Day: October 13, 2022

Electric Literature of C23H22N4OOn June 1, 2001, Banic Tomisic, Zrinka; Cempuh, Andreja; Malnar, Ivica published an article in Acta Crystallographica, Section E: Structure Reports Online. The article was 《7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine-4-ylamine, a lck tyrosine kinase inhibitor》. The article mentions the following:

The mol. and crystal structures of the potent and selective lck tyrosine kinase inhibitor, C23H22N4O, were determined by single-crystal x-ray diffraction. The pyrrolopyrimidine and Ph rings are planar while the cyclopentyl ring adopts a conformation between envelope and half-chair. The overall conformation is defined by the spatial arrangement of the ring moieties. Crystallog. data are given. In the part of experimental materials, we found many familiar compounds, such as 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(cas: 213743-31-8Electric Literature of C23H22N4O)

7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(cas: 213743-31-8) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Electric Literature of C23H22N4O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of C8H10N2O2On October 31, 1994 ,《The crafting of uracils with enhanced stacking potential》 appeared in Proceedings – Indian Academy of Sciences, Chemical Sciences. The author of the article were Ranganathan, Subramania; Kundu, Dinabandhu; Mehrotra, Sanjiv. The article conveys some information:

Uracils having enhanced stacking profile are of interest from diverse vantages ranging from the chem. simulation of transcription to the design of novel antiviral agents. This objective has been realized by synthetic strategies leading to uracils having, inter alia, pseudo aromatic and hydrophobic rings crafted to the 5-6 location and ionophore and hydrophobic chains affixed at the C-5 and nitrogen atoms. Endeavors to prepare a 5-2′ uracil-pyrimidine composite have led to novel uracil arising from 2-O → =CH(COOR)2 transformation and a tethered malonic acid pyrimidine complex. The results came from multiple reactions, including the reaction of Ethyl 2-(pyrimidin-2-yl)acetate(cas: 63155-11-3Synthetic Route of C8H10N2O2)

Ethyl 2-(pyrimidin-2-yl)acetate(cas: 63155-11-3) is a member of pyrimidine. Pyrimidine derivatives are an important class of N-heterocycles. They are well-known for their wide spectrum of promising biological activities such as antitumors, bactericidals, and fungicidal.Synthetic Route of C8H10N2O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 1952,Bollettino Scientifico della Facolta di Chimica Industriale di Bologna included an article by Andrisano, R.; Modena, G.. Category: pyrimidines. The article was titled 《Ultraviolet spectroscopic characteristics at different pH of 5-nitro-2X-substituted pyrimidines》. The information in the text is summarized as follows:

cf. C.A. 46, 9422c. The wave length of maximum absorption, λ, and the extinction coefficient of compounds of the type 5-nitro-2X-pyrimidine, in which X is Me, Ph, furyl, OH, OMe, SH, SMe, NH2, or Cl, were determined in 0.1 N HCl (pH 1), H2O (pH 7), and 0.1 N NaOH (pH 15), to discover if the NO2 group in position 5 would alter results previously found for mono-substituted compounds of the same type. In general the λ is fairly constant at pH 1-7, with the exception of X = CH3, when it jumps from 3065 to 3505 A. The compounds measured are classified as follows: symmetrical when X = NH2, quasisymmetrical when X = OH or SCH3, nonsymmetrical for the other 6 derivatives measured. In addition to this study using 2-Methoxy-5-nitropyrimidine, there are many other studies that have used 2-Methoxy-5-nitropyrimidine(cas: 14001-69-5Category: pyrimidines) was used in this study.

2-Methoxy-5-nitropyrimidine(cas: 14001-69-5) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Underlying mechanism of CO2 adsorption onto conjugated azacyclo-copolymers: N-doped adsorbents capture CO2 chiefly through acid-base interaction?》 were Qi, Shi-Chao; Wu, Ju-Kang; Lu, Jie; Yu, Guo-Xing; Zhu, Rong-Rong; Liu, Yu; Liu, Xiao-Qin; Sun, Lin-Bing. And the article was published in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2019. COA of Formula: C4HCl3N2 The author mentioned the following in the article:

The empiricism that extrinsic or doped materials universally perform much better than their intrinsic counterparts has been verified to be feasible in the adsorptive CO2 capture. Thus, a variety of N-doped solid adsorbents are well-engineered to adsorb CO2. However, the true nature of the N-doped sites in the aggregation state and the underlying mechanism of CO2 adsorption therein are difficult to determine In the present study, four well-defined azacyclo copolymers with peculiar textural characteristics, uniformly arrays and tunably effective N-doped sites were fabricated to exptl. determine the precise relation between adsorbed CO2 mols. and the N-doped sites incorporated into an adsorbent. With multifaceted quantum chem. computations, induction forces were proven to account for the improved CO2 adsorption on the N-doped sites instead of the conventionally assumed generalized acid-base interaction. The neg. electrostatic potentials were demonstrated to be the real cause for improving the CO2 adsorption and a robust indicator for the effectiveness of the N-doped sites. Besides, a precise linear function is proposed to quant. describe this subject-object relationship for the first time. In the experimental materials used by the author, we found 2,4,6-Trichloropyrimidine(cas: 3764-01-0COA of Formula: C4HCl3N2)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.COA of Formula: C4HCl3N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Cheng, Cong; Jiang, Yongshi; Wang, Haonan; Lou, Weiwei; Zhu, Yunhui; Deng, Chao; Wang, Dan; Tsuboi, Taiju; Li, Guijie; Zhang, Qisheng published their research in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2021. The article was titled 《Efficient and stable deep blue thermally activated delayed fluorescent molecules based on a bipyridine acceptor core》.HPLC of Formula: 3764-01-0 The article contains the following contents:

High efficiency and low cost organic light-emitting diodes (OLEDs) employing thermally activated delayed fluorescent (TADF) materials have attracted great attention. However, combining high quantum efficiency and stability is still challenging for deep blue TADF OLEDs. Here, we report a type of novel blue TADF emitter consisting of a bipyridine weak acceptor and four carbazole donors. These D-A-type emitters exhibit a high fluorescence rate of 9.8 x 107 s-1 and a small ΔEST of 0.08 eV owing to the energy approach of the frontier orbitals on the isolated D/A segments and adequate overlap of the frontier orbitals in the D-A systems. The organic light-emitting diodes containing these emitters offer deep blue emission with a half-width of 58 nm. High external quantum efficiencies of 15.3% and 18.7% are achieved in devices with emission maxima at 459 nm and 471 nm, resp. In comparison to the structurally analogous TADF emitters with a π-bridge between the donor and acceptor moieties, the bipyridine/carbazole derivatives with a compact “”donors-surrounding-acceptor”” structure exhibit superior stability in both photoluminescence and electroluminescence. The experimental process involved the reaction of 2,4,6-Trichloropyrimidine(cas: 3764-01-0HPLC of Formula: 3764-01-0)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.HPLC of Formula: 3764-01-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2017,Xiang, Yepeng; Zhao, Yongbiao; Xu, Nan; Gong, Shaolong; Ni, Fan; Wu, Kailong; Luo, Jiajia; Xie, Guohua; Lu, Zheng-Hong; Yang, Chuluo published 《Halogen-induced internal heavy-atom effect shortening the emissive lifetime and improving the fluorescence efficiency of thermally activated delayed fluorescence emitters》.Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published the findings.Synthetic Route of C4HCl3N2 The information in the text is summarized as follows:

Halogenation of an electron acceptor in TADF emitters is presented as a feasible strategy for shortening the DF lifetimes of TADF emitters without sacrificing their photoluminescence quantum yields. A greenish-yellow device based on the chloride-substituted emitter (ClPPM) achieves a high external quantum efficiency of 22.2% and an ultra-slow efficiency roll-off of 12.3% at a practical luminance of 1000 cd m-2, which is comparable to the state-of-the-art device performance for green-to-yellow TADF OLEDs at the practical luminance. The results came from multiple reactions, including the reaction of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Synthetic Route of C4HCl3N2)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Synthetic Route of C4HCl3N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pander, Piotr; Zaytsev, Andrey V.; Sil, Amit; Williams, J. A. Gareth; Lanoe, Pierre-Henri; Kozhevnikov, Valery N.; Dias, Fernando B. published an article in 2021. The article was titled 《The role of dinuclearity in promoting thermally activated delayed fluorescence (TADF) in cyclometalated, N-C-N-coordinated platinum(II) complexes》, and you may find the article in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices.Related Products of 1193-21-1 The information in the text is summarized as follows:

We present the synthesis and in-depth photophys. anal. of a di-Pt(II) complex with a ditopic bis-N-C-N ligand. The complex exhibits a dual luminescent behavior by emitting simultaneously delayed fluorescence and phosphorescence. By comparing with the mono-Pt(II) analog, we demonstrate that thermally activated delayed fluorescence (TADF) is turned on in the di-Pt(II) complex due to the occurrence of three main differences relative to the mono-Pt(II) analog: a larger singlet radiative rate constant (kSr), a smaller singlet-triplet energy gap (ΔEST) and a longer phosphorescence decay lifetime (τPH). We observe similar trends among other di-Pt(II) complexes and conclude that bimetallic structures promote conditions favorable for TADF to occur. The diplatinum(II) complex also shows a long wavelength-emissive excimer which yields near IR electroluminescence, λel = 805 nm, in a solution-processed OLED device with EQEmax = 0.51%. We believe this is the highest efficiency reported to date for an excimer Pt(II) emitter with λel > 800 nm in a solution-processed OLED device.4,6-Dichloropyrimidine(cas: 1193-21-1Related Products of 1193-21-1) was used in this study.

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Related Products of 1193-21-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Azoles and azines: CVII. Synthesis of 5H-pyrano[2,3-d:6,5-d’]dipyrimidine-2,4,6,8(1H,3H,7H,9H)-tetrones and their 2,8-dithio analogs》 was written by Moskvin, A. V.; Polkovnikova, I. I.; Ivin, B. A.. Formula: C5H6N2O3 And the article was included in Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) on August 31 ,1998. The article conveys some information:

5H-Pyrano[2,3-d:6,5-d’]dipyrimidine-2,4,6,8(1H,3H,7H,9H)-tetrones were prepared by treatment with a POCl3-P2O5 mixture of pyridinium salts of 5,5′-arylmethylenebisbarbituric acids or by condensation of 6-methoxyuracil with aromatic aldehydes or formaldehyde, followed by demethylation of intermediate 4,6-dimethoxy-5H-pyrano[2,3-d:6,5-d’]dipyrimidine-2,8(1H,9H)-diones. 2,8-Dithioxo-1,2,3,4,6,7,8,9-octahydro-5H-pyrano[2,3-d:6,5-d’]dipyrimidine-4,6-diones are formed by reaction of pyridinium salts of 5,5′-arylmethylenebis(2-thiobarbituric) acids with trifluoroacetic anhydride. After reading the article, we found that the author used 6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6Formula: C5H6N2O3)

6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Formula: C5H6N2O3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《High-throughput identification of small molecules that affect human embryonic vascular development》 was written by Vazao, Helena; Rosa, Susana; Barata, Tania; Costa, Ricardo; Pitrez, Patricia R.; Honorio, Ines; de Vries, Margreet R.; Papatsenko, Dimitri; Benedito, Rui; Saris, Daniel; Khademhosseini, Ali; Quax, Paul H. A.; Pereira, Carlos F.; Mercader, Nadia; Fernandes, Hugo; Ferreira, Lino. Product Details of 213743-31-8 And the article was included in Proceedings of the National Academy of Sciences of the United States of America on April 11 ,2017. The article conveys some information:

Birth defects, which are in part caused by exposure to environmental chems. and pharmaceutical drugs, affect 1 in every 33 babies born in the United States each year. The current standard to screen drugs that affect embryonic development is based on prenatal animal testing; however, this approach yields low-throughput and limited mechanistic information regarding the biol. pathways and potential adverse consequences in humans. To develop a screening platform for mols. that affect human embryonic development based on endothelial cells (ECs) derived from human pluripotent stem cells, we differentiated human pluripotent stem cells into embryonic ECs and induced their maturation under arterial flow conditions. These cells were then used to screen compounds that specifically affect embryonic vasculature. Using this platform, we have identified two compounds that have higher inhibitory effect in embryonic than postnatal ECs. One of them was fluphenazine (an antipsychotic), which inhibits calmodulin kinase II. The other compound was pyrrolopyrimidine (an antiinflammatory agent), which inhibits vascular endothelial growth factor receptor 2 (VEGFR2), decreases EC viability, induces an inflammatory response, and disrupts preformed vascular networks. The vascular effect of the pyrrolopyrimidine was further validated in prenatal vs. adult mouse ECs and in embryonic and adult zebrafish. We developed a platform based on human pluripotent stem cell-derived ECs for drug screening, which may open new avenues of research for the study and modulation of embryonic vasculature. In the experiment, the researchers used many compounds, for example, 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(cas: 213743-31-8Product Details of 213743-31-8)

7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(cas: 213743-31-8) belongs to pyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Product Details of 213743-31-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Optimization of the carbazole-pyrimidine linking pattern for achieving efficient TADF》 was published in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2020. These research results belong to Serevicius, Tomas; Dodonova, Jelena; Skaisgiris, Rokas; Banevicius, Dovydas; Kazlauskas, Karolis; Jursenas, Saulius; Tumkevicius, Sigitas. Formula: C4H2Cl2N2 The article mentions the following:

A high fluorescence quantum yield is essential for achieving a high OLED efficiency. Due to their typically strong charge-transfer (CT) character, thermally activated delayed fluorescence (TADF) compounds usually have a lower prompt fluorescence efficiency, and therefore the boosting of the total emission yield (ϕPL) mostly relies on the enhancement of the delayed fluorescence efficiency. In this paper, we present a less frequently used approach for achieving a high ϕPL by maximising both prompt and delayed emission yields of carbazole-pyrimidine compounds Strong decoupling of HOMO and LUMO and the subsequent emergence of TADF were achieved by introducing four carbazole units at both meta positions of the Ph unit, though was low due to the prominent nonradiative triplet decay rate. Crowding the relatively loose carbazole units together at the para position and both meta positions, conversely, was shown to diminish the nonradiative decay, enhance the radiative decay rate and subsequently boost the fluorescence yield. Efficient blue electroluminescence with a nearly 20% yield was demonstrated for the optimized compound In the experiment, the researchers used many compounds, for example, 4,6-Dichloropyrimidine(cas: 1193-21-1Formula: C4H2Cl2N2)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Formula: C4H2Cl2N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia