Month: April 2022

Cabello-Sanchez, Noemi; Jean, Ludovic; Maddaluno, Jacques; Lasne, Marie-Claire; Rouden, Jacques published the article 《Palladium-mediated N-arylation of heterocyclic diamines: insights into the origin of an unusual chemoselectivity》. Keywords: palladium arylation heterocyclic diamine chemoselectivity.They researched the compound: Piperidin-4-amine dihydrochloride( cas:35621-01-3 ).Recommanded Product: 35621-01-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:35621-01-3) here.

The chemoselectivity of the palladium-mediated reaction of bromobenzene with various heterocyclic diamines was studied. Whatever the ligand used, 3-aminopyrrolidine underwent arylation of the secondary amine function (>82%), whereas the more flexible 3-aminoazepine was arylated on its primary function (>70%). The ratio “”arylation of primary amine vs. arylation of secondary amine”” of 3-aminopiperidine with bromobenzene varied from 90:10 (BINAP, electron-enriched and hindered biphenyls L2 or L3) to 32:68 with the Josiphos-type ligand L10. The same trend was observed when 4-aminopiperidine was used (82:18 with L2 and 17:83 with L10). This selectivity can be tuned by the choice of aryl halide partners having different steric and electronic properties. A cooperative effect of both nitrogens of diamines during the reaction was deduced from competitive experiments Finally, 13C and 31P NMR experiments, carried out with 3-aminopyrrolidine at room temperature, support a fast coordination of the primary amine to the metal. Indeed, a palladium complex resulting from the unusual displacement of one phosphine group of the intermediate ArPdX(BINAP) by the primary amino group was characterized.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Singh, Nitesh; Mansoori, Aadil; Jiwani, Gitanjali; Solanke, Amolkumar U.; Thakur, Tarun K.; Kumar, Rakesh; Chaurasiya, Mona; Kumar, Anirudh published the article 《Antioxidant and antimicrobial study of Schefflera vinosa leaves crude extracts against rice pathogens》. Keywords: Xanthomonas Magnaporthe Schefflera leaf histone deacetylase antioxidant antimicrobial.They researched the compound: 5-Methylfuran-2(3H)-one( cas:591-12-8 ).Application In Synthesis of 5-Methylfuran-2(3H)-one. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:591-12-8) here.

Plant extracts are one of the best possible sources of bioactive mols., and are being used globally as an antioxidants and natural antimicrobial compounds In current study, Schefflera vinosa leaves extract was prepared through Soxhlet extraction procedure using methanol and chloroform as solvents. The extract was investigated for total antioxidant, phenolic and flavonoid contents, free radical scavenging and antimicrobial activities. The free radical scavenging activities were evaluated through 2,2- diphenyl-1-picrylhydrazyl (DPPH), 2,2-azino-bis-3-ethylbenzotiazolin-6-sulfonic acid (ABTS) and Ferric-reducing/ antioxidant power (FRAP) assay. The antimicrobial activity of extract was determined through poisoned food method. The methanolic extract has exhibited high antioxidant, phenolic, and flavonoid activities compared to chloroform extract Similarly, free radical scavenging activities (ABTS, DPPH and FRAP) were higher in methanolic extract Further, Fourier-Transform IR Spectroscopy (FTIR) used to determine the functional group and Gas chromatog.-mass spectrometry (GC-MS) to elucidate volatile composition of the crude extract Different functional group like N-H, O-H, C-O, C-N, C-H, C=O, C≃C and C-O-H presence indicate the existence of many metabolites in the extracts GC-MS study identified 61 compounds and subsequently, these mols. were screened virtually using DockThor. Furthermore, antimicrobial study was confirmed against rice pathogens like Magnaporthe oryzae (M. oryzae) and Xanthomonas oryzae pv. oryzae (Xoo). Mol. docking study further suggested that phytomols. (3-Isopropoxy-1,1,1,7,7,7-hexamethyl-3,5,5-tris (trimethylsiloxy) tetrasiloxane, and 2-Methoxy-5-methylthiophene) targets Histone Deacetylase (HDAC) of M. oryzae and Peptide Deformylase (PDF) of Xoo, which could inhibit their growth. Hence, this study indicated that Schefflera vinosa extracts could be an important ingredient as an antioxidant as well as antimicrobial agent against rice pathogens.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Quality Control of 5-Methylfuran-2(3H)-one. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Methylfuran-2(3H)-one, is researched, Molecular C5H6O2, CAS is 591-12-8, about Humins with Efficient Electromagnetic Wave Absorption: A By-Product of Furfural Conversion to Isopropyl Levulinate via a Tandem Catalytic Reaction in One-Pot. Author is Ma, Mingwei; Liang, Na; Hou, Pan; Zhang, Peng; Cao, Jingjie; Liu, Hui; Xu, Xingliang; Yue, Huijuan; Tian, Ge; Feng, Shouhua.

Both one-pot catalytic conversion of furfural (FAL) to iso-Pr levulinate (PL) and carbonization of byproduct (humins) for electromagnetic wave absorption are discussed, which provides inspiration that humins can be applied to electromagnetic wave absorption. In the former, phosphotungstic acid (PW) is employed as a homogeneous catalyst to convert FAL to PL via a tandem reaction in one pot, with the formation of a vast amount of humins. With FAL and various intermediates as substrates, it was found that humins was a polymerization product of FAL, furfuryl alc. (FOL) and furfuryl ester (FE) with furan rings. In addition, the in situ attenuated total reflection IR (ATR-IR) spectra also provided a basis for the proposed reaction route. In the latter, with the humins as raw material, P species and WO3 doped nano-porous carbon (Humins-700) platform formed after high-temperature annealing is used for electromagnetic wave absorption and manifests desirable absorption performance. The min. reflection loss (RLmin) value is -47.3 dB at 13.0 GHz with a thickness of 2.0 mm and the effective absorption bandwidth reaches 4.5 GHz (11.2-5.7 GHz).

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Pyridoxine chemistry. IV. Proton magnetic resonance spectra of compounds in the vitamin B6 group》. Authors are Korytnyk, W.; Singh, R. P..The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).Application of 148-51-6. Through the article, more information about this compound (cas:148-51-6) is conveyed.

cf. CA 58, 5622h. The proton magnetic resonance (p.m.r.) spectra of compounds in the vitamin B6 group have been determined in D2O solution, and the proton peaks have been assigned on the basis of comparison with several analogs of pyridoxol (I). Considerable changes in p.m.r. spectra have been observed in acid, neutral, and alk. solutions and have been rationalized on the basis of the electronic properties of the various ionic forms. A facile base-catalyzed deuterium exchange has been observed in I derivatives in which the heterocyclic N is quaternized. The nature of the aldehyde group in pyridoxal and in pyridoxal phosphate has been elucidated.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Product Details of 18436-73-2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 4-Chloro-8-methylquinoline, is researched, Molecular C10H8ClN, CAS is 18436-73-2, about Nucleophilic substitution reaction of chloroquinolines with 1,2,4-triazole. I. Synthesis of 4-(1H-1,2,4-triazol-1-yl)quinolines. Author is Korodi, Ferenc.

Synthesis of 4-(1H-1,2,4-triazol-1-yl)quinolines by the reaction of 4-chloroquinolines with 1,2,4-triazole was studied under neutral, acidic and basic reaction conditions. The significant role of acid and base catalysis as well as substituent effects on the reactivity of 4-chloroquinolines in these reactions are reported.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Preparation of 5-hydroxy-4,6-dimethyl-3-pyridinemethanol (4-deoxypyridoxine) by the use of hydrazine》. Authors are Taborsky, Robert G..The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).Reference of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride. Through the article, more information about this compound (cas:148-51-6) is conveyed.

2-Methyl-3-hydroxy-4-methoxymethyl-5-hydroxymethylpyridine-HCl (10 g.) and 50 ml. 95% N2H4 refluxed 18 hrs., most of the N2H4 removed in vacuo, and the residue extracted with 60 ml. refluxing MeOH yielded N2H4.HCl, m. 91-2°. The volume of the filtrate reduced to 20 ml., 15 ml. 11.2% MeOH-HCl added, the precipitate isolated, and 50 ml. Et2O added gave a further precipitate The total yield was 8.1 g. 2-methyl-3-hydroxy-4-methyl-5-hydroxymethylpyridine-HCl (I), m. 273° (decomposition). All conditions and isolation procedures were as above except that instead of the 4-Me ether, 5 g. pyridoxine-HCl and 25 ml. 95% N2H4 were used to give 98% I.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Gao, Zengrong published the article 《Separation and identification of water-soluble vitamins and vitamin B6 analogs》. Keywords: vitamin identification chromatog spectrometry TLC; liquid chromatog vitamin identification; IR spectrometry vitamin identification; UV spectrometry vitamin identification.They researched the compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride( cas:148-51-6 ).SDS of cas: 148-51-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:148-51-6) here.

Vitamin B12  [68-19-9], vitamin B1  [59-43-8], folic acid  [59-30-3], calcium pantothenate  [137-08-6], rutin  [153-18-4], vitamin C  [50-81-7], vitamin B2  [83-88-5], nicotinamide  [98-92-0], nicotinic acid  [59-67-6], p-aminobenzoic acid  [150-13-0], pyridoxal 5-phosphate  [54-47-7], pyridoxol-HCl  [58-56-0], pyridoxamine-2HCl  [524-36-7], pyridoxal-HCl  [65-22-5], and 4-deoxypyridoxol-HCl  [148-51-6] were identified by TLC (using various solvent systems), high-performance liquid chromatog., IR and UV spectrophotometry. Characteristics (Rf values, retention times, absorbances) of these compounds are tabulated.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 591-12-8, is researched, SMILESS is O=C1OC(C)=CC1, Molecular C5H6O2Journal, Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov’t, Non-P.H.S., Organic Letters called Construction of Enantioenriched γ,γ-Disubstituted Butenolides Enabled by Chiral Amine and Lewis Acid Cascade Cocatalysis, Author is Yu, Chenguang; Ji, Peng; Zhang, Yueteng; Meng, Xiang; Wang, Wei, the main research direction is butenolide preparation enantioselective regioselective chemoselective; alkynoic acid aldehyde tandem cyclization amine Lewis catalyst.COA of Formula: C5H6O2.

A cascade cocatalysis strategy for the facile construction of chiral γ,γ-disubstituted butenolides I (R1 = Me, Et; R2 = Ph, 1-naphthyl, 2-furyl, etc.) has been described. The synthetic manifold employs simple alkynoic acids R1CCCH2C(O)2H instead of the preformed silyloxy furans or 5-substituted furan-2(3H)-ones II. In situ formed 5-substituted furan-2(3H)-ones II by AgNO3 or Ph3PAuCl/AgOTf catalyzed cyclization of alkynoic acids can smoothly engage in the subsequent chiral diphenylprolinol TMS-ether catalyzed Michael and Michael-aldol reactions. The cascade process serves as a general approach to chiral quaternary γ,γ-disubstituted butenolides I.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

HPLC of Formula: 18436-73-2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 4-Chloro-8-methylquinoline, is researched, Molecular C10H8ClN, CAS is 18436-73-2, about Synthesis and antimicrobial activity of novel substituted ethyl 2-(quinolin-4-yl)-propanoates. Author is Khan, M. Akram; Miller, Keith; Rainsford, Kim Drummond; Zhou, Yong.

4-Hydroxyquinolines were synthesized from anilines and EtOCH:C(CO2Et)2 by Gould-Jacobs reaction via cyclization of the intermediate (anilinomethylene)malonate followed by hydrolysis and decarboxylation. The 4-hydroxyquinolines reacted with POCl3 to form 4-chloroquinolines, which reacted on heating with Na+MeC-(CO2Et)2 in DMF to yield moderate yields of 2-(quinolin-4-yl)propanoates, many of which showed potent antimicrobial activity against Helicobacter pylori.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of 2-ethylthioisonicotinamide》. Authors are Gustak, E.; Koruncev, D.; Gluncic, B..The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).Recommanded Product: 148-51-6. Through the article, more information about this compound (cas:148-51-6) is conveyed.

2-Ethylisonicotinaldehyde diethylacetal (I), b14 125-8°, was prepared in 61% yield from EtBr 112.2, Mg 33, 2-ethyl-4-bromopyridine 62, tri-Et orthoformate 180, and NH4Cl 215 g. Hydrolysis of 15.3 g. I with 150 ml. 10% HCl gave 83% free aldehyde (II), b20 92-5°; hydrazone m. 46-8°; thiosemicarbazone m. 215-16°. Willgerodt reaction of 0.75 g. II with 0.16 g. S in 30 ml. pyridine and 20 ml. NH3 yielded 56.5% of 2-ethylthioisonicotinoylamide.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia