Day: March 24, 2022

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 29509-91-9, name is 4-Chloro-2,6-diphenylpyrimidine. A new synthetic method of this compound is introduced below., Product Details of 29509-91-9

4-Chloro-2.6-diphenylpyrimidine (10.00g, 37.49mmol), 4′-bromo-4-biphenylboronic acid (10.34g, 37.35mmol), tetrakis (triphenylphosphine) palladium (2.15g, 1.87 mmol), potassium carbonate (10.32g, 74.70mmol), tetrabutylammonium chloride (0.43g, 1.86mmol), toluene (80mL), ethanol (40mL) and deionized water (20mL) were added to a round bottom flask, and nitrogen The temperature was increased to 78 C under protection and stirred for 10 hours. The reaction solution was cooled to room temperature, and toluene (300 mL) was added for extraction. The organic phases were combined, dried over anhydrous magnesium sulfate, filtered, and the solvent was removed under reduced pressure. The alkane was purified by silica gel column chromatography as a mobile phase, and then recrystallized from a dichloromethane / ethyl acetate system to obtain a white solid intermediate IF-1 (12.18 g, yield 84%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 29509-91-9, 4-Chloro-2,6-diphenylpyrimidine.

Reference:
Patent; Shanxi Laite Optoelectric Materials Co., Ltd.; Ma Tiantian; Yang Min; Nan Peng; (69 pag.)CN110615759; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1192813-64-1, name is 2-Chloro-5-(difluoromethoxy)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 1192813-64-1

16. Reaction of 2-chloro-5-(difluoromethoxy)pyrimidine with zinc cyanide, tris(dibenzylideneacetone)dipalladium(0), 1 , 1 ‘-bis(diphenylphosphino)ferrocene, and zinc dust in Lambda/,/V-dimethylacetamide at elevated temperature provided 5- (difluoromethoxy)pyrimidine-2-carbonitrile. This material was hydrolyzed with aqueous sodium hydroxide solution to afford the requisite 5-(difluoromethoxy)pyrimidine-2- carboxylic acid.

With the rapid development of chemical substances, we look forward to future research findings about 1192813-64-1.

Reference:
Patent; PFIZER INC.; BRODNEY, Michael Aaron; BECK, Elizabeth Mary; BUTLER, Christopher Ryan; ZHANG, Lei; O’NEILL, Brian Thomas; BARREIRO, Gabriela; LACHAPELLE, Erik Alphie; ROGERS, Bruce Nelsen; WO2015/155626; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 14248-01-2 ,Some common heterocyclic compound, 14248-01-2, molecular formula is C5H5BrN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 5-bromo-1-methylpyrimidin-2(1H)-one (S2, 1 equiv) in DMF/H2O (9:1, 10 vol) was added compound S1 (1 equiv), K2CO3(2 equiv), and tetrakis(triphenylphosphine)palladium (0.1 equiv). The reaction mixture was stirred at 90 C. for 5 h and then concentrated under reduced pressure. The remaining residue was purified by column chromatography on silica gel to give compound S3.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14248-01-2, its application will become more common.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAK, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; (905 pag.)WO2017/35353; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 77232-38-3, Adding some certain compound to certain chemical reactions, such as: 77232-38-3, name is 4-(Pyrimidin-2-yl)benzaldehyde,molecular formula is C11H8N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 77232-38-3.

[0360] A mixture of 4-(2-pyrimidinyl)benzaldehyde (1.83 g, 9.94 mmol, prepared as described in WO 9828264), (1,3-dioxolan-2-ylmethyl)triphenylphosphonium bromide (6.45 g, 15.02 mmol), and TDA-1 (3.20 mL,10.00 mmol) in dichloromethane (50 mL) and sat. aq. K2CO3 (50 mL) was heated to reflux for 20 h. The layers were separated and the aqueous layer was extracted with dichloromethane (2×25 mL). The combined organic layers were washed with water (50 mL) and brine (50 mL), dried (MgSO4), and concentrated. THF (25 mL) and 10% HCl (25 mL) were added and the mixture was stirred for 1 h at rt. The mixture was cooled to 0 C., the precipitated solids were removed by filtration, washed with water and air-dried. Recrystallization from 2-propanol provided 1.20 g (57%) of the title compound as a light yellow solid. MS 211 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 77232-38-3, 4-(Pyrimidin-2-yl)benzaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Henninger, Todd C.; Macielag, Mark J.; Marinelli, Brett A.; Zhu, Bin; US2004/18994; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.830346-47-9, name is 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione, molecular formula is C13H10F4N2O2, molecular weight is 302.22, as common compound, the synthetic route is as follows.Safety of 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione

To a 50 mL round botom flask was added AcOH (20 mL), compound IX (2 g) and N-Iodosuccinimide (1.5 g). The reaction mixture was heated to 50 °C for lh. After completion of the reaction, LLO (10 mL) was added to the reaction mixture. The resulting suspension was filtered. The cake was washed with MeOH (4 mL). The solid was slurried with MeOH (20 mL) to give the product as a white solid (2.3 g, 82percent yield, 96.1percent purity). NMR (400 MHz, DMSO-d6) d 11.75 (s, 1H), 77.67-7.61 (m, 1H), 7.59-7.50 (m, 2H), 5.39 (s, 1H), 2.56 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,830346-47-9, 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.

Reference:
Patent; WANG, Peng; LI, Pixu; GU, Xiangyong; YANG, Hailong; WANG, Zhong; JIANG, Qianghua; LIU, Yuanhua; XIA, Hui; (24 pag.)WO2019/112968; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 5807-14-7, Adding some certain compound to certain chemical reactions, such as: 5807-14-7, name is 2,3,4,6,7,8-Hexahydro-1H-pyrimido[1,2-a]pyrimidine,molecular formula is C7H13N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5807-14-7.

To a solution of 1, 3,6, 7, [8-HEXAHYDRO-2H-PYRIMIDO [1, 2-A] PYRIMIDINE] (5.6 g) in 80 mL of THF was added 3- (perfluorooctyl) propyl iodide (11.8 g) and triethylamine (2.6 mL). The mixture was stirred at [25 C] for 12 h. The precipitate was collected by filtration. The solid was mixed with 50 mL of 30% [NAOH,] extracted with EtOAc. The organic layer was concentrated to give desired product as a semisolid (3.8 g, 32%).

According to the analysis of related databases, 5807-14-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FLUOROUS TECHNOLOGIES INCORPORATED; WO2004/7407; (2004); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 14631-08-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14631-08-4, name is 2-Chloropyrimidine-4,5-diamine. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 6; (2-{4-[2-(Trifluoromethyl)phenoxylpiperidin-l-yl}-9H-purin-8-yl)methanol; Step 1: 2-{4-[2-(Trifluoromethyl)phenoxylpiperidin-l-yl}pyrimidine-4,5-diamine; A mixture of 2-chloropyrimidine-4,5-diamine (200 mg, 1.4 mmol), 4-[2- (trifluoromethyl)phenoxy]piperidine (0.4 mL, 1.6 mmol) and triethylamine (0.58 mL, 4.1 mmol) in 2-methoxyethanol/water (4:1, 2.8 mL) was heated at 13O 0C for 16 h. The solvent was evaporated, diluted with water (5 mL) and extracted three times with EtOAc (5 mL). The combined organic layers were dried over Na2SO4. Evaporation of the solvent followed by purification by Combiflash (SiO2, 5 % MeOeta/EtOAc) afforded the title compound as a solid. MS (+ESI) m/z 354 (MH+).

According to the analysis of related databases, 14631-08-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK FROSST CANADA LTD.; WO2008/17161; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1993-63-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1993-63-1, name is 5-Fluoro-2-methoxypyrimidin-4-amine, molecular formula is C5H6FN3O, molecular weight is 143.12, as common compound, the synthetic route is as follows.

1 Added 14.3 g to the reaction device4-amino-5-fluoro-2-methoxypyrimidine (0.10 mol),17.55gIsothiocyanatoFormic acidMethyl ester(0.15mol) and 100gEthyl acetate, stirring and warming to reflux, reaction 18h, unseparated[(2-Methoxy-5-fluoropyrimidin-4-yl)amino]thiocarbonylcarbamate methyl ester.Hydroxylamine hydrochloride aqueous sodium hydroxide solution is added to the reacted material[Contains 13.9g of hydroxylamine hydrochloride (0.20mol), 8g of sodium hydroxide (0.20mol)And 70g of water], after the addition of reflux reaction continued 6h.After the reaction is completed, it is lowered to room temperature (15 to 25C, the same below).Stirring, cooling, suction filtration, washing with water, and drying yield 16.8 g of pale yellow solid5-Methoxy-8-fluoro-[1,2,4]-triazolo[1,5-c]pyrimidin-2-amine,The yield was 91.8%.

Statistics shows that 1993-63-1 is playing an increasingly important role. we look forward to future research findings about 5-Fluoro-2-methoxypyrimidin-4-amine.

Reference:
Patent; Jiangsu Nongyong Hormone Engineering Technology Research Center Co., Ltd.; Nanjing Gaoheng Biological Technology Co., Ltd.; Kong Fanlei; Sun Yonghui; Zhang Yuanyuan; Shi Yueping; Gao Jianhong; (5 pag.)CN107602566; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 13053-88-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13053-88-8, name is N-(Pyrimidin-2-yl)acetamide. A new synthetic method of this compound is introduced below.

A solution of 2-acpym (0.0184 g, 0.134 mmol) in CH2Cl2 (5 ml) containing three drops of NEt3 was added to a yellow suspension of 1 (0.0395 g, 0.067 mmol) in CH2Cl2 (10 ml). The yellow solution was stirred for 3 h, filtered and slow evaporation at room temperature gave a yellow precipitate which was recrystallized from CH2Cl2 and MeOH to give a yellow powder (0.041 g, 71%). Anal. Calc. for C17H15ClN4OPd, 47.1, H, 3.5, N, 12.9. Found: C, 47.3, H, 3.4, N, 13.2% IR (KBr) 3330s, 3170s, 3278s, 1649s, 1562s, 460 s cm-1. 1H NMR (dmso-d6) delta 9.42 (d, 1H, J 4.0), 8.66 (d, 1H, J 4.0), 8.57 (s, 1H, NH), 8.47 (s, 1H), 7.84 (dd, 1H, J 7.9, 4.0), 7.67 (d, 1H, J 7.9), 7.47 (d, 1H, J 7.9), 7.19 (dd, 1H, J 4.0, 4.0), 7.13 (dd, 1H, J 7.9, 4.0), 6.97 (dd, 1H, J 7.9, 3.8), 6.78 (dd, 1H, J 4.0, 4.0), 6.31 (d, 1H, J 7.9), 1.63 (s, 3H). Mp 182-184 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13053-88-8, its application will become more common.

Reference:
Article; Al-Jibori, Subhi A.; Gergees, Hayfa M.; Al-Rubaye, Mousa S.; Basak-Modi, Sucharita; Ghosh, Shishir; Schmidt, Harry; Laguna, Mariano; Luquin, M. Asuncion; Hogarth, Graeme; Inorganica Chimica Acta; vol. 450; (2016); p. 50 – 56;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 890094-38-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.890094-38-9, name is 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine, molecular formula is C7H9ClN4O2, molecular weight is 216.63, as common compound, the synthetic route is as follows.

4-morpholinophenylamine(3.6g) was added to a solution of Compound 2-3(4.3g) in n-butanol(150ml). The mixture was reacted at 90C for 4 hours, cooled to room temperature, filtered, washed and dried to obtain a red solid(5.3g) in a yield of 74.7%. MS m/z(ESI): 359[M+H]+.

Statistics shows that 890094-38-9 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine.

Reference:
Patent; Si Chuan University; CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; YANG, Shengyong; WEI, Yuquan; EP2578584; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia