Day: October 20, 2022

《Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood-brain barrier permeability》 was written by Borsari, Chiara; Keles, Erhan; Treyer, Andrea; De Pascale, Martina; Hebeisen, Paul; Hamburger, Matthias; Wymann, Matthias P.. Computed Properties of C4HCl3N2This research focused ontricyclic pyrimido pyrrolooxazine mTOR inhibitor blood brain barrier permeability. The article conveys some information:

Highly selective mTOR inhibitors have been discovered through the exploration of the heteroaromatic ring engaging the binding affinity region in mTOR kinase. Compound 11 showed predicted BBB permeability in a MDCK-MDR1 permeability in vitro assay, being the first pyrimido-pyrrolo-oxazine with potential application in the treatment of neurol. disorders. In addition to this study using 2,4,6-Trichloropyrimidine, there are many other studies that have used 2,4,6-Trichloropyrimidine(cas: 3764-01-0Computed Properties of C4HCl3N2) was used in this study.

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Computed Properties of C4HCl3N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

COA of Formula: C5H6N2O3On November 20, 1995 ,《Metabolism of ALS inhibitory herbicide Bispyribac-sodium [KIH-2023] in rats》 appeared in Nippon Noyaku Gakkaishi. The author of the article were Fukai, Yasushi; Unai, Tadaaki; Ishikawa, Kanji; Yusa, Yoshio; Wada, Nobuhide; Tezuka, Masakatsu; Okada, Shoji. The article conveys some information:

Absorption, distribution and metabolism of Bispyribac-sodium [sodium 2,6-bis(4,6-dimethoxypyrimidin-2-yloxy)benzoate] or [KIH-2023] in rats orally dosed with 14C-KIH-2023 were investigated. More than 90% of the dosed radioactivity was detected in the excreta within 96 h after dosing. Level of the radioactivity in the blood of male and female rats reached maximum at 2 and 1 h after dosing, resp., and then decreased rapidly to about a half level of maximum (C1/2). The radioactivity of tissues was lower at 96 h after dosing than that at C1/2-time. Most of the radioactivity in the urine, feces, liver, and plasma was detected as unchanged KIH-2023. The major radioactive compounds excreted into the bile were KIH-2023 and its glucuronide. Repeated oral administration of KIH-2023 for 15 days gave similar results from the single oral one in the excretion, tissue distribution and metabolism of 14C-KIH-2023. In the experiment, the researchers used many compounds, for example, 6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6COA of Formula: C5H6N2O3)

6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.COA of Formula: C5H6N2O3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Dreher, Spencer D.; Ikemoto, Norihiro; Gresham, Venita; Liu, Jinchu; Dormer, Peter G.; Balsells, Jaume; Mathre, David; Novak, Thomas J.; Armstrong, Joseph D. published an article in Tetrahedron Letters. The title of the article was 《Highly selective synthesis of 2-substituted-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid derivatives using a novel protected dihydroxyfumarate》.Recommanded Product: 5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid The author mentioned the following in the article:

A high yielding (50-96%) route to 2-substituted-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid derivatives, e.g. I, has been developed using a rationally designed dihydroxyfumarate derivative The fully unprotected pyrimidinone heterocycle II was prepared in quant. yield upon treatment of I with HCl. In the experiment, the researchers used 5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid(cas: 62222-38-2Recommanded Product: 5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid)

5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid(cas: 62222-38-2) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Recommanded Product: 5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Onys’ko, P. P.; Gololobov, Yu. G.; Remennikov, G.; Cherkasov, V. M. published an article in Zhurnal Obshchei Khimii. The title of the article was 《Anion σ-complexes of phosphorus compounds. VII. σ-Complexes of dialkylphosphites with 5-nitropyrimidines》.Formula: C5H5N3O3 The author mentioned the following in the article:

Reaction of I (R = H, MeO, Ph; R1 = H) with (R2O)2P(O)H (R2 = Me, Et) in presence of Et3N gave II (R, R1, R2, as above). Similar reaction of I (R = H, MeO, R1 = MeO) with (R2O)2P(O)H (R2 = Me, Et) gave III via the corresponding intermediate II. In the experiment, the researchers used many compounds, for example, 2-Methoxy-5-nitropyrimidine(cas: 14001-69-5Formula: C5H5N3O3)

2-Methoxy-5-nitropyrimidine(cas: 14001-69-5) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Formula: C5H5N3O3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Zwitterionic σ-complexes: their role as intermediates in phosphorylation of aromatics by phosphorus compounds》 were Gololobov, Yu. G.; Onys’ko, P. P.. And the article was published in ACS Symposium Series in 1981. COA of Formula: C5H5N3O3 The author mentioned the following in the article:

Reaction of P(III) compounds with 1,3,5-(O2N)3C6H3 in Me2SO gave σ-complexes I [PR3 = P(OEt)3, PPh(OEt)2, P(OEt)Ph2, P(O)(OEt)2], which were stabilized without a dissociated cation in contrast to ordinary Meisenheimer σ-complexes. 5-Nitropyrimidines do not form stable σ-complexes with (RO)3P or (RO)2P(O)H without bases. II [R = alkyl; R1 = H, MeO, Ph, R2 = H; R1 = H, MeO, R2 = MeO] were prepared only in the presence of Et3N. In addition to this study using 2-Methoxy-5-nitropyrimidine, there are many other studies that have used 2-Methoxy-5-nitropyrimidine(cas: 14001-69-5COA of Formula: C5H5N3O3) was used in this study.

2-Methoxy-5-nitropyrimidine(cas: 14001-69-5) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.COA of Formula: C5H5N3O3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 1984,Seela, Frank; Driller, Hansjuergen published 《7-(β-D-Arabinofuranosyl)-2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine – synthesis, selective displacement of halogen, and effect of glyconic protecting groups on the reactivity of the aglycon》.Liebigs Annalen der Chemie published the findings.Application of 90213-66-4 The information in the text is summarized as follows:

Phase-transfer glycosylation of 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine with 2,3,5-tri-O-benzyl-α-D-arabinofuranosyl bromide, followed by column chromatog. gave 67% nucleoside I (R = PhCH2) (II), which on debenzylation with BCl3 gave the title compound I (R = H) (III). Nucleophilic displacement on III resulted in selective substitution of Cl in position 4. Under more vigorous conditions the C-4 as well as the C-2 substituents were replaced. In contrast nucleophilic substitution of II was hindered. In addition to this study using 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine, there are many other studies that have used 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Application of 90213-66-4) was used in this study.

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Application of 90213-66-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 1985,Seela, Frank; Driller, Hansjuergen; Liman, Ulrich published 《7-Deaza isosters of 2′-deoxyxanthosine and 2′-deoxyspongosine – synthesis via glycosylation of 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine》.Liebigs Annalen der Chemie published the findings.Recommanded Product: 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine The information in the text is summarized as follows:

Glycosylation of 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine with 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride in DMF in the presence of NaH gave the nucleoside derivative I (R = R1 = Cl; R2 = p-toluoyl) (II) and its α-anomer. II on treatment with NaOMe in MeOH gave I (R = R1 = MeO; R2 = H), which on demethylation with HBr-AcOH in THF gave 7-deaza-2′-deoxyxanthosine (III). II was also converted into 7-deaza-2′-deoxyspongosine (I; R = MeO, R1 = NH2, R2 = H). In the part of experimental materials, we found many familiar compounds, such as 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Recommanded Product: 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. Recommanded Product: 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidineThey have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 1987,Seela, Frank; Steker, Herbert; Driller, Hans Juergen; Bindig, Uwe published 《2-Amino-2′-deoxytubercidin and related pyrrolo[2,3-d]pyrimidinyl-2′-deoxyribofuranosides》.Liebigs Annalen der Chemie published the findings.Category: pyrimidines The information in the text is summarized as follows:

Phase-transfer glycosylation of 2-amino-4-chloro-7H-pyrrolo[2,3-d]pyrimidine with 1-chloro-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranose (I) yielded the crystalline nucleoside II in a regio- and diastereoselective reaction. Nucleophilic displacement of the 4-chloro substituent of II or the nonprotected analog opened a route to 2-amino-2′-deoxytubercidin (III) or the thionucleoside IV. The anomers of I were isolated from the glycosylation reaction carried out in the absence of the nucleobase. In the part of experimental materials, we found many familiar compounds, such as 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Category: pyrimidines)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2018,Wang, Hui-Yan; Shen, Ying; Zhang, Hao; Hei, Yuan-Yuan; Zhao, Hong-Yi; Xin, Minhang; Lu, She-Min; Zhang, San-Qi published 《Discovery of 2-(aminopyrimidin-5-yl)-4-(morpholin-4-yl)-6- substituted triazine as PI3K and BRAF dual inhibitor》.Future Medicinal Chemistry published the findings.Safety of 2,4,6-Trichloropyrimidine The information in the text is summarized as follows:

The discovery and development of novel agents simultaneously targeting PI3K/AKT/mammalian target of rapamycin and Ras/RAF/MEK, two signaling pathways, are urgent to improve the curative effect of kinase inhibitors and overcome acquired resistance. In the present study, 2-(2-aminopyrimidin-5-yl)-4-(morpholin-4-yl)-6-(N-cyclopropyl-N- (1-benzoylpiperidin-4-yl))triazines/pyrimidines were designed as PI3K and BRAF dual inhibitors. The synthesized 20 compounds exhibited potent antiproliferative effects in vitro against HCT116, A375, MCF-7, Colo205, A549 and LOVO cancer cell lines. The tested compounds A6, A7, A9 and A11 remarkably displayed inhibitory activities toward both PI3Kα and BRAFV600E. These results indicated that our design compounds can serve as potent PI3Kα and BRAFV600E dual inhibitors and effective antiproliferative agents, which can be further optimized to discover more potent PI3Kα and BRAFV600E dual inhibitors.2,4,6-Trichloropyrimidine(cas: 3764-01-0Safety of 2,4,6-Trichloropyrimidine) was used in this study.

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Safety of 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2019,Chemie Ingenieur Technik included an article by Xie, Xiangzhong; Schenkendorf, Rene; Krewer, Ulrike. COA of Formula: C4H2Cl2N2. The article was titled 《The Effect of Correlated Kinetic Parameters on (Bio)Chemical Reaction Networks》. The information in the text is summarized as follows:

Exploiting the information provided by (bio)chem. reaction networks has proved beneficial for process anal. and design. To this end, parameter uncertainties have to be included in the anal. and design of (bio)chem. processes to ensure reliable model-based results. The goal is to investigate the impact of parameter correlations on (bio)chem. reaction networks and parameter sensitivities. An efficient sensitivity anal. concept is demonstrated with two simulation studies, and the results indicate a significant impact of the parameter correlations on the derived parameter sensitivities and the model-based results in general. The experimental part of the paper was very detailed, including the reaction process of 2,4-Dichloropyrimidine(cas: 3934-20-1COA of Formula: C4H2Cl2N2)

2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.COA of Formula: C4H2Cl2N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia