Month: April 2022

COA of Formula: C5H6O2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Methylfuran-2(3H)-one, is researched, Molecular C5H6O2, CAS is 591-12-8, about α-Angelica Lactone in a New Role: Facile Access to N-Aryl Tetrahydroisoquinolinones and Isoindolinones via Organocatalytic α-CH2 Oxygenation. Author is Thatikonda, Thanusha; Deepake, Siddharth K.; Das, Utpal.

A method for the direct oxidation of various N-aryl tetrahydroisoquinolines and isoindolines to the corresponding lactams using α-angelica lactone as a catalyst was developed. The utility of the method was further demonstrated by synthesis of indoprofen and indobufen.

There is still a lot of research devoted to this compound(SMILES：O=C1OC(C)=CC1)COA of Formula: C5H6O2, and with the development of science, more effects of this compound(591-12-8) can be discovered.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthetic and natural phellandrene.》. Authors are Kondakow, J.; Schindelmeiser, J..The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).Quality Control of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride. Through the article, more information about this compound (cas:148-51-6) is conveyed.

[Machine Translation of Descriptors]. Carvomenthene, from carvomenthylchloride represented, became after REYCHLER into tertiary carvomenthol and over with 12 mm and 83.5-84.5° boiling. Chloride, D204; 0.932, into tertiary carvomenthene, C10H18, transferred. Boiling point 174-176°; D204; 0.811; nD = 1.45709, molecular refraction 46.23. Dibromide, under strong cooling in petroleum-ether prepared, Kp11; 130-144°. D204; 1.208, optical-inactively, separates no HBr, however alcoholic KOH supplies a hydrocarbon, from the main quantity with 175-180° with boiling D204; 0.825, nD = 1.46693, the smaller part with 180-185°. D204; 0.828, nD = 1.4673; molecular refraction 45.56. Both optical-inactive fractions color intensively raspberry red in a solution of acetic anhydride by H2SO4 and are undoubtedly different from the output hydrocarbon. Under consideration of the formation of the new hydrocarbon from carvomenthol author writes it from SEMMLER, (Ber. German Chem. Society 36. 1779; C. 1903. II. 116) for the phellandrene determined constitution without being able to prove the identity. Phellandrene from phellandrum aquaticum, boiling point 165-168°, D204; 0.844, nD = 1.47575, [α] D20 = 8° 37′. Molecular refraction a mixture of monochloride and dichloride gives 45.28, which probably contains an optical-inactive isomer, with HCl in glacial acetic acid. Monochloride, C10H17Cl, Kp11; 86°, melting point about 110° in the melted out tube, optically dextrorotatory. Dichloride, C10H18Cl2, Kp16; 122.5-125°, D204, 1.006, nD20 = 1.48516.

There is still a lot of research devoted to this compound(SMILES：OC1=C(C)C(CO)=CN=C1C.[H]Cl)Quality Control of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, and with the development of science, more effects of this compound(148-51-6) can be discovered.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 18436-73-2, is researched, Molecular C10H8ClN, about Tricyclic heteroaromatic ring systems. II. A convenient synthesis of 1H-pyrrolo[3,2-c]quinolines, the main research direction is pyrroloquinoline; quinolinyl hydrazone cyclization.Synthetic Route of C10H8ClN.

Quinol-4-yl hydrazones I (R = H, Me, Et; R1 = Me, Ph, Et; RR1 = (CH2)n, n = 3, 4; R2 = H, Me; R3 = H, 6-, 7-, 8-Cl, 6-, 7-, 8-Me, 6-, 7-, 8-MeO) on heating in high boiling solvents undergo cyclizations to give 1H-pyrrolo[3,2-c]quinolines II in good yields. Some of these I were alkylated to provide their N-alkyl derivatives

There is still a lot of research devoted to this compound(SMILES：CC1=C2N=CC=C(Cl)C2=CC=C1)Synthetic Route of C10H8ClN, and with the development of science, more effects of this compound(18436-73-2) can be discovered.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Computed Properties of C5H6O2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Methylfuran-2(3H)-one, is researched, Molecular C5H6O2, CAS is 591-12-8, about A Predictive Strategy Based on Volatile Profile and Chemometric Analysis for Traceability and Authenticity of Sugarcane Honey on the Global Market. Author is Silva, Pedro; Freitas, Jorge; Nunes, Fernando M.; Camara, Jose S..

Sugarcane honey (SCH) is a syrup produced on Madeira Island and recognized by its unique aroma, a complex attribute of quality with an important influence on the final consumer’s acceptance of the product, and determined by a complex mixture of a large number of volatile organic compounds (VOCs) generated during its traditional making process and storage. Therefore, the purpose of this study was to establish the volatile profile of genuine SCH produced by a regional certified producer for seven years and compare it with syrups from non-certified regional producers and with producers from different geog. regions (Spain, Egypt, Brazil and Australia), as a powerful strategy to define the volat. fingerprint of SCH. Different volatile profiles were recognized for all samples, with 166 VOCs being identified belonging to different chem. classes, including furans, ketones, carboxylic acids, aldehydes and alcs. Chemometric anal. allowed (i) the differentiation between all syrups, being more pronounced between SCH and other syrups; and (ii) the identification of 32 VOCs as potential markers for the traceability and authenticity of SCH on the global market.

There is still a lot of research devoted to this compound(SMILES：O=C1OC(C)=CC1)Computed Properties of C5H6O2, and with the development of science, more effects of this compound(591-12-8) can be discovered.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Computed Properties of C10H8ClN. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-Chloro-8-methylquinoline, is researched, Molecular C10H8ClN, CAS is 18436-73-2, about Synthesis and photochemistry of two quinoline analogs of the perimidinespirohexadienone family of photochromes. Author is Moerdyk, Jonathan P.; Speelman, Amy L.; Kuper, Kenneth E.; Heiberger, Brian R.; Ter Louw, Ryan P.; Zeller, Daniel J.; Radler, Andrew J.; Gillmore, Jason G..

The authors report the detailed synthesis and photochem. of two analogs (specifically 3,5-di-tert-butyl-7′-methyl- and 3,5-di-tert-butyl-7′,9′-dimethyl-1′,3′-dihydrospirocyclohexa[2,5]diene-1,2′-pyrido[4,3,2-de]quinazolin-4-one) of the perimidinespirohexadienone (3,5-di-tert-butyl-1′,3′-dihydrospirocyclohexa[2,5]diene-1,2′-perimidin-4-one) family of photochromes in which the naphthalene moiety of the parent is replaced by a quinoline, and compare them to the parent compound Molar absorptivities of both the short wavelength spirocyclic isomer (SW) and long wavelength quinonimine isomer (LW) of each were determined by a combination of proton NMR and UV-vis spectroscopy in solvents of varying polarity. Quantum yield measurements for photoisomerization of SW to LW are reported in those same solvents, with qual. extrapolation to addnl. solvents. The position and rate of the thermal equilibrium reverting LW to SW is estimated for these compounds The 9′-Me in SW (6-Me in LW) is found to be essential for complete reversion of LW to SW in the dark. Finally one-dimensional NOE NMR spectroscopy was used to conclusively determine the structure of LW for the quinoline analogs as the 4-(5-aminoquinolin-4-ylimino)-2,6-di-tert-butylcyclohexa-2,5-dienone resulting from opening toward the quinoline nitrogen, rather than the 4-(4-aminoquinolin-5-ylimino) structure that would result from spirocyclic ring opening away from the quinoline nitrogen which had been initially proposed by V.I Minkin et al. (1999) for very similar compounds

There is still a lot of research devoted to this compound(SMILES：CC1=C2N=CC=C(Cl)C2=CC=C1)Computed Properties of C10H8ClN, and with the development of science, more effects of this compound(18436-73-2) can be discovered.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Preparation of 5-hydroxy-4,6-dimethyl-3-pyridinemethanol (4-deoxypyridoxine) by the use of hydrazine》. Authors are Taborsky, Robert G..The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).COA of Formula: C8H12ClNO2. Through the article, more information about this compound (cas:148-51-6) is conveyed.

2-Methyl-3-hydroxy-4-methoxymethyl-5-hydroxymethylpyridine-HCl (10 g.) and 50 ml. 95% N2H4 refluxed 18 hrs., most of the N2H4 removed in vacuo, and the residue extracted with 60 ml. refluxing MeOH yielded N2H4.HCl, m. 91-2°. The volume of the filtrate reduced to 20 ml., 15 ml. 11.2% MeOH-HCl added, the precipitate isolated, and 50 ml. Et2O added gave a further precipitate The total yield was 8.1 g. 2-methyl-3-hydroxy-4-methyl-5-hydroxymethylpyridine-HCl (I), m. 273° (decomposition). All conditions and isolation procedures were as above except that instead of the 4-Me ether, 5 g. pyridoxine-HCl and 25 ml. 95% N2H4 were used to give 98% I.

There is still a lot of research devoted to this compound(SMILES：OC1=C(C)C(CO)=CN=C1C.[H]Cl)COA of Formula: C8H12ClNO2, and with the development of science, more effects of this compound(148-51-6) can be discovered.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 591-12-8, is researched, Molecular C5H6O2, about Ozonolysis of α-angelica lactone: a renewable route to malonates, the main research direction is angelica lactone ozone ozonolysis; malonic acid preparation; malonate preparation; oxopropionate preparation.Recommanded Product: 591-12-8.

Industrially relevant intermediates such as malonic acid, malonates and 3-oxopropionates waseasily accessed by ozonolysis of α-angelica lactone, derived from the platform chem. levulinic acid. The roles of the solvent and of the quenching conditions were of key importance for the outcome of the reaction.

There is still a lot of research devoted to this compound(SMILES：O=C1OC(C)=CC1)Recommanded Product: 591-12-8, and with the development of science, more effects of this compound(591-12-8) can be discovered.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthetical and natural phellandrene, published in 1905, which mentions a compound: 148-51-6, mainly applied to , Category: pyrimidines.

Compare Abstract, 1903, i, 845. tert.-Carvomenthyl chloride, obtained from tert.-carvomenthol, boils at 83.5-84.5° under 12 mm. pressure, has a sp. gr. 0.932 at 20°/4°, and forms tert.-carvomenthene, which boils at 174-176°, has a sp. gr. 0.811 at 20°/4°, and nD 1.45709. On treatment with bromine in strongly cooled light petroleum solution, this yields carvomenthene dibromide, which boils between 130° and 144° under 11 mm. pressure, has a sp. gr. 1.208 at 20°/4°, is optically inactive, and by alcoholic potassium hydroxide is converted into a hydrocarbon or mixture of hydrocarbons which must have the constitution (the original abstract includes an equation). This distils in two fractions: the larger boils at 175-180°, has a sp. gr. 0.825 at 20°/4°, and nD 1.46693; the smaller boils at 180-185°, has a sp. gr. 0.828 at 20°/4°, and nD 1.4673. The hydrocarbon is not identical therefore with natural phellandrene. Both fractions are optically inactive and give a red coloration with sulphuric acid in acetic acid solution. A specimen of phellandrene from Phellandrum aquaticum, which boils at 165-168°, has a sp. gr. 0.844 at 20°/4°, nD 1.47575, and [α]D +8°37′ at 20°, reacts with hydrochloric acid in acetic acid solution to form a dextrorotatory chloro-derivative, C10H17Cl, which melts at 110° and boils at 86° under 11 mm. pressure, and a dichloride, C10H18Cl2, which boils at 122.5-125° under 16 mm. pressure, and has a sp. gr. 1.006 at 20°/4° and nD 1.48516 at 20° (compare Pesci, Abstract, 1886, 1038).

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Piperidin-4-amine dihydrochloride( cas:35621-01-3 ) is researched.SDS of cas: 35621-01-3.Takai, Haruki; Obase, Hiroyuki; Nakamizo, Nobuhiro; Teranishi, Masayuki; Kubo, Kazuhiro; Shuto, Katsuichi; Hashimoto, Tamotsu published the article 《Synthesis and pharmacological evaluation of piperidine derivatives with various heterocyclic rings at the 4-position》 about this compound( cas:35621-01-3 ) in Chemical & Pharmaceutical Bulletin. Keywords: antiulcer antiinflammatory antihypertensive heterocyclylpiperidine preparation; structure activity antihypertensive heterocyclylpiperidine; piperidine heterocyclyl preparation biol activity. Let’s learn more about this compound (cas:35621-01-3).

A series of piperidine derivatives with various heterocyclic rings at the 4-position, e.g. I, II, was prepared and tested for antihypertensive activity and other biol. activities. The antihypertensive effects of the present compounds in the spontaneous hypertensive rat were less potent than those of previously reported compounds However, some exhibited antiulcer and/or antiinflammatory activity. Structure-activity relationships are discussed.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Biological comparison of synthetic and natural adermin》. Authors are Moller, E. F.; Zima, O.; Jung, F.; Moll, Th..The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).Reference of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride. Through the article, more information about this compound (cas:148-51-6) is conveyed.

Synthetic adermin was assayed by its influence on growth and acid formation by Streptobact. plantarum (C. A. 32, 9165.1); curves of growth (turbidity) and acidity vs. time are given. The synthetic preparation is slightly more active than the vitamin preparation made from rice hulls. A growth effect upon Streptobact. plantarum is likewise exhibited by 2,4-dimethyl-3-hydroxy-5-(hydroxymethyl)pyridine (hydrochloride m. 254°) although in 50-fold dose the result was only 30-40% of that of the B6 hydrochloride. The 4-desoxyadermin in single doses of 1000 γ is inactive on dermatitic rats.

There is still a lot of research devoted to this compound(SMILES：OC1=C(C)C(CO)=CN=C1C.[H]Cl)Reference of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, and with the development of science, more effects of this compound(148-51-6) can be discovered.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia