Day: September 22, 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1193-21-1, name is 4,6-Dichloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4,6-Dichloropyrimidine

4,6-Dichloropyrimidine (190 mg, 1.28 mmol, 1.0 equiv.),157 mg p-anisidine (1.27 mmol, 1.0 equiv.), and 180 mg N,N-diisopropylethylamine (1.39 mmol, 1.1 equiv.) were introduced into a Falcon tube, dissolved in NMP, and filled up to a volume of 12.7 cm3 with NMP. The solution was reacted according to general procedure A at 160 Cusing a 4 cm3 coil at a flow rate of 0.5 cm3/min. Crude product was purified as described for the batch synthesis giving pyrimidine 1 as a white, fluffy solid in 81 % yield (243 mg, 1.03 mmol).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1193-21-1, 4,6-Dichloropyrimidine.

Reference:
Article; Schoen, Michael; Dreier, Dominik; Schnuerch, Michael; Mihovilovic, Marko D.; Monatshefte fur Chemie; vol. 147; 3; (2016); p. 523 – 532;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 81560-03-4, Adding some certain compound to certain chemical reactions, such as: 81560-03-4, name is 5-Bromo-2-(methylthio)pyrimidin-4(3H)-one,molecular formula is C5H5BrN2OS, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 81560-03-4.

Example 11 Synthetic route

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 81560-03-4, 5-Bromo-2-(methylthio)pyrimidin-4(3H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ZHOU, Changyou; ZOU, Wuxin; HUA, Yuxia; DANG, Qun; WO2011/133444; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 16357-83-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16357-83-8, name is 4-Aminopyrimidine-5-carbaldehyde, molecular formula is C5H5N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Appropriate substituted benzoyl hydrazine 4 (1 equiv) was added to a solution of intermediate 2 (1mmol) in ethanol (10mL). The reaction mixture was stirred for 3h at reflux under the condition of the presence of acetic acid as catalyzer, then poured into cold water and the resulting solid was collected by filtrated, washed with EtOH (10mL), and dried in the atmospheric pressure to give the desired title compounds A, B, and C.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 16357-83-8, 4-Aminopyrimidine-5-carbaldehyde.

Reference:
Article; He, Haifeng; Xia, Hongying; Xia, Qin; Ren, Yanliang; He, Hongwu; Bioorganic and Medicinal Chemistry; vol. 25; 20; (2017); p. 5652 – 5661;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.157335-93-8, name is 4,6-Dimethylpyrimidine-5-carboxylic acid, molecular formula is C7H8N2O2, molecular weight is 152.15, as common compound, the synthetic route is as follows.name: 4,6-Dimethylpyrimidine-5-carboxylic acid

step 9-To a mixture of A-5a (98 mg, assuming 100% purity, 0.21 mmol), 4,6-dimethyl-pyrimidine-5-carboxylic acid (48 mg, 0.32 mmol), EDCI (92 mg, 0.42 mmol), HOBt hydrate (65 mg, 0.48 mmol) at RT were added sequentially DCM (6 mL) and DIPEA (0.67 mL, 3.8 mmol). The mixture was stirred at RT overnight, quenched with saturated aqueous NaHCO3, and extracted with EtOAc. The combined extracts were dried (Na2SO4), filtered, and concentrated in vacuo. The residue was purified on a preparative SiO2 chromatography plate and developed with a solution of 60% DCM and 40% DCM/MeOH/28% aqueous NH4OH (60:10:1) to afford 40 mg of A-1 as a white powder: MS calc’d for C35H58N5O3 [M+H]+ 596; Found, 596.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,157335-93-8, 4,6-Dimethylpyrimidine-5-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; Roche Palo Alto LLC; US2009/281133; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 862730-04-9, name is 3-Iodo-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 3-Iodo-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Synthesis of 1-isopropyl-3-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (BA48); A solution of (4-Methoxyphenylboronic acid (17 mg, 0.11 mmol) in EtOH (3.3 ml) was added to a solution of 3-iodo-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (30 mg, 0.10 mmol) in DME (12 ml). Pd(PPh3)4 (30 mg, 0.03 mmol) and saturated Na2CO3 (1.9 ml) were added and the reaction was heated to 80 C. under an argon atmosphere overnight. After cooling, the reaction was extracted with saturated NaCl and CH2Cl2. Organic phases were combined, concentrated in vacuo and purified by RP-HPLC (MeCN:H2O:0.1% TFA) to yield BA48 (4.5 mg, 16% yield). ESI-MS (M+H)+ m/z calcd 284.1, found 284.1.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 862730-04-9, 3-Iodo-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine.

Reference:
Patent; Regents of the University of California; US2007/293516; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5751-20-2, name is 2-(Methylthio)pyrimidin-4(3H)-one. A new synthetic method of this compound is introduced below., Product Details of 5751-20-2

B) 2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4(3H)-one To a solution of 2-(methylsulfanyl)pyrimidin-4(3H)-one (5.2 g) obtained in Step A in diethylene glycol dimethyl ether (50 mL) was added 1-methyl-1H-pyrazol-4-amine (4.1 g), the mixture was stirred overnight at 150°C, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/methanol) to give the title compound (5.4 g). 1H NMR(300 MHz, DMSO-d6) delta 3.79 (3H, s), 5.62-5.78 (1H, m), 7.45 (1H, s), 7.63-7.78 (1H, m), 7.89 (1H, s), 8.47-8.75 (1H, m), 10.77 (1H, dd, J = 15.5, 8.7 Hz). MS (ESI+) : [M+H]+192.1.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5751-20-2, 2-(Methylthio)pyrimidin-4(3H)-one.

Reference:
Patent; Takeda Pharmaceutical Company Limited; TSUKAMOTO, Tetsuya; OHBA, Yusuke; YUKAWA, Takafumi; NAGAMIYA, Hiroyuki; KAMEI, Taku; TOKUNAGA, Norihito; SAITOH, Morihisa; OKABE, Atsutoshi; EP2832734; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16490-02-1, name is Pyrimidine-4,6-dicarboxylic acid. A new synthetic method of this compound is introduced below., category: pyrimidines

Dimethyl pyrimidine-4,6-dicalpharboxylalphate (llalpha)To a heated solution (75C) of 4,6-dimethylpyrimidine (846 mg, 8.00 mmol) and NaOH (211 mg, 5.28 mmol) in water (3 mL) was added a solution OfKMnO4 (5.28 g in 25 mL water) overl5 min. The resulting mixture was stirred at 80C for 3 hrs. The hot solution was filtered hot and manganese dioxide washed with hot water (8 mL). The filtrate and washings were concentrated to 5 mL and acidified with cone. HCl to pH 2-3. After cooling, the precipitation was collected, yielding 591 mg of crude pyridine-4,6-dicarboxylic acid. The diacid was then dissolved in MeOH (15 mL) and cone. H2SO4 (1.5 mL) was added dropwise carefully. The mixture was refluxed for 24 hrs, cooled to room temperature and concentrated in vacuo. The resultant oily residue was neutralised with sat. NaHCO3 and extracted with EtOAc (3 x 30 mL). The combined organic extracts were washed with H2O (50 mL) and brine (5OmL), dried over Na2SO4, filtered and concentrated. The product was then purified by column chromatography (petroleum ether 40-60 : EtOAc 5 : 5 to 3 :7) yielding 311 mg (20%) of 11 a as a white solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 16490-02-1, Pyrimidine-4,6-dicarboxylic acid.

Reference:
Patent; ISIS INNOVATION LIMITED; SCHOFIELD, Christopher, Joseph; MCDONOUGH, Michael; ROSE, Nathan; THALHAMMER, Armin; WO2010/43866; (2010); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 3680-69-1, Adding some certain compound to certain chemical reactions, such as: 3680-69-1, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine,molecular formula is C6H4ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3680-69-1.

A mixture of compound Int-4-1 (14.5 g, 94.42 mmol, 1 eq.) and Selectfluor (50.17 g, 141.63 mmol, 1.5 eq.) was addedACN (725 mE),AcOH (152.25 g, 2.54 mol, 145 mE, 26.85 eq.) and degassed and purged with N2 for 3 times, and then the mixture was stirred at 70 C. for 16 hr under N2 atmosphere. ECMS showed no compound Int-4-1 was remained. Several new peaks were shown on ECMS and 45% of desired compound was detected. The reaction mixture was concentrated under reduced pressure to remove solvent. The residue was diluted with toluene (200 mE) and concentrated under reduced pressure to remove solvent twice. The residue was purified by column chromatography (Si02, petroleum ether/ethyl acetate=30/1 to 8/1) to give compound Int-4 (10 g, 54.46 mmol, 57.68% yield, ECMS purity 93.43%) as a yellow solid. ?H NMR (400 MHz, DMSO-d5) oe ppm 12.49 (br s, 1H) 8.55-8.67 (m, 1H) 7.71 (t, J=2.63 Hz, 1H); ECMS: (M+Hj: 171.9.

According to the analysis of related databases, 3680-69-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Prelude Therapeutics, Incorporated; Lin, Hong; Luengo, Juan; Shetty, Rupa; Hawkins, Michael; (96 pag.)US2019/48014; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1004-40-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1004-40-6, name is 6-Amino-4-hydroxy-2-mercaptopyrimidine, molecular formula is C4H5N3OS, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of 0.174 g of 3-methyl-1-phenyl-2-pyrazoline-5-one (1, 1.0 mmol), 0.150 g of 4-chlorobenzaldehyde (2,1 mmol), 0.160 g of 6-amino-2-thiouracil (3, 1 mmol) and 9.8 mm3 of piperidine as a catalyst (10%) in 8 cm3 of ethanol in a 100-cm3 round-bottomed flask fitted with areflux condenser was heated with stirring in an oil bath maintained at 80 C. After the complete appearance of the white solid and monitored by TLC, the reaction mixture was cooled to room temperature and resulting solid product was filtered, washed with ethanol to give products 4a-4r.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1004-40-6, 6-Amino-4-hydroxy-2-mercaptopyrimidine.

Reference:
Article; Bayat, Mohammad; Nasri, Shima; Mohammadali, Mohammad Reza; Monatshefte fur Chemie; vol. 148; 10; (2017); p. 1833 – 1842;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 914802-11-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 914802-11-2, name is 4-((Benzyloxy)methyl)-6-chloropyrimidine, molecular formula is C12H11ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a 5-L 4-neck round bottom flask equipped with a mechanical stirrer, a thermometer, a heating mantle, a reflux condenser and a nitrogen inlet, was charged at 23 C, 5-hydroxyindole (1 , 257.7g, 1.94 mol) and acetonitrile (3 L). The dark mixture was stirred for 15 min. The internal temperature decreased to 15 C. In one portion, 4- (benzyloxymethyl)-6-chloropyrimidine (2, 386.6g, 1.65mol) was added. The flask was rinsed with acetonitrile (2 x 50 ml_) which was added to the batch. The reaction mixture was warmed to 20 C, and 1 ,8-diazabicyclo[5.4.0]undec-7-ene (DBU) (380g, ~376ml_, 2.5 mol) was added drop wise via an addition funnel over 25 min. The reaction mixture turned from a yellow-tan slurry into a dark solution and was heated at an internal temperature of 64 – 66 C for 18h. The reaction mixture was concentrated at a bath temperature of 50 C to remove the majority of the acetonitrile. The residue was diluted with methyl t-butyl ether (MTBE)(1.5 L) and water (1.2 L). The layers were separated and the aqueous layer was extracted with MTBE (2 x 500 ml_). The organic layers were combined and washed with water (800 ml_), 0.5 N sodium hydroxide solution (800 ml_) and a mixture of saturated sodium chloride solution (500 ml_) and water (100 ml_). The organic layer wasconcentrated at a bath temperature of 50 C to afford crude 5-(6- (benzyloxymethyl)pyrimidin-4-yloxy)-1 H-indole (3, 707 g, >100%) as a dark viscous liquid which was used in the next step without further purification.

According to the analysis of related databases, 914802-11-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; GLAENZEL, Ulrike; NUFER, Robert; WO2014/184778; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia