Month: October 2022

Hasegawa, Tetsuya; Seki, Toshinobu; Juni, Kazuhiko; Saneyoshi, Mineo; Kawaguchi, Takeo published their research in Journal of Pharmaceutical Sciences on December 31 ,1993. The article was titled 《Prodrugs of 2′,3′-didehydro-3′-deoxythymidine》.Recommanded Product: 122567-97-9 The article contains the following contents:

Six ester prodrugs of 2′,3′-didehydro-3′-deoxythymidine (I) were prepared, and their physicochem. properties evaluated. Marked differences were observed All of the prodrugs were chem. stable within the pH range 2-7. Hydrolysis of these esters was observed in all cases for 4 rat enzyme systems (plasma, liver, duodenum, and kidney), with I being regenerated. I or the prodrug was administered orally to rats, and the plasma concentrations of I and a corresponding prodrug were measured. The half-life of I after i.v. administration was 35.9 min. The half-life calculated from the terminal phase and the maximum concentration in plasma following oral administration of I were 35.9 min and 48.4 μM, resp. After oral prodrug administration (with water or olive oil as a solvent), though none of the prodrugs was detected in plasma except for 5′-hemisuccinyl derivative of I and 5′-hemiglutaryl derivative of I with olive oil as a solvent, retention time of plasma I concentration was extended and the elevated I concentration in plasma decreased.((2S,5R)-5-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methyl benzoate(cas: 122567-97-9Recommanded Product: 122567-97-9) was used in this study.

((2S,5R)-5-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methyl benzoate(cas: 122567-97-9) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Recommanded Product: 122567-97-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Interaction of heterocycles and nucleophiles: sigma complexes formed from methoxide ion and some 5-nitropyrimidines and comparison with those from 2,4,6-trinitroanisole》 were Biffin, Malcolm E. C.; Miller, Joseph; Moritz, A. G.; Paul, David B.. And the article was published in Australian Journal of Chemistry in 1969. HPLC of Formula: 14001-69-5 The author mentioned the following in the article:

The sigma complexes formed from the reaction of MeO- with 5-nitropyrimidine and its monomethoxy derivatives were examined spectroscopically. Structural ambiguities resulting from the lower symmetry of the nitropyrimidines compared with the trinitrobenzenes were resolved by selective deuteration. Comparison is made with sigma complex formation from 2,4,6-trinitroanisole and the question of kinetic against thermodynamic control is considered with reference to theoretically derived potential energy-reaction coordinate profiles for protic solvents. The calculations are extended qual. to consider reactions in an aprotic solvent.2-Methoxy-5-nitropyrimidine(cas: 14001-69-5HPLC of Formula: 14001-69-5) was used in this study.

2-Methoxy-5-nitropyrimidine(cas: 14001-69-5) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.HPLC of Formula: 14001-69-5

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2015,Argade, Ankush; Bhamidipati, Somasekhar; Li, Hui; Carroll, David; Clough, Jeffrey; Keim, Holger; Sylvain, Catherine; Rossi, Alexander B.; Coquilla, Christina; Issakani, Sarkiz D.; Masuda, Esteban S.; Payan, Donald G.; Singh, Rajinder published 《Application of cultured human mast cells (CHMC) for the design and structure-activity relationship of IgE-mediated mast cell activation inhibitors》.Bioorganic & Medicinal Chemistry Letters published the findings.Product Details of 3764-01-0 The information in the text is summarized as follows:

Here we report the optimization of small mol. inhibitors of human mast cell degranulation via anti-IgE-mediated tryptase release following crosslinking and activation of IgE-loaded FcεR1 receptors. The compounds are selective upstream inhibitors of FcεR1-dependent human mast cell degranulation and proved to be devoid of activity in downstream ionomycin mediated degranulation. Structure-activity relationship (SAR) leading to compound 26 is outlined. In the experiment, the researchers used many compounds, for example, 2,4,6-Trichloropyrimidine(cas: 3764-01-0Product Details of 3764-01-0)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Product Details of 3764-01-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2015,Linton, Maria Angelica; Burke, Benjamin J.; Johnson, Ted W.; Ninkovic, Sacha; Gajiwala, Ketan S.; Richardson, Paul; Le, Phuong T. published 《Effect of water solvation on the lipophilicity of isomeric pyrimidine-carboxamides》.Bioorganic & Medicinal Chemistry published the findings.Related Products of 3764-01-0 The information in the text is summarized as follows:

Incorporation of nitrogen is a common medicinal chem. tactic to reduce log D values. Neighboring group participation influences log D, so the results are isomer dependent. The log D and log P differences observed between isomeric pyrimidines 1, 2 and 3 presumably result when the carbonyl or ether lone pairs are in close proximity to a heterocyclic nitrogen lone pair, recruiting water to bridge between the electron rich atoms. Various lipophilicity calculators did not discriminate between 1 (log D = 2.6) and 3 (log D = 1.0), but solvation energies using Poisson-Boltzmann and 3D-RISM methods rationalize the observed differences in lipophilicity among pyrimidine carboxamide isomers. After reading the article, we found that the author used 2,4,6-Trichloropyrimidine(cas: 3764-01-0Related Products of 3764-01-0)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Related Products of 3764-01-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Recommanded Product: 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidineIn 2014 ,《Five-membered heteroaromatic ring fused-pyrimidine derivatives: Design, synthesis, and hedgehog signaling pathway inhibition study》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Zhang, Liandi; Xin, Minhang; Shen, Han; Wen, Jun; Tang, Feng; Tu, Chongxing; Zhao, Xinge; Wei, Ping. The article conveys some information:

A series of novel five-membered heteroaromatic ring fused-pyrimidine derivatives I [X = N, Y = NH, NMe; X = CH, Y = NH, NMe, S; R1 = Me, R2 = H; R1 = H, R2 = 4-morpholinylmethyl, 4-methyl-1-piperazinylmethyl, 2-(4-morpholinyl)ethoxy] and II (Z = NH, NMe, O, S; the same R1 and R2), including purines, pyrrolo[2,3-d]pyrimidines, pyrrolo[3,2-d]pyrimidines, thieno[2,3-d]pyrimidines, thieno[3,2-d]pyrimidines and furo[3,2-d]pyrimidines, have been prepared and identified to be potent inhibitors of hedgehog signaling pathway. Among this new series of hedgehog signaling pathway inhibitors, most compounds exhibited significant inhibitory activity compared to vismodegib, indicating that the five-membered heteroaromatic ring fused-pyrimidines stand out as encouraging scaffolds among the currently reported structural skeletons for hedgehog signaling pathway inhibitors, deserving more exploration and further investigation. In the experiment, the researchers used 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Recommanded Product: 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. Recommanded Product: 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidineThey have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Quality Control of 6-Methoxypyrimidine-2,4(1H,3H)-dioneOn May 4, 2006 ,《On the Electron Donor and the Electrophilic Substitution Activating Abilities of Substituents in Uracil》 appeared in Journal of Physical Chemistry A. The author of the article were Gonzalez Moa, Maria J.; Mosquera, Ricardo A.. The article conveys some information:

QTAIM properties for uracil and 18 derivatives containing the substituents -NH2, -OH, -OCH3, -SH, -F, -Cl, -CH3 -NO2, and -Li in position 5 or 6 were computed on MP2/6-31++G**//MP2/6-31G** charge densities. The results indicate that -OH, -OCH3, and -NH2 groups are really retrieving charge from the ring. Also, the activating ability of the substituent groups, usually considered as the variation of electron population at the carbon where the electrophilic attack takes place, C*, was studied. The study shows that the activating ability is reflected by the variation of π charge or quadrupole moment at C*, and also by the variation of the Laplacian of the charge d. in the secondary charge concentration points around C* (SCC-C*). They indicate a similar, but not exactly equal, graduation of activating ability. The relative behavior of the substituents is basically the same as in benzene, though benzene has more tendency to concentrate charge in the SCC-C* regions than uracil, where this tendency is larger for 6- than for 5-derivatives σ+/-R Taft parameters are found to display good correlations with the above indicated activating indexes. Finally, the resonance model predicts most of the main variations displayed by QTAIM at. π electron populations of derivatives with regard to uracil, but there are still some significant variations of the π electron charge that it cannot predict. In the experiment, the researchers used many compounds, for example, 6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6Quality Control of 6-Methoxypyrimidine-2,4(1H,3H)-dione)

6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Quality Control of 6-Methoxypyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Pd/PTABS: Low-Temperature Thioetherification of Chloro(hetero)arenes》 were Bandaru, Siva Sankar Murthy; Bhilare, Shatrughn; Cardozo, Jesvita; Chrysochos, Nicolas; Schulzke, Carola; Sanghvi, Yogesh S.; Gunturu, Krishna Chaitanya; Kapdi, Anant R.. And the article was published in Journal of Organic Chemistry in 2019. Category: pyrimidines The author mentioned the following in the article:

Heteroaryl aryl and alkyl thioethers were prepared by thioetherification reactions of aryl chlorides with aryl and alkyl thiols in the presence of Pd(OAc)2 and a phosphatriazaadamantanebutanesulfonate ligand using K3PO4 as the base in DMF at 50°. Using this method, Imuran (azathioprine) was prepared The electrostatic potentials and at. charges of phosphine ligands were calculated to understand their effect on the palladium-catalyzed thioetherification reactions. In the experiment, the researchers used many compounds, for example, 2,4-Dichloropyrimidine(cas: 3934-20-1Category: pyrimidines)

2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Novel influenza polymerase PB2 inhibitors for the treatment of influenza A infection》 were Zhang, Hongwang; Zhou, Longhu; Amichai, Sarah; Zandi, Keivan; Cox, Bryan; Schinazi, Raymond; Amblard, Franck. And the article was published in Bioorganic & Medicinal Chemistry Letters in 2019. COA of Formula: C4HCl3N2 The author mentioned the following in the article:

Exploration of the chem. space of known influenza polymerase PB2 inhibitor Pimodivir, was performed by our group. We synthesized and identified compounds I and II, two novel thienopyrimidine derivatives displaying anti-influenza A activity in the single digit nanomolar range in cell culture. Binding of these unique compounds in the influenza polymerase PB2 pocket was also determined using mol. modeling. In the experiment, the researchers used many compounds, for example, 2,4,6-Trichloropyrimidine(cas: 3764-01-0COA of Formula: C4HCl3N2)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.COA of Formula: C4HCl3N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Manzoor, Shoaib; Petreni, Andrea; Raza, Kausar Md; Supuran, Claudiu T.; Hoda, Nasimul published their research in Bioorganic & Medicinal Chemistry Letters in 2021. The article was titled 《Novel triazole-sulfonamide bearing pyrimidine moieties with carbonic anhydrase inhibitory action: Design, synthesis, computational and enzyme inhibition studies》.Quality Control of 2,4-Dichloropyrimidine The article contains the following contents:

A series of new triazole-sulfonamide bearing pyrimidine derivatives I [R = H, Me; R1 = morpholino, 4-methylpiperazin-1-yl, 4-(4-methoxyphenyl)piperazin-1-yl, etc.] were designed and synthesized via click chem. All new compounds I were validated by 1HNMR, 13CNMR, HRMS and compound I [R = H, R1 = 1-piperidyl] was further structurally validated by X-Ray single diffraction study. These compounds I were tested as inhibitors of human carbonic anhydrase (hCA) isoforms, such as hCA I, II, IX and XII, using a stopped flow CO2 hydrase assay. Most of the compounds exhibited significant inhibitory activity against hCA II and weak inhibitory activity against hCA I. The target compounds also displayed moderate to excellent inhibitory activity against tumor-related hCAs IX and XII. Some compounds, e.g., I [R = Me, R1 = 4-(4-methoxyphenyl)piperazin-1-yl, 4-ethoxycarbonylpiperazin-1-yl, 4-(2-methoxyphenyl)piperazin-1-yl] with Ki = 9.4 nM, 1.8 nM, 0.82 nM resp. exhibited excellent inhibitory activity and selectivity profile against hCAs XII over IX. Compound I [R = Me, R1 = 4-(4-chlorobenzyl)piperazin-1-yl] displayed promising inhibitory activity and selectivity profile against both tumor-related hCAs IX (Ki = 2.9 nM) as well as XII (Ki = 0.82 nM) over hCA I and II. To understand the mol. interactions, mol. docking study of compounds I [R = Me, R1 = 4-methoxyphenyl, 4-(4-chlorobenzyl)piperazin-1-yl, 4-ethoxycarbonylpiperazin-1-yl, 4-(2-methoxyphenyl)piperazin-1-yl] with hCA XII and I [R = Me, R1 = 4-(4-chlorobenzyl)piperazin-1-yl] also with hCA IX were performed. The computational study evidenced favorable interaction between the inhibitors and active residues of both proteins. Some of these derivatives are promising leads for the development of selective, anticancer agents based on CA inhibitors. In the part of experimental materials, we found many familiar compounds, such as 2,4-Dichloropyrimidine(cas: 3934-20-1Quality Control of 2,4-Dichloropyrimidine)

2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Quality Control of 2,4-Dichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Maimaitiyiming, Xieraili; Shi, Caijin published their research in Materials Chemistry and Physics in 2021. The article was titled 《Poly(1,4-diethynylphenylene-4,6-pyrimidine)s for fluorescence detection of mercury(II) ion》.Category: pyrimidines The article contains the following contents:

A series of alternating conjugated polymers (poly (1,4-diethynylphenylene-4,6-pyrimidine) (PI) and poly (2,5-diheptyloxy-1,4-diethynyl-phenylene-4,6-pyrimidine) (PII) were synthesized via Sonogashira coupled reaction. Chem. structure of conjugated polymers were certified by NMR and FT-IR. The PIII(poly(2,5-bis(dodecoxy)-1,4-diethynyl-phenylene-4,6-pyrimidine) previously reported by our group to illustrate the application of such polymer. The fluorescence of PIII were efficiently quenched when introduced I-, the specificity of the polymer for I- was verified by experiments and detection limit reaches 5.19 x 10-7 mol/L. Thanks to the high association constant between Hg2+ and I-, the fluorescence of PIII/I- system recovered with the addition of Hg2+. The detection limit of Hg2+ reaches ∼4.92 x 10-6 mol/L for PIII/I- complex system. PIII/I- could act as high selective, sensitive and anti-interference optical probe for Hg2+. In the part of experimental materials, we found many familiar compounds, such as 4,6-Dichloropyrimidine(cas: 1193-21-1Category: pyrimidines)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia