Month: April 2022

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(SMILESS: OC1=C(C)C(CO)=CN=C1C.[H]Cl,cas:148-51-6) is researched.Application of 1193-62-0. The article 《Transmitter synthesis and convulsant drugs: effects of pyridoxal phosphate antagonists and allylglycine》 in relation to this compound, is published in Biochemical Pharmacology. Let’s take a look at the latest research on this compound (cas:148-51-6).

Glutamic acid decarboxylase (EC 4.1.1.15) (I) [9024-58-2] and dopa decarboxylase (EC 4.1.1.26) (II) [9042-64-2] in mouse brain homogenates were inhibited after administration of methyldithiocarbazinate [5397-03-5] (45 mg/kg, i.p.), thiosemicarbazide [79-19-6] (100 mg/kg, i.p.), or 4-deoxypyridoxine-HCl (III) [148-51-6] (250 mg/kg, i.p.); addition of pyridoxal phosphate [54-47-7] abolished the inhibition. I activity was inhibited by allylglycine (IV) [3182-77-2] in vivo (200 mg/kg, i.p.) and in vitro whereas II activity was unaffected. III (250 mg/kg, i.p.) decreased brain GABA [56-12-2] levels, increased homovanillic acid [306-08-1] and 5-hydroxyindoleacetic acid [54-16-0] levels, and did not alter dopamine [51-61-6] and serotonin [50-67-9] levels. Brain GABA levels were decreased by IV while monoamine and monoamine metabolite levels were unchanged. Inhibition of II activity is not the primary or critical mechanism in the convulsant action of hydrazides and IV.

Here is a brief introduction to this compound(148-51-6)Category: pyrimidines, if you want to know about other compounds related to this compound(148-51-6), you can read my other articles.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Methylfuran-2(3H)-one, is researched, Molecular C5H6O2, CAS is 591-12-8, about Cigar leaf differences from different producing areas based on aroma component analysis, the main research direction is cigar leaf aroma component.HPLC of Formula: 591-12-8.

In order to investigate the leaf aroma chem. differences for cigar samples from different producing areas, 79 aroma components in 47 cigar samples from different countries were determined In addition, the differences in contents and odor activity values of aroma components among Cuban cigars, foreign non-Cuban cigars and Chinese cigars were compared by significance tests. The results showed that there were significant differences in the contents of 43 aroma components among the cigars from different producing areas, and the differences in the contents of α-curcumene and cedrol were the most significant. The contents of degradation products from chlorophyll and cembranoids in Cuban cigars were higher, those of phenylalanines and labdanums in foreign non-Cuban cigars and that of chlorophyll in Chinese cigars were lower. The 79 aroma components had higher odor activity values in fruit and flower flavors. Cuban cigars had higher odor activity values in herbal spices, fruit, flower and other flavors. Foreign non-Cuban cigars had lower odor activity values in plant, fruit, nut, flower and other flavors. The discriminant functions established by taking the contents of aroma components as variables can distinguish the producing areas of com. cigars.

Here is a brief introduction to this compound(591-12-8)HPLC of Formula: 591-12-8, if you want to know about other compounds related to this compound(591-12-8), you can read my other articles.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Category: pyrimidines. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-Methylfuran-2(3H)-one, is researched, Molecular C5H6O2, CAS is 591-12-8, about Inverse-Electron-Demand Palladium-Catalyzed Asymmetric [4+2] Cycloadditions Enabled by Chiral P,S-Ligand and Hydrogen Bonding.

Catalytic asym. cycloadditions of ambident Pd-containing dipolar species with nucleophilic dipolarophiles, namely, inverse-electron-demand cycloadditions, are challenging and underdeveloped. Possibly, the inherent linear selectivity of Pd-catalyzed intermol. allylations and the lack of efficient chiral ligands are responsible for this limitation. Herein, two cycloadditions of such intermediates with deconjugated butenolides and azlactones were accomplished by using a novel chiral hybrid P,S-ligand and hydrogen bonding [e.g., vinyl carbamate I + butenolide II → dihydroquinol-2-one III (92%, 93% ee, >95:5 d.r.)]. By doing so, highly functionalized, optically active dihydroquinol-2-ones were produced with generally high reaction efficiencies and selectivities. Preliminary DFT calculations were performed to explain the high enantio- and diastereoselectivities.

Here is a brief introduction to this compound(591-12-8)Category: pyrimidines, if you want to know about other compounds related to this compound(591-12-8), you can read my other articles.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The relation between iodine-131 metabolism, tumor growth, and regression》. Authors are Scott, Kenneth G.; Daniels, Marie B..The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).Product Details of 148-51-6. Through the article, more information about this compound (cas:148-51-6) is conveyed.

Ability of tumors to alter the normal metabolic pathway of I131 and compounds labeled with it (iodide-trapping syndrome) (I) is characterized by higher than normal retention of I131 by skin, muscle, gastrointestinal tract, and plasma, and a lower than normal thyroid uptake and urinary excretion of I131. I was elicited in rats by isografts and homografts of a transmissible fibrosarcoma, but not by homoiografts (which regressed after 5-7 days of growth). The data suggest that local and systemic I parallels progressive tumor growth and is absent in tumor implants destined to regress.

Here is a brief introduction to this compound(148-51-6)Product Details of 148-51-6, if you want to know about other compounds related to this compound(148-51-6), you can read my other articles.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

COA of Formula: C8H12ClNO2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, is researched, Molecular C8H12ClNO2, CAS is 148-51-6, about Synthesis of aflatoxins by the non-growing mycelia of Aspergillus parasiticus and the effect of inhibitors. Author is Gupta, S. R.; Prasanna, H. R.; Viswanathan, L.; Venkitasubramanian, T. A..

Aflatoxins were synthesized by nongrowing mycelia of A. parasiticus, the amount and type (B or G) being dependent on the buffer used in the suspension medium. Incorporation of acetate-14C into aflatoxin was decreased by compounds that inhibit ATP production or interfere with the utilization of certain amino acids. In contrast, the specific activities of aflatoxins were increased by compounds that diverted acetate from metabolic pathways other than those leading to aflatoxin formation.

In some applications, this compound(148-51-6)COA of Formula: C8H12ClNO2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Methylfuran-2(3H)-one( cas:591-12-8 ) is researched.Recommanded Product: 5-Methylfuran-2(3H)-one.Lukic, Igor; Carlin, Silvia; Horvat, Ivana; Vrhovsek, Urska published the article 《Combined targeted and untargeted profiling of volatile aroma compounds with comprehensive two-dimensional gas chromatography for differentiation of virgin olive oils according to variety and geographical origin》 about this compound( cas:591-12-8 ) in Food Chemistry. Keywords: volatile aroma compound virgin olive oil 2D GC; Comprehensive two-dimensional gas chromatography; Croatia; Geographical origin; Mono-dimensional; Multivariate analysis; Variety; Virgin olive oil; Volatile aroma compounds. Let’s learn more about this compound (cas:591-12-8).

Comprehensive two-dimensional gas chromatog. with time-of-flight mass spectrometry (GC × GC-TOF-MS) was combined with conventional mono-dimensional GC-MS to differentiate Croatian virgin olive oils (VOO) according to variety and geog. origin, based on the profile of volatile aroma compounds isolated by HS-SPME. More than 1000 compounds were detected after untargeted profiling and 256 were identified or tentatively identified, providing one of the most detailed profiles of volatile aroma compounds in VOO up to date. Among them, 131 volatile compounds were significantly different across monovarietal VOOs, while 60 were found useful for the discrimination according to geog. origin. Many major lipoxygenase and minor non-lipoxygenase-generated compounds were shown to have discriminating ability with respect to both factors. Multivariate statistical anal. extracted twenty-one volatile markers with the highest discriminant power for varietal differentiation. The approach reported may have practical application in better understanding, defining, managing, and communicating the varietal or geog. typicity of monovarietal VOOs.

In some applications, this compound(591-12-8)Recommanded Product: 5-Methylfuran-2(3H)-one is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Feng, Yuxin; Xiao, Senhao; Chen, Yantao; Jiang, Hao; Liu, Na; Luo, Cheng; Chen, Shijie; Chen, Hua researched the compound: (S)-3-Methoxypyrrolidine( cas:120099-61-8 ).Reference of (S)-3-Methoxypyrrolidine.They published the article 《Design, synthesis and biological evaluation of benzo[cd]indol-2(1H)-one derivatives as BRD4 inhibitors》 about this compound( cas:120099-61-8 ) in European Journal of Medicinal Chemistry. Keywords: benzoindolone preparation BRD4 inhibitor antitumor cancer human; Acetyl-lysine binding pocket; BRD4 inhibitor; Benzo[cd]indol-2(1H)-one; Bromodomain and extra-terminal domain; Sulfonamide. We’ll tell you more about this compound (cas:120099-61-8).

A series of benzo[cd]indol-2(1H)-one derivatives were designed by structural optimization based on compound I and evaluated for their BRD4 (bromodomain-containing protein 4) inhibitory activity. The results showed that four compounds are the most potential ones with the IC50 values of 1.02 μM, 1.43 μM, 1.55 μM and 3.02 μM. According to their co-crystal structures in complex with BRD4_BD1 and the protein thermal shift assays, the binding modes were revealed that the addnl. indirect hydrogen bonds and hydrophobic interactions make such four compounds more active than I against BRD4. Furthermore, compounds I, 1-((1-ethyl-2-oxo-1,2-dihydrobenzo[cd]indol-6-yl)sulfonyl)pyrrolidine-2-carbohydrazide and 1-((1-ethyl-2-oxo-1,2-dihydrobenzo[cd]indol-6-yl)sulfonyl)pyrrolidine-2-carboxylic acid were chosen to evaluate for their antiproliferative activities on the MLL-AF4-expression acute leukemia cell line (MV4-11), other cancer cell lines and the non-cancer cell lines. The results showed that these compounds exhibited good and selective inhibitory activities against MV4-11 cells with the IC50 values of 11.67 μM, 5.55 μM, and 11.54 μM, resp., and could act on the cell proliferation by blocking cell cycle at G1 phase. They could markedly down-regulate the expressions of the c-Myc, Bcl-2 and CDK6 oncogenes in MV4-11 in the qRT-PCR and western blot studies, which further demonstrated that compound I and its derivatives could serve as a promising therapeutic strategy for MLL leukemia by targeting BRD4_BD1 protein.

In some applications, this compound(120099-61-8)Reference of (S)-3-Methoxypyrrolidine is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Morisawa, Yasuhiro; Kataoka, Mitsuru; Sakamoto, Toshiaki; Saito, Fumiko researched the compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride( cas:148-51-6 ).Reference of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride.They published the article 《Studies on anticoccidial agents. Part VI. Modification at the 2-position of 4-deoxypyridoxol and α4-norpyridoxol》 about this compound( cas:148-51-6 ) in Agricultural and Biological Chemistry. Keywords: pyridoxol derivative anticoccidial; norpyridoxol derivative anticoccidial; coccidiostat pyridoxol norpyridoxol. We’ll tell you more about this compound (cas:148-51-6).

The title derivatives I (R = Me, R1 = Et; R = R1 = H; R = H, R1 = HOCH2; R = H, R1 = MeO) were prepared Thus, I (R = H, R1 = Me) was treated with PhCH2Cl and the product oxidized and treated with Ac2O to give 2-(acetoxymethyl)-3-(benzyloxy)-5-(benzyloxymethyl)pyridine, which was hydrolyzed and hydrogenated to give I (R = H, R1 = HOCH2). At 200 ppm I (R = H, R1 = MeO) had anticoccidial activity against Eimeria acervulina.

In some applications, this compound(148-51-6)Reference of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Quality Control of 2-Bromo-3-methoxypropanoic acid. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Bromo-3-methoxypropanoic acid, is researched, Molecular C4H7BrO3, CAS is 65090-78-0, about N-Substituted amino acid N’-benzylamides: synthesis, anticonvulsant, and metabolic activities. Author is Beguin, Cecile; LeTiran, Arnaud; Stables, James P.; Voyksner, Robert D.; Kohn, Harold.

Amino acid amides (AAA) were prepared and evaluated in seizure models. The AAA displayed moderate-to-excellent activity in the maximal electroshock seizure (MES) test and were devoid of activity in the s.c. Metrazol-induced (scMet) seizure test. The AAA anticonvulsant activity was neither strongly influenced by the C(2) substituent nor by the degree of terminal amine substitution. An in vitro metabolism study suggested that the structure-activity relationship pattern was due, in part, to metabolic processes that occurred at the N-terminal amine unit.

In some applications, this compound(65090-78-0)Quality Control of 2-Bromo-3-methoxypropanoic acid is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《β-Amino acids. IV. β-Methionine and β-ethionine》. Authors are Birkofer, Leonhard; Storch, Ingeborg.The article about the compound:2-Bromo-3-methoxypropanoic acidcas:65090-78-0,SMILESS:O=C(O)C(Br)COC).Recommanded Product: 2-Bromo-3-methoxypropanoic acid. Through the article, more information about this compound (cas:65090-78-0) is conveyed.

cf. C.A. 49, 2317d. HO2CCHAcCH2CO2Et and NaH gave the Na salt, which with ClCH2SMe yielded EtO2CAc(CH2SMe)CH2CO2Et (I), b3 153° (2,4-dinitrophenylhydrazone, m. 92-3°). Refluxed 10 hrs. with 18% HCl I gave AcCH(CH2SMe)CH2CO2H, isolated as the Et ester (II), b3 123° (2,4-dinitrophenylhydrazone, m. 62-3°), as well as AcC(:CH2)CH2CO2H (2,4-dinitrophenylhydrazone, m. 210°), and 3-acetyl-γ-butyrolactone (2,4-dinitrophenylhydrazone, m. 193°). I refluxed with HCl only 4 hrs. gave mono-Et 2-acetyl-2-(methylthiomethyl)succinate, b0.001 115-17° (2,4-dinitrophenylhydrazone, m. 169-70°). I was saponified with Ba(OH)2 to HO2CCH(CH2SMe)CH2CO2H, m. 114-15°. II and HN3 in the presence of HCl gave β-methionine (III), m. 197-8° (picrolonate, m. 190-2°; 3,5-dinitrobenzoyl derivative, m. 200°). MeSCH2CH:CHCO2H, m. 58.5°, obtained from MeSCH2CHO and CH2(CO2H)2 (IV), gave III with NH3 in a sealed tube at 150-60°. EtSNa, obtained from EtSH with Na, and bromoacetal gave EtSCH2CH(OEt)2, converted by HCl to the aldehyde, b14 45-6°, which with IV gave EtSCH2CH:CHCO2H, which with NH3 in a sealed tube yielded β-ethionine (V), m. 198° (picrolonate, m. 180-3°). III and V do not react with aqueous ninhydrin, but give a blue color with it in 95% BuOH-5% 2N HOAc.

In some applications, this compound(65090-78-0)Recommanded Product: 2-Bromo-3-methoxypropanoic acid is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia