Day: October 13, 2022

《On the Way Towards Greener Transition-Metal-Catalyzed Processes as Quantified by E Factors》 was published in Angewandte Chemie, International Edition in 2013. These research results belong to Lipshutz, Bruce H.; Isley, Nicholas A.; Fennewald, James C.; Slack, Eric D.. Reference of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine The article mentions the following:

Transition-metal-catalyzed carbon-carbon and carbon-heteroatom bond formations are among the most heavily used types of reactions in both academic and industrial settings. As important as these are to the synthetic community, such cross-couplings come with a heavy price to our environment, and sustainability. E Factors are one measure of waste created, and organic solvents, by far, are the main contributors to the high values associated, in particular, with the pharmaceutical and fine-chem. companies which utilize these reactions. An alternative to organic solvents in which cross-couplings are run can be found in the form of micellar catalysis, wherein nanoparticles composed of newly introduced designer surfactants enable the same cross-couplings, albeit in water, with most taking place at room temperature In the absence of an organic solvent as the reaction medium, organic waste and hence, E Factors, drop dramatically. After reading the article, we found that the author used 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine(cas: 659729-09-6Reference of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine)

4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine(cas: 659729-09-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Reference of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

COA of Formula: C11H8N2O4On October 1, 2015 ,《N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Chapman, Timothy M.; Wallace, Claire; Gillen, Kevin J.; Bakrania, Preeti; Khurana, Puneet; Coombs, Peter J.; Fox, Simon; Bureau, Emilie A.; Brownlees, Janet; Melton, David W.; Saxty, Barbara. The article contains the following contents:

A high throughput screen allowed the identification of N-hydroxyimide inhibitors of ERCC1-XPF endonuclease activity with micromolar potency, but they showed undesirable selectivity profiles against FEN-1. A scaffold hop to a hydroxypyrimidinone template gave compounds with similar potency but allowed selectivity to be switched in favor of ERCC1-XPF over FEN-1. Further exploration of the structure-activity relationships around this chemotype gave sub-micromolar inhibitors with >10-fold selectivity for ERCC1-XPF over FEN-1. In the experiment, the researchers used many compounds, for example, 5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid(cas: 62222-38-2COA of Formula: C11H8N2O4)

5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid(cas: 62222-38-2) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. COA of Formula: C11H8N2O4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Efficient solvent free synthesis of tertiary α-aminophosphonates using H2Ti3O7 nanotubes as a reusable solid-acid catalyst》 were Rajendra Prasad Reddy, Bhoomireddy; Vasu Govardhana Reddy, Peddiahgari; Reddy, Bijivemula N.. And the article was published in New Journal of Chemistry in 2015. Related Products of 640769-70-6 The author mentioned the following in the article:

In this paper, TiO2 fine particles, TiO2-P25, protonated trititanate (H2Ti3O7) nanorods and nanotubes were used as recyclable solid-acid catalysts for the solvent free synthesis of tertiary α-aminophosphonates through Kabachnik-Fields reaction. Among them, H2Ti3O7 nanotubes showed remarkable catalytic performance and it was due to strong and sufficient Lewis and Bronsted acid sites on a large nanotubular surface. More importantly, for the first time we reported some novel 5,8-dioxa-10-azadispiro[2.0.4.3]undecane bearing tertiary α-aminophosphonates. After reading the article, we found that the author used 3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6Related Products of 640769-70-6)

3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. Related Products of 640769-70-6They have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Synthesis, biological profile and computational studies of some trichloropyrimidine derivatives》 were Sandeep, Thummar; Vasishta, Bhatt. And the article was published in Research Journal of Chemistry and Environment in 2019. Name: 2,4,6-Trichloropyrimidine The author mentioned the following in the article:

A series of (((oxadiazolyl-thio)(nitrophenyl-amino)pyrimidinyl)hydrazinyl)-N-phenylacetamide motifs I [R = Ph, 2-furyl, 3-pyridyl, etc.] was synthesized and studied for their antibacterial and antifungal activities as well as for mol. docking and FMO studies. All the synthesized mols. were characterized by 1H NMR and 13C NMR spectroscopic anal. Compounds I [R = 3-pyridyl, 4-pyridyl] were found to be potentially active against gram neg. and gram-pos. bacteria with MIC value between 62.5 to 500μg/mL. The mol. docking studies of compounds I [R = Ph, 3-pyridyl] were further carried out to discover the interaction with active sites. In the experimental materials used by the author, we found 2,4,6-Trichloropyrimidine(cas: 3764-01-0Name: 2,4,6-Trichloropyrimidine)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Name: 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Product Details of 6297-80-9On November 1, 2012 ,《Discovery of phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, an effective antithrombotic agent without associated bleeding and insulin resistance》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Giordanetto, Fabrizio; Waallberg, Andreas; Ghosal, Saswati; Iliefski, Tommy; Cassel, Johan; Yuan, Zhong-Qing; von Wachenfeldt, Henrik; Andersen, Soeren M.; Inghardt, Tord; Tunek, Anders; Nylander, Sven. The article conveys some information:

Structure-based evolution of the original fragment leads resulted in the identification of 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, (S)-21, a potent, selective phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor with favorable in vivo antiplatelet effect. Despite its antiplatelet action, (S)-21 did not significantly increase bleeding time in dogs. Addnl., due to its enhanced selectivity over p110α, (S)-21 did not induce any insulin resistance in rats. In addition to this study using 4,6-Dichloropyrimidin-2(1H)-one, there are many other studies that have used 4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9Product Details of 6297-80-9) was used in this study.

4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Product Details of 6297-80-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 1987,Biochemical and Clinical Aspects of Pteridines included an article by Huebsch, Walter. HPLC of Formula: 6297-80-9. The article was titled 《Synthesis and biological activity of 8-substituted thiolumazines》. The information in the text is summarized as follows:

I (X and Y = O or S, R = Me, CH2CH2OH, Ph, or ribityl were prepared as precursors and converted to thiolumazine derivatives II (X and Y = O or S, R = Me, CH2CH2OH, Ph, or ribityl, R1 and R2 = H, Me, OH, or Ph) were prepared and then structure-activity relation discussed with regard to enzyme inhibition in chemotherapy. The 2-oxo group was important for enzyme substrate interaction. Replacement by S had a strong neg. effect. In addition to this study using 4,6-Dichloropyrimidin-2(1H)-one, there are many other studies that have used 4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9HPLC of Formula: 6297-80-9) was used in this study.

4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.HPLC of Formula: 6297-80-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 1984,Kazimierczuk, Zygmunt; Cottam, Howard B.; Revankar, Ganapathi R.; Robins, Roland K. published 《Synthesis of 2′-deoxytubercidin, 2′-deoxyadenosine, and related 2′-deoxynucleosides via a novel direct stereospecific sodium salt glycosylation procedure》.Journal of the American Chemical Society published the findings.Recommanded Product: 90213-66-4 The information in the text is summarized as follows:

A general and stereospecific synthesis has been developed for the direct preparation of 2′-deoxy-β-D-ribofurnaosylpurine analogs including 2′-deoxyadenosine derivatives The reaction of the Na salt of chloropyrrolo[2,3-d]pyrimidines I (R = H, Cl) with 1-chloro-2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranose (II) provided the corresponding N-1 2′-deoxy-β-D-ribofuranosyl blocked derivatives which, on ammonolysis, gave 2′-deoxytubercidin (III, R = H) and 2-chloro-2′-deoxyrubercidin (III, R = Cl), resp., in good yields. This glycosylation also readily proceeds in the presence of a 2-methylthio group. Application of this glycosylation procedure to 4,6-dichloroimidazo[4,5-c]pyridine, 6-chloropurine, 2,6-dichloropurine, and 4-chloropyrazolo[3,4-d]pyrimidine gave 2-chloro-2′-deoxy-3-deazaadenosine, 2′-deoxyadenosine, 2-chloro-2′-deoxyadenosine, and 4-amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)pyrazolo[3,4-d]pyrimidine, resp. Similarly, glycosylation and ammonolysis of 4,6-dichloro-1H-pyrrolo[3,2-c]pyridine gave 4,6-dichloro-1-(2-deoxy-β-D-erythro-pentofuranosyl)pyrrolo[3,2-c]pyridine. This stereospecific attachment of the 2-deoxy-β-D-ribofuranosyl moiety appears to be due to a Walden inversion at the C-1 carbon of II. The results came from multiple reactions, including the reaction of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Recommanded Product: 90213-66-4)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Recommanded Product: 90213-66-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2014,Rodriguez, Rodrigo A.; Pan, Chung-Mao; Yabe, Yuki; Kawamata, Yu; Eastgate, Martin D.; Baran, Phil S. published 《Palau’chlor: A Practical and Reactive Chlorinating Reagent》.Journal of the American Chemical Society published the findings.Product Details of 90213-66-4 The information in the text is summarized as follows:

Unlike its other halogen atom siblings, the utility of chlorinated arenes and (hetero)arenes are twofold: they are useful in tuning electronic structure as well as acting as points for diversification via cross-coupling. Herein we report the invention of a new guanidine-based chlorinating reagent I, CBMG or “”Palau’chlor””, inspired by a key chlorospirocyclization en route to pyrrole imidazole alkaloids. This direct, mild, operationally simple, and safe chlorinating method is compatible with a range of nitrogen-containing heterocycles as well as select classes of arenes, conjugated π-systems, sulfonamides, and silyl enol ethers. Comparisons with other known chlorinating reagents revealed CBMG to be the premier reagent. After reading the article, we found that the author used 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Product Details of 90213-66-4)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Product Details of 90213-66-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2016,Kim, Juae; Shim, Joo Young; Lee, Jihoon; Lee, Dal Yong; Chae, Sangmin; Kim, Jinwoo; Kim, Il; Kim, Hyo Jung; Park, Sung Heum; Suh, Hongsuk published 《Syntheses of pyrimidine-based polymers containing electron-withdrawing substituent with high open circuit voltage and applications for polymer solar cells》.Journal of Polymer Science, Part A: Polymer Chemistry published the findings.Related Products of 3764-01-0 The information in the text is summarized as follows:

Polymers using new electron-deficient units, 2-pyriminecarbonitrile and 2-fluoropyrimidine, were synthesized and utilized for the photovoltaics. Donor-acceptor (D-A) types of conjugated polymers (PBDTCN, PBDTTCN, PBDTF, and PBDTTF) containing 4,8-bis(2-octyldodecyloxy)benzo[1,2-b;3,4-b’]dithiophene (BDT) or 4,8-bis(5-(2-octyldodecyloxy)thiophen-2-yl)benzo[1,2-b:4,5-b’]dithiophene (BDTT) as electron rich unit and 2-pyriminecarbonitrile or 2-fluoropyrimidine as electron deficient unit were synthesized. We designed pyrimidine derivatives in which strong electron-withdrawing group (CN or fluorine) was introduced to the C2 position for the generation of strong electron-deficient property. By the combination with the electron-rich unit, the pyrimidines will provide low band gap polymers with low HOMO energy levels for higher open-circuit voltages (VOC). For the syntheses of the polymers, the electron-rich and the electron-deficient units were combined by Stille coupling reaction with Pd(0)-catalyst. Absorption spectra of the thin films of PBDTTCN and PBDTTF with BDTT unit show shift to a longer wavelength region than PBDTCN and PBDTF with BDT unit. Four synthesized polymers provided low electrochem. bandgaps of 1.56 to 1.96 eV and deep HOMO energy levels between -5.67 and -5.14 eV. © 2015 The Authors. Journal of Polymer Science Part A: Polymer Chem. Published by Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015. The results came from multiple reactions, including the reaction of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Related Products of 3764-01-0)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Related Products of 3764-01-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《A chemoproteomic strategy for direct and proteome-wide covalent inhibitor target-site identification》 were Browne, Christopher M.; Jiang, Baishan; Ficarro, Scott B.; Doctor, Zainab M.; Johnson, Jared L.; Card, Joseph D.; Sivakumaren, Sindhu Carmen; Alexander, William M.; Yaron, Tomer M.; Murphy, Charles J.; Kwiatkowski, Nicholas P.; Zhang, Tinghu; Cantley, Lewis C.; Gray, Nathanael S.; Marto, Jarrod A.. And the article was published in Journal of the American Chemical Society in 2019. Recommanded Product: 2,4-Dichloropyrimidine The author mentioned the following in the article:

Despite recent clin. successes for irreversible drugs, potential toxicities mediated by unpredictable modification of off-target cysteines represents a major hurdle for expansion of covalent drug programs. Understanding the proteome-wide binding profile of covalent inhibitors can significantly accelerate their development; however, current mass spectrometry strategies typically do not provide a direct, amino acid level readout of covalent activity for complex, selective inhibitors. Here we report the development of CITe-Id, a novel chemoproteomic approach that employs covalent pharmacol. inhibitors as enrichment reagents in combination with an optimized proteomic platform to directly quantify dose-dependent binding at cysteine-thiols across the proteome. CITe-Id anal. of our irreversible CDK inhibitor THZ1 identified dose-dependent covalent modification of several unexpected kinases, including a previously unannotated cysteine (C840) on the understudied kinase PKN3. These data streamlined our development of JZ128 as a new selective covalent inhibitor of PKN3. Using JZ128 as a probe compound, we identified novel potential PKN3 substrates, thus offering an initial mol. view of PKN3 cellular activity. CITe-Id provides a powerful complement to current chemoproteomic platforms to characterize the selectivity of covalent inhibitors, identify new, pharmacol. addressable cysteine-thiols, and inform structure-based drug design programs. After reading the article, we found that the author used 2,4-Dichloropyrimidine(cas: 3934-20-1Recommanded Product: 2,4-Dichloropyrimidine)

2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Recommanded Product: 2,4-Dichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia