Month: September 2021

Reference of 1193-24-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1193-24-4, name is 4,6-Dihydroxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

With a reflux condenser, thermometer,In the device of the agitator and the constant pressure dropping funnel,Add 4,6-dihydroxypyrimidine (114.3 g, content 98%, 1 mol), phosphorus oxychloride (1140 g, 99%) and mix well.The temperature was raised to 95-100 C, and phosgene (220 g, 99%, 2.2 mol) was slowly added to carry out the reaction, and the sample was taken after 8 hours.HPLC analysis of 4,6-dihydroxypyrimidine content of 0.9%,The content of 4,6-dichloropyrimidine was 98.3%, and the reaction was over.Vacuum distillation reaction mixture (oil bath temperature 95 C,Vacuum degree -0.095MPa),Obtained 1082 g of phosphorus oxychloride (content 99%); 142.8 g of 4,6-dichloropyrimidine (content 99.0%),Yield 94.9% (based on 4,6-dihydroxypyrimidine), wherein W (DCP) refers to the mass of DCP, and W (DHP) refers to the mass of DHP.The content refers to the mass content of DCP, and 112 is the molecular weight of DHP.149 is the molecular weight of DCP.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1193-24-4, 4,6-Dihydroxypyrimidine.

Reference:
Patent; Lianyungang Guosheng Chemical Co., Ltd.; Xu Chen; Zhu Guoqing; Zhang Xin; Zhou Tulin; (6 pag.)CN108178749; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2565-47-1, name is 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, molecular formula is C5H6N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 2565-47-1

General procedure: A mixture of compound 4a (1 mmol, 245 mg) and 5a (1 mmol, 156 mg) was taken in a round bottomed flask containing ethanol (5 ml). To this, catalytic amount of diisopropylethylamine (DIPEA) was added and the reaction mixture was stirred at room temperature for 1 h. The solid formed in the reaction process was filtered and purified by washing with ethanol and dried. The structure of the compound was ascertained as 6a from spectroscopic data.

With the rapid development of chemical substances, we look forward to future research findings about 2565-47-1.

Reference:
Article; Borah, Pallabi; Bhuyan, Pulak J.; Tetrahedron Letters; vol. 54; 50; (2013); p. 6949 – 6951;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 32779-36-5, Adding some certain compound to certain chemical reactions, such as: 32779-36-5, name is 5-Bromo-2-chloropyrimidine,molecular formula is C4H2BrClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 32779-36-5.

Step 1: tent-Butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate Into a 200 mL pressure flask equipped with a magnetic stir bar was added tert-butyl piperazine-1-carboxylate (4.8 g, 25.8 mmol), 5-bromo-2-chloropyrimidine (5.0 g, 25.8 mmol) and 2-propanol (50 mL). DIPEA (5.0 mL, 28.4 mmol) was added, the vial was sealed and the reaction mixture heated to 120 C. for 1 h. The cooled reaction mixture was poured into a 250 mL separatory funnel containing water (125 mL) and extracted with EtOAc (3*75 mL). The combined organic layers were washed with brine, dried over MgSO4, filtered and concentrated. Recrystallization from EtOAc (about 40 mL) and hexanes (about 150 mL) at -78 C. afforded crystals which were collected by filtration through filter paper on a Hirsch funnel under vacuum.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 32779-36-5, 5-Bromo-2-chloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Isabel, Elise; Lachance, Nicolas; Leclerc, Jean-Philippe; Leger, Serge; Oballa, Renata M.; Powell, David; Ramtohul, Yeeman K.; Roy, Patrick; Tranmer, Geoffrey K.; Aspiotis, Renee; Li, Lianhai; Martins, Evelyn; US2011/301143; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 28485-17-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 28485-17-8, name is 5-Carbethoxyuracil, molecular formula is C7H8N2O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a 100 ml three-necked flask was added ethyl uracil-5-carboxylate (2.2 g, 11.95 mmol)N, N-dimethylaniline (2 g, 16.50 mmol).Under ice bath, phosphorus oxychloride (9.2 g, 60 mmol) was gradually added and stirred continuously.After the addition of 10 minutes, gradually heating 110 C, and insulation 3h reaction.The reaction solution was slowly poured into an ice-water mixture (100 ml) and quenched and kept at a temperature below 5 C. And extracted twice with ethyl acetate (200 ml).The organic phases were combined, washed with saturated brine, dried and concentrated to give the crude product.The crude product was purified by column chromatography to give 1.8 g of solid in 68% yield.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 28485-17-8, 5-Carbethoxyuracil.

Reference:
Patent; SUZHOU WANGSHAN WANGSHUI BIOMEDICAL CO LTD; TOPHARMAN SHANGHAI CO LTD; SHANDONG TOPHARMAN PHARMACEUTICAL CO LTD; TIAN, GUANGHUI; LI, JUNQI; (17 pag.)CN104650045; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 38275-56-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 38275-56-8, name is 5-Chloropyrimidine-2-carbonitrile, molecular formula is C5H2ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of 5-chloropyrimidine-2-carbonitrile (4.9 g, 35.5 mmol, 1 equiv) in MeOH (10 mL) was added HCl/MeOH (4 mol/L, 155 mL, 620.0 mmol, 17.5 equiv) at 0C. The mixture was stirred at 65C overnight. The reaction mixture was concentrated and the residue was charged with Na2CCh (10% aq., 50 mL), extracted with DCM (3*50 mL). The combined organic phase was washed with brine, dried over anhydrous Na2S04 and concentrated in vacuo. The residue was purified by reverse phase HPLC (eluted with MeOfWLO = 5/95 ~ 95/5) to afford the title compound methyl 5-chloropyrimidine-2- carboxylate as a white solid (3.0 g, 49.0% yield). H NMR (400 MHz, DMSO-de) d: 9.12 (s, 2 H), 3.92 (s, 3 H). LC-MS: m/z 173.0 (M+H)+

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 38275-56-8, 5-Chloropyrimidine-2-carbonitrile.

Reference:
Patent; ANNAPURNA BIO INC.; TANG, Haifeng; BOYCE, Sarah; HANSON, Michael; NIE, Zhe; (213 pag.)WO2019/169193; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1753-50-0, name is 2-Chloropyrimidine-5-carbonitrile. A new synthetic method of this compound is introduced below., Computed Properties of C5H2ClN3

To a stirred solution of compound FO (0.5 g, 3.02 mmol) in ethanol (10 mL), 2-chloropyrimidine-5-carbonitrile (AF, 0.5 g, 3.63 mmol) and DIPEA (2.63 mL, 15.1 mmol) were added and the reaction mixture was heated to 90C for 12 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using 30% EtOAc/hexane to afford compound FP (0.2 g, 24.6%) as a pale yellow solid. LC-MS: m/z 269.03 [M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1753-50-0, 2-Chloropyrimidine-5-carbonitrile.

Reference:
Patent; VPS-3, INC.; YATES, Christopher, M.; (397 pag.)WO2018/165520; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 65-71-4, 5-Methylpyrimidine-2,4(1H,3H)-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 5-Methylpyrimidine-2,4(1H,3H)-dione, blongs to pyrimidines compound. Application In Synthesis of 5-Methylpyrimidine-2,4(1H,3H)-dione

Thymine (T) was purchased from Sigma Aldrich and K2S2O8from SRL. All the solutions were prepared with water purified by Cascada Lab Water Systems and of resistivity 18.2M Omega cm. The sulfate radicals were produced by the UV-photolysis of peroxide asreported elsewhere [39]. The solution containing T (10-4 M) and K2S2O8 (10-3 M) was subjected to UV irradiation at a wavelength of 254 nm for about 2 min. The solution was then directly subjected to UPLC-ESI-CID analysis.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,65-71-4, 5-Methylpyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.

Reference:
Article; Chandran, Jisha; Vishnu; Aravind, Usha K.; Aravindakumar; International Journal of Mass Spectrometry; vol. 443; (2019); p. 53 – 60;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 785777-90-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 785777-90-4, name is 5-Bromo-4-(trifluoromethyl)pyrimidin-2(1H)-one, molecular formula is C5H2BrF3N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The title compound was prepared using a modified procedure based on Ondi, L. et al., Eur. J. Org. Chem. 2 A mixture of 4-(trifluoromethyl)pyrimidin-2-ol (6.05g, 36.9mmol), KOAc (10.85g, 3eq.), acetic acid (80mL), and bromine (5.9g, leq.) was heated for 2h at 80 C. After being cooled to rt, the mixture was concentrated. The residue was partitioned between EtOAc and water. The aqueous layer was extracted with EtOAc (2x). The combined organic layers were washed with brine, dried over Na2S04. After filtration and concentration, the crude white solid product (9.38g, quant, yield) was used for next steps without further purification. A mixture of 5-bromo-4-(trifluoromethyl)pyrimidin-2-ol (1.35g, 5.56mmol), POCI3 (15mL), and DMF(2 drops, cat. Amount) was heated for 2h at 80 C. The mixture was cooled to 0 C by ice/water bath. Some ice pellets were added to the stirred mixture (exotherm). After stirring for 20min. (the ice added should have melted), some sat. aq. NaHCC”3 (c.a. 15mL) was added carefully to neutralize some acid. The mixture was extracted with hexanes (3x). The combined organic layers were washed with brine, dried over Na2S04. After filtration and concentration (by rotavapor only The product is volatile), 5-bromo-2- chloro-4-(trifluoromethyl)pyrimidine, as a clear oil (1.32g, 91% yield) was used as crude for next steps without further purification.

According to the analysis of related databases, 785777-90-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; VITAE PHARMACEUTICALS, INC.; DONG, Chengguo; FAN, Yi; LEFTHERIS, Katerina; LOTESTA, Stephen; SINGH, Suresh, B.; TICE, Colin; ZHAO, Wei; ZHENG, Yajun; ZHUANG, Linghang; WO2013/138568; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 7461-50-9, 2-Chloropyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C4H4ClN3, blongs to pyrimidines compound. Formula: C4H4ClN3

To a glass vial was added (4-methoxyphenyl)boronic acid (0.15 g, 1.0 mmol), 2-chloropyrimidin- 4-amine (0.13 mg, 1.0 mmol), Pd(Amphos)2Cl2 (35 mg, 0.050 mmol), a 2M solution of Na2C03 (0.75 mL, 1.5 mmol) and acetonitrile (2.5 mL). The mixture was degassed by nitrogen bubbling for 20 min. The reaction vial was sealed and stirred at 110 C in an oil bath for 2 h. The reaction mixture was cooled to room temperature, filtered and concentrated. The crude product was purified by flash chromatography on silica to give the title compound (141 mg, 70%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7461-50-9, 2-Chloropyrimidin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; GENENTECH, INC.; BRYAN, Marian C.; CHAN, Bryan; HANAN, Emily; HEFFRON, Timothy; PURKEY, Hans; ELLIOTT, Richard Leonard; HEALD, Robert; KNIGHT, Jamie; LAINCHBURY, Michael; SEWARD, Eileen M.; WO2014/81718; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 916420-27-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 916420-27-4, name is tert-Butyl 2,4-dichloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate, molecular formula is C12H15Cl2N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Benzyl 1-piperazinecarboxylate (1.268 mL, 6.575 mmol) and tert-Butyl 2,4-dichloro-5,6-dihydropyrido[3 4-d]pyrimidine-7(8H)-carboxylate (2 g, 6.575 mmol) were dissolved in dimethyl acetamide (10 mL) and treated with N-ethyl-N-isopropylpropan-2-amine (3.445 mL, 19.73 mmol). The reaction mixture was stirred at 85° C. for 2 hours. The reaction mixture was cooled to room temperature, diluted with ethyl acetate, washed with water and brine, dried over MgSO 4, filtered and concentrated. The concentrate was purified by chromatography (CombiFlash , 0%-50% ethyl acetate:Hexanes as the eluent to provide the product (2.69 g, 83%). ES+APCI MS m/z 488.2, 490.2 [M+H] +.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 916420-27-4, tert-Butyl 2,4-dichloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate.

Reference:
Patent; Mirati Therapeutics, Inc.; Array BioPharma Inc.; Blake, James F.; Burgess, Laurence E.; Chicarelli, Mark Joseph; Christensen, James Gail; Cook, Adam; Fell, Jay Bradford; Fischer, John P.; Marx, Matthew Arnold; Mejia, Macedonio J.; Savechenkov, Pavel; Vigers, Guy P.A.; Smith, Christopher Ronald; Rodriguez, Martha E.; US2019/144444; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia