Day: October 13, 2022

In 2018,Espinosa-Bustos, Christian; Frank, Annika; Arancibia-Opazo, Sandra; Salas, Cristian O.; Fierro, Angelica; Stark, Holger published 《New lead elements for histamine H3 receptor ligands in the pyrrolo[2,3-d]pyrimidine class》.Bioorganic & Medicinal Chemistry Letters published the findings.Category: pyrimidines The information in the text is summarized as follows:

This work describes the microwave assisted synthesis of twelve novel histamine H3 receptor ligands. They display pyrrolo[2,3-d]pyrimidine derivatives with rigidized aliphatic amines as warheads. The compounds were screened for H3R and H4R binding affinities in radioligand displacement assays and the most potent compounds were evaluated for H3R binding properties in vitro and in docking studies. The combination of a rigidized H3R warhead and the pyrrolo[2,3-d]pyrimidine scaffold resulted in selective activity at the H3 receptor with a pKi value of 6.90 for the most potent compound A bipiperidine warhead displayed higher affinity than a piperazine or morpholine motif, while a naphthyl moiety in the arbitrary region increased affinity compared to a Ph derivative The compounds can be starting points for novel, simply synthesized histamine H3 receptor ligands. The experimental part of the paper was very detailed, including the reaction process of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Category: pyrimidines)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Bonanno, Nico M.; Watts, Zackery; Mauws, Cole; Patrick, Brian O.; Wiebe, Christopher R.; Shibano, Yuki; Sugisaki, Kenji; Matsuoka, Hideto; Shiomi, Daisuke; Sato, Kazunobu; Takui, Takeji; Lemaire, Martin T. published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Valence tautomerism in a [2 x 2] Co4 grid complex containing a ditopic arylazo ligand》.HPLC of Formula: 1193-21-1 The article contains the following contents:

The authors describe the structural and magnetic properties of a tetranuclear [2 x 2] Co4 grid complex containing a ditopic arylazo ligand. At low temperatures and in solution the complex is comprised of Co3+ and singly reduced trianion-radical ligands. In the solid state the authors demonstrate the presence of valence tautomerization via variable temperature magnetic susceptibility experiments and powder-pattern EPR spectroscopy. Valence tautomerism in polynuclear complexes is very rare and to our knowledge is unprecedented in [2 x 2] grid complexes. In the experiment, the researchers used 4,6-Dichloropyrimidine(cas: 1193-21-1HPLC of Formula: 1193-21-1)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.HPLC of Formula: 1193-21-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 90213-66-4In 2017 ,《A convenient and simple synthesis of N-arylpirrolopyrimidines using boronic acids and promoted by copper (II) acetate》 appeared in ARKIVOC (Gainesville, FL, United States). The author of the article were Espinosa-Bustos, Christian; Villegas, Alondra; Salas, Cristian O.. The article conveys some information:

A convenient and simple synthesis of novel N-aryl 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidines I [Ar = 4-HOC6H4, 4-NCC6H4, 2-naphthyl, etc.] via copper (II) acetate catalyzed N-arylation of 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine using arylboronic acids was described. The yields obtained for all derivatives were in the range of 45-70% and this synthetic approach was extensible to other heterocycles such as 1H-indazoles. In the experimental materials used by the author, we found 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Related Products of 90213-66-4)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. Related Products of 90213-66-4They have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2022,Chen, Chia-Hsun; Lin, Shih-Chun; Lin, Bo-Yen; Li, Che-Yu; Kong, Yu-Cheng; Chen, Yi-Sheng; Fang, Shao-Cheng; Chiu, Ching-Huang; Lee, Jiun-Haw; Wong, Ken-Tsung; Lin, Chi-Feng; Hung, Wen-Yi; Chiu, Tien-Lung published an article in Chemical Engineering Journal (Amsterdam, Netherlands). The title of the article was 《New bipolar host materials for high power efficiency green thermally activated delayed fluorescence OLEDs》.SDS of cas: 3764-01-0 The author mentioned the following in the article:

Four bipolar mols., namely I, II, III, and IV, with carbazole (Cz) donor and a benzonitrile-substituted pyrimidine (Pym) or triazine (Trz) acceptor core were synthesized and characterized. The electron deficiency of heteroaryl cores together with the substitution pattern of benzonitrile were employed to tune the energy levels as well as the thermally activated delayed fluorescence (TADF) characteristics. The four mols. exhibited TADF behavior with inferior photoluminescent quantum yields (PLQYs) that limit their applications as emitters. These bipolar mols. were employed as TADF host materials for the benchmark TADF emitter 4CzIPN to achieve high-performing green TADF organic light-emitting diodes (OLEDs). Among the mols., I-hosted TADF-OLEDs achieved a maximum external quantum efficiency (EQEmax) of 31.5%, maximum power efficiency (PEmax) of 95.6 lm/W, and maximum current efficiency (CEmax) of 100.2 cd/A. Notably, II-hosted TADF-OLEDs also achieved a PEmax of 116.5 lm/W, turn-on voltage of 2.5 V, and impressive low efficiency roll-off performance (>89% of EQEmax at 5000 cd/m2), representing one of the highest efficiencies ever reported in 4CzIPN-doped devices. The high device efficiency can be ascribed to the balanced ambipolar carrier-transporting character of the host materials and high PLQY as well as the outstanding light outcoupling efficiency of the emitting layer.2,4,6-Trichloropyrimidine(cas: 3764-01-0SDS of cas: 3764-01-0) was used in this study.

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.SDS of cas: 3764-01-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Pyrimidines. II. Nucleophilic substitution reactions of ethyl 4-chloro-2-methylthiopyrimidine-5-carboxylate》 were Shadbolt, Roy S.; Ulbricht, Tilo L. V.. And the article was published in Journal of the Chemical Society [Section] C: Organic in 1967. Application In Synthesis of Ethyl 2,4-diaminopyrimidine-5-carboxylate The author mentioned the following in the article:

cf. CA 56: 470b. Treatment of ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate (I) with dimethylamine, PhONa, PhSNa, KF, or the triethylamine salt of N-hydroxyphthalimide yielded normal substitution products. However, when the chloropyrimidine was treated with NaCN in Me2SO, or LiCN in dimethylformamide, in attempts to prepare the 4-cyano derivative, ethyl 2,4-bis(methylthio)pyridmidine-5-carboxylate was obtained. Investigation of this reaction, and of the other products, suggested that the methylthio group in ethyl-4-chloro-2-(methylthio)pyrimidine-5-carboxylate is displaced by cyanide ion. 4-Chloro-2-(methylthio)pyrimidine reacts similarly to give 2,4-bis(methylthio)pyrimidine, indicating that this reaction may be a general one. The lability of the methylthio group in ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate is also shown by the reaction with an excess of MeONa to give methyl 2,4-dimethoxy-pyrimidine-5-carboxylate. A number of other nucleophilic substitution products derived from ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate are described. 33 references. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2,4-diaminopyrimidine-5-carboxylate(cas: 15400-54-1Application In Synthesis of Ethyl 2,4-diaminopyrimidine-5-carboxylate)

Ethyl 2,4-diaminopyrimidine-5-carboxylate(cas: 15400-54-1) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Application In Synthesis of Ethyl 2,4-diaminopyrimidine-5-carboxylate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 1970,Journal of the Chemical Society [Section] C: Organic included an article by Brown, Desmond J.; Sugimoto, T.. Application of 30561-07-0. The article was titled 《Aza analogs of pteridine. II. Novel use of silver oxide in transetherification of alkoxy-1,2,4,6,8-pentaazanaphthalenes, alkoxynitropyrimidines, and related systems》. The information in the text is summarized as follows:

Alkoxy derivatives of 1,2,4,6,8-pentaazanaphthalene (pyrimido[5,4-e]-as-triazine) (I) undergo transetherification when treated with boiling alcs. in the presence of silver oxide. Appropriate methoxy compounds give 5-ethoxy-3-methyl-, 5-propoxy-3-methyl-, and (more slowly) 5-isopropoxy-3-methyl-pentaazanaphthalene; also 5,7-diethoxy-, 5,7-dipropoxy-, 5,7-diisopropoxy-, 5,7-diethoxy-3-methyl-, and 5-ethoxy-3,7-di-methylpentaazanaphthalene. Synthetic routes to the methoxy substrates and to one of the products are reported; other structures are confirmed by uv and 1H NMR spectra. 4-Methoxypteridine undergoes transetherification similarly but simple alkoxypyrimidines and alkoxypyridines are resistant. However, the more highly activated 2-methoxy-5-nitro-, 4-methoxy-5-nitro-, and 2,4-dimethoxy-5-nitropyrimidine easily give their resp. propoxy homologs, and so does 2-methoxy-3,5-dinitropyridine. In contrast, 2,4-dimethoxy-6-methyl-5-nitropyrimidine gives only its 4-methoxy-2-propoxy homolog, and both 4,6-dimethoxy-5-nitro- and 4-methoxy-2,6-dimethyl-5-nitropyrimidine remain unchanged. The classical transetherification agent, ethanolic EtONa, reacts with 5,7-dimethoxypentaazanaphthalene to give the 7-ethoxy-5-hydroxy analog. This was identified by spectral comparison with its 5-hydroxy-7-methoxy homolog, itself synthesized by 5,6-addition of methanethiol to 7-methoxy-pentaazanaphthalene followed by dehydrogenation and selective hydrolysis. In the part of experimental materials, we found many familiar compounds, such as 2,4-Dimethoxy-5-nitropyrimidine(cas: 30561-07-0Application of 30561-07-0)

2,4-Dimethoxy-5-nitropyrimidine(cas: 30561-07-0) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Application of 30561-07-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Repurposing strategies on pyridazinone-based series by pharmacophore- and structure-driven screening》 were Floresta, Giuseppe; Crocetti, Letizia; Giovannoni, Maria Paola; Biagini, Pierfrancesco; Cilibrizzi, Agostino. And the article was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020. COA of Formula: C11H8N2O The author mentioned the following in the article:

We report here in silico repurposing studies on 52 new pyridazinone-based small-mols. through inverse virtual screening (iVS) methodologies. These analogs were originally designed as formyl peptide receptor (FPR) ligands. As it is sometimes the case in drug discovery programs, subsequent biol. screening demonstrated the inefficacy of the mols. in binding FPRs, failing in the identification of new hits. Through a focussed drug-repurposing approach we have defined a variety of potential targets that are suitable to interact with this library of pyridazinone-based analogs. A two-step approach has been conducted for computational anal. Specifically, the mols. were initially processed through a pharmacophore-based screening. Secondly, the resulting features of binding were investigated by docking studies and following mol. dynamic simulations, in order to univocally confirm “”pyridazinone-based ligand-target protein”” interactions. Our findings propose aspartate aminotransferase as the most favorable repurposed target for this small-mol. series, worth of addnl. medicinal chem. investigations in the field. The results came from multiple reactions, including the reaction of 3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6COA of Formula: C11H8N2O)

3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. COA of Formula: C11H8N2O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2015,Varalakshmi, Mavallur; Srinivasulu, Doddaga; Kotakadi, Venkata S. published 《Nano-BF3.SiO2 Catalyst-Promoted Michaelis-Arbuzov Reaction: Solvent-Free Synthesis and Antimicrobial Evaluation》.Phosphorus, Sulfur and Silicon and the Related Elements published the findings.HPLC of Formula: 3764-01-0 The information in the text is summarized as follows:

A simple, convenient synthetic route for the synthesis of novel dialkyl heteroaryl phosphonates by a reusable and green nano-BF3. SiO2 solid catalyst under solvent-free conditions through Michaelis-Arbuzov reaction with high yields is presented. All the newly synthesized compounds were characterized by spectral data and screened for their antimicrobial activity. Some of the compounds exhibited potent antibacterial activity against all the tested pathogens, and warrant further investigation. After reading the article, we found that the author used 2,4,6-Trichloropyrimidine(cas: 3764-01-0HPLC of Formula: 3764-01-0)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.HPLC of Formula: 3764-01-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2015,Esmaeilpour, Mohsen; Javidi, Jaber published 《Magnetically-recoverable Schiff Base Complex of Pd (II) Immobilized on Fe3O4@SiO2 Nanoparticles: An Efficient Catalyst for Mizoroki-Heck and Suzuki-Miyaura Coupling Reactions》.Journal of the Chinese Chemical Society (Weinheim, Germany) published the findings.Name: 2,4,6-Trichloropyrimidine The information in the text is summarized as follows:

The activity of Pd(II)-Schiff base complex mols. grafted on the surface of Fe3O4@SiO2 particles were investigated in the palladium-catalyzed coupling reactions of aryl halides with alkenes (Mizoroki-Heck reaction) and phenylboronic acids (Suzuki-Miyaura reaction) in the absence of phosphorous ligands. This method shows notable advantages such as heterogeneous nature of the catalyst, excellent yields, short reaction times, easy preparation, simplicity of operation, and cleaner reaction profiles. The catalyst can be separated from the reaction mixture by applying a permanent magnet externally and can be reused for several times without significant loss of activity. The amount of palladium leaching has been determined by ICP anal. The results came from multiple reactions, including the reaction of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Name: 2,4,6-Trichloropyrimidine)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Name: 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2017,Davodian, Tayebeh; Ranjbar-Karimi, Reza; Mehrabi, Hossein published 《Synthesis of diheteroaryl sulfides via chemoselective reaction of 4,6-diaminopyrimidine-2(1H)-thione with haloheteroaryl compounds》.Chemistry of Heterocyclic Compounds (New York, NY, United States) published the findings.Recommanded Product: 3764-01-0 The information in the text is summarized as follows:

A series of substituted diheteroaryl sulfides was synthesized by the reaction of 4,6-diaminopyrimidine-2(1H)-thione with fluoro- and chloroheteroarom. compounds in the presence of Na2CO3 in acetonitrile under reflux conditions. The study indicated that 4,6-diaminopyrimidine-2(1H)-thione reacts with fluoro- and chloroheteroarom. compounds chemoselectively as S- rather than N-nucleophile. The structures of the synthesized compounds were confirmed by IR, 1H, 19F, and 13C NMR spectroscopy, as well as elemental anal. and X-ray structural anal. The experimental process involved the reaction of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Recommanded Product: 3764-01-0)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Recommanded Product: 3764-01-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia