Month: March 2022

Application of 43024-61-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 43024-61-9, name is Ethyl 7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

(b) Ethyl 4,7-dihydro-4-ethyl-7-oxo-pyrazolo[1,5-a]pyrimidine-6-carboxylate4 A mixture of ethyl 7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylate (2.07g, 10mM), anhydrous potassium carbonate (1.38g, 10mM) and ethyl iodide (2.34g, 15mM) in dry N,N-dimethylformamide (50ml) was heated under reflux for 5 hours. The reaction mixture was evaporated in vacuo to given an oil, which was dissolved in water (50ml) and the pH adjusted to 1.0 with 5N hydrochloric acid. The solution was extracted with chloroform and dried over anhydrous magnesium sulphate. The chloroform extract was evaporated in vacuo and the residue was recrystallized from acetone. Yield 980 mg (41.7%). m.p. 164-5 C. delta (DMSO-d6), STR43 4.36 (4H, q, –CH2 CH3), 1.45 (3H, t, –CH2 CH3), 1.33 (3H, t, –CH2 CH3); numax (nujol) 17.12 (ester C=O), 1680 (lactam C=O)cm-1 (Found: C, 56.21; H, 5.67; N, 18.13%. C11 H13 N3 O3 requires C, 56.12; H, 5.57; N, 17.80%).

According to the analysis of related databases, 43024-61-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Beecham Group Limited; US4081545; (1978); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 392326-81-7 ,Some common heterocyclic compound, 392326-81-7, molecular formula is C10H8BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound 8a (12.5 g, 50.0 mmol), 2-bromo-2-phenylacetophenone (16.5 g, 60.0 mmol), NaHCO3(5.04g, 60.0mmol) were dissolved in isopropanol (100 mL), refluxed and Stir for 12h.The isopropanol was removed by rotary evaporation in vacuo, and then dichloromethane (60 mL) and water (30 mL) were added to the solid residue.After the organic phase was separated, it was washed twice with saturated saline.The solvent was removed by vacuum rotary evaporation, and the residue was purified by silica gel chromatography to obtain solid compound 8b (13.2 g, 31.0 mmol) in a yield of 62%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 392326-81-7, 4-(4-Bromophenyl)pyrimidin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shenzhen Huaxing Optoelectric Semiconductor Display Co., Ltd.; Wang Shipan; (37 pag.)CN110357882; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 59864-30-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59864-30-1, name is 2,6-Dimethoxypyrimidine-4-carboxylic acid, molecular formula is C7H8N2O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 43 Preparation of (S)-3-[(2,6-dimethoxy-pyrimidine-4-carbonyl)-amino]-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophene-2-carbonyl]-amino}-propionic acid (S)-3-amino-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophene-2-carbonyl]-amino}-propionic acid methyl ester (HCl salt) (100 mg, 0.23 mmol) was dissolved in DMF (2.5 ml) and the following reagents were successively added at rt: 2,6-dimetoxy-pyrimidine-4-carboxylic acid (47 mg, 0.26 mmol), triethylamine (0.10 ml, 0.70 mmol), HOBT (38 mg, 0.28 mmol), and HBTU (110 mg, 0.28 mmol). The mixture was stirred at rt for 1 h, then quenched with 1N HCl and extracted with EtOAc. The layers were separated. The organic layer was successively washed with water and brine, then dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by flash chromatography with 50-100% EtOAc in hexane to afford the desired methyl ester (60 mg, 46% yield). This ester was dissolved in THF/water (2 ml/1 ml) and treated with LiOH.H2O (44 mg, 1.0 mmol) at 40 C. for 40 min. The mixture was quenched with 1N HCl and concentrated. The crude was purified by reverse phase HPLC to afford the desired product (39 mg, 72% yield). MS m/e 544.0 (M+H+).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 59864-30-1, 2,6-Dimethoxypyrimidine-4-carboxylic acid.

Reference:
Patent; Gillespie, Paul; Michoud, Christophe; Rupert, Kenneth Carey; Thakkar, Kshitij Chhabilbhai; US2012/238569; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 60025-06-1, Adding some certain compound to certain chemical reactions, such as: 60025-06-1, name is 1-(4,6-Dichloropyrimidin-5-yl)ethanone,molecular formula is C6H4Cl2N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 60025-06-1.

Step 2 – Synthesis of Compound 13B; Compound 13A (860 mg) was dissolved in DMF (5 mL) and to the resulting solution was added DIPEA (1.1 mL, 1.4 eq), followed by compound 12B (1.36 g, 1.4 eq). The resulting reaction was allowed to stir at room temperature under nitrogen atmosphere for 2.5 hours, then the reaction mixture was heated at 60 0C and allowed to stir at this temperature for an additional 19 hours. The reaction mixture was cooled to room temperature and concentrated in vacuo to provide a brown oily residue which was purified using flash column chromatography on silica gel to provide compound 13B (192 mg, 12%).

According to the analysis of related databases, 60025-06-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SCHERING CORPORATION; NEELAMKAVIL, Santhosh, Francis; BOYLE, Craig, D.; HARRIS, Joel, M.; STAMFORD, Andrew, W.; HAO, Jinsong; NEUSTADT, Bernardt, R.; CHACKALAMANNIL, Samuel; XIA, Yan; GREENLEE, William, J.; WO2010/9207; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 175277-33-5, 4-(Dimethoxymethyl)-2-methylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 175277-33-5, blongs to pyrimidines compound. Quality Control of 4-(Dimethoxymethyl)-2-methylpyrimidine

1.1.2 2-Methyl-pyrimidine-4-carbaldehyde oxime; To a solution of 4-dimethoxymethyl-2-methyl-pyrimidine (10 g) from 1.1.1 in methanol (100 ml.) was added 8.2 g of hydroxylamine hydrochloride and 10% HCI and the reaction mixture was heated under reflux for 2 h. After cooling to room temperature, the pH was adjusted to 8 using solid sodium carbonate. The mixture was stirred for 30 minutes. The solid was sucked off, dried at 500C under reduced pressure to yield 6.0 g (73%) of the title compound as white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,175277-33-5, its application will become more common.

Reference:
Patent; BASF SE; WO2008/62011; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 3438-61-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3438-61-7, name is 5-Amino-4-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

[00115] To the solution of methyl 4-(5-ethyl-2-(5-methylisoxazol-3-yl)thiazol-4-yl)benzoate (73 mg, 0.22 mmol) in toluene (4 mL) was added 4-methylpyrimidin-5-amine (46 mg, 0.42 mmol) and AlMe3 (2M solution in toluene, 0.21 mL, 0.42 mmol). The reaction was heated in microwave at 110C for 15 min before it was diluted with EtOAc (15 mL) and washed with IN NaOH (25 mL chi 2). The organic phase was dried over magnesium sulfate, filtered, and concentrated. Column chromatography gave Compound 6 in 73% yield. [00116] NMR (400 MHz, CDCls) delta 9.27 (s, 1H), 8.96 (s, 1H), 8.03 – 7.96 (m, 2H), 7.87 – 7.81 (m, 2H), 7.70 (s, 1H), 6.60 (d, / = 1.1 Hz, 1H), 3.07 (q, / = 7.5 Hz, 2H), 2.61 (s, 3H), 2.52 (d, / = 1.0 Hz, 3H), 1.42 (t, / = 7.5 Hz, 3H). ESMS cacld (C21H19N5O2S): 405.1; found: 406.3 (M+H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3438-61-7, 5-Amino-4-methylpyrimidine.

Reference:
Patent; SYNTA PHARMACEUTICALS CORP.; CHEN, Shoujun; ZHANG, Junyi; JIANG, Jun; KOWALCZYK-PRZEWLOKA, Teresa; XIA, Zhiqiang; ZHANG, Shijie; WO2013/63385; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 30129-57-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 30129-57-8, name is 6-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one, molecular formula is C6H6N4O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

6-Methyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one (134 mg, 0.89 mmol.) was taken into thionyl chloride (3 mL) followed by addition of DMF (0.2 mL) and the mixture was brought to reflux over 30 minutes. The resulting solution was concentrated and the residue partitioned with ethyl acetate and saturated aqueous sodium bicarbonate. The organic phase was washed with brine then dried over anhydrous sodium sulfate, filtered and concentrated to afford a yellow oil.

According to the analysis of related databases, 30129-57-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; EXELIXIS, INC.; WO2005/117909; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 557-01-7 ,Some common heterocyclic compound, 557-01-7, molecular formula is C4H4N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In a 250 mL three-necked flask,Compound 2 (11.5 g, 0.081 mol) was added,Then, 115 mL of dichloromethane was added successively,Thionyl chloride (17.6 mL, 0.24 mol) and a catalytic amount of N, N-dimethylformamide,Add the temperature to reflux and stir the reaction for 2 hours.Cooled to room temperature,Filter,Dichloromethane wash,dry,11.8 g of 6-chloromethyluracil was obtained in a yield of 90.8%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,557-01-7, its application will become more common.

Reference:
Patent; Shandong Chuangxin Pharmaceutical Research And Development Co., Ltd.; Jiang Hong; Lv Chuantao; Ma Chonglei; Lin Hongjie; Hao Lianfeng; Liu Yongyong; Lu Jingjing; (7 pag.)CN106831607; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 42821-92-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 42821-92-1, name is Methyl 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 94 In 60 ml. of water is suspended methyl 1,2,3,4-tetrahydro-2,4-dioxopyrimidine-5-carboxylate (2.55 g., 15.0 mmoles) and, under intense stirring at room temperature, chlorine gas is bubbled into the suspension. The reaction is complete when the solid has dissolved. Following addition of 10 ml. of concentrated hydrochloric acid, the reaction mixture is refluxed for 16 hours. It is then concentrated under reduced pressure to one-fifth of its initial volume to give 1.39 g. of 5-chlorouracil as pale yellow needles. Melting Point: above 300 C. UV spectrum: lambdamaxpH 1.0 274 nm, lambdamaxpH 7.0 275 nm. NMR spectrum (DMSO-d6) delta: 7.75(1H, d, J=6HZ), 11.17(1H, broad), 11.48(1H, broad). Elemental analysis, for C4 H3 ClN2 O2: Calcd.: C, 32.78; H, 2.06; N, 19.12; Cl, 24.20. Found: C, 32.54; H, 1.97; N, 19.02; Cl, 24.30.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 42821-92-1, Methyl 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US4329460; (1982); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 4472-44-0 ,Some common heterocyclic compound, 4472-44-0, molecular formula is C6H7ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Hydrazine monohydrate (1.02 mL, 21.0 mmol) was added to a solution of 2-chloro 4,6-dimethylpyrimidine (2 g, 14.0 mmol) in ethanol (5 mL). The mixture was allowed to stir at room temperature for 2 h. The precipitate that formed was collected by filtration and washed with methanol. The solid was allowed to dry in a stream of air to afford 1 g of 2- hydrazinyl-4,6-dimethylpyrimidine as a white solid (1 g). Yield: 52%; m/z (ESI+) 139 (MH+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4472-44-0, its application will become more common.

Reference:
Patent; PROTEOSTASIS THERAPEUTICS, INC.; TAIT, Bradley; POWELL, Noel, A.; CULLEN, Matthew; WO2012/154880; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia