formula: C6H7N3O2S)

4-Amino-2-(methylthio)pyrimidine-5-carboxylic acid(cas: 771-81-3) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.COA of Formula: C6H7N3O2S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2018,Espinosa-Bustos, Christian; Frank, Annika; Arancibia-Opazo, Sandra; Salas, Cristian O.; Fierro, Angelica; Stark, Holger published 《New lead elements for histamine H3 receptor ligands in the pyrrolo[2,3-d]pyrimidine class》.Bioorganic & Medicinal Chemistry Letters published the findings.Category: pyrimidines The information in the text is summarized as follows:

This work describes the microwave assisted synthesis of twelve novel histamine H3 receptor ligands. They display pyrrolo[2,3-d]pyrimidine derivatives with rigidized aliphatic amines as warheads. The compounds were screened for H3R and H4R binding affinities in radioligand displacement assays and the most potent compounds were evaluated for H3R binding properties in vitro and in docking studies. The combination of a rigidized H3R warhead and the pyrrolo[2,3-d]pyrimidine scaffold resulted in selective activity at the H3 receptor with a pKi value of 6.90 for the most potent compound A bipiperidine warhead displayed higher affinity than a piperazine or morpholine motif, while a naphthyl moiety in the arbitrary region increased affinity compared to a Ph derivative The compounds can be starting points for novel, simply synthesized histamine H3 receptor ligands. The experimental part of the paper was very detailed, including the reaction process of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Category: pyrimidines)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Bonanno, Nico M.; Watts, Zackery; Mauws, Cole; Patrick, Brian O.; Wiebe, Christopher R.; Shibano, Yuki; Sugisaki, Kenji; Matsuoka, Hideto; Shiomi, Daisuke; Sato, Kazunobu; Takui, Takeji; Lemaire, Martin T. published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Valence tautomerism in a [2 x 2] Co4 grid complex containing a ditopic arylazo ligand》.HPLC of Formula: 1193-21-1 The article contains the following contents:

The authors describe the structural and magnetic properties of a tetranuclear [2 x 2] Co4 grid complex containing a ditopic arylazo ligand. At low temperatures and in solution the complex is comprised of Co3+ and singly reduced trianion-radical ligands. In the solid state the authors demonstrate the presence of valence tautomerization via variable temperature magnetic susceptibility experiments and powder-pattern EPR spectroscopy. Valence tautomerism in polynuclear complexes is very rare and to our knowledge is unprecedented in [2 x 2] grid complexes. In the experiment, the researchers used 4,6-Dichloropyrimidine(cas: 1193-21-1HPLC of Formula: 1193-21-1)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.HPLC of Formula: 1193-21-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 90213-66-4In 2017 ,《A convenient and simple synthesis of N-arylpirrolopyrimidines using boronic acids and promoted by copper (II) acetate》 appeared in ARKIVOC (Gainesville, FL, United States). The author of the article were Espinosa-Bustos, Christian; Villegas, Alondra; Salas, Cristian O.. The article conveys some information:

A convenient and simple synthesis of novel N-aryl 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidines I [Ar = 4-HOC6H4, 4-NCC6H4, 2-naphthyl, etc.] via copper (II) acetate catalyzed N-arylation of 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine using arylboronic acids was described. The yields obtained for all derivatives were in the range of 45-70% and this synthetic approach was extensible to other heterocycles such as 1H-indazoles. In the experimental materials used by the author, we found 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Related Products of 90213-66-4)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. Related Products of 90213-66-4They have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2022,Chen, Chia-Hsun; Lin, Shih-Chun; Lin, Bo-Yen; Li, Che-Yu; Kong, Yu-Cheng; Chen, Yi-Sheng; Fang, Shao-Cheng; Chiu, Ching-Huang; Lee, Jiun-Haw; Wong, Ken-Tsung; Lin, Chi-Feng; Hung, Wen-Yi; Chiu, Tien-Lung published an article in Chemical Engineering Journal (Amsterdam, Netherlands). The title of the article was 《New bipolar host materials for high power efficiency green thermally activated delayed fluorescence OLEDs》.SDS of cas: 3764-01-0 The author mentioned the following in the article:

Four bipolar mols., namely I, II, III, and IV, with carbazole (Cz) donor and a benzonitrile-substituted pyrimidine (Pym) or triazine (Trz) acceptor core were synthesized and characterized. The electron deficiency of heteroaryl cores together with the substitution pattern of benzonitrile were employed to tune the energy levels as well as the thermally activated delayed fluorescence (TADF) characteristics. The four mols. exhibited TADF behavior with inferior photoluminescent quantum yields (PLQYs) that limit their applications as emitters. These bipolar mols. were employed as TADF host materials for the benchmark TADF emitter 4CzIPN to achieve high-performing green TADF organic light-emitting diodes (OLEDs). Among the mols., I-hosted TADF-OLEDs achieved a maximum external quantum efficiency (EQEmax) of 31.5%, maximum power efficiency (PEmax) of 95.6 lm/W, and maximum current efficiency (CEmax) of 100.2 cd/A. Notably, II-hosted TADF-OLEDs also achieved a PEmax of 116.5 lm/W, turn-on voltage of 2.5 V, and impressive low efficiency roll-off performance (>89% of EQEmax at 5000 cd/m2), representing one of the highest efficiencies ever reported in 4CzIPN-doped devices. The high device efficiency can be ascribed to the balanced ambipolar carrier-transporting character of the host materials and high PLQY as well as the outstanding light outcoupling efficiency of the emitting layer.2,4,6-Trichloropyrimidine(cas: 3764-01-0SDS of cas: 3764-01-0) was used in this study.

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.SDS of cas: 3764-01-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia