Day: June 11, 2021

Reference of 944129-00-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 944129-00-4, name is Methyl 6-amino-2-chloropyrimidine-4-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of methyl 6-amino-2-chloropyrimidine-4-carboxylate (260 mg, 1.39 mmol, 1.00 equiv) and 2-bromo-1,1-dimethoxyethane (1.1 g, 6.51 mmol, 4.00 equiv) in acetonitrile (6 mL) was irradiated with microwave radiation for 1 h at 120 C. The solids were collected by filtration to give the title compound (162 mg, 55%) as an off-white solid. LC-MS (ES, m/z): 212 [M+H].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 944129-00-4, Methyl 6-amino-2-chloropyrimidine-4-carboxylate.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BLAQUIERE, Nicole; BURCH, Jason; CASTANEDO, Georgette; FENG, Jianwen A.; HU, Baihua; LIN, Xingyu; STABEN, Steven; WU, Guosheng; YUEN, Po-wai; WO2015/25026; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 58536-46-2 ,Some common heterocyclic compound, 58536-46-2, molecular formula is C22H15BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

11.9 g (34 mmol) of 4-(4-bromophenyl)-2,6-diphenylpyrimidine are dissolved in 300 ml of THF and subsequently cooled to -100 C. 22 ml (38 mmol) of a 1.6M solution of n-butyllithium in hexane are slowly added dropwise to the reaction mixture with stirring. The reaction mixture is stirred for 30 min. 200 ml (34 mmol) of a solution of 2-bromo-1,3-diphenyl-2,3-dihydro-1H-benzo-1,3,2-diazaborole in toluene are subsequently added dropwise. The reaction mixture is warmed to 0 C. over a period of 4 h, then 600 ml of ethanol are added dropwise. The precipitated solid is recrystallised from toluene and subsequently sublimed. Yield: 11 g (60% of theory, purity >99.9%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 58536-46-2, 4-(4-Bromophenyl)-2,6-diphenylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Merck Patent GmbH; Mujica-Fernaud, Teresa; Parham, Amir Hossain; Stoessel, Philipp; Pflumm, Christof; Buesing, Arne; Eberle, Thomas; (30 pag.)US10032992; (2018); B2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 56-09-7, 2-Amino-6-hydroxypyrimidin-4(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 56-09-7, blongs to pyrimidines compound. SDS of cas: 56-09-7

a 2-Amino-4,6-dichloro-pyrimidine-5-carbaldehyde Following the method of Bell et al. (J. Heterocyclic Chem. 1983, 20, 41), to 97.0 ml (1.06 mol) phosphorus oxychloride in a 2-necked flask cooled to 5 C. was added dropwise with stirring 32.5 ml (0.42 mol) DMF. The mixture was allowed to warm to room temperature and then 25.0 g (0.20 mol) 2-amino-4,6-dihydroxy-pyrimidine was added in small portions over 30 minutes. The reaction mixture was then heated at 100 C. for 4.5 hours before being poured cautiously onto water cooled to 10 C. and left standing at room temperature overnight. The resulting crystals were collected by filtration, and extracted with 4*450 ml hot ethyl acetate.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56-09-7, its application will become more common.

Reference:
Patent; Borroni, Edilio Maurizio; Huber-Trottmann, Gerda; Kilpatrick, Gavin John; Norcross, Roger David; US2001/27196; (2001); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 3524-87-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3524-87-6, name is 6-Methylpyrimidin-4(3H)-one, molecular formula is C5H6N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To 70 g (0.64 mol) A-1 in acetic acid is added 127 g (0.56 mol) NIS portion wise at RT within 15 min. The reaction is stirred at RT until all starting material is consumed (30 h). The reaction mixture is diluted with water and the solid product is filtered off, washed with an aqueous sodium thiosulfate solution to remove excess iodine and dried in vacuo. Yield: 90 g (60%).

According to the analysis of related databases, 3524-87-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WUNBERG, Tobias; KRAEMER, Oliver; van der VEEN, Lars; US2013/23533; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 330786-24-8 , The common heterocyclic compound, 330786-24-8, name is 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, molecular formula is C17H13N5O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediate 4 A mixture of about 60.67 g (0.2 mol) of (S) -2- (hydroxymethyl) piperidine-1-carboxylic acid tert-(0.3 mol) was dissolved in 360 mL of THF while 78.698 (0.3 1 01) triphenylphosphine was added. (0.3mol) of diisopropyl azodicarboxylate and 300mL of tetrahydrofuran solution, lh drop complete system slowly warming up to 30 C insulation reaction 24h, the system temperature to 0-5 (: After the reaction was complete, the solvent was evaporated, and 450 mL of methylene chloride (DCM) was added. The mixture was stirred at room temperature for 10 min, filtered, and the filtrate was bubbled with hydrogen chloride gas. The mixture was stirred for 4 h. After the reaction was complete, The organic layer was washed with 5% sodium hydrogencarbonate solution to neutral and then saturated brine, and the organic layer was dried and filtered to dryness to obtain about 62.18 g of intermediate 5 in a yield of 80.45%.

The synthetic route of 330786-24-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jiangsu Zhongbang Pharmacy Limited Company; Li, Weisi; Huang, Shuang; Wu, Xiaogang; Yang, Jian; Chen, Guoping; Liu, Liping; (14 pag.)CN105859728; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 42754-96-1, name is 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine. A new synthetic method of this compound is introduced below., Product Details of 42754-96-1

A mixture of Compound IA (94.5 mg, 0.5 mmol) and sulfanilamide Compound IB (161.8 mg, 0.6 mmol) in dioxane (5 mL) was refluxed overnight; and was cooled to room temperature. The yellow precipitate was collected by filtration and was separated by HPLC to give Compound 1 as a pale yellow solid (70 mg, 41% based on TFA salt). 1H NMR ((CD3)2CO) delta 10.10 (s, IH), 9.70 (s, IH), 8.22 (s, IH), 8.20 (d, 2H), 8.00 (d, 2H), 7.80 (d, 2H), ), 7.75 (d, 2H), 7.30 (s, 2H), 7.15 (s, 2H); MS 461 (M-HH+), 483 (M+Na+).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 42754-96-1, 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2008/39359; (2008); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 62802-38-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 62802-38-4, name is 5-Bromo-2-fluoropyrimidine. A new synthetic method of this compound is introduced below.

General procedure: 5-Bromo-2-fluoropyridine (0.5 mmol), an N-heterocyclic amine (1.0 mmol) and K2CO3 (1.0 mmol) were added to a 25-mL Schlenk tube, followed by addition of DMSO (2 mL). The reaction mixture was heated to 70 C for 24 h under air atmosphere. Then, the reaction mixture was added to brine (15 mL) and this mixture was extracted with CH2Cl2 (3 × 15 mL). The combined extracts were concentrated under reduced pressure and the product was isolated by flash chromatography on a silica gel (200-300 mesh) column.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,62802-38-4, its application will become more common.

Reference:
Article; Tao, Sheng; Ji, Enhui; Shi, Lei; Liu, Ning; Xu, Liang; Dai, Bin; Synthesis; vol. 49; 23; (2017); p. 5120 – 5130;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 33034-67-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.33034-67-2, name is 2-Chloro-4-(trifluoromethyl)pyrimidine, molecular formula is C5H2ClF3N2, molecular weight is 182.531, as common compound, the synthetic route is as follows.

Step 7: To a solution of l-isopropyl-7-(methylthio)-l,2,3,4-tetrahydropyrazino[l,2-a]indole (50 mg, 0.19 mmol) in ‘PrOH (2 mL) was added 2-chloro-4-(trifluoromethyl)pyrimidine (105 mg, 0.58 mmol) and DIEA (185 mg, 0.96 mmol). The mixture was stirred at 100 °C for 4 h. The mixture was concentrated under vacuum and the residue was purified by preparative TLC to afford l-isopropyl-7-(methylthio)-2-(4-(trifluoromethyl)pyrimidin-2-yl)-l,2,3,4- tetrahydropyrazino[l,2-a]indole (45 mg, 57.7percent yield) as a yellow oil.LC-MS MS (ESI) m/z 407.1 [M + H]+.

Statistics shows that 33034-67-2 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-4-(trifluoromethyl)pyrimidine.

Reference:
Patent; VITAE PHARMACEUTICALS, INC.; DONG, Chengguo; FAN, Yi; LEFTHERIS, Katerina; LOTESTA, Stephen; SINGH, Suresh, B.; TICE, Colin; ZHAO, Wei; ZHENG, Yajun; ZHUANG, Linghang; WO2013/138565; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 7752-72-9, 5-Chloro-6-methylpyrimidin-4(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 5-Chloro-6-methylpyrimidin-4(3H)-one, blongs to pyrimidines compound. Application In Synthesis of 5-Chloro-6-methylpyrimidin-4(3H)-one

2) The Preparation of Intermediate 4,5-dichloro-6-methylpyrimidine 50 ml of POCl3 was added dropwise to a solution of 14.5 g (0.1 mol) of 4-hydroxyl-5-chloro-6-methylpyrimidine in 50 mL of toluene, the mixture was refluxed for 5-7 h after addition. After the reaction was over by Thin-Layer Chromatography monitoring, the reaction mixture was concentrated under reduced pressure to remove toluene and extra POCl3, and then poured into ice water. The water phase was extracted with ethyl acetate (3*50 ml), the organic phases were emerged, dried over anhydrous magnesium sulfate, filtered and then concentrated under reduced pressure. The residue was purified through silica column to give 14.43 g as yellow liquid with yield of 88.5%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7752-72-9, 5-Chloro-6-methylpyrimidin-4(3H)-one, and friends who are interested can also refer to it.

Reference:
Patent; SINOCHEM CORPORATION; Liu, Changling; Guan, Aiying; Lan, Jie; Wang, Lizeng; Wang, Bin; Zhu, Minna; Sun, Qin; Ren, Weijing; Feng, Cong; Ren, Lanhui; Chai, Baoshan; Li, Zhinian; US2015/225378; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 7627-44-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7627-44-3, name is 2,4-Dichloro-5-(iodomethyl)pyrimidine, molecular formula is C5H3Cl2IN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 2,4-dichloro-5-(iodomethyl)pyrimidine 2 (7.0 g, 24.2 mmol), 2,6- dimethylaniline (3.8 g, 31.4 mmol), K2CO3 (5.0 g, 36.2 mmol) in acetone (60 mL) was stirred at 55 C overnight. The solvent was removed and the residue was extracted with EtOAc (150 mL x 3). The combined organic phase was washed with brine (80 mL x 3), dried with Na2S04, filtered, and concentrated. The residue was purified by column chromatography on silica gel (petroleum ether / EtOAc = 8/1, 4/1, 1/1) to get N-((2,4-dichloropyrimidin-5- yl)methyl)-2,6-dimethylaniline 3 as a light brown solid (4.5 g, yield 66%). LCMS (m/z): 282.3 [M + H]+.

According to the analysis of related databases, 7627-44-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE GENERAL HOSPITAL CORPORATION; DANA-FARBER CANCER INSTITUTE, INC.; MURAKAMI, Ryo; FISHER, David, E.; MUJAHID, Nisma; GRAY, Nathanael, S.; (0 pag.)WO2018/160774; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia