Analyzing the synthesis route of 77232-38-3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 77232-38-3, 4-(Pyrimidin-2-yl)benzaldehyde, other downstream synthetic routes, hurry up and to see.

Application of 77232-38-3, Adding some certain compound to certain chemical reactions, such as: 77232-38-3, name is 4-(Pyrimidin-2-yl)benzaldehyde,molecular formula is C11H8N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 77232-38-3.

[0360] A mixture of 4-(2-pyrimidinyl)benzaldehyde (1.83 g, 9.94 mmol, prepared as described in WO 9828264), (1,3-dioxolan-2-ylmethyl)triphenylphosphonium bromide (6.45 g, 15.02 mmol), and TDA-1 (3.20 mL,10.00 mmol) in dichloromethane (50 mL) and sat. aq. K2CO3 (50 mL) was heated to reflux for 20 h. The layers were separated and the aqueous layer was extracted with dichloromethane (2×25 mL). The combined organic layers were washed with water (50 mL) and brine (50 mL), dried (MgSO4), and concentrated. THF (25 mL) and 10% HCl (25 mL) were added and the mixture was stirred for 1 h at rt. The mixture was cooled to 0 C., the precipitated solids were removed by filtration, washed with water and air-dried. Recrystallization from 2-propanol provided 1.20 g (57%) of the title compound as a light yellow solid. MS 211 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 77232-38-3, 4-(Pyrimidin-2-yl)benzaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Henninger, Todd C.; Macielag, Mark J.; Marinelli, Brett A.; Zhu, Bin; US2004/18994; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
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A new synthetic route of 830346-47-9

At the same time, in my other blogs, there are other synthetic methods of this type of compound,830346-47-9, 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.830346-47-9, name is 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione, molecular formula is C13H10F4N2O2, molecular weight is 302.22, as common compound, the synthetic route is as follows.Safety of 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione

To a 50 mL round botom flask was added AcOH (20 mL), compound IX (2 g) and N-Iodosuccinimide (1.5 g). The reaction mixture was heated to 50 °C for lh. After completion of the reaction, LLO (10 mL) was added to the reaction mixture. The resulting suspension was filtered. The cake was washed with MeOH (4 mL). The solid was slurried with MeOH (20 mL) to give the product as a white solid (2.3 g, 82percent yield, 96.1percent purity). NMR (400 MHz, DMSO-d6) d 11.75 (s, 1H), 77.67-7.61 (m, 1H), 7.59-7.50 (m, 2H), 5.39 (s, 1H), 2.56 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,830346-47-9, 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.

Reference:
Patent; WANG, Peng; LI, Pixu; GU, Xiangyong; YANG, Hailong; WANG, Zhong; JIANG, Qianghua; LIU, Yuanhua; XIA, Hui; (24 pag.)WO2019/112968; (2019); A1;,
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Brief introduction of 5807-14-7

According to the analysis of related databases, 5807-14-7, the application of this compound in the production field has become more and more popular.

Synthetic Route of 5807-14-7, Adding some certain compound to certain chemical reactions, such as: 5807-14-7, name is 2,3,4,6,7,8-Hexahydro-1H-pyrimido[1,2-a]pyrimidine,molecular formula is C7H13N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5807-14-7.

To a solution of 1, 3,6, 7, [8-HEXAHYDRO-2H-PYRIMIDO [1, 2-A] PYRIMIDINE] (5.6 g) in 80 mL of THF was added 3- (perfluorooctyl) propyl iodide (11.8 g) and triethylamine (2.6 mL). The mixture was stirred at [25 C] for 12 h. The precipitate was collected by filtration. The solid was mixed with 50 mL of 30% [NAOH,] extracted with EtOAc. The organic layer was concentrated to give desired product as a semisolid (3.8 g, 32%).

According to the analysis of related databases, 5807-14-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FLUOROUS TECHNOLOGIES INCORPORATED; WO2004/7407; (2004); A2;,
Pyrimidine | C4H4N2 – PubChem,
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Introduction of a new synthetic route about 14631-08-4

According to the analysis of related databases, 14631-08-4, the application of this compound in the production field has become more and more popular.

Synthetic Route of 14631-08-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14631-08-4, name is 2-Chloropyrimidine-4,5-diamine. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 6; (2-{4-[2-(Trifluoromethyl)phenoxylpiperidin-l-yl}-9H-purin-8-yl)methanol; Step 1: 2-{4-[2-(Trifluoromethyl)phenoxylpiperidin-l-yl}pyrimidine-4,5-diamine; A mixture of 2-chloropyrimidine-4,5-diamine (200 mg, 1.4 mmol), 4-[2- (trifluoromethyl)phenoxy]piperidine (0.4 mL, 1.6 mmol) and triethylamine (0.58 mL, 4.1 mmol) in 2-methoxyethanol/water (4:1, 2.8 mL) was heated at 13O 0C for 16 h. The solvent was evaporated, diluted with water (5 mL) and extracted three times with EtOAc (5 mL). The combined organic layers were dried over Na2SO4. Evaporation of the solvent followed by purification by Combiflash (SiO2, 5 % MeOeta/EtOAc) afforded the title compound as a solid. MS (+ESI) m/z 354 (MH+).

According to the analysis of related databases, 14631-08-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK FROSST CANADA LTD.; WO2008/17161; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
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Application of 5-Fluoro-2-methoxypyrimidin-4-amine

Statistics shows that 1993-63-1 is playing an increasingly important role. we look forward to future research findings about 5-Fluoro-2-methoxypyrimidin-4-amine.

Electric Literature of 1993-63-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1993-63-1, name is 5-Fluoro-2-methoxypyrimidin-4-amine, molecular formula is C5H6FN3O, molecular weight is 143.12, as common compound, the synthetic route is as follows.

1 Added 14.3 g to the reaction device4-amino-5-fluoro-2-methoxypyrimidine (0.10 mol),17.55gIsothiocyanatoFormic acidMethyl ester(0.15mol) and 100gEthyl acetate, stirring and warming to reflux, reaction 18h, unseparated[(2-Methoxy-5-fluoropyrimidin-4-yl)amino]thiocarbonylcarbamate methyl ester.Hydroxylamine hydrochloride aqueous sodium hydroxide solution is added to the reacted material[Contains 13.9g of hydroxylamine hydrochloride (0.20mol), 8g of sodium hydroxide (0.20mol)And 70g of water], after the addition of reflux reaction continued 6h.After the reaction is completed, it is lowered to room temperature (15 to 25C, the same below).Stirring, cooling, suction filtration, washing with water, and drying yield 16.8 g of pale yellow solid5-Methoxy-8-fluoro-[1,2,4]-triazolo[1,5-c]pyrimidin-2-amine,The yield was 91.8%.

Statistics shows that 1993-63-1 is playing an increasingly important role. we look forward to future research findings about 5-Fluoro-2-methoxypyrimidin-4-amine.

Reference:
Patent; Jiangsu Nongyong Hormone Engineering Technology Research Center Co., Ltd.; Nanjing Gaoheng Biological Technology Co., Ltd.; Kong Fanlei; Sun Yonghui; Zhang Yuanyuan; Shi Yueping; Gao Jianhong; (5 pag.)CN107602566; (2018); A;,
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New downstream synthetic route of 13053-88-8

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13053-88-8, its application will become more common.

Reference of 13053-88-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13053-88-8, name is N-(Pyrimidin-2-yl)acetamide. A new synthetic method of this compound is introduced below.

A solution of 2-acpym (0.0184 g, 0.134 mmol) in CH2Cl2 (5 ml) containing three drops of NEt3 was added to a yellow suspension of 1 (0.0395 g, 0.067 mmol) in CH2Cl2 (10 ml). The yellow solution was stirred for 3 h, filtered and slow evaporation at room temperature gave a yellow precipitate which was recrystallized from CH2Cl2 and MeOH to give a yellow powder (0.041 g, 71%). Anal. Calc. for C17H15ClN4OPd, 47.1, H, 3.5, N, 12.9. Found: C, 47.3, H, 3.4, N, 13.2% IR (KBr) 3330s, 3170s, 3278s, 1649s, 1562s, 460 s cm-1. 1H NMR (dmso-d6) delta 9.42 (d, 1H, J 4.0), 8.66 (d, 1H, J 4.0), 8.57 (s, 1H, NH), 8.47 (s, 1H), 7.84 (dd, 1H, J 7.9, 4.0), 7.67 (d, 1H, J 7.9), 7.47 (d, 1H, J 7.9), 7.19 (dd, 1H, J 4.0, 4.0), 7.13 (dd, 1H, J 7.9, 4.0), 6.97 (dd, 1H, J 7.9, 3.8), 6.78 (dd, 1H, J 4.0, 4.0), 6.31 (d, 1H, J 7.9), 1.63 (s, 3H). Mp 182-184 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13053-88-8, its application will become more common.

Reference:
Article; Al-Jibori, Subhi A.; Gergees, Hayfa M.; Al-Rubaye, Mousa S.; Basak-Modi, Sucharita; Ghosh, Shishir; Schmidt, Harry; Laguna, Mariano; Luquin, M. Asuncion; Hogarth, Graeme; Inorganica Chimica Acta; vol. 450; (2016); p. 50 – 56;,
Pyrimidine | C4H4N2 – PubChem,
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A new synthetic route of 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine

Statistics shows that 890094-38-9 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine.

Reference of 890094-38-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.890094-38-9, name is 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine, molecular formula is C7H9ClN4O2, molecular weight is 216.63, as common compound, the synthetic route is as follows.

4-morpholinophenylamine(3.6g) was added to a solution of Compound 2-3(4.3g) in n-butanol(150ml). The mixture was reacted at 90C for 4 hours, cooled to room temperature, filtered, washed and dried to obtain a red solid(5.3g) in a yield of 74.7%. MS m/z(ESI): 359[M+H]+.

Statistics shows that 890094-38-9 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine.

Reference:
Patent; Si Chuan University; CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; YANG, Shengyong; WEI, Yuquan; EP2578584; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
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The origin of a common compound about 5600-21-5

The synthetic route of 5600-21-5 has been constantly updated, and we look forward to future research findings.

Application of 5600-21-5 , The common heterocyclic compound, 5600-21-5, name is 4-Chloro-6-methylpyrimidin-2-amine, molecular formula is C5H6ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound 7 (1.5 g, 6.5 mmol) was dissolved in 40 ml of dichloromethane under argon, and aluminum chloride (4.4 g, 32.5 mmol) was slowly added portionwise.Then, pyridine (10.5 ml, 129.8 mmol) was gradually added to the above reaction liquid, and the mixture was heated under reflux in an oil bath at 45 C for 30 hours.The reaction was monitored by TLC until compound 7 was completely reacted.The reaction solution was cooled to room temperature, the pH of the reaction mixture was adjusted to 1 with 6M hydrochloric acid, and dichloromethane was evaporated under reduced pressure.The ether layer was washed with 1 M of dilute hydrochloric acid and saturated brine, and the ether layer was dried over anhydrous sodium sulfate.The crude product was recrystallized from ethyl acetate / n-hexane.1.3 g of solid compound 6, yield 96%.

The synthetic route of 5600-21-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sichuan University; Wu Yong; Hai Li; Zhang Yong; Cheng Xu; Guo Lingmei; Li Weijian; Zhan Zhen; (11 pag.)CN108191878; (2018); A;,
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Introduction of a new synthetic route about 1060815-89-5

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1060815-89-5, 7H-Pyrrolo[2,3-d]pyrimidine-5-carbaldehyde.

Electric Literature of 1060815-89-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1060815-89-5, name is 7H-Pyrrolo[2,3-d]pyrimidine-5-carbaldehyde, molecular formula is C7H5N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a O C solution of 7H-pyrrolo[2,3-djpyrimidine-5-carbaldehyde (5.41 g, 36.8mmol) and cesium carbonate (13.18 g, 40.4 mmol) in DMF (147 ml) was added tert-butyl 2-bromoacetate (5.90 ml, 40.4 mmol). The mixture was allowed to warm up to RT byremoving from ice bath. The reaction was stirred for 2 hs. The reaction was poured ontoice water (500 mL) and EtOAc (300 mL) mixture. The product was extracted in theEtOAc. The layers were separated and the aqueous phase was extracted a second time with EtOAc (2x 150 mL). The combined EtOAc layers were washed with brine. The organic layer was collected and dried over sodium sulfate and concentrated undervacuum. The crude product was purified by silica gel chromatography to get tert-butyl 2-(5-formyl-7H-pyrrolo[2,3-djpyrimidin-7-yl)acetate 6.60 g (69%) as clean product. ESIMS(-): MS m/z 262.0.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1060815-89-5, 7H-Pyrrolo[2,3-d]pyrimidine-5-carbaldehyde.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; MILLER, Michael Matthew; ALLEN, Martin Patrick; LI, Ling; BOWSHER, Michael S.; GILLIS, Eric P.; MULL, Eric; ZHAO, Qian; SUN, Li-Qiang; LANGLEY, David R.; SCOLA, Paul Michael; (214 pag.)WO2017/176608; (2017); A1;,
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Pyrimidine – Wikipedia

Sources of common compounds: 7-Chloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,923282-39-7, 7-Chloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidine, and friends who are interested can also refer to it.

Related Products of 923282-39-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 923282-39-7, name is 7-Chloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidine. A new synthetic method of this compound is introduced below.

Example 4: Preparation of N-[2-[3-methoxy-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl] ethyl]-1 – methyl-pyrazolo[4,3-d]pyrimidin-7-amine (1-10) To a solution of 2-[3-methoxy-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethanamine (0.39 g, 1 .2 mmol) in acetonitrile (30 ml.) was added triethylamine (1 .5 g, 4.8 mmol). The solution was stirred for 5 min at room temperature at which time 7-chloro-1 -methyl-pyrazolo[4,3-d]pyrimidine (0.25 g, 1 .2 mmol) was added. The reaction mixture was stirred at room temperature overnight. Water was added and was extracted with ethyl acetate (3x). The combined organic layers were washed with water, dried over Na2S04 and concentrated in vacuo. The residue was purified by HPLC to provide 85 mg (0.19 mmol, 17%) of the product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,923282-39-7, 7-Chloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; BASF SE; BASF SCHWEIZ AG; GRAMMENOS, Wassilios; CRAIG, Ian Robert; BOUDET, Nadege; MueLLER, Bernd; DIETZ, Jochen; LAUTERWASSER, Erica May Wilson; LOHMANN, Jan Klaas; MONTAG, Jurith; WO2013/113715; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia