Month: October 2022

Sharma, Ashok K.; Wen, Lian; Hall, Larry R.; Allan, John G.; Clark, Brett J. published an article in Journal of Agricultural and Food Chemistry. The title of the article was 《Metabolism of Pyrithiobac Sodium in Soils and Sediment, Addressing Bound Residues via Kinetics Modeling》.Related Products of 29458-38-6 The author mentioned the following in the article:

Degradation of pyrithiobac sodium (PE350) was examined in a number of soils and sediments using 14C-PE350. It degrades primarily via microbial degradation which leads to the separation of the two rings of the mol. Identification of several metabolites, many of which were minor products, helped to understand the formation of nonextractable residues (NER) and 14CO2. In all studies, unextractable residues accounted for a large portion (20-60%) of the residues. Traditional kinetics modeling treats NER and CO2 as a single compartment, stated as sink, and formation mechanism of such components individually is ignored. Since studies conducted with radiolabeled test substance provides an accurate measurement of NER and CO2, we have demonstrated that kinetics modeling with these compartments sep. can be used to clarify degradation pathways, including the origin of NER and CO2. This work demonstrated that overall metabolism in soils and sediments proceeded via similar pathways, and kinetics modeling was useful in clarifying the degradation route and formation of NER in all studies. In the experimental materials used by the author, we found 6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6Related Products of 29458-38-6)

6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Related Products of 29458-38-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Benzylic Fluorination of Aza-Heterocycles Induced by Single-Electron Transfer to Selectfluor》 were Danahy, Kelley E.; Cooper, Julian C.; Van Humbeck, Jeffrey F.. And the article was published in Angewandte Chemie, International Edition in 2018. HPLC of Formula: 951884-36-9 The author mentioned the following in the article:

A selective and mild method for the benzylic fluorination of aromatic azaheterocycles with Selectfluor is described. These reactions take place by a previously unreported mechanism, in which electron transfer from the heterocyclic substrate to the electrophilic fluorinating agent Selectfluor eventually yields a benzylic radical, thus leading to the desired C-F bond formation. This mechanism enables high intra- and intermol. selectivity for aza-heterocycles over other benzylic components with similar C-H bond-dissociation energies. After reading the article, we found that the author used 5-Bromo-4-ethylpyrimidine(cas: 951884-36-9HPLC of Formula: 951884-36-9)

5-Bromo-4-ethylpyrimidine(cas: 951884-36-9) is a member of pyrimidine. Pyrimidine derivatives are an important class of N-heterocycles. They are well-known for their wide spectrum of promising biological activities such as antitumors, bactericidals, and fungicidal.HPLC of Formula: 951884-36-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2008,Gillespie, Roger J.; Cliffe, Ian A.; Dawson, Claire E.; Dourish, Colin T.; Gaur, Suneel; Jordan, Allan M.; Knight, Antony R.; Lerpiniere, Joanne; Misra, Anil; Pratt, Robert M.; Roffey, Jonathan; Stratton, Gemma C.; Upton, Rebecca; Weiss, Scott M.; Williamson, Douglas S. published 《Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines》.Bioorganic & Medicinal Chemistry Letters published the findings.COA of Formula: C6H3Cl2N3 The information in the text is summarized as follows:

A series of pyrazolo[3,4-d]pyrimidine, pyrrolo[2,3-d]pyrimidine and 6-arylpurine adenosine A2A antagonists is described. Many examples were highly selective against the human A1 receptor sub-type and were active in an in vivo model of Parkinson’s disease. In the experimental materials used by the author, we found 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4COA of Formula: C6H3Cl2N3)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. COA of Formula: C6H3Cl2N3They have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2016,Hammer, Sebastian G.; Gobleder, Susanne; Naporra, Franziska; Wittmann, Hans-Joachim; Elz, Sigurd; Heinrich, Markus R.; Strasser, Andrea published 《2,4-Diaminopyrimidines as dual ligands at the histamine H1 and H4 receptor-H1/H4-receptor selectivity》.Bioorganic & Medicinal Chemistry Letters published the findings.Formula: C4HCl3N2 The information in the text is summarized as follows:

Distinct diaminopyrimidines, for example, 4-(4-methylpiperazin-1-yl)-5,6-dihydrobenzo[h]quinazolin-2-amine are histamine H4 receptor (H4R) antagonists and show high affinity to the H4R, but only a moderate affinity to the histamine H1 receptor (H1R). Within previous studies it was shown that an aromatic side chain with a distinct distance to the basic amine and aromatic core is necessary for affinity to the human H1R (hH1R). Thus, a rigid aminopyrimidine with a tricyclic core was used as a lead structure. There, (1) the flexible aromatic side chain was introduced, (2) the substitution pattern of the pyrimidine core was exchanged and (3) rigidity was decreased by opening the tricyclic core. Within the present study, two compounds with similar affinity in the one digit μM range to the human H1R and H4R were identified. While the affinity at the hH1R increased about 4- to 8-fold compared to the parent diaminopyrimidine, the affinity to the hH4R decreased about 5- to 8-fold. In addition to the parent diaminopyrimidine, two selected compounds were docked into the H1R and H4R and mol. dynamic studies were performed to predict the binding mode and explain the exptl. results on a mol. level. The two new compounds may be good lead structures for the development of dual H1/H4 receptor ligands with affinities in the same range. The experimental process involved the reaction of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Formula: C4HCl3N2)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Formula: C4HCl3N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2019,Bioorganic & Medicinal Chemistry Letters included an article by Wormald, Michael M.; Ernst, Glen; Wei, Huijun; Barrow, James C.. Synthetic Route of C6H3Cl2N3. The article was titled 《Synthesis and characterization of novel isoform-selective IP6K1 inhibitors》. The information in the text is summarized as follows:

Diaminopurines and diaminopurine analogs such as (methoxyindolylethylamino)purine I were prepared as selective inositol hexakisphosphate kinases (IP6K) inhibitors. Selected diaminopurines such as I were selective inhibitors of IP6K1 over IP6K2 and IP6K3; I was a more potent inhibitor of IP6K1 and was more water-soluble than the previously known pan-IP6K inhibitor TNP. The experimental part of the paper was very detailed, including the reaction process of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Synthetic Route of C6H3Cl2N3)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Synthetic Route of C6H3Cl2N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《A novel one-pot and efficient procedure for synthesis of new fused uracil derivatives for DNA binding》 was written by Mousa, Bothaina A.; Bayoumi, Ashraf H.; Korraa, Makarem M.; Assy, Mohamed G.; El-Kalyoubi, Samar A.. Electric Literature of C4HCl3N2This research focused onxanthine arylidineaniline indenopyrrolopyrimidine indenopteridine ninhydrin DNA damage nucleobase; hydrazone oxidative cyclization thionyl chloride pyrazolopyrimidine nitrosation aminouracil; DNA uracil fused synthesis hydrazinolysis chloromethyluracil condensation aromatic aldehyde. The article conveys some information:

Hydrazinolysis of 6-chloro-1-methyluracil followed by condensation of the product with different aromatic aldehyde gives the resp. hydrazones which undergoes oxidative cyclization using thionyl chloride to obtain pyrazolo[3,4-d]pyrimidines in good yields. On the other hand, nitrosation of 6-aminouracils followed by the reaction with different arylidineanilines gives new xanthine derivatives Finally, indenopyrrolopyrimidine and indenopteridine are obtained in good yields via the reaction of 6-aminouracils and 5,6-diaminouracil with ninhydrin resp. The newly synthesized compounds show binding, chelation and fragmentation of the nucleic acid DNA. The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Electric Literature of C4HCl3N2)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Electric Literature of C4HCl3N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《On the Way Towards Greener Transition-Metal-Catalyzed Processes as Quantified by E Factors》 was published in Angewandte Chemie, International Edition in 2013. These research results belong to Lipshutz, Bruce H.; Isley, Nicholas A.; Fennewald, James C.; Slack, Eric D.. Reference of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine The article mentions the following:

Transition-metal-catalyzed carbon-carbon and carbon-heteroatom bond formations are among the most heavily used types of reactions in both academic and industrial settings. As important as these are to the synthetic community, such cross-couplings come with a heavy price to our environment, and sustainability. E Factors are one measure of waste created, and organic solvents, by far, are the main contributors to the high values associated, in particular, with the pharmaceutical and fine-chem. companies which utilize these reactions. An alternative to organic solvents in which cross-couplings are run can be found in the form of micellar catalysis, wherein nanoparticles composed of newly introduced designer surfactants enable the same cross-couplings, albeit in water, with most taking place at room temperature In the absence of an organic solvent as the reaction medium, organic waste and hence, E Factors, drop dramatically. After reading the article, we found that the author used 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine(cas: 659729-09-6Reference of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine)

4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine(cas: 659729-09-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Reference of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

COA of Formula: C11H8N2O4On October 1, 2015 ,《N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Chapman, Timothy M.; Wallace, Claire; Gillen, Kevin J.; Bakrania, Preeti; Khurana, Puneet; Coombs, Peter J.; Fox, Simon; Bureau, Emilie A.; Brownlees, Janet; Melton, David W.; Saxty, Barbara. The article contains the following contents:

A high throughput screen allowed the identification of N-hydroxyimide inhibitors of ERCC1-XPF endonuclease activity with micromolar potency, but they showed undesirable selectivity profiles against FEN-1. A scaffold hop to a hydroxypyrimidinone template gave compounds with similar potency but allowed selectivity to be switched in favor of ERCC1-XPF over FEN-1. Further exploration of the structure-activity relationships around this chemotype gave sub-micromolar inhibitors with >10-fold selectivity for ERCC1-XPF over FEN-1. In the experiment, the researchers used many compounds, for example, 5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid(cas: 62222-38-2COA of Formula: C11H8N2O4)

5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid(cas: 62222-38-2) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. COA of Formula: C11H8N2O4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Efficient solvent free synthesis of tertiary α-aminophosphonates using H2Ti3O7 nanotubes as a reusable solid-acid catalyst》 were Rajendra Prasad Reddy, Bhoomireddy; Vasu Govardhana Reddy, Peddiahgari; Reddy, Bijivemula N.. And the article was published in New Journal of Chemistry in 2015. Related Products of 640769-70-6 The author mentioned the following in the article:

In this paper, TiO2 fine particles, TiO2-P25, protonated trititanate (H2Ti3O7) nanorods and nanotubes were used as recyclable solid-acid catalysts for the solvent free synthesis of tertiary α-aminophosphonates through Kabachnik-Fields reaction. Among them, H2Ti3O7 nanotubes showed remarkable catalytic performance and it was due to strong and sufficient Lewis and Bronsted acid sites on a large nanotubular surface. More importantly, for the first time we reported some novel 5,8-dioxa-10-azadispiro[2.0.4.3]undecane bearing tertiary α-aminophosphonates. After reading the article, we found that the author used 3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6Related Products of 640769-70-6)

3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. Related Products of 640769-70-6They have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Synthesis, biological profile and computational studies of some trichloropyrimidine derivatives》 were Sandeep, Thummar; Vasishta, Bhatt. And the article was published in Research Journal of Chemistry and Environment in 2019. Name: 2,4,6-Trichloropyrimidine The author mentioned the following in the article:

A series of (((oxadiazolyl-thio)(nitrophenyl-amino)pyrimidinyl)hydrazinyl)-N-phenylacetamide motifs I [R = Ph, 2-furyl, 3-pyridyl, etc.] was synthesized and studied for their antibacterial and antifungal activities as well as for mol. docking and FMO studies. All the synthesized mols. were characterized by 1H NMR and 13C NMR spectroscopic anal. Compounds I [R = 3-pyridyl, 4-pyridyl] were found to be potentially active against gram neg. and gram-pos. bacteria with MIC value between 62.5 to 500μg/mL. The mol. docking studies of compounds I [R = Ph, 3-pyridyl] were further carried out to discover the interaction with active sites. In the experimental materials used by the author, we found 2,4,6-Trichloropyrimidine(cas: 3764-01-0Name: 2,4,6-Trichloropyrimidine)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Name: 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia